- Title
- Continuous flow synthesis of a key intermediate towards the antidiabetic drug repaglinide
- Creator
- Williams, Arushan
- Subject
- Diabetes -- Miscellanea -- South Africa
- Subject
- Diabetes –Treatment
- Date Issued
- 2023-04
- Date
- 2023-04
- Type
- Master's theses
- Type
- text
- Identifier
- http://hdl.handle.net/10948/61064
- Identifier
- vital:69715
- Description
- Across the world, diabetes is one of the leading causes of deaths attributed to noncommunicable diseases (NCDs). In Africa, a huge proportion of African countries’ annual healthcare budgets are consumed by diabetes (7 %) with many already experiencing healthcare budget deficits. The prevalence of diabetes is rapidly growing and threatens the economic productivity and livelihood of many families within the region. The world leaders have invested heavily in reducing the pandemic by focusing on increasing the availability of affordable essential medicines in developing countries. The majority of diabetes cases are due to type 2 diabetes (90 %) and may be treated using oral hypoglycaemic drugs (OHDs). Repaglinide (REP) is a non-sulfonylurea insulin secretagogue (meglitinide) with greater HbA1c reduction than metformin in newly onset type 2 diabetic patients, however due to the high price of REP outside Asia, cheaper and less effective OHDs are prescribed to patients. Many of the reported synthetic routes towards REP utilize a key intermediate, 2-(3-ethoxy-4- iethoxycarbonyl)phenyl)acetic acid. The key intermediate contributes significantly to the price of REP as many of the intermediate’s synthetic routes suffer from long reaction times, low yields and industrial complex approaches. Therefore, this has prompted us to investigate an efficient process towards the synthesis of 2-(3-ethoxy-4-(ethoxycarbonyl)phenyl)acetic acid using multiple continuous flow systems.
- Description
- Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (177 pages)
- Format
- Publisher
- Nelson Mandela University
- Publisher
- Faculty of Science
- Language
- English
- Rights
- Nelson Mandela University
- Rights
- All Rights Reserved
- Rights
- Open Access
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Williams, A.pdf | 3 MB | Adobe Acrobat PDF | View Details Download |