Analysis of macrolide antibiotics

Kanfer, Isadore; Skinner, Michael F; Walker, Roderick B

Title: Analysis of macrolide antibiotics
Creator: Kanfer, Isadore
Creator: Skinner, Michael F
Creator: Walker, Roderick B
Date Issued: 1998
Date: 1998
Type: Article
Type: text
Identifier: vital:7011
Identifier: http://hdl.handle.net/10962/d1008394
Identifier: http://www.sciencedirect.com/science/article/pii/S0021967398002763
Description: The following macrolide antibiotics have been covered in this review: erythromycin and its related substances, azithromycin, clarithromycin, dirithromycin, roxithromycin, flurithromycin, josamycin, rokitamycin, kitasamycin, mycinamycin, mirosamycin, oleandomycin, rosaramicin, spiramycin and tylosin. The application of various thin-layer chromatography, paper chromatography, gas chromatography, high-performance liquid chromatography and capillary zone electrophoresis procedures for their analysis are described. These techniques have been applied to the separation and quantitative analysis of the macrolides in fermentation media, purity assessment of raw materials, assay of pharmaceutical dosage forms and the measurement of clinically useful macrolide antibiotics in biological samples such as blood, plasma, serum, urine and tissues. Data relating to the chromatographic behaviour of some macrolide antibiotics as well as the various detection methods used, such as bioautography, UV spectrophotometry, fluorometry, electrochemical detection, chemiluminescence and mass spectrometry techniques are also included.
Format: 49 pages
Format: pdf
Language: English
Relation: Kanfer, I. and Skinner, M.F. and Walker, R.B. (1998) Analysis of macrolide antibiotics. Journal of Chromatography A, 812 (1/2). pp. 255-286. ISSN 0021-9673. Available: http://www.sciencedirect.com/science/article/pii/S0021967398002763

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RU Biopharmaceutics Research Unit (BRU)

Walker, Roderick Bryan (Prof)

Kanfer, Isadore (Prof)

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