Study of the formation of artifacts following Dichloromethane reaction with some nitrogenous drugs

Title: Study of the formation of artifacts following Dichloromethane reaction with some nitrogenous drugs
Creator: Mohammadi, Ali
Creator: Amini, Mohsen
Creator: Hamedani, Moteza P
Creator: Torkabadi, Hossein H
Creator: Walker, Roderick B
Date Issued: 2008
Date: 2008
Type: Article
Identifier: vital:6409
Identifier: http://hdl.handle.net/10962/d1006495
Description: In this work, the quaternization reaction of some nitrogenous drugs in dichloromethane under stress condition and room temperature at different times are studied. Under these conditions, drug-chloromethochloride adducts or artifacts were found to be formed for clozapine, ofloxacin and olanzapine. The structures of the resultant adducts were elucidated using 1H NMR spectroscopy. In addition, the amount of intact drug was determined using in-house validated HPLC methods with UV detection.
Format: 8 pages
Format: pdf
Language: English
Relation: Mohammadi, A. and Amini, M. and Hamedani, M.P. and Torkabadi, H.H. and Walker, R.B. (2008) Study of the formation of artifacts following Dichloromethane reaction with some nitrogenous drugs. Asian Journal of Chemistry, 20 (7). pp. 5573-5580.

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Walker, Roderick Bryan (Prof)

RU Department of Pharmacy

SDG 03. Good Health and Well-Being

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