Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin:
- Kituyi, Sarah N, Edkins, Adrienne L
- Authors: Kituyi, Sarah N , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164435 , vital:41118 , https://doi.org/10.1016/j.bbrc.2018.11.073
- Description: Hop/STIP1 is a co-chaperone of Hsp70 and Hsp90 that regulates a number of cell biology processes via interactions with cellular proteins. Here we report a new relationship between Hop and the nuclear structural protein emerin in maintenance of nuclear morphology. Depletion or overexpression of Hop resulted in the reduction of emerin protein levels via proteasomal and lysosomal pathways.
- Full Text:
- Date Issued: 2018
- Authors: Kituyi, Sarah N , Edkins, Adrienne L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164435 , vital:41118 , https://doi.org/10.1016/j.bbrc.2018.11.073
- Description: Hop/STIP1 is a co-chaperone of Hsp70 and Hsp90 that regulates a number of cell biology processes via interactions with cellular proteins. Here we report a new relationship between Hop and the nuclear structural protein emerin in maintenance of nuclear morphology. Depletion or overexpression of Hop resulted in the reduction of emerin protein levels via proteasomal and lysosomal pathways.
- Full Text:
- Date Issued: 2018
The state's role in the regulation and provision of legal services in South Africa and the United States: supporting, nudging, or interfering
- Kruuse, Helen, Genty, Philip
- Authors: Kruuse, Helen , Genty, Philip
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129153 , vital:36225 , https://heinonline.org/HOL/P?h=hein.journals/frdint42amp;i=390
- Description: An independent legal profession is said to be "the bulwark of a free and democratic society."1 It is also said that a high measure of independence of mind and action by legal actors is necessary for the maintenance of the rule of law.2 However, too often, there is the allegation (within the sociological literature in particular) that the legal profession has used the concepts of independence and the rule of law as a shield or cuirass rather than as a sword.3 The image of lawyers representing unpopular clients fearlessly and advocating on behalf of unpopular causes, so as to uphold legal rights, is replaced with images of lawyers using these self-same concepts to preserve the status quo,4 favor those with high social status5 and pursue self-regulation for self-interest rather than for any so-called public interest. 6
- Full Text:
- Date Issued: 2018
- Authors: Kruuse, Helen , Genty, Philip
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129153 , vital:36225 , https://heinonline.org/HOL/P?h=hein.journals/frdint42amp;i=390
- Description: An independent legal profession is said to be "the bulwark of a free and democratic society."1 It is also said that a high measure of independence of mind and action by legal actors is necessary for the maintenance of the rule of law.2 However, too often, there is the allegation (within the sociological literature in particular) that the legal profession has used the concepts of independence and the rule of law as a shield or cuirass rather than as a sword.3 The image of lawyers representing unpopular clients fearlessly and advocating on behalf of unpopular causes, so as to uphold legal rights, is replaced with images of lawyers using these self-same concepts to preserve the status quo,4 favor those with high social status5 and pursue self-regulation for self-interest rather than for any so-called public interest. 6
- Full Text:
- Date Issued: 2018
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