Peacekeeping in Africa: problems and prospects
- Authors: Juma, Laurence
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129113 , vital:36219 , https://heinonline.org/HOL/P?h=hein.journals/unbotslj9amp;i=3
- Description: Against the background of an expanded need for peacekeeping, the complexity that its programmes entail, and the belief that it will endure for a long time to come, this article discusses the propriety of international peacekeeping operations, its inherent features and weaknesses in creating or preserving peace, and the role that regional organisations play, or should play, in its enhancement.
- Full Text: false
- Date Issued: 2009
- Authors: Juma, Laurence
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129113 , vital:36219 , https://heinonline.org/HOL/P?h=hein.journals/unbotslj9amp;i=3
- Description: Against the background of an expanded need for peacekeeping, the complexity that its programmes entail, and the belief that it will endure for a long time to come, this article discusses the propriety of international peacekeeping operations, its inherent features and weaknesses in creating or preserving peace, and the role that regional organisations play, or should play, in its enhancement.
- Full Text: false
- Date Issued: 2009
Peer-to-Peer Web Services for Distributed Rural ICTs
- Wertlen, Ronald, Terzoli, Alfredo
- Authors: Wertlen, Ronald , Terzoli, Alfredo
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428508 , vital:72516 , https://www.researchgate.net/profile/Alfredo-Terzoli/publication/265184410_Peer-to-Peer_Web_Services_for_Distributed_Rural_ICTs/links/5523cb9a0cf223eed37fe0b3/Peer-to-Peer-Web-Services-for-Distributed-Rural-ICTs.pdf
- Description: In this paper we look at the context and design of a distributed web ser-vices platform called P2PMW. P2PMW uses P2P principles to automat-ically build a robust network with flexible routing and practically no ad-ministrative overhead in order to share resources between nodes. P2PMW uses open source and widely adopted standards. Our argu-ment is that the context of rural ICTs is being shaped by high speed wireless networks with limited span that we call “islands” and that the architecture we introduce is a good fit for the context. We further argue that by employing widely adopted open standards and open source software, we can speed the development of effective custom made ap-plications for marginalised rural areas.
- Full Text:
- Date Issued: 2009
- Authors: Wertlen, Ronald , Terzoli, Alfredo
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428508 , vital:72516 , https://www.researchgate.net/profile/Alfredo-Terzoli/publication/265184410_Peer-to-Peer_Web_Services_for_Distributed_Rural_ICTs/links/5523cb9a0cf223eed37fe0b3/Peer-to-Peer-Web-Services-for-Distributed-Rural-ICTs.pdf
- Description: In this paper we look at the context and design of a distributed web ser-vices platform called P2PMW. P2PMW uses P2P principles to automat-ically build a robust network with flexible routing and practically no ad-ministrative overhead in order to share resources between nodes. P2PMW uses open source and widely adopted standards. Our argu-ment is that the context of rural ICTs is being shaped by high speed wireless networks with limited span that we call “islands” and that the architecture we introduce is a good fit for the context. We further argue that by employing widely adopted open standards and open source software, we can speed the development of effective custom made ap-plications for marginalised rural areas.
- Full Text:
- Date Issued: 2009
Performance Effects of Concurrent Virtual Machine Execution in VMware Workstation 6
- Barnett, Richard J, Irwin, Barry V W
- Authors: Barnett, Richard J , Irwin, Barry V W
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429966 , vital:72655 , https://doi.org/10.1007/978-90-481-3660-5_56
- Description: The recent trend toward virtualized computing both as a means of serv-er consolidation and as a powerful desktop computing tool has lead into a wide variety of studies into the performance of hypervisor products. This study has investigated the scalability of VMware Workstation 6 on the desktop platform. We present comparative performance results for the concurrent execution of a number of virtual machines. A through statistical analysis of the performance results highlights the perfor-mance trends of different numbers of concurrent virtual machines and concludes that VMware workstation can scale in certain contexts. We find that there are different performance benefits dependant on the ap-plication and that memory intensive applications perform less effective-ly than those applications which are IO intensive. We also find that run-ning concurrent virtual machines offers a significant performance de-crease, but that the drop thereafter is less significant.
- Full Text:
- Date Issued: 2009
- Authors: Barnett, Richard J , Irwin, Barry V W
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/429966 , vital:72655 , https://doi.org/10.1007/978-90-481-3660-5_56
- Description: The recent trend toward virtualized computing both as a means of serv-er consolidation and as a powerful desktop computing tool has lead into a wide variety of studies into the performance of hypervisor products. This study has investigated the scalability of VMware Workstation 6 on the desktop platform. We present comparative performance results for the concurrent execution of a number of virtual machines. A through statistical analysis of the performance results highlights the perfor-mance trends of different numbers of concurrent virtual machines and concludes that VMware workstation can scale in certain contexts. We find that there are different performance benefits dependant on the ap-plication and that memory intensive applications perform less effective-ly than those applications which are IO intensive. We also find that run-ning concurrent virtual machines offers a significant performance de-crease, but that the drop thereafter is less significant.
- Full Text:
- Date Issued: 2009
Photophysical, photochemical and electrochemical properties of water soluble silicon, titanium and zinc phthalocyanines
- Masilela, Nkosiphile, Idowu, Mopelola, Nyokong, Tebello
- Authors: Masilela, Nkosiphile , Idowu, Mopelola , Nyokong, Tebello
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/264496 , vital:53739 , xlink:href="https://doi.org/10.1016/j.jphotochem.2008.10.009"
- Description: The photophysical, and photochemical properties of titanium, silicon and zinc octacarboxy phthalocyanine (OTiOCPc, (OH)2SiOCPc and ZnOCPc) and their tetrasulfonated counterparts (OTiTSPc, (OH)2SiTSPc and ZnTSPc) in phosphate-buffer solution (PBS), pH 10 were studied. The tetrasulfonated derivatives were also studied in the presence of a surfactant, cremophore EL (CEL) due to their high aggregation tendency in aqueous solutions. Triplet quantum yields ranged from 0.20 to 0.48 for MOCPcs and 0.32–0.65 for MTSPcs in the presence of CEL and in pH 10. High triplet lifetimes were observed for ZnTSPc (270 μs, in the presence of CEL) or ZnOCPc (130 μs) compared to values ranging from 50 to 70 μs for the rest of the complexes.
- Full Text:
- Date Issued: 2009
- Authors: Masilela, Nkosiphile , Idowu, Mopelola , Nyokong, Tebello
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/264496 , vital:53739 , xlink:href="https://doi.org/10.1016/j.jphotochem.2008.10.009"
- Description: The photophysical, and photochemical properties of titanium, silicon and zinc octacarboxy phthalocyanine (OTiOCPc, (OH)2SiOCPc and ZnOCPc) and their tetrasulfonated counterparts (OTiTSPc, (OH)2SiTSPc and ZnTSPc) in phosphate-buffer solution (PBS), pH 10 were studied. The tetrasulfonated derivatives were also studied in the presence of a surfactant, cremophore EL (CEL) due to their high aggregation tendency in aqueous solutions. Triplet quantum yields ranged from 0.20 to 0.48 for MOCPcs and 0.32–0.65 for MTSPcs in the presence of CEL and in pH 10. High triplet lifetimes were observed for ZnTSPc (270 μs, in the presence of CEL) or ZnOCPc (130 μs) compared to values ranging from 50 to 70 μs for the rest of the complexes.
- Full Text:
- Date Issued: 2009
Photophysicochemical and fluorescence quenching studies of tetra-and octa-carboxy substituted silicon and germanium phthalocyanines
- Idowu, Mopelola, Nyokong, Tebello
- Authors: Idowu, Mopelola , Nyokong, Tebello
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/263500 , vital:53633 , xlink:href="https://doi.org/10.1016/j.jphotochem.2009.02.002"
- Description: Spectral, photophysical and photochemical properties of tetra- and octa-carboxy substituted metallophthalocyanines containing silicon and germanium as central metals ((OH)2GeTCPc, (OH)2SiTCPc, (OH)2GeOCPc and (OH)2SiOCPc) have been studied in dimethylsulfoxide (DMSO) and the trends in triplet, fluorescence, singlet oxygen quantum yields and triplet lifetimes are described for these compounds. The GePc derivatives exhibited high triplet quantum yields (ΦT = 0.79 for (OH)2GeOCPc and 0.82 for (OH)2GeTCPc compared to ΦT = 0.66 for (OH)2SiTCPc and 0.48 for (OH)2SiOCPc) due to the spin–orbit coupling induced by Ge(IV). The triplet lifetimes were higher for MOCPc (τT = 760 μs for (OH)2SiOCPc and 480 μs for (OH)2GeOCPc compared to τT = 210 μs for (OH)2SiTCPc and 260 μs for (OH)2GeTCPc). The fluorescent states of the metallophthalocyanine (MPc) complexes were effectively quenched by benzoquinone (BQ) and the quenching course was found to follow a diffusion-controlled (dynamic) bimolecular mechanism. Theoretical values of bimolecular rate constant for the interaction of the complexes with BQ were determined using the Stokes–Einstein–Smoluchowski model, and values together with the Stern–Volmer quenching constants were used in calculating the fluorescence lifetimes of the complexes.
- Full Text:
- Date Issued: 2009
- Authors: Idowu, Mopelola , Nyokong, Tebello
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/263500 , vital:53633 , xlink:href="https://doi.org/10.1016/j.jphotochem.2009.02.002"
- Description: Spectral, photophysical and photochemical properties of tetra- and octa-carboxy substituted metallophthalocyanines containing silicon and germanium as central metals ((OH)2GeTCPc, (OH)2SiTCPc, (OH)2GeOCPc and (OH)2SiOCPc) have been studied in dimethylsulfoxide (DMSO) and the trends in triplet, fluorescence, singlet oxygen quantum yields and triplet lifetimes are described for these compounds. The GePc derivatives exhibited high triplet quantum yields (ΦT = 0.79 for (OH)2GeOCPc and 0.82 for (OH)2GeTCPc compared to ΦT = 0.66 for (OH)2SiTCPc and 0.48 for (OH)2SiOCPc) due to the spin–orbit coupling induced by Ge(IV). The triplet lifetimes were higher for MOCPc (τT = 760 μs for (OH)2SiOCPc and 480 μs for (OH)2GeOCPc compared to τT = 210 μs for (OH)2SiTCPc and 260 μs for (OH)2GeTCPc). The fluorescent states of the metallophthalocyanine (MPc) complexes were effectively quenched by benzoquinone (BQ) and the quenching course was found to follow a diffusion-controlled (dynamic) bimolecular mechanism. Theoretical values of bimolecular rate constant for the interaction of the complexes with BQ were determined using the Stokes–Einstein–Smoluchowski model, and values together with the Stern–Volmer quenching constants were used in calculating the fluorescence lifetimes of the complexes.
- Full Text:
- Date Issued: 2009
Predicting geographic distribution of seven blowfly species (Diptera: Calliphoridae) in South Africa
- Richards, C S, Williams, K A, Villet, Martin H
- Authors: Richards, C S , Williams, K A , Villet, Martin H
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6854 , http://hdl.handle.net/10962/d1011135
- Description: The predicted geographic distributions of seven forensically important blowfly species are modelled using the computer program Maxent, based on selected climatic variables for South Africa, a country with large climatic and environmental gradients. It is shown that although temperature was hypothesized to most influence the distributions of these ectotherms, moisture, and particularly humidity, was in fact usually paramount. Chrysomya albiceps (Wiedemann) and C. marginalis (Robineau-Desvoidy) had the most widespread geographic and climatic distribution, while the forest-associated C. inclinata(Walker) was the least widespread. Chrysomya putoria (Wiedemann) and C. megacephala (Fabricius) had very similar predicted distributions that were restricted mainly to Limpopo, Mpumalanga, KwaZulu-Natal and the coast of the Eastern Cape. Chrysomya chloropyga (Wiedemann) and Calliphora croceipalpis (Jaennicke) were the only species predicted to occur at high altitudes. Blowfly distributions restricted to part of the map area were predicted better than those that were more widespread in the region, presumably because species with extremely widespread distributions in a study area occupy nearly the whole range of variation of most predictor variables, leaving little variation with which themaximumentropy modelling method can discriminate between presence and absence of the organism.
- Full Text:
- Date Issued: 2009
Predicting geographic distribution of seven blowfly species (Diptera: Calliphoridae) in South Africa
- Authors: Richards, C S , Williams, K A , Villet, Martin H
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6854 , http://hdl.handle.net/10962/d1011135
- Description: The predicted geographic distributions of seven forensically important blowfly species are modelled using the computer program Maxent, based on selected climatic variables for South Africa, a country with large climatic and environmental gradients. It is shown that although temperature was hypothesized to most influence the distributions of these ectotherms, moisture, and particularly humidity, was in fact usually paramount. Chrysomya albiceps (Wiedemann) and C. marginalis (Robineau-Desvoidy) had the most widespread geographic and climatic distribution, while the forest-associated C. inclinata(Walker) was the least widespread. Chrysomya putoria (Wiedemann) and C. megacephala (Fabricius) had very similar predicted distributions that were restricted mainly to Limpopo, Mpumalanga, KwaZulu-Natal and the coast of the Eastern Cape. Chrysomya chloropyga (Wiedemann) and Calliphora croceipalpis (Jaennicke) were the only species predicted to occur at high altitudes. Blowfly distributions restricted to part of the map area were predicted better than those that were more widespread in the region, presumably because species with extremely widespread distributions in a study area occupy nearly the whole range of variation of most predictor variables, leaving little variation with which themaximumentropy modelling method can discriminate between presence and absence of the organism.
- Full Text:
- Date Issued: 2009
Pseudopolydora species associated with mollusc shells on the south coast of South Africa, with the description of Ps. dayii, sp nov
- Authors: Simon, Carol A
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6875 , http://hdl.handle.net/10962/d1011623
- Description: Two species of the genus Pseudopolydora, Ps. dayii, sp. nov. and Ps. antennata, were associated with gastropods on the south and south-east coasts of South Africa. Pseudopolydora dayii is characterized by prominent post-chaetal notopodial lobes on chaetiger 1 with very long chaetae, a prominent occipital tentacle, having hooded hooks that start on chaetiger 9, branchiae that start on chaetiger 6, stout hooks and lobes placed latero-posteriorly to the hooded hooks in posterior chaetigers. It is a surface-fouler and was found on several species of wild gastropods at four of the five sites sampled and from additional material from the south-west coast and on cultured abalone (Haliotis midae) at a farm on the south-west coast. Three individuals of Ps. antennata were found only with oysters at the easternmost site. This was the first record of this species outside of the Western Cape Province and it is possible that their association with the oysters was fortuitous.
- Full Text:
- Date Issued: 2009
- Authors: Simon, Carol A
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6875 , http://hdl.handle.net/10962/d1011623
- Description: Two species of the genus Pseudopolydora, Ps. dayii, sp. nov. and Ps. antennata, were associated with gastropods on the south and south-east coasts of South Africa. Pseudopolydora dayii is characterized by prominent post-chaetal notopodial lobes on chaetiger 1 with very long chaetae, a prominent occipital tentacle, having hooded hooks that start on chaetiger 9, branchiae that start on chaetiger 6, stout hooks and lobes placed latero-posteriorly to the hooded hooks in posterior chaetigers. It is a surface-fouler and was found on several species of wild gastropods at four of the five sites sampled and from additional material from the south-west coast and on cultured abalone (Haliotis midae) at a farm on the south-west coast. Three individuals of Ps. antennata were found only with oysters at the easternmost site. This was the first record of this species outside of the Western Cape Province and it is possible that their association with the oysters was fortuitous.
- Full Text:
- Date Issued: 2009
Putting the ‘T’ into South African human rights: transsexuality in the post-apartheid order
- Vincent, Louise, Camminga, Bianca
- Authors: Vincent, Louise , Camminga, Bianca
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141606 , vital:37989 , DOI: 10.1177/1363460709346108
- Description: Informed by narratives provided by self-identified South African transsexuals, whose lives span different periods of South Africa’s political and social history, this article seeks to explore how South Africa’s medical, legal and military establishments have exerted power over the transsexual body. A variety of studies outline the extent to which the apartheid state was a highly gendered state characterized by inflexible patriarchal norms and the dominance of violent and authoritarian forms of masculine expression. Hyper masculinization and militarization were explicit goals of the apartheid state. Deviance from the state’s prescribed gender norms was not simply socially unacceptable, it was, in many cases, punishable. South Africa’s post-1994 democratic Constitution, in contrast, explicitly outlaws discrimination on the basis of sexual orientation. But the democratic legal framework, which provides significant protections for freedom of sexual expression and freedom from discrimination for homosexuals has arguably had less of an impact on the lives of South Africa’s transsexual community. The state, even the post-apartheid state, has been loathe to move beyond the idea of a necessary correlation between the physical make-up of the body and the gender identity of a person in the way in which it has treated the idea of transsexualism.
- Full Text:
- Date Issued: 2009
- Authors: Vincent, Louise , Camminga, Bianca
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141606 , vital:37989 , DOI: 10.1177/1363460709346108
- Description: Informed by narratives provided by self-identified South African transsexuals, whose lives span different periods of South Africa’s political and social history, this article seeks to explore how South Africa’s medical, legal and military establishments have exerted power over the transsexual body. A variety of studies outline the extent to which the apartheid state was a highly gendered state characterized by inflexible patriarchal norms and the dominance of violent and authoritarian forms of masculine expression. Hyper masculinization and militarization were explicit goals of the apartheid state. Deviance from the state’s prescribed gender norms was not simply socially unacceptable, it was, in many cases, punishable. South Africa’s post-1994 democratic Constitution, in contrast, explicitly outlaws discrimination on the basis of sexual orientation. But the democratic legal framework, which provides significant protections for freedom of sexual expression and freedom from discrimination for homosexuals has arguably had less of an impact on the lives of South Africa’s transsexual community. The state, even the post-apartheid state, has been loathe to move beyond the idea of a necessary correlation between the physical make-up of the body and the gender identity of a person in the way in which it has treated the idea of transsexualism.
- Full Text:
- Date Issued: 2009
Rapid biological assessment of the fishery potential of Xonxa Dam, near Queenstown, South Africa
- Richardson, T J, Booth, Anthony J, Weyl, Olaf L F
- Authors: Richardson, T J , Booth, Anthony J , Weyl, Olaf L F
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125798 , vital:35818 , https://doi.10.2989/AJAS.2009.34.1.9.734
- Description: In Africa, the harvesting of fish from small reservoirs has been identified as an important food resource for small rural communities, particularly those living close to waterbodies (Kapetsky and Petr 1984, Marshall and Maes 1994, van der Knaap 1994). Development of fisheries to utilize these resources has recently been identified by the African Union as a priority investment area for poverty alleviation and regional economic development (NEPAD 2005). Within a South African context, it is suspected that there will be increased interest in developing these fisheries to address major national policy objectives, which include food security, economic empowerment, optimal economic benefit from water, and poverty eradication (RSA 1998a, 1998b). South Africa, however, presents a somewhat anomalous situation. The lack of a fishing history in communities, the lack of species with a high fisheries potential, inadequate inland fisheries policy and a lack of directed fisheries development have resulted in low utilisation levels of fish resources in South African reservoirs (Weyl et al. 2007).
- Full Text:
- Date Issued: 2009
- Authors: Richardson, T J , Booth, Anthony J , Weyl, Olaf L F
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125798 , vital:35818 , https://doi.10.2989/AJAS.2009.34.1.9.734
- Description: In Africa, the harvesting of fish from small reservoirs has been identified as an important food resource for small rural communities, particularly those living close to waterbodies (Kapetsky and Petr 1984, Marshall and Maes 1994, van der Knaap 1994). Development of fisheries to utilize these resources has recently been identified by the African Union as a priority investment area for poverty alleviation and regional economic development (NEPAD 2005). Within a South African context, it is suspected that there will be increased interest in developing these fisheries to address major national policy objectives, which include food security, economic empowerment, optimal economic benefit from water, and poverty eradication (RSA 1998a, 1998b). South Africa, however, presents a somewhat anomalous situation. The lack of a fishing history in communities, the lack of species with a high fisheries potential, inadequate inland fisheries policy and a lack of directed fisheries development have resulted in low utilisation levels of fish resources in South African reservoirs (Weyl et al. 2007).
- Full Text:
- Date Issued: 2009
Rapid UPLC - MS/MS method for the determination of ketoprofen in human dermal microdialysis samples
- Tettey-Amlalo, Ralph N O, Kanfer, Isadore
- Authors: Tettey-Amlalo, Ralph N O , Kanfer, Isadore
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6444 , http://hdl.handle.net/10962/d1006631
- Description: Dermal microdialysis (DMD) is a technique capable of determining the percutaneous penetration of drugs from topical formulations intended for local and/or regional activity. Typically, the concentrations of drug collected in dialysates are very low, generally in the ng/ml or even pg/ml range. An additional challenge is the very low volume of sample collected at each collection time and which can range from 1 to 30 μl only. Hence the objective was to develop and validate a rapid, accurate, precise, reproducible and highly sensitive LC–MS/MS method for the quantitative analysis of ketoprofen (KET) in dialystes following application of a topical gel product to the skin of human subjects. UPLC–MS/MS was used and KET was separated on an Acquity™ UPLC BEH C18 column (100 mm × 2.1 mm i.d., 1.7 μm) and analysed in negative-ion (NI) electrospray ionisation (ESI) mode. The mobile phase (MP) consisted of acetonitrile:methanol:water (60:20:20, v/v/v) under isocratic conditions at a flow rate of 0.3 ml/min. Samples were extracted using ethyl acetate with ibuprofen (IBU) as internal standard (IS) and the organic solvent was then evaporated to dryness and the residue re-constituted in methanol. 5 μl samples were injected and analysis was performed at ambient temperature 22 ± 0.5 °C. KET and IBU eluted at 1.07 and 1.49 min, respectively. KET and IBU responses were optimised at the transitions 253.00 > 209.00 and 205.00 > 161.00, respectively. Calibration curves were linear over the range 0.5–500 ng/ml with correlation coefficients > 0.999. The accuracy and precision of the method were found to be between 99.97% and 104.67% (R.S.D. < 2%) and the mean recovery of KET from normal saline was 88.03 ± 0.3% (R.S.D. < 2.20%). The LLOQ and LOD values were found to be 0.5 and 0.1 ng/ml respectively whereas the ULOD was set at 500 ng/ml. The method was successfully applied to determine the bioavailability of KET following application of topical KET gel, Fastum® gel, to the skin of human volunteers.
- Full Text:
- Date Issued: 2009
- Authors: Tettey-Amlalo, Ralph N O , Kanfer, Isadore
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:6444 , http://hdl.handle.net/10962/d1006631
- Description: Dermal microdialysis (DMD) is a technique capable of determining the percutaneous penetration of drugs from topical formulations intended for local and/or regional activity. Typically, the concentrations of drug collected in dialysates are very low, generally in the ng/ml or even pg/ml range. An additional challenge is the very low volume of sample collected at each collection time and which can range from 1 to 30 μl only. Hence the objective was to develop and validate a rapid, accurate, precise, reproducible and highly sensitive LC–MS/MS method for the quantitative analysis of ketoprofen (KET) in dialystes following application of a topical gel product to the skin of human subjects. UPLC–MS/MS was used and KET was separated on an Acquity™ UPLC BEH C18 column (100 mm × 2.1 mm i.d., 1.7 μm) and analysed in negative-ion (NI) electrospray ionisation (ESI) mode. The mobile phase (MP) consisted of acetonitrile:methanol:water (60:20:20, v/v/v) under isocratic conditions at a flow rate of 0.3 ml/min. Samples were extracted using ethyl acetate with ibuprofen (IBU) as internal standard (IS) and the organic solvent was then evaporated to dryness and the residue re-constituted in methanol. 5 μl samples were injected and analysis was performed at ambient temperature 22 ± 0.5 °C. KET and IBU eluted at 1.07 and 1.49 min, respectively. KET and IBU responses were optimised at the transitions 253.00 > 209.00 and 205.00 > 161.00, respectively. Calibration curves were linear over the range 0.5–500 ng/ml with correlation coefficients > 0.999. The accuracy and precision of the method were found to be between 99.97% and 104.67% (R.S.D. < 2%) and the mean recovery of KET from normal saline was 88.03 ± 0.3% (R.S.D. < 2.20%). The LLOQ and LOD values were found to be 0.5 and 0.1 ng/ml respectively whereas the ULOD was set at 500 ng/ml. The method was successfully applied to determine the bioavailability of KET following application of topical KET gel, Fastum® gel, to the skin of human volunteers.
- Full Text:
- Date Issued: 2009
Reflections on the sine causa requirements and the condictiones in South African law
- Authors: Glover, Graham B
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70668 , vital:29687 , https://hdl.handle.net/10520/EJC54716
- Description: The condictiones present interesting and difficult challenges of classification for the modern South African jurist. Their casuistic development has made them difficult to work with, and for a long time it was argued that a single general enrichment action should take their place. But the Supreme Court of Appeal in McCarthy Retail Ltd v Shortdistance Carriers CC 2001 3 SA 482 (SCA) chose not to follow this path, and instead preferred the idea that a general enrichment action should be subsidiary to the traditional actions. This has breathed new life into debates on the future of the condictiones. This article first examines the current range of application of the condictiones. It then proceeds to show how the courts in the first decade of the 21st century seem to have eschewed the technicalities inherent in pleading the condictiones, and have preferred rather to resolve cases by applying the general requirements of enrichment liability, in contrast to the injunction in McCarthy. The difficulty with this approach is the lack of substance that is given to the sine causa requirement. The article proceeds to examine the various theories about how we in South Africa should understand and give content to the sine causa requirement. This provides a springboard for considering the possible futures of the condictiones. Broadly, it seems that two options are possible: either to collapse the condictiones into one action to deal with cases of enrichment by transfer; or largely to retain the status quo. The most recent decisions of the Supreme Court of Appeal indicate that the latter, more conservative option is likely to be chosen in the short-term. If this approach is to be adopted, it will require a further review of how each of the constituent condictiones fulfils a particular function. A revisionist view of the condictio indebiti is postulated by way of example.
- Full Text: false
- Date Issued: 2009
- Authors: Glover, Graham B
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70668 , vital:29687 , https://hdl.handle.net/10520/EJC54716
- Description: The condictiones present interesting and difficult challenges of classification for the modern South African jurist. Their casuistic development has made them difficult to work with, and for a long time it was argued that a single general enrichment action should take their place. But the Supreme Court of Appeal in McCarthy Retail Ltd v Shortdistance Carriers CC 2001 3 SA 482 (SCA) chose not to follow this path, and instead preferred the idea that a general enrichment action should be subsidiary to the traditional actions. This has breathed new life into debates on the future of the condictiones. This article first examines the current range of application of the condictiones. It then proceeds to show how the courts in the first decade of the 21st century seem to have eschewed the technicalities inherent in pleading the condictiones, and have preferred rather to resolve cases by applying the general requirements of enrichment liability, in contrast to the injunction in McCarthy. The difficulty with this approach is the lack of substance that is given to the sine causa requirement. The article proceeds to examine the various theories about how we in South Africa should understand and give content to the sine causa requirement. This provides a springboard for considering the possible futures of the condictiones. Broadly, it seems that two options are possible: either to collapse the condictiones into one action to deal with cases of enrichment by transfer; or largely to retain the status quo. The most recent decisions of the Supreme Court of Appeal indicate that the latter, more conservative option is likely to be chosen in the short-term. If this approach is to be adopted, it will require a further review of how each of the constituent condictiones fulfils a particular function. A revisionist view of the condictio indebiti is postulated by way of example.
- Full Text: false
- Date Issued: 2009
Reform in defence of sovereignty: South Africa in the UN Security Council, 2007–2008
- Authors: Bischoff, Paul, 1954-
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/161431 , vital:40626 , https://0-doi.org.wam.seals.ac.za/10.1177/000203970904400205
- Description: After 1994, South Africa became the sine qua non of an internationalist state, willing to promote cooperation amongst a plurality of actors, believing common interests to be more important than their differences. This raised the hopes of constitutionalists, and those who believed in the expansion of a liberal democratic peace. South Africa has acted out two seemingly contradictory roles: those of a reformer and those of a conserver. By 2007–2008 she had shifted towards the latter, conservative-reformist position. Thus, South Africa's voting record at the General Assembly expressed her overriding concern to regionalise African issues and minimise the US and the West shaping political events. This brought her foreign policy into sharper relief. But while in some sense successful, it came at a price: a controversy about her surrendering her internationalism and principles on human rights for African unity and traditional sovereignty. But it also marked the arrival of South Africa in the world of international Realpolitik.
- Full Text:
- Date Issued: 2009
- Authors: Bischoff, Paul, 1954-
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/161431 , vital:40626 , https://0-doi.org.wam.seals.ac.za/10.1177/000203970904400205
- Description: After 1994, South Africa became the sine qua non of an internationalist state, willing to promote cooperation amongst a plurality of actors, believing common interests to be more important than their differences. This raised the hopes of constitutionalists, and those who believed in the expansion of a liberal democratic peace. South Africa has acted out two seemingly contradictory roles: those of a reformer and those of a conserver. By 2007–2008 she had shifted towards the latter, conservative-reformist position. Thus, South Africa's voting record at the General Assembly expressed her overriding concern to regionalise African issues and minimise the US and the West shaping political events. This brought her foreign policy into sharper relief. But while in some sense successful, it came at a price: a controversy about her surrendering her internationalism and principles on human rights for African unity and traditional sovereignty. But it also marked the arrival of South Africa in the world of international Realpolitik.
- Full Text:
- Date Issued: 2009
Review of South African research and interventions in the development of a policy strategy on teen-aged pregnancy
- Macleod, Catriona I, Tracey, Tiffany
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/434425 , vital:73058 , ISBN review , https://www.researchgate.net/profile/Catriona-Macleod-3/publication/43108043_Review_of_South_African_Research_and_Interventions_in_the_Development_of_a_Policy_Strategy_on_Teen-Aged_Pregnancy/links/0c960539ff3f3595e6000000/Review-of-South-African-Research-and-Interventions-in-the-Development-of-a-Policy-Strategy-on-Teen-Aged-Pregnancy.pdf
- Description: In line with international trends, current South African policy and plans identify sexual and reproductive health as a key priority area for health intervention. Both the prevention of unwanted pregnancies amongst teenagers and the provision of support to those who do conceive contribute to the overall aim of enhancing reproductive health. This report represents a first step in the review of youth and adolescent health policy with regards to pregnancy amongst teenagers. It consists of a review of the scientific literature published in the last 10 years supplemented by information gathered in interviews with key informants from a range of key directorates and organisations. Two broad principles frame this report. The first is the adoption of a nuanced and criti cal approach to understanding ‘adolescent pregnancy’ in context. The second is the adoption of a human rights based perspective that underlies much of South Africa’s legislation and policy with respect to youth sexuality and reproduction.
- Full Text:
- Date Issued: 2009
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2009
- Subjects: To be catalogued
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/434425 , vital:73058 , ISBN review , https://www.researchgate.net/profile/Catriona-Macleod-3/publication/43108043_Review_of_South_African_Research_and_Interventions_in_the_Development_of_a_Policy_Strategy_on_Teen-Aged_Pregnancy/links/0c960539ff3f3595e6000000/Review-of-South-African-Research-and-Interventions-in-the-Development-of-a-Policy-Strategy-on-Teen-Aged-Pregnancy.pdf
- Description: In line with international trends, current South African policy and plans identify sexual and reproductive health as a key priority area for health intervention. Both the prevention of unwanted pregnancies amongst teenagers and the provision of support to those who do conceive contribute to the overall aim of enhancing reproductive health. This report represents a first step in the review of youth and adolescent health policy with regards to pregnancy amongst teenagers. It consists of a review of the scientific literature published in the last 10 years supplemented by information gathered in interviews with key informants from a range of key directorates and organisations. Two broad principles frame this report. The first is the adoption of a nuanced and criti cal approach to understanding ‘adolescent pregnancy’ in context. The second is the adoption of a human rights based perspective that underlies much of South Africa’s legislation and policy with respect to youth sexuality and reproduction.
- Full Text:
- Date Issued: 2009
Reviews: Unsettling Questions: Palestine, Israel, the Holy Land and Zion
- Stähler, A, Vice, S, Brauner, D, Bassi, S, Naidu, Samantha, King, B, O'Neal, G S, Aldama, F L, Gibbs, J, Rotstein, J R U, Calderaro, M A
- Authors: Stähler, A , Vice, S , Brauner, D , Bassi, S , Naidu, Samantha , King, B , O'Neal, G S , Aldama, F L , Gibbs, J , Rotstein, J R U , Calderaro, M A
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157948 , vital:40133 , https://doi.org/10.1080/02690050802589479
- Description: Reviews: Unsettling Questions: Palestine, Israel, the Holy Land and Zion
- Full Text:
- Date Issued: 2009
- Authors: Stähler, A , Vice, S , Brauner, D , Bassi, S , Naidu, Samantha , King, B , O'Neal, G S , Aldama, F L , Gibbs, J , Rotstein, J R U , Calderaro, M A
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157948 , vital:40133 , https://doi.org/10.1080/02690050802589479
- Description: Reviews: Unsettling Questions: Palestine, Israel, the Holy Land and Zion
- Full Text:
- Date Issued: 2009
Rhodes University 2009 Graduation Ceremonies Address
- Authors: Badat, Saleem
- Date: 2009
- Language: English
- Type: text
- Identifier: vital:7585 , http://hdl.handle.net/10962/d1006575
- Description: From introduction: To be awarded a degree or diploma from Rhodes University entails dedicated endeavour. When you joined us you were told that at Rhodes learning and education is a partnership, a relationship of mutual commitment to the pursuit of knowledge and understanding, to the development of expertise and skills, and to the embrace of appropriate values and attitudes. Your graduation is testimony that you have fulfilled your side of the partnership. You have displayed the necessary commitment and willingness to learn, to acquire knowledge and to develop expertise. Your achievement, the fruits of many months and years of toil, is,ultimately, your own great accomplishment.
- Full Text:
- Date Issued: 2009
- Authors: Badat, Saleem
- Date: 2009
- Language: English
- Type: text
- Identifier: vital:7585 , http://hdl.handle.net/10962/d1006575
- Description: From introduction: To be awarded a degree or diploma from Rhodes University entails dedicated endeavour. When you joined us you were told that at Rhodes learning and education is a partnership, a relationship of mutual commitment to the pursuit of knowledge and understanding, to the development of expertise and skills, and to the embrace of appropriate values and attitudes. Your graduation is testimony that you have fulfilled your side of the partnership. You have displayed the necessary commitment and willingness to learn, to acquire knowledge and to develop expertise. Your achievement, the fruits of many months and years of toil, is,ultimately, your own great accomplishment.
- Full Text:
- Date Issued: 2009
Rhodes University Graduation Ceremony 2009
- Authors: Rhodes University
- Date: 2009
- Language: English
- Type: text
- Identifier: vital:8138 , http://hdl.handle.net/10962/d1007250
- Description: Rhodes University Graduation Ceremonies [at] 1820 Settlers National Monument Thursday, 16 April at 18:00 [and] Friday, 17 April at 10:30; 14:30 & 18:00 [and] Saturday, 18 April at 10:30
- Full Text:
- Date Issued: 2009
- Authors: Rhodes University
- Date: 2009
- Language: English
- Type: text
- Identifier: vital:8138 , http://hdl.handle.net/10962/d1007250
- Description: Rhodes University Graduation Ceremonies [at] 1820 Settlers National Monument Thursday, 16 April at 18:00 [and] Friday, 17 April at 10:30; 14:30 & 18:00 [and] Saturday, 18 April at 10:30
- Full Text:
- Date Issued: 2009
Rhodes University Library Annual Report 2009: Library Director’s Review
- Authors: Thomas, G M E
- Date: 2009
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/59941 , vital:27713
- Description: [From the Introduction] As you read through this annual overview of the work carried out by the staff of the Rhodes University Library Services Division, I am sure you will be impressed by their achievements during a year marked by major building construction and a demanding institutional review of our services and staffing structures.
- Full Text:
- Date Issued: 2009
- Authors: Thomas, G M E
- Date: 2009
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/59941 , vital:27713
- Description: [From the Introduction] As you read through this annual overview of the work carried out by the staff of the Rhodes University Library Services Division, I am sure you will be impressed by their achievements during a year marked by major building construction and a demanding institutional review of our services and staffing structures.
- Full Text:
- Date Issued: 2009
Rich Representation and Visualisation of Time-Series Data
- Kerr, Simon, Foster, Greg, Irwin, Barry V W
- Authors: Kerr, Simon , Foster, Greg , Irwin, Barry V W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428130 , vital:72488 , https://www.researchgate.net/profile/Barry-Ir-win/publication/265821926_Rich_Representation_and_Visualisation_of_Time-Series_Data/links/5548a1350cf26a7bf4daefb1/Rich-Representation-and-Visualisation-of-Time-Series-Data.pdf
- Description: Currently the majority of data is visualized using static graphs and ta-bles. However, static graphs still leave much to be desired and provide only a small insight into trends and changes between values. We pro-pose a move away from purely static representations of data towards a more fluid and understandable environment for data representation. This is achieved through the use of an application which animates time based data. Animating time based data allows one to see nuances within a dataset from a more comprehensive perspective. This is espe-cially useful within the time based data rich telecommunications indus-try. The application comprises of two parts-the backend manages raw data which is then passed to the frontend for animation. A play function allows one to play through a time series. Which creates a fluid and dy-namic environment for exploring data. Both the advantages and disad-vantages of this approach are investigated and an application is intro-duced which can be used to animate and explore datasets.
- Full Text:
- Date Issued: 2009
- Authors: Kerr, Simon , Foster, Greg , Irwin, Barry V W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/428130 , vital:72488 , https://www.researchgate.net/profile/Barry-Ir-win/publication/265821926_Rich_Representation_and_Visualisation_of_Time-Series_Data/links/5548a1350cf26a7bf4daefb1/Rich-Representation-and-Visualisation-of-Time-Series-Data.pdf
- Description: Currently the majority of data is visualized using static graphs and ta-bles. However, static graphs still leave much to be desired and provide only a small insight into trends and changes between values. We pro-pose a move away from purely static representations of data towards a more fluid and understandable environment for data representation. This is achieved through the use of an application which animates time based data. Animating time based data allows one to see nuances within a dataset from a more comprehensive perspective. This is espe-cially useful within the time based data rich telecommunications indus-try. The application comprises of two parts-the backend manages raw data which is then passed to the frontend for animation. A play function allows one to play through a time series. Which creates a fluid and dy-namic environment for exploring data. Both the advantages and disad-vantages of this approach are investigated and an application is intro-duced which can be used to animate and explore datasets.
- Full Text:
- Date Issued: 2009
SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines:
- Acharya, Mridu, Edkins, Adrienne L, Ozanne, B, Cushley, W
- Authors: Acharya, Mridu , Edkins, Adrienne L , Ozanne, B , Cushley, W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165044 , vital:41204 , DOI: 10.1038/leu.2009.126
- Description: CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by αvβ5 and anti-αvβ5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of αvβ5 with anti-αvβ5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1.
- Full Text:
- Date Issued: 2009
- Authors: Acharya, Mridu , Edkins, Adrienne L , Ozanne, B , Cushley, W
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165044 , vital:41204 , DOI: 10.1038/leu.2009.126
- Description: CD23 acts through the αvβ5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. αvβ5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by αvβ5 and anti-αvβ5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of αvβ5 with anti-αvβ5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1.
- Full Text:
- Date Issued: 2009
Seeing is natural, but viewing is not: teaching visual literacy in a rural classroom
- Mbelani, Madeyandile, Murray, Sarah R
- Authors: Mbelani, Madeyandile , Murray, Sarah R
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:7022 , http://hdl.handle.net/10962/d1007203
- Description: This paper reports on a collaborative action research case study into Grade 10 teaching and learning of visual literacy in a rural high school into the Eastern Cape, South Africa. Visual literacy is a new aspect that has been incorporated in English First Additional Language National Curriculum Statement (Grade 10-12), which has been implemented in Grade 10 from 2006. With the aim of gaining knowledge and improving performance in visual literacy, I designed a unit of lessons, which exposed learners to visual grammar and visual texts and I collected data around the implementation of the lesson unit as evidenced by journal writing, interviews and non-participant observation. The data revealed that visual literacy could be taught meaningfully in a rural high school as the learners could identify, cut, paste and critically discuss elements of visual language and they finally designed their own advertisements in groups. However, the following factors emerged as hindrances to the successful teaching of visual literacy in this case: lack of resources; learners' lack of a foundation in visual literacy from Grades 7-9; and problems revolving around time management and pacing.
- Full Text:
- Date Issued: 2009
- Authors: Mbelani, Madeyandile , Murray, Sarah R
- Date: 2009
- Language: English
- Type: text , Article
- Identifier: vital:7022 , http://hdl.handle.net/10962/d1007203
- Description: This paper reports on a collaborative action research case study into Grade 10 teaching and learning of visual literacy in a rural high school into the Eastern Cape, South Africa. Visual literacy is a new aspect that has been incorporated in English First Additional Language National Curriculum Statement (Grade 10-12), which has been implemented in Grade 10 from 2006. With the aim of gaining knowledge and improving performance in visual literacy, I designed a unit of lessons, which exposed learners to visual grammar and visual texts and I collected data around the implementation of the lesson unit as evidenced by journal writing, interviews and non-participant observation. The data revealed that visual literacy could be taught meaningfully in a rural high school as the learners could identify, cut, paste and critically discuss elements of visual language and they finally designed their own advertisements in groups. However, the following factors emerged as hindrances to the successful teaching of visual literacy in this case: lack of resources; learners' lack of a foundation in visual literacy from Grades 7-9; and problems revolving around time management and pacing.
- Full Text:
- Date Issued: 2009