Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

Managa, Muthumuni; Amuhaya, Edith; Nyokong, Tebello

Title: Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)
Creator: Managa, Muthumuni
Creator: Amuhaya, Edith
Creator: Nyokong, Tebello
Date Issued: 2015
Date: 2015
Type: Article
Identifier: vital:7296
Identifier: http://hdl.handle.net/10962/d1020359
Description: (5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1) was conjugated to platinum nanoparticles (PtNPs) (represented as 1-PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared to 1 alone. Complex 1 and 1-PtNPs showed promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus, Escherichia coli and Candida albicans in solution where the log reductions obtained were 4.92, 3.76, and 3.95, respectively for 1-PtNPs. The singlet oxygen quantum yields obtained were higher at 0.56 for 1-PtNPs in DMF while that of 1 was 0.52 in the same solvent. This resulted in improved PACT activity for 1-PtNPs compared to 1 alone.
Description: Original publication is available at http://dx.doi.org/10.1016/j.saa.2015.06.088
Format: 8 pages
Format: pdf
Publisher: Elsevier
Language: English
Relation: Managa, M., Amuhaya, E. K. & Nyokong, T. 2015. Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 151:867–874. Available: http://dx.doi.org/10.1016/j.saa.2015.06.088.

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Nyokong, Tebello (Distinguished Professor)