56 years old and growing : Geography
- Authors: Lewis, Colin A
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6708 , http://hdl.handle.net/10962/d1006745
- Description: This article traces the growth and development of the Rhodes University Geography Department from 1936 to 1992, the academic staff and students associated with it, and the research emanating from it.
- Full Text: false
- Date Issued: 1992
How taboo are taboo words for girls?
- Authors: De Klerk, Vivian A
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6143 , http://hdl.handle.net/10962/d1011596
- Description: In the past five years, there has been much interest in the question of whether women are really as concerned about politeness and status as they have been made out to be by such writers as Baroni and D'Urso (1984), Crosby and Nyquist (1977), Lakoff (1973), Spender (1980), and Trudgill (1972). Despite the commonly held perception that it is only males who bandy about derogatory and taboo words (Bailey 1985; Flexner 1975), Risch (1987) provided counterevidence based on data obtained in the United States. The results of the present study, based on data obtained in South Africa, strongly support her findings and challenge the assumption that women stick to standard speech, citing evidence that young females are familiar with, and use, a wide range of highly taboo/slang items themselves. In particular, attention is devoted to the question of pejorative words applicable to males and females, respectively, and the view that there are only a few pejorative terms commonly used to describe males (particularly by females) is challenged. (Women's language, politeness, linguistic taboo, stereotypes, slang, expletives, prestige forms).
- Full Text:
- Date Issued: 1992
In vitro diffusion cell design and validation. II. Temperature, agitation and membrane effects on betamethasone 17-valerate permeation
- Authors: Smith, Eric W , Haigh, John M
- Date: 1992
- Language: English
- Type: text , Article
- Identifier: vital:6422 , http://hdl.handle.net/10962/d1006557
- Description: An in vitro permeation cell has been designed and validated for use in monitoring the transmembrane permeation of betamethasone 17-valerate. The design utilizes common laboratory equipment and incorporates as many beneficial features as possible from other designs. The importance of fully validating the hydrodynamic performance of the cell prior to experimentation is stressed. The cell was validated by monitoring the diffusion of betamethasone 17-valerate in isopropyl myristate solution into purified isopropyl myristate receptor phase at different temperatures, different agitation rates and through different synthetic and biological membranes. The results of the hydrodynamic validation agree with data from other researchers and show that the permeation cell is adequately sensitive to these experimental parameters. The results of the membrane evaluation allow appropriate selection of the barrier material for representative transdermal experiments to be conducted. While human and porcine stratum corneum/epidermis are similar in diffusive properties, hairless mouse skin appears to be the most convenient animal membrane for these studies. Although silicone and cellulose membranes appear to be useful in this application, porous filter membranes and egg-shell membranes are insufficiently discriminatory to betamethasone 17-valerate diffusion to provide useful in vitro permeation data.
- Full Text: false
- Date Issued: 1992
Influence of the oil phase dispersion in a cream base on the in vivo release of betamethasone 17-valerate
- Authors: Haigh, J M , Smith, E W , Meyer, E , Fassihi, A R
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6365 , http://hdl.handle.net/10962/d1006065
- Description: Release of betamethasone valerate (betamethasone 17-valerate) from 3 extemporaneous cream formulations (1 control, 1 containing propylene glycol, and 1 containing \b/-cyclodextrin) and a commercial cream formulation (Betnovate) was compared using the human skin blanching assay in 12 healthy male volunteers. All 3 extemporaneous formulations showed similar drug release rates, equivalent to or better than the commercial preparation containing betamethasone in a 10 fold higher concentration. Electron microscopic examination showed considerably finer dispersion of the oil phase in the extemporaneous formulations. It was concluded that the increased surface area available for partitioning of betamethasone between the cream and the skin is responsible for the improved topical availability of the drug from the extemporaneous formulations.
- Full Text: false
- Date Issued: 1992
Introduction and extinction of brown trout (Salmo trutta L.) in an impoverished subantarctic stream
- Authors: Cooper, J , Crafford, J E , Hecht, Thomas
- Date: 1992
- Subjects: Anadromous fishes -- Marion Island
- Language: English
- Type: Article
- Identifier: vital:6767 , http://hdl.handle.net/10962/d1008044
- Description: Brown trout were introduced to the Van den Boogaard River on subantarctic Marion Island in 1964, and a small population became established. The last individual was seen in 1984, and the species is now considered to be extinct on the island. Their diet was exclusively allochthonous, with snails and spiders predominating. Ages estimated at six to eleven years showed that spawning must have occurred since the original introduction. Since the Van den Boogaard River enters the sea via a waterfall, it is postulated that trout were not able to practice an anadromous life-style, and that this, as well as other factors connected with the impoverished nature of the stream, led to dwarfing of the resident population. No further introductions of alien fish to Marion Island should be contemplated.
- Full Text:
- Date Issued: 1992
Sensitivity of different areas of the flexor aspect of the human forearm to corticosteroid-induced skin blanching
- Authors: Meyer, Eric , Smith, Eric W , Haigh, John M
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6394 , http://hdl.handle.net/10962/d1006317
- Description: The intensity of corticosteroid-induced blanching has been found to vary at different areas of the flexor aspect of the human forearm. A retrospective analysis of 38,880 observations of skin blanching in 56 volunteers was conducted to assess the sensitivity of forearm skin to betamethasone 17-valerate. The mid-forearm appears to be more sensitive to the blanching response than do the areas close to the wrist or elbow. These results indicate that each preparation under evaluation should be applied to several sites along the forearm when using the human skin blanching assay in order to obtain an accurate comparative assessment of corticosteroid release from topical delivery vehicles.
- Full Text: false
- Date Issued: 1992