In vitro antimalarial, antitrypanosomal and HIV-1 integrase inhibitory activities of two Cameroonian medicinal plants: Antrocaryon klaineanum (Anacardiaceae) and Diospyros conocarpa (Ebenaceae)
- Fouokeng, Y, Feusso, H M Feumo, Noundou, Xavier S, Krause, Rui W M, Teinkela, Jean E Mb, Wintjens, R, Hoppe, Heinrich C, Azebaze, Anatole G B, Vardamides, Juliette C, Isaacs, Michelle
- Authors: Fouokeng, Y , Feusso, H M Feumo , Noundou, Xavier S , Krause, Rui W M , Teinkela, Jean E Mb , Wintjens, R , Hoppe, Heinrich C , Azebaze, Anatole G B , Vardamides, Juliette C , Isaacs, Michelle
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126653 , vital:35908 , https://doi.org/10.1016/j.sajb.2018.10.008
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value
- Full Text:
- Date Issued: 2018
- Authors: Fouokeng, Y , Feusso, H M Feumo , Noundou, Xavier S , Krause, Rui W M , Teinkela, Jean E Mb , Wintjens, R , Hoppe, Heinrich C , Azebaze, Anatole G B , Vardamides, Juliette C , Isaacs, Michelle
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126653 , vital:35908 , https://doi.org/10.1016/j.sajb.2018.10.008
- Description: Antiplasmodial, antitrypanosomal and anti-HIV-1 activities of crude extracts, fractions and some isolated compounds from two Cameroonian medicinal plants: Antrocaryon klaineanum Pierre (Anacardiaceae) and Diospyros conocarpa Gürke ex K. Schum. (Ebenaceae) were assessed. The phytochemical studies led to the isolation of eight compounds (1–8) from Diospyros conocarpa and six compounds (6, 9–13) from Antrocaryon klaineanum. These compounds were identified as mangiferolic acid (1), 3β, 22(S)-dihydroxycycloart-24E-en-26-oic acid (2), lupeol (3), aridanin (4), betulin (5), betulinic acid (6), bergenin (7), D-quercitol(8), entilin C(9), entilin A(10), antrocarine A(11), 7R,20(S)-dihydroxy-4,24(28)-ergostadien-3-one(12) and stigmasterol glucoside (13). The criteria for activity were set as follows: an IC50 value
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- Date Issued: 2018
Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae)
- Mbeunkeu, Ahri B D, Noundou, Xavier S, Krause, Rui W M, Teinkela, Jean E M, Laatsch, Hartmut, Azebaze, Anatole G B, Vardamides, Juliette C, Tala, Michel F
- Authors: Mbeunkeu, Ahri B D , Noundou, Xavier S , Krause, Rui W M , Teinkela, Jean E M , Laatsch, Hartmut , Azebaze, Anatole G B , Vardamides, Juliette C , Tala, Michel F
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126782 , vital:35922 , https://doi.org/10.1016/j.phytol.2018.06.019
- Description: Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-Dglucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of 4.0%; the other compounds were inactive in this test.
- Full Text:
- Date Issued: 2018
- Authors: Mbeunkeu, Ahri B D , Noundou, Xavier S , Krause, Rui W M , Teinkela, Jean E M , Laatsch, Hartmut , Azebaze, Anatole G B , Vardamides, Juliette C , Tala, Michel F
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/126782 , vital:35922 , https://doi.org/10.1016/j.phytol.2018.06.019
- Description: Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-Dglucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of 4.0%; the other compounds were inactive in this test.
- Full Text:
- Date Issued: 2018
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