No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:

Kimuda, Magambo P; Noyes, Harry; Mulindwa, Julius; Enyaru, John; Alibu, Vincent P; Sidibe, Issa; Mumba Ngoyi, Dieuodonne; Hertz-Fowler, Christiane; MacLeod, Annette; Tastan Bishop, Özlem; Matovu, Enock

Title: No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:
Creator: Kimuda, Magambo P
Creator: Noyes, Harry
Creator: Mulindwa, Julius
Creator: Enyaru, John
Creator: Alibu, Vincent P
Creator: Sidibe, Issa
Creator: Mumba Ngoyi, Dieuodonne
Creator: Hertz-Fowler, Christiane
Creator: MacLeod, Annette
Creator: Tastan Bishop, Özlem
Creator: Matovu, Enock
Date Issued: 2018
Date: 2018
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/162924
Identifier: vital:40997
Identifier: https://doi.org/10.1371/journal.pntd.0006300
Description: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
Format: 11 page
Format: pdf
Language: English
Relation: PLoS neglected tropical diseases
Relation: Kimuda, M.P., Noyes, H., Mulindwa, J., Enyaru, J., Alibu, V.P., Sidibe, I., Mumba Ngoyi, D., Hertz-Fowler, C., MacLeod, A., Tastan Bishop, Ö. and Matovu, E., 2018. No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. PLoS neglected tropical diseases, 12(2), p.e0006300
Relation: PLoS neglected tropical diseases volume 12 number 2 1 10 February 2018 1935-2735
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the PLOS Terms of Use Statement ( https://www.plos.org/terms-of-use)

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Tastan Bishop, Ozlem (Prof)

RU Research Unit in Bioinformatics (RUBi)

SDG 03. Good Health and Well-Being

RU Department of Biochemistry, Microbiology and Bioinformatics

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