Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors

Olomola, Temitope O; Klein, Rosalyn; Lobb, Kevin A; Sayed, Yasien; Kaye, Perry T

Title: Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors
Creator: Olomola, Temitope O
Creator: Klein, Rosalyn
Creator: Lobb, Kevin A
Creator: Sayed, Yasien
Creator: Kaye, Perry T
Subject: To be catalogued
Date Issued: 2010
Date: 2010
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/448963
Identifier: vital:74774
Identifier: xlink:href="https://doi.org/10.1016/j.tetlet.2010.09.121"
Description: 3-(Chloromethyl)coumarins, obtained via acid-catalysed cyclisation of salicylaldehyde-derived Baylis– Hillman adducts, have been treated with propargylamine; reaction of the resulting 3-alkynylmethylcoumarins with azidothymidine (AZT) in the presence of a Cu(I) catalyst has afforded a series of cycloaddition products for evaluation, in their own right, as potential dual-action HIV-1 protease and non-nucleoside reverse transcriptase inhibitors, and as scaffolds for further structural elaboration.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (6 pages)
Format: pdf
Publisher: Elsevier
Language: English
Relation: Tetrahedron Letters
Relation: Olomola, T.O., Klein, R., Lobb, K.A., Sayed, Y. and Kaye, P.T., 2010. Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors. Tetrahedron Letters, 51(48), pp.6325-6328
Relation: Tetrahedron Letters volume 51 number 48 p. 6325 2010 0040-4039
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Closed Access

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Klein, Rosalyn (Assoc Prof)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Lobb, Kevin Allan (Assoc Prof)

Kaye, Perry T (Distinguished Fellow Emeritus Professor)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

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