- Title
- DSC screening of potential prochlorperazine-excipient interactions in preformulation studies
- Creator
- Brown, Michael E
- Creator
- Antunes, Edith M
- Creator
- Glass, Beverley M
- Creator
- Lebete, Mosimotsana L
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 1999
- Date
- 1999
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184367
- Identifier
- vital:44212
- Identifier
- xlink:href="https://doi.org/10.1023/A:1010150305542"
- Description
- Differential scanning calorimetry was used to examine the thermal behaviour of mixtures of the drug prochlorperazine with standard excipients, to assess potential interactions, and of mixtures with cyclodextrins, to investigate inclusion complexation which could increase the photostability of the drug. For most of the excipients (magnesium stearate, stearic acid, Explotab®, Ac-Di-Sol®, Encompress® and Ludipress®, lactose and Starch 1500) disappearance or broadening of the melting endotherm of the drug indicated interactions. Lubritab® was the only 'inert' excipient tested. Mixtures of prochlorperazine and the cyclodextrins gave incomplete inclusion complexation as shown by only partial disappearance of the melting endotherm of the drug.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (6 pages)
- Format
- Publisher
- SpringerLink
- Language
- English
- Relation
- Journal of Thermal Analysis and Calorimetry
- Relation
- Brown, M.E., Antunes, E.M., Glass, B.D., Lebete, M. and Walker, R.B., 1999. DSC screening of potential prochlorperazine-excipient interactions in preformulation studies. Journal of thermal analysis and calorimetry, 56(3), pp.1317-1322
- Relation
- Journal of Thermal Analysis and Calorimetry volume 56 number 3 p.1317 1999 1572-8943
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the SpringerLink Terms of Use Statement ( https://link.springer.com/termsandconditions)
- Rights
- Open Access
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Collections
Walker, Roderick Bryan (Prof)
Antunes, Edith Martins (Dr)
Brown, Michael Ewart 1938- (Prof)
RU Department of Chemistry
RU Department of Pharmacy
SDG 03. Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | DSC screening of potential prochlorperazine-excipient interactions in preformulation studies.pdf | 215 KB | Adobe Acrobat PDF | View Details Download |