Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance

Kadye, Rose; Kramer, Adam H

Title: Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance
Creator: Kadye, Rose
Creator: Kramer, Adam H
Creator: Joos-Vandewalle, Julia
Creator: Parsons, Michelle
Creator: Njengele, Zikhona
Creator: Hoppe, Heinrich C
Creator: Prinsloo, Earl
Subject: To be catalogued
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/431119
Identifier: vital:72745
Identifier: xlink:href="https://doi.org/10.1002/iub.1234"
Description: Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (3 pages)
Format: pdf
Publisher: Wiley
Language: English
Relation: IUBMB Life
Relation: Kadye, R., Kramer, A.H., Joos‐Vandewalle, J., Parsons, M., Njengele, Z., Hoppe, H. and Prinsloo, E., 2014. Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance. IUBMB life, 66(1), pp.42-45
Relation: IUBMB Life volume 66 number 1 p. 62 2014 1521-6551
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Wiley Library Online Terms of Use Statement (https://onlinelibrary.wiley.com/terms-and-conditions)
Rights: Closed Access

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Prinsloo, Earl (Dr)

RU DST/NRF SARChI for Biotechnology Innovation and Engagement

Hoppe, Heinrich C (Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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