Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:

Title: Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells:
Creator: Hunter, Morgan C
Creator: O’Hagan, Kyle L
Creator: Kenyon, Amy
Creator: Dhanani, Karim C H
Creator: Prinsloo, Earl
Creator: Edkins, Adrienne L
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164841
Identifier: vital:41177
Identifier: DOI: 10.1371/journal.pone.0086842
Description: Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isolate a complex containing Hsp90 and the matrix protein fibronectin (FN) from breast cancer cells.
Format: 18 pages
Format: pdf
Language: English
Relation: PloS one
Relation: Hunter, M.C., O’Hagan, K.L., Kenyon, A., Dhanani, K.C., Prinsloo, E. and Edkins, A.L., 2014. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PloS one, 9(1), p.e86842
Relation: PloS one volume 9 number 1 1 17 January 2014 1932-6203
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the PLOSOne Terms of Use Statement (https://www.plos.org/terms-of-use )

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

RU Department of Biochemistry, Microbiology and Biotechnology

Prinsloo, Earl (Dr)

Edkins, Adrienne Lesley (Associate Prof)

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