Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes

Mkabayi, Lithalethu; Viljoen, Zenobia; Krause, Rui W M; Lobb, Kevin A; Pletschke, Brett I; Frost, Carminita L

Title: Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes
Creator: Mkabayi, Lithalethu
Creator: Viljoen, Zenobia
Creator: Krause, Rui W M
Creator: Lobb, Kevin A
Creator: Pletschke, Brett I
Creator: Frost, Carminita L
Subject: To be catalogued
Date Issued: 2024
Date: 2024
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/452760
Identifier: vital:75168
Identifier: xlink:href="https://doi.org/10.1016/j.heliyon.2023.e23289"
Description: Ethnopharmacological relevance: In recent times the decriminalisation of cannabis globally has increased its use as an alternative medication. Where it has been used in modern medicinal practises since the 1800s, there is limited scientific investigation to understand the biological activities of this plant. Aim of the study: Dipeptidyl peptidase IV (DPP-IV) plays a key role in regulating glucose homeostasis, and inhibition of this enzyme has been used as a therapeutic approach to treat type 2 diabetes. However, some of the synthetic inhibitors for this enzyme available on the market may cause undesirable side effects. Therefore, it is important to identify new inhibitors of DPP-IV and to understand their interaction with this enzyme.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (15 pages)
Format: pdf
Publisher: Elsevier
Language: English
Relation: Heliyon
Relation: Mkabayi, L., Viljoen, Z., Krause, R.W., Lobb, K.A., Pletschke, B.I. and Frost, C.L., 2024. Inhibitory effects of selected cannabinoids against dipeptidyl peptidase IV, an enzyme linked to type 2 diabetes. Heliyon, 10(1)
Relation: Heliyon volume 10 number 1 2024 2405-8440
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Open Access

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Krause, Rui Werner Maçedo (Prof)

Lobb, Kevin Allan (Assoc Prof)

Pletschke, Brett (Prof)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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