The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream

Title: The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream
Creator: Magnus, Ashley D
Creator: Haigh, John M
Creator: Kanfer, Isadore
Date Issued: 1981
Date: 1981
Type: Article
Identifier: vital:6397
Identifier: http://hdl.handle.net/10962/d1006322
Description: Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate@ (betamethasone 17-valerate, 0.1 %) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
Format: 7 pages
Format: pdf
Language: English
Relation: Magnus, A.D. and Haigh, J.M. and Kanfer, I. (1981) The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream. Dermatologica, 163 . pp. 331-337.

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Kanfer, Isadore (Prof)

RU Department of Pharmacy

Haigh, JM (Prof)

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