A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat

Title: A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat
Creator: Skeef, Noel S
Creator: Duncan, John R
Date Issued: 1988
Date: 1988
Type: Article
Identifier: vital:6473
Identifier: http://hdl.handle.net/10962/d1006154
Identifier: http://dx.doi.org/10.1079/BJN19880052
Description: The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.
Format: 6 pages
Format: pdf
Language: English
Relation: Skeef, N.S. and Duncan, J.R. (1988) A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat. British Journal of Nutrition, 59 (3). pp. 437-442. Available: http://dx.doi.org/10.1079/BJN19880052

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RU Department of Biochemistry, Microbiology and Biotechnology

Duncan, John (Prof Emeritus)

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