A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection

Title: A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection
Creator: Stubbs, Christopher
Creator: Haigh, John M
Creator: Kanfer, Isadore
Date Issued: 1987
Date: 1987
Type: Article
Identifier: vital:6430
Identifier: http://hdl.handle.net/10962/d1006592
Description: A simple, sensitive and reliable high-performance liquid chromatographic procedure has been developed for the determination of erythromycin in human serum and urine using amperometric detection. A solid-phase extraction procedure was used followed by chromatography on a reverse-phase column. The mean recovery of erythromycin from serum and urine was 80%. This method allows both erythromycin and its principle degradation product, anhydroeythromycin, to be determined during a period of sample storage at 4 degree C and minus 15 degree C. The method is sufficiently sensitive and precise and is thus highly suited for use in both pharmacokinetic and stability studies.
Format: 11 pages
Format: pdf
Language: English
Relation: Stubbs, C. and Haigh, J.M. and Kanfer, I. (1987) A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection. Journal of Liquid Chromatography, 10 (11). pp. 2547-2557. Available: http://dx.doi.org/10.1080/01483918708068934

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Kanfer, Isadore (Prof)

RU Department of Pharmacy

Haigh, JM (Prof)

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