- Title
- The complex immunological and inflammatory network of adipose tissue in obesity
- Creator
- Apostolopoulos, Vasso
- Creator
- De Courten, Maximilian P J
- Creator
- Stojanovska, Lily
- Creator
- Blatch, Gregory L
- Creator
- Tangalakis, Kathy
- Creator
- De Courten, Barbora
- Date Issued
- 2016
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/66120
- Identifier
- vital:28905
- Identifier
- https://doi.org/10.1002/mnfr.201500272
- Description
- publisher version
- Description
- A number of approaches have been utilized in the prevention, management, and treatment of obesity, including, surgery, medication, diet, exercise, and overall lifestyle changes. Despite these interventions, the prevalence of obesity and the various disorders related to it is growing. In obesity, there is a constant state of chronic low‐grade inflammation which is characterized by activation and infiltration of pro‐inflammatory immune cells and a dysregulated production of high levels of pro‐inflammatory cytokines. This pro‐inflammatory milieu contributes to insulin resistance, type‐2 diabetes, cardiovascular disease, and other related co‐morbidities. The roles of the innate (macrophages, neutrophils, eosinophils, mast cells, NK cells, MAIT cells) and the adaptive (CD4 T cells, CD8 T cells, regulatory T cells, and B cells) immune responses and the roles of adipokines and cytokines in adipose tissue inflammation and obesity are discussed. An understanding of the crosstalk between the immune system and adipocytes may shed light in better treatment modalities for obesity and obesity‐related diseases.
- Format
- 15 pages
- Format
- Language
- English
- Relation
- Molecular Nutrition and Food Research
- Relation
- Apostolopoulos, V., De Courten, M. P. J., Stojanovska, L., Blatch, G. L., Tangalakis, K., De Courten, B. (2016) The complex immunological and inflammatory network of adipose tissue in obesity. Molecular Nutrition and Food Research, 60 (1) p.43 – 57. SN - 1613-4133. http:https://doi.org/10.1002/mnfr.201500272.
- Relation
- Molecular Nutrition and Food Research volume 60 number 1 43 57 2016 1613-4133
- Rights
- John Wiley and Sons, Inc.
- Rights
- The use of this resource is governed by the terms and conditions of the Wiley Online Library OnlineOpen Licenses, Funding requirements and Copyright Statement (https://onlinelibrary.wiley.com/page/journal/16134133/homepage/2216_forauthors.html)
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