Synthesis of 2, 3-dihydroxy-3-(N-substituted carbamoyl) propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues

Mutorwa, Marius K; Lobb, Kevin A; Klein, Rosalyn; Blatch, Gregory L; Kaye, Perry T

Title: Synthesis of 2, 3-dihydroxy-3-(N-substituted carbamoyl) propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues
Creator: Mutorwa, Marius K
Creator: Lobb, Kevin A
Creator: Klein, Rosalyn
Creator: Blatch, Gregory L
Creator: Kaye, Perry T
Subject: To be catalogued
Date Issued: 2022
Date: 2022
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/453212
Identifier: vital:75231
Identifier: xlink:href="https://doi.org/10.1016/j.molstruc.2022.132453"
Description: A six-step synthetic pathway has been established to access a series of racemic 2,3-dihydroxy-3-(Nsubstituted carbamoyl)propylphosphonic acid derivatives, designed to contain structural features common to both the natural substrate 1-deoxy-D-xylulose 5-phosphate (DOXP) of the Plasmodium falciparum (Pf) DXR enzyme and its known inhibitor, fosmidomycin. Positive STD-NMR and in silico docking data obtained for some of the compounds indicate their capacity to bind to the analogous E.coli DXR enzyme.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (6 pages)
Format: pdf
Publisher: Elsevier
Language: English
Relation: Journal of Molecular Structure
Relation: Mutorwa, M.K., Lobb, K.A., Klein, R., Blatch, G.L. and Kaye, P.T., 2022. Synthesis of 2, 3-dihydroxy-3-(N-substituted carbamoyl) propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues. Journal of Molecular Structure, 1256, p.132453
Relation: Journal of Molecular Structure volume 1256 number p. 132453 2022 1872-8014
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
Rights: Closed Access

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Klein, Rosalyn (Assoc Prof)

Blatch, Gregory Lloyd (Prof)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Lobb, Kevin Allan (Assoc Prof)

Kaye, Perry T (Distinguished Fellow Emeritus Professor)

RU Department of Chemistry

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

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