Prolongation of Acid-Fast Bacilli Sputum Smear Positivity in Patients with Multidrug Pulmonary Tuberculosis

Mvo, Sidwell; Bokop, Carine; Longo-Mbenza, Benjamin; Vasaikar, D Sandeep; Apalata, Teke

Title: Prolongation of Acid-Fast Bacilli Sputum Smear Positivity in Patients with Multidrug Pulmonary Tuberculosis
Creator: Mvo, Sidwell
Creator: Bokop, Carine
Creator: Longo-Mbenza, Benjamin
Creator: Vasaikar, D Sandeep
Creator: Apalata, Teke
Subject: MDR-TB
Subject: HIV status
Subject: Time to sputum microscopy conversion
Subject: Smear positivity
Date Issued: 2023
Date: 2023
Type: Article
Identifier: http://hdl.handle.net/11260/13621
Identifier: vital:78968
Identifier: DOI: https://doi.org/10.3390/pathogens12091133
Description: The study sought to determine factors associated with prolonged smear positivity in multidrug-resistant tuberculosis (MDR-TB) patients following appropriate management. Newly diagnosed patients were enrolled between June 2017 and May 2018. Sputum samples were collected for Xpert® MTB/RIF and line probe assays (LiPAs). Microscopic tests were performed at baseline and 4, 8, and 12 weeks post-anti-TB therapy. Of the 200 patients, 114 (57%) were HIV-positive. After 12 weeks of treatment, there was a significant microscopy conversion rate among DS-TB patients compared to MDR-TB patients irrespective of their HIV status (p = 0.0013). All MDR-TB patients who had a baseline smear grade ranging from scanty to +1 converted negative, while 25% ranging from +2 to +3 remained positive until the end of 12 weeks (p = 0.014)…
Language: English
Relation: pathogens
Relation: Mvo, S.; Bokop, C.; Longo-Mbenza, B.; Vasaikar, S.D.; Apalata, T. Prolongation of Acid-Fast Bacilli Sputum Smear Positivity in Patients with Multidrug-Resistant Pulmonary Tuberculosis. Pathogens 2023, 12, 1133. https://doi.org/ 10.3390/pathogens12091133
Relation: pathogens 9 vol 12 1 17 2023 https://doi.org/10.3390/pathogens12091133

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