Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
- Olsen, Elisabeth, De Cerf, Christopher, Dziwornu, Godwin A, Puccinelli, Eleonora, Parker-Nance, Shirley, Ansorge, Isabelle J, Samaai, Toufiek, Dingle, Laura M K, Edkins, Adrienne L, Sunassee, Suthananda N
- Authors: Olsen, Elisabeth , De Cerf, Christopher , Dziwornu, Godwin A , Puccinelli, Eleonora , Parker-Nance, Shirley , Ansorge, Isabelle J , Samaai, Toufiek , Dingle, Laura M K , Edkins, Adrienne L , Sunassee, Suthananda N
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66300 , vital:28931 , https://doi.org/10.17159/sajs.2016/20160202
- Description: publisher version , Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. , University of Cape Town; South African Medical Research Council; National Research Foundation (South Africa); CANSA; Rhodes University; Department of Science and Technology; Department of Environmental Affairs; SANAP
- Full Text:
- Date Issued: 2016
- Authors: Olsen, Elisabeth , De Cerf, Christopher , Dziwornu, Godwin A , Puccinelli, Eleonora , Parker-Nance, Shirley , Ansorge, Isabelle J , Samaai, Toufiek , Dingle, Laura M K , Edkins, Adrienne L , Sunassee, Suthananda N
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66300 , vital:28931 , https://doi.org/10.17159/sajs.2016/20160202
- Description: publisher version , Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. , University of Cape Town; South African Medical Research Council; National Research Foundation (South Africa); CANSA; Rhodes University; Department of Science and Technology; Department of Environmental Affairs; SANAP
- Full Text:
- Date Issued: 2016
Observations of the habitats and biodiversity of the submarine canyons at Sodwana Bay
- Sink, K J, Boshoff, W, Samaai, Toufiek, Timm, P G, Kerwath, S E
- Authors: Sink, K J , Boshoff, W , Samaai, Toufiek , Timm, P G , Kerwath, S E
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6771 , http://hdl.handle.net/10962/d1008065
- Description: The discovery of coelacanths, Latimeria chalumnae, in Jesser Canyon off Sodwana Bay in northern KwaZulu-Natal in 2000 triggered renewed interest in the deep subtidal habitats associated with submarine canyons. Information stemming from three recreational Trimix diving expeditions in Wright and Jesser canyons between April 1998 and June 2001 revealed distinct and diverse invertebrate and fish communities in the canyons of the Greater St Lucia Wetland Park (GSLWP). In total, 69 invertebrate taxa were collected from Wright Canyon, including at least 15 new records for South Africa plus 11 potential new species and 16 range or depth extensions. Divers documented the first five coelacanth specimens and obtained information on fish distribution and abundance. Five different habitat types were recognized supporting distinct biological communities; the sandy plains outside of the canyons, scattered rock outcrops within the sandy plains, the canyon margin, canyon walls and caves and overhangs. The canyon margin is the richest habitat and supports dense communities of invertebrate suspension feeders, as well as a diverse and abundant fish fauna. Dominant canyon invertebrates included sponges, black corals, gorgonians, alcyonarian soft corals and stylasterine lace corals. These invertebrates support a diverse epifauna including basket- and brittlestars, winged oysters and other molluscs. The canyons within the GSLWP protect large populations of commercially important linefish species including the sparids, Chrysoblephus puniceus, C. anglicus, Polysteganus praeorbitalis and P. caeruleopunctatus, as well as several species of serranids and lutjanids. Additional biological sampling and standardized quantitative sampling within the canyons and deep reefs is required to develop a better understanding of their biological communities and the factors that shape them.
- Full Text:
- Date Issued: 2006
- Authors: Sink, K J , Boshoff, W , Samaai, Toufiek , Timm, P G , Kerwath, S E
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6771 , http://hdl.handle.net/10962/d1008065
- Description: The discovery of coelacanths, Latimeria chalumnae, in Jesser Canyon off Sodwana Bay in northern KwaZulu-Natal in 2000 triggered renewed interest in the deep subtidal habitats associated with submarine canyons. Information stemming from three recreational Trimix diving expeditions in Wright and Jesser canyons between April 1998 and June 2001 revealed distinct and diverse invertebrate and fish communities in the canyons of the Greater St Lucia Wetland Park (GSLWP). In total, 69 invertebrate taxa were collected from Wright Canyon, including at least 15 new records for South Africa plus 11 potential new species and 16 range or depth extensions. Divers documented the first five coelacanth specimens and obtained information on fish distribution and abundance. Five different habitat types were recognized supporting distinct biological communities; the sandy plains outside of the canyons, scattered rock outcrops within the sandy plains, the canyon margin, canyon walls and caves and overhangs. The canyon margin is the richest habitat and supports dense communities of invertebrate suspension feeders, as well as a diverse and abundant fish fauna. Dominant canyon invertebrates included sponges, black corals, gorgonians, alcyonarian soft corals and stylasterine lace corals. These invertebrates support a diverse epifauna including basket- and brittlestars, winged oysters and other molluscs. The canyons within the GSLWP protect large populations of commercially important linefish species including the sparids, Chrysoblephus puniceus, C. anglicus, Polysteganus praeorbitalis and P. caeruleopunctatus, as well as several species of serranids and lutjanids. Additional biological sampling and standardized quantitative sampling within the canyons and deep reefs is required to develop a better understanding of their biological communities and the factors that shape them.
- Full Text:
- Date Issued: 2006
Anti-oesophageal cancer activity in extracts of deep-water Marion Island sponges
- Davies-Coleman, Michael T, Froneman, P William, Keyzers, Robert A, Whibley, Catherine, Hendricks, Denver T, Samaai, Toufiek, McQuaid, Christopher D
- Authors: Davies-Coleman, Michael T , Froneman, P William , Keyzers, Robert A , Whibley, Catherine , Hendricks, Denver T , Samaai, Toufiek , McQuaid, Christopher D
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6569 , http://hdl.handle.net/10962/d1004132
- Description: Oesophageal cancer is one of the most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004.
- Full Text:
- Date Issued: 2005
- Authors: Davies-Coleman, Michael T , Froneman, P William , Keyzers, Robert A , Whibley, Catherine , Hendricks, Denver T , Samaai, Toufiek , McQuaid, Christopher D
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6569 , http://hdl.handle.net/10962/d1004132
- Description: Oesophageal cancer is one of the most common causes of cancer-related deaths in South African black males. The limited efficacy of chemotherapeutic agents to treat this disease has prompted a search for potential new chemical entities with anticancer properties. We report here on the evidence for anti-oesophageal cancer activity in the methanolic extracts of five species of sponges dredged from a depth of approximately 100 m in the vicinity of Marion Island in the Southern Ocean during the autumn of 2004.
- Full Text:
- Date Issued: 2005
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