Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum

van Wyk, Albert W W; Lobb, Kevin A; Mino, Caira R; Hoppe, Heinrich C; Davies-Coleman, Michael T

Title: Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum
Creator: van Wyk, Albert W W
Creator: Lobb, Kevin A
Creator: Mino, Caira R
Creator: Hoppe, Heinrich C
Creator: Davies-Coleman, Michael T
Subject: To be catalogued
Date Issued: 2007
Date: 2007
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/450511
Identifier: vital:74956
Identifier: xlink:href="https://doi.org/10.1021/np0701071"
Description: The known 17-norisopimar-15-ene-8‚,13‚-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13-(15)-E-en-8‚-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8‚-ol-16-oate (7), 17-norpimaran-13R-ethoxy-8,16-olactone(8), 17-norisopimarane-8‚,15-diol (9), and 17-norarabiet-13(15)-ene-8‚,16-diol (10), were prepared from manool (11).Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of5-10. All fivecompounds exhibited in Vitroantiplasmodial activity against the malarial parasitePlasmodium falciparumat varyingÌgmL-1concentrations.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (6 pages)
Format: pdf
Publisher: ACS Publications
Language: English
Relation: Journal of Natural Products
Relation: van Wyk, A.W., Lobb, K.A., Caira, M.R., Hoppe, H.C. and Davies-Coleman, M.T., 2007. Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum. Journal of natural products, 70(8), pp.1253-1258
Relation: Journal of Natural Products volume 70 number 8 p. 1253 2007 1520-6025
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the ACS Publications Terms of Use Statement (https://0-www.acs.org.wam.seals.ac.za/content/acs/en/terms.html)
Rights: Closed Access

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Davies-Coleman, Michael Trevor (Prof)

Hoppe, Heinrich C (Prof)

Lobb, Kevin Allan (Assoc Prof)

RU Department of Chemistry

SDG 03. Good Health and Well-Being

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