The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations

Fauzee, Ayesha F B

Title: The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations
Creator: Fauzee, Ayesha F B
Creator: Khamanga, Sandile M
Creator: Walker, Roderick B
Subject: To be catalogued
Date Issued: 2014
Date: 2014
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/183872
Identifier: vital:44077
Identifier: xlink:href="https://doi.org/10.3109/03639045.2013.842579"
Description: The purpose of the study was to evaluate the effect of different homogenization speeds and times, anchor speeds and cooling times on the viscosity and cumulative % clobetasol 17-propionate released per unit area at 72 h from pilot scale cream formulations. A 24 full factorial central composite design for four independent variables were investigated. Thirty pilot scale batches of cream formulations were manufactured using a Wintech® cream/ointment plant. The viscosity and in vitro release of CP were monitored and compared to an innovator product that is commercially available on the South African market, namely, Dermovate® cream. Contour and three-dimensional response surface plots were produced and the viscosity and cumulative % CP released per unit area at 72 h were found to be primarily dependent on the homogenization and anchor speeds. An increase in the homogenization and anchor speeds appeared to exhibit a synergistic effect on the resultant viscosity of the cream whereas an antagonistic effect was observed for the in vitro release of CP from the experimental cream formulations. The in vitro release profiles were best fitted to a Higuchi model and diffusion proved to be the dominant mechanism of drug release that was confirmed by use of the Korsmeyer–Peppas model. The research was further validated and confirmed by the high prognostic ability of response surface methodology (RSM) with a resultant mean percentage error of (±SD) 0.17 ± 0.093 suggesting that RSM may be an efficient tool for the development and optimization of topical formulations.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (8 pages)
Format: pdf
Publisher: Taylor and Francis Online
Language: English
Relation: Drug Development and Industrial Pharmacy
Relation: Fauzee, A.F.B., Khamanga, S.M. and Walker, R.B., 2014. The impact of manufacturing variables on in vitro release of clobetasol 17-propionate from pilot scale cream formulations. Drug development and industrial pharmacy, 40(12), pp.1683-1692
Relation: Drug Development and Industrial Pharmacy volume 40 number 12 p.1683 2014 1520-5762
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
Rights: Open Access

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Walker, Roderick Bryan (Prof)

RU Department of Pharmacy

Khamanga, Sandile S M (Assoc Prof)

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