- Title
- Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities
- Creator
- Mbosso, Emmanuel
- Creator
- Siwe-Noundou, Xavier
- Creator
- Fannang, Simone V
- Creator
- Song, Achille M
- Creator
- Assob, Jules C N
- Creator
- Hoppe, Heinrich C
- Creator
- Krause, Rui W M
- Subject
- To be catalogued
- Date Issued
- 2021
- Date
- 2021
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/191779
- Identifier
- vital:45163
- Identifier
- xlink:href="https://doi.org/10.1080/14786419.2019.1647425"
- Description
- Terminaliamide (1), a new ceramide was isolated from the roots of Terminalia mantaly H. Perrier (Combretaceae) along with 4 known compounds (2–5). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound 1 exhibited moderated antibacterial activity towards Staphylococcus aureus with MIC value of 62.5 μg/mL. The crude MeOH extract (TMr) highly reduced Plasmodium falciparum growth with an IC50 value of 10.11 μg/mL, while hexane fraction (F1) highly reduced Trypanosoma brucei brucei growth with an IC50 value of 5.60 µg/mL. All tested samples presented little or no in vitro cytotoxicity on HeLa cell line. The present work confirms that T. mantaly is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (9 pages)
- Format
- Publisher
- Taylor and Francis Online
- Language
- English
- Relation
- Natural Product Research
- Relation
- Mbosso Teinkela, J.E., Siwe Noundou, X., Fannang, S., Mbem Song, A., Assob Nguedia, J.C., Hoppe, H.C. and Krause, R.W.M., 2021. Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities. Natural product research, 35(8), pp.1313-1322
- Relation
- Natural Product Research volume 35 number 8 p. 1313 2021 1478-6427
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Taylor and Francis Online Terms and Conditions Statement (https://www.tandfonline.com/terms-and-conditions)
- Rights
- Open Access
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Collections
Krause, Rui Werner Maçedo (Prof)
Hoppe, Heinrich C (Prof)
RU Department of Chemistry
SDG 03. Good Health and Well-Being
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