- Title
- Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets
- Creator
- Chaibva, Faith A
- Creator
- Khamanga, Sandile M
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 2010
- Date
- 2010
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184139
- Identifier
- vital:44177
- Identifier
- xlink:href="https://doi.org/10.3109/03639045.2010.488648"
- Description
- Background: Hydrophilic matrix formulations are important and simple technologies that are used to manufacture sustained release dosage forms. Method: Hydroxypropyl methylcellulose-based matrix tablets, with and without additives, were manufactured to investigate the rate of hydration, rate of erosion, and rate and mechanism of drug release. Scanning electron microscopy was used to assess changes in the microstructure of the tablets during drug release testing and whether these changes could be related to the rate of drug release from the formulations. Results: The results revealed that the rate of hydration and erosion was dependent on the polymer combination(s) used, which in turn affected the rate and mechanism of drug release from these formulations. It was also apparent that changes in the microstructure of matrix tablets could be related to the different rates of drug release that were observed from the test formulations. Conclusion: The use of scanning electron microscopy provides useful information to further understand drug release mechanisms from matrix tablets.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (15 pages)
- Format
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Drug Development and Industrial Pharmacy
- Relation
- Chaibva, F.A., Khamanga, S.M. and Walker, R.B., 2010. Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets. Drug development and industrial pharmacy, 36(12), pp.1497-1510
- Relation
- Drug Development and Industrial Pharmacy volume 36 number 12 p.1497 2010 1520-5762
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
RU Department of Pharmacy
Khamanga, Sandile S M (Assoc Prof)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Swelling, erosion and drug release characteristics of salbutamol sulfate.pdf | 6 MB | Adobe Acrobat PDF | View Details Download |