Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective

Edkins, Adrienne L; Price, John T; Pockley, A Graham; Blatch, Gregory L

Title: Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective
Creator: Edkins, Adrienne L
Creator: Price, John T
Creator: Pockley, A Graham
Creator: Blatch, Gregory L
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164332
Identifier: vital:41109
Identifier: DOI: 10.1098/rstb.2016.0521
Description: Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguably among the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a number of different diseases. Although the concept was initially controversial, it is now widely accepted that HSPs have additional biological functions over and above their role in proteostasis (so-called ‘protein moonlighting’).
Format: 8 pages
Format: pdf
Language: English
Relation: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B
Relation: Edkins AL, Price JT, Pockley AG, Blatch GL. 2017 Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. Phil. Trans. R. Soc. B 373: 20160521. http://dx.doi.org/10.1098/rstb.2016.0521
Relation: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B volume 373 number 1738 1 7 December 2017 1471-2970
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Royal Society Publishing Terms and Conditions Statement (https://royalsociety.org/about-us/terms-conditions-policies/)

Hits: 1393
Visitors: 1529
Downloads: 152

Collections

RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

Edkins, Adrienne Lesley (Associate Prof)

Blatch, Gregory Lloyd (Prof)

RU Department of Biochemistry, Microbiology and Bioinformatics

SDG 03. Good Health and Well-Being

		Thumbnail	File	Description	Size	Format
View Details Download			SOURCE1	Heat shock proteins as modulators and therapeutic targets of chronic disease.pdf	532 KB	Adobe Acrobat PDF	View Details Download