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An investigation into the possible neuroprotective or neurotoxic properties of metrifonate

  • Authors: Ramsunder, Adrusha
  • Date: 2005 , 2013-06-11
  • Subjects: Nervous system -- Degeneration -- Treatment , Neurotoxic agents , Alzheimer's disease -- Treatment , Metrifonate
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3833 , http://hdl.handle.net/10962/d1007560 , Nervous system -- Degeneration -- Treatment , Neurotoxic agents , Alzheimer's disease -- Treatment , Metrifonate
  • Description: Alzheimer's disease is a progressive neurodegenerative disorder, in which there is a marked decline in neurotransmitters, especially those of the cholinergic pathways. One of the approaches to the symptomatic treatment of Alzheimer's disease is the inhibition of the breakdown of the neurotransmitter acetylcholine, using an acetylcholinesterase inhibitor. One such drug tested, is the organophosphate, metrifonate. Any drug used for the treatment of neurodegenerative disorders should preferably not induce further neurological damage. Thus, in the present study, we investigated whether or not metrifonate is neuroprotective. The in vivo and in vitro effect of this drug on free radicals generation shows that metrifonate increases the level ofthese reactive species. Lipid peroxidation induced using quinolinic acid (QA) and iron (II) and show that metrifonate increased the peroxidative damage induced by using quinolinic acid. Metrifonate is also able to induce lipid peroxidation both in vivo and in vitro. This was reduced in vitro in the presence of melatonin. Using iron (II), in vi/ro, there was no significant difference in the level of lipid peroxidation in the presence of this drug. An investigation of the activity of the mitochondrial electron transport chain and complex I of the electron transport chain in the presence of metrifonate revealed that metrifonate reduces the activity of the electron transport chain at the level of complex I. The activity of the mitochondrial electron transport chain was restored in the presence of melatonin. Pineal organ culture showed that metrifonate does not increase melatonin production. Histological and apoptosis studies show that tissue necrosis and apoptosis respectively, occur in the presence of this agent, which is reduced in the presence of melatonin. Metal binding studies were performed USing ultraviolet spectroscopy, and electrochemical analysis to examine the interaction of metrifonate with iron (II) and iron (III). No shift in the peak was observed in the ultraviolet spectrum when iron (ll) was added to metrifonate. Electrochemical studies show that there may be a very weak or no ligand formed between the metal and drug. This study shows that while drugs such as metrifonate may be beneficial in restoring cognitive function in Alzheimer's disease, it could also have the potential to enhance neurodegeneration, thus worsening the condition, in the long term. , KMBT_363 , Adobe Acrobat 9.54 Paper Capture Plug-in
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  • Date Issued: 2005

An investigation into unintentional information leakage through electronic publication

  • Authors: Forrester, Jock , Irwin, Barry V W
  • Date: 2005
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/428814 , vital:72538 , https://digifors.cs.up.ac.za/issa/2005/Proceedings/Poster/012_Article.pdf
  • Description: Organisations are publishing electronic documents on their websites, via email to clients and potentially un-trusted third parties. This trend can be attributed to the ease of use of desktop publishing/editing soft-ware as well as the increasingly connected environment that employ-ees work in. Advanced document editors have features that enable the use of group editing, version control and multi-user authoring. Unfortu-nately these advanced features also have their disadvantages. Metadata used to enable the collaborative features can unintentionally expose confidential data to unauthorised users once the document has been published.
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  • Date Issued: 2005

An investigation of an undergraduate course module on the ethical aspects of information systems

An investigation of female leaders' perceptions of organisational culture and leadership in a Catholic High School

  • Authors: Jean-Louis, Lily-Claire Virginie
  • Date: 2005
  • Subjects: Catholic schools -- South Africa -- Administration School management and organization -- South Africa Educational leadership -- South Africa Corporate culture -- South Africa Women school administrators -- South Africa
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1625 , http://hdl.handle.net/10962/d1003507
  • Description: For the past thirty years, leadership theories have focused on the importance of the individual within the school organisation. The shared assumptions and beliefs of the individuals working in the same organisation shape the school’s organisational culture, and organisational culture is a salient factor which should be considered when understanding educational leadership. The focus of my study is to explore the relationship between organisational culture and leadership. In the same context, new approaches to the study of leadership have explored the issue of gender in leadership. Female leadership studies - the second focus of this study - seek not only to restore the place of the individual but also argue a place for women in educational leadership. Based in the interpretive paradigm, this is a case study of a Catholic all-girl secondary school called the Loreto Convent School of Pretoria. Historically, the Loreto schools have aimed at promoting and empowering girls’ education and female leadership. It was therefore an appropriate site in which to explore organisational culture and its relationship with leadership, particularly female leadership. I purposefully chose three of the school’s female leaders - the school’s principal, the High school Head of Department and the High school head girl - focusing on their perceptions and experiences of their leadership and the school’s culture. My research findings show that an understanding of the relationship between organisational culture and leadership cannot be complete without acknowledging the importance of the leader as an individual, with his/her personal background and values, taking into account gender as well as the multiple roles that the individual has in society. Furthermore, the ‘humane’ characteristic of educational leadership leads to an understanding that the leader is often confronted with conflicting situations where he/she is caught between personal/organisational values and the need to achieve the task. Finally, my findings show that contemporary leaders are now called upon to work and participate in the promotion of social justice in order to fight against society’s socio-economic inequality and improve the quality of education and life.
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  • Date Issued: 2005

An investigation of hair modelling and rendering techniques with emphasis on African hairstyles

  • Authors: Patrick, Deborah Michelle
  • Date: 2005 , 2013-10-17
  • Subjects: RenderMan , Hairstyles -- Africa , Hairstyles -- Computer simulation -- Africa , Hairdressing of Black people , Computer graphics
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:4639 , http://hdl.handle.net/10962/d1006561 , RenderMan , Hairstyles -- Africa , Hairstyles -- Computer simulation -- Africa , Hairdressing of Black people , Computer graphics
  • Description: Many computer graphics applications make use of virtual humans. Methods for modelling and rendering hair are needed so that hairstyles can be added to the virtual humans. Modelling and rendering hair is challenging due to the large number of hair strands and their geometric properties, the complex lighting effects that occur among the strands of hair, and the complexity and large variation of human hairstyles. While methods have been developed for generating hair, no methods exist for generating African hair, which differs from hair of other ethnic groups. This thesis presents methods for modelling and rendering African hair. Existing hair modelling and rendering techniques are investigated, and the knowledge gained from the investigation is used to develop or enhance hair modelling and rendering techniques to produce three different forms of hair commonly found in African hairstyles. The different forms of hair identified are natural curly hair, straightened hair, and braids or twists of hair. The hair modelling techniques developed are implemented as plug-ins for the graphics program LightWave 3D. The plug-ins developed not only model the three identified forms of hair, but also add the modelled hair to a model of a head, and can be used to create a variety of African hairstyles. The plug-ins significantly reduce the time spent on hair modelling. Tests performed show that increasing the number of polygons used to model hair increases the quality of the hair produced, but also increases the rendering time. However, there is usually an upper bound to the number of polygons needed to produce a reasonable hairstyle, making it feasible to add African hairstyles to virtual humans. The rendering aspects investigated include hair illumination, texturing, shadowing and antialiasing. An anisotropic illumination model is developed that considers the properties of African hair, including the colouring, opacity and narrow width of the hair strands. Texturing is used in several instances to create the effect of individual strands of hair. Results show that texturing is useful for representing many hair strands because the density of the hair in a texture map does not have an effect on the rendering time. The importance of including a shadowing technique and applying an anti-aliasing method when rendering hair is demonstrated. The rendering techniques are implemented using the RenderMan Interface and Shading Language. A number of complete African hairstyles are shown, demonstrating that the techniques can be used to model and render African hair successfully. , GNU Ghostscript 7.07
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  • Date Issued: 2005

An investigation of how Kampala teenagers who read Straight talk negotiate HIV/AIDS messages

  • Authors: Kaija, Barbara Night Mbabazi
  • Date: 2005
  • Subjects: AIDS (Disease) -- Uganda -- Kampala Straight talk AIDS (Disease) -- Social aspects -- Uganda -- Kampala AIDS (Disease) in adolescence -- Uganda -- Kampala Teenagers -- Diseases -- Uganda -- Kampala AIDS (Disease) -- Study and teaching AIDS (Disease) in mass media Teenagers -- Sexual behavior -- Uganda -- Kampala AIDS (Disease) -- Prevention -- Uganda -- Kampala
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:3440 , http://hdl.handle.net/10962/d1002894
  • Description: This study is a qualitative ethnographic investigation of how teenagers in Kampala, Uganda, who read the HIV/AIDS publication aimed at adolescents, Straight Talk, negotiate HIV/AIDS messages. It seeks to establish to what extent these secondary school teenagers accept the key messages (known as ABC; Abstain, Be faithful or use a Condom) and understand the factual aspects of the messages about HIV/AIDS, its process of transmission and prevention. It also seeks to probe how the lived realities of the teenagers affect their particular negotiations of the HIV/AIDS messages. It includes a focus on how proximity to HIV/AIDS, gender and family economic disposition might affect teenagers, negotiation of the HIV/AIDS meanings. To investigate the respondents’ reception of HIV/AIDS messages, the study employed focus groups that consisted of two stages, namely the ‘news game’ and group discussions. In the ‘news game’ stage (Philo, 1990; Kitzinger, 1993) the teenage participants were required to produce a version of a one-page copy of an HIV/AIDS newspaper targeting teenagers. In the second stage of the focus group a structured discussion probed the teenagers’ negotiation of the HIV/AIDS media messages. In the news game, the teenagers on the whole reproduced the key Straight Talk HIV/AIDS messages ‘Abstain, Be faithful or use a Condom’ and also images showing the effects of HIV/AIDS but featured fewer images depicting the factual aspects of HIV/AIDS process of transmission and risky behaviour. In the structured discussion that followed the news game, it was evident that not all the teenagers necessarily believed the messages they produced. In spite of producing the ABC Straight Talk messages, some of them were uncertain and confused about the absolute safety of the condom because of fears that they were either porous, expired or would interfere with sexual pleasure. Secondly, though many of the teenagers in the study reproduced images that showed that they consider marriage as desirable and talked about their desire to abstain from sex till marriage, a considerable number think abstinence is not achievable due to competing values. Thirdly, the participant teenagers could differentiate between HIV and AIDS but many did not realise that with the advent of anti-retroviral drugs even people who have AIDS can look normal. In spite of repeating the Straight Talk message that “no one was safe” and being aware of the risky behaviour that their fellow teenagers get involved in, the teenagers seemed to think that their age cohort is safe from HIV and it is the adults who are likely to infect them. The study findings further indicate that the teenagers’ lived experience at times influence their negotiation of HIV/AIDS media messages. This was probed in terms of economic standing, gender and proximity to HIV/AIDS. In relation to gender one surprising discovery was that certain girls in the study feared getting pregnant more than getting HIV/AIDS. The study finally suggests that these findings are of significance for designing future media initiatives in relation to HIV/AIDS.
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  • Date Issued: 2005

An investigation of information security in small and medium enterprises (SME's) in the Eastern Cape

  • Authors: Upfold, Christopher Tennant
  • Date: 2005
  • Subjects: Small business -- South Africa -- Eastern Cape Computer security -- South Africa Information technology -- South Africa -- Eastern Cape Management information systems -- South Africa -- Eastern Cape Computer security -- Standards -- South Africa
  • Language: English
  • Type: Thesis , Masters , MBA
  • Identifier: vital:727 , http://hdl.handle.net/10962/d1003847
  • Description: Small and Medium Enterprises (SME’s) embrace a wide range of information systems and technology that range from basic bookkeeping and general purpose office packages, through to advanced E-Business Web portals and Electronic Data Interchange (EDI). A survey, based on SABS ISO/IEC 17799 was administered to a select number of SME’s in the services sector, in the Eastern Cape. The results of the survey revealed that the level of information security awareness amongst SME leadership is as diverse as the state of practice of their information systems and technology. Although a minority of SME’s do embrace security frameworks such as SABS ISO/IEC 17799 or the International equivalent, BS7799, most SME leaders have not heard of security standards, and see information security as a technical intervention designed to address virus threats and data backups. Furthermore, there are several “stripped-down” standards and guidelines for SME’s, based mostly on SABS ISO/IEC 17799, but designed as streamlined, more easily implemented options. Again, these “lighter” frameworks are scarcely used and largely unknown by SME’s. Far from blaming SME leadership for not understanding the critical issues surrounding information security, the research concludes that SME leadership need to engage, understand and implement formal information security processes, failing which their organisations may be severely impacted by inadvertent threats / deliberate attacks on their information systems which could ultimately lead to business failure.
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  • Date Issued: 2005

An investigation of instructional leadership in a Namibian teacher training college

  • Authors: Alexander, Christa Henriette
  • Date: 2005
  • Subjects: Windhoek College of Education Educational leadership -- Namibia Education -- Namibia Teachers -- Training of -- Namibia
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1634 , http://hdl.handle.net/10962/d1003516
  • Description: This thesis investigates how instructional leaders at the Windhoek College of Education (in Namibia) make sense of their roles. The Windhoek College of Education (WCE) was selected for this study because that is where I work, therefore it would be easy to observe some of the responses provided by the interviewees. It was also observed that instructional leadership is little researched in Namibia and hence study would contribute towards understanding the various perceptions that instructional leaders have of their roles. There is a need for information about the skills and tasks required to support practices of instructional leadership so that the best possible instruction can be provided. The thesis examines and presents such skills. A qualitative research framework, in particular an interpretative approach was used for the study. As my research is concerned with people’s perceptions, it is located in the interpretative paradigm. Semi-structured, open-ended interview questions were asked in order to gather information on how the participants make meaning of their roles as instructional leaders. The sample for the study consisted of eleven instructional leaders over different levels, i.e., executive leaders, leaders on middle-management level and leaders on classroom-instructional level. The findings indicated a narrow view of instructional leadership at the college. Factors contributing to this narrowness are addressed, e.g., the way concepts such as delegation, guidance and monitoring/supervision are perceived. The findings also addressed certain expectations that are needed from instructional leaders in order to ensure efficiency in their practice. The study concludes by recommending alternative, expansive ways of thinking about instructional leadership.
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  • Date Issued: 2005

An investigation of local community contributions to the Malawi College of Fisheries curriculum: a case study focussing on the Chambo fishery

  • Authors: Kachilonda, Dick Daffu Kachanga
  • Date: 2005
  • Subjects: Malawi College of Fisheries -- Curricula Fishery management -- Study and teaching Fishery management -- Malawi Fisheries -- Malawi Fishes -- Nyasa, Lake
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1857 , http://hdl.handle.net/10962/d1004537
  • Description: The aim of the study was to investigate local community contributions to the existing Malawi College of Fisheries curriculum with a focus on Chambo fishery. Chambo fish (Oreochromis species) is the most favoured fish in Lake Malawi. Chambo catches have declined over the years. Responding to the declining catches, the Fisheries Department is engaged in a number of management options to address the issues. Most of these management options are governed by scientific recommendations and do not consider the socio-economic situation of the people who are dependent on fishery. This approach to fishery has influenced the Malawi College of Fisheries curriculum. The existing curriculum is product-centred, developed by a consultant. During the development of the curriculum, there was little consultation with the lecturers and no consultation with the local communities who are using the resource. The fishing communities have been fishing for a long time and have acquired knowledge, skills and experience worth investigating for its potential role in improving the existing curriculum. Through the use of interviews, focus group discussions and workshops with local communities local knowledge was identified for inclusion into the curriculum. A review of the existing curriculum revealed that it has primarily technical focus, grounded in the protection, control and management of the fish stocks, while the local knowledge has a practical focus based on existing practices and requiring an understanding of the sources of the issues. There is also more emphasis on a historical perspective and the context in which fishing practices take place at the moment. It was evident from the study that local communities have much of knowledge, skills and experience gained over the years of fishing , and if properly utilised, it can improve the MCF curriculum. I therefore recommend in this study that the curriculum be reviewed in order to integrate and draw on the local knowledge through a deliberative and participatory process between the local communities and the government so that it addresses the needs of the local communities and improves the training of the extension workers.
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  • Date Issued: 2005

An investigation of specific contributing factors affecting quality assurance in the diagnosis of conventional cervical smears

  • Authors: Jordaan, Suzette Mirietta
  • Date: 2005
  • Subjects: Cervix uteri -- Cancer -- Cytodiagnosis -- Quality control , Vaginal smears -- Quality control , Pap test -- Quality control
  • Language: English
  • Type: Thesis , Masters , MTech
  • Identifier: vital:10117 , http://hdl.handle.net/10948/173 , Cervix uteri -- Cancer -- Cytodiagnosis -- Quality control , Vaginal smears -- Quality control , Pap test -- Quality control
  • Description: The purpose of this study is to investigate specific contributing factors affecting quality assurance in the diagnosis of conventional cervical smears. More than half of South- African women fail to have one cervical smear in their lifetime and +/- 50 percent of those who do have cervical smears taken, are lost to follow-up. Since cervical cancer is the most common malignancy amongst women in developing countries, the medical profession will have to endeavor to screen a higher rate of women and ensure a 100 percent quality assurance with every patient treated in order to reduce the unacceptable high incidence of cervical carcinoma. At this stage it seems like an impossible task to screen all women in South Africa, due to far-off rural areas, shortage of medical professionals and the lack of knowledge of some women of the necessity of cervical smears. Many newly qualified South-African doctors leave the country to go and work elsewhere. South Africa then in turn has to recruit doctors from other countries to staff the State hospitals and clinics. Some areas have one doctor to thousands of patients, insufficient nursing personnel and inadequate equipment. Doctors in some areas cannot cope with the volume of work and the long hours. One has to accept that the quality of the management of some patients is affected negatively. There are a number of medico-legal issues (world wide) in relation to aspects of cervical cancer prevention practices which are controversial and are of particular concern to all of those involved in cervical cancer prevention. Various countries have therefore formed different national organizations to address the medico-legal issues in screening for the prevention of cancer. These organizations monitors procedures, internal quality control as well as external quality control. In South Africa, medico-legal cases are not so prevalent, but may become so shortly. The South-African medical professionals therefore have to ensure that their quality of work conforms to accepted good practice in all circumstances. State hospitals serve thousands of patients per month and it is an every day occurrence to see long queues of patients sitting waiting for doctors and who often have to come back the following day. The situation appears to be much improved in private practice and since patients have medical cover and accessible medical facilities. Since cervical cancer is the most common malignancy amongst women in developing countries, the medical profession will have to endeavor to screen a higher rate of women and ensure a 100 percent quality assurance with every patient treated in order to reduce the unacceptable high incidence of cervical carcinoma. At this stage it seems like an impossible task to screen 100 percent of women in South Africa, due to far-off rural areas, the shortage of medical professionals and ignorance of patients. Quality assurance is therefore of paramount importance to every medical professional for every patient treated. Laboratories all worldwide have been, or are in the process of being accredited by their specific accreditation authorities. The main reason for this is improvement of quality control and therefore quality assurance. The South African National Accreditation Society (SANAS) now accredits various laboratories in South Africa with the view of accreditting all laboratories within a certain time limit. The Ampath laboratory Port Elizabeth was successfully accredited during 2001. Accredited laboratories have to uphold a very high degree of quality to remain accredited. A team of professionals inspects the laboratory every 2 years and other quality assurance staff inspects the laboratories every few months. All aspects of the laboratory are checked, e.g. the qualification of staff, their registration with the Health Professions Council of South Africa (HPCSA), their curriculum vitaes, equipment, safety of the laboratory etc. Since the laboratory chosen for this study, is accredited, the author evaluated every cervical smear that was received in the laboratory since the year 2000, with the following objectives in mind: · Whether the presence or absence of an endocervical component has an effect on the adequacy of cervical smears · To determine the effect of using smaller coverslips on quality assurance in the cytology laboratory · Evaluate the effect that manual re-screening of smears has on quality assurance in the cytology laboratory. As there is a shortage of cytotechnologists and pathologists worldwide, several countries make use of automated screening devices as primary screening or secondary screening for quality assurance. These devices were tested in some laboratories in South Africa but were found to be very expensive and sensitivity and specificity were not up to standard. Sensitivity is a measure of the ability of a test to detect the abnormal - Sensitivity is the ratio of true positives to true positives + false negatives. Specificity is a measure of the ability of a test to correctly identify the negative - Specificity is the ratio of true negative to true negatives + false positives. The automated screening machines failed to identify abnormal cells amongst inflammatory cells, as well as in very blood stained smears. Several other problems also occurred and an increasing number of smears had to be manually rescreened, thus making this exercise costly and not helpful as a quality assurance instrument. The slides used for this thesis, have been retrieved from the archives of the Ampath laboratory in Port Elizabeth. Fourteen specific contributing factors affecting quality assurance in the diagnosis of cervical smears are also discussed and conclusions and recommendations given.
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  • Date Issued: 2005

An investigation of the development and adoption of educational metadata standards for the widespread use of learning objects

  • Authors: Krull, Greig Emil
  • Date: 2005
  • Subjects: Metadata , Internet in education , Web databases , Education -- Standards , Educational technology , Computer-assisted instruction
  • Language: English
  • Type: Thesis , Masters , MCom
  • Identifier: vital:1142 , http://hdl.handle.net/10962/d1002771 , Metadata , Internet in education , Web databases , Education -- Standards , Educational technology , Computer-assisted instruction
  • Description: This research investigates the development and adoption of educational metadata standards for the widespread use of learning objects. Learning objects, metadata, the related IEEE standard and the various application profiles derived from the standard are discussed. A number of standards and specifications for educational metadata used to describe learning objects are explored, namely the Dublin Core, IMS, SCORM, ARIADNE, CanCore and the UK LOM Core. Three metadata editors and the experience with using one of them, RELOAD, is described. These educational metadata specifications are used in a practical metadata implementation scenario and the experiences are extrapolated to derive a localised instance of the generic IEEE standard. A new application profile is proposed, “RU LOM Core”, for the South African higher education context. Some existing results are confirmed about the complexity of using the IEEE standard and it is demonstrated that it is possible to instantiate the standard for South African conditions. The results are largely qualitative and based on practical experience. However, the results concur with results from related research. Although the development of an application profile is certainly not new, the development of RU LOM Core illustrates that the IEEE standard, developed largely within the northern hemisphere, can be adapted to work in the South African scenario. RU LOM Core has been developed for the South African higher education environment and takes linguistic and cultural diversity and the low rate of technological literacy into consideration. The lessons learned and the proposed LOM core can be built upon in further research and collaboration to use and support the use of such standards within South Africa.
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  • Date Issued: 2005

An investigation of the experiences and perceptions of teachers with regards to staff development in a Namibian secondary school

  • Authors: Nasima, Gideon Emmanuel
  • Date: 2005
  • Subjects: Education -- Namibia Teachers -- In-service training -- Namibia School management and organization -- Namibia School principals -- Namibia
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1649 , http://hdl.handle.net/10962/d1003532
  • Description: Staff development (SD) is regarded as an important process, both for the professional growth of teachers and the organizational development of schools. The literature on SD uses the concepts of ‘SD’, ‘professional development’ and ‘in-service training of teachers’ interchangeably. The purpose of this study is to investigate the teachers’ experiences and perceptions of SD practices in a Namibian secondary school. This qualitative case study was carried out at the school where I am teaching. Two methods were used to collect the data, namely a blend of semi-structured and unstructured interviews with three teachers and one focus group interview with five teachers. The analysis of the data collected was carried using the method suggested by Taylor and Bogdan (1998) which includes discovery, coding and discounting. These concepts are discussed in Chapter Three. The main finding of this research regards SD at the school as mainly in line with the traditional view. The study also made three other unusual findings that differ from the traditional view of SD held at the school. First, the principal’s role as a human resource manager of SD; second the pastoral role of a principal in SD and third the role of teachers’ unions in SD. All these findings are important for SD practices in schools and for further research because little is known in the current literature on SD. Finally, this study proposes further research to develop an organizational development (OD) cycle of problem solving to help create an internal policy on SD, which is currently nonexistent at the school.
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  • Date Issued: 2005

An investigation of the factors that influence Grahamstown East grade 12 learners to aspire to higher education : a case study

  • Authors: Burns-Ncamashe, Zimasa Nomsawezulu Ancilla
  • Date: 2005
  • Subjects: Education -- South Africa -- Grahamstown -- Case studies , Education, Secondary -- South Africa -- Grahamstown -- Case studies , Education, Higher -- South Africa -- Grahamstown -- Case studies , Student aspirations -- South Africa -- Grahamstown -- Case studies , High school graduates -- South Africa -- Attitudes -- Case studies , Vocational interests -- South Africa -- Grahamstown -- Case studies
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1650 , http://hdl.handle.net/10962/d1003533 , Education -- South Africa -- Grahamstown -- Case studies , Education, Secondary -- South Africa -- Grahamstown -- Case studies , Education, Higher -- South Africa -- Grahamstown -- Case studies , Student aspirations -- South Africa -- Grahamstown -- Case studies , High school graduates -- South Africa -- Attitudes -- Case studies , Vocational interests -- South Africa -- Grahamstown -- Case studies
  • Description: This research is an investigation into the factors that influence the decisions of grade 12 learners from Grahamstown East disadvantaged communities to pursue higher education. Research on learner aspirations has largely focused on access to higher education and little or no attention has been has been paid to the enabling or limiting factors and what can be done to increase the numbers of learners from disadvantaged communities who enrol at higher education institutions. This study aims to fill that gap. The research was a qualitative case study located in the interpretive paradigm. The data was gathered using questionnaires and focus group interviews for grade 12 learners. Individual interviews were conducted with the parents of the grade 12 research participants, educators and the school management team. Observation and documentary evidence from school documents were also used for data collection. The data were analysed using systematic patterning, were interpreted, and given meaning linking it to the literature surveyed. The main findings indicate that a number of enabling factors that influence grade 12 learners to pursue higher education co-exist with limiting factors. Recommendations arising from the main findings are presented and the limitations of the research are identified. Areas for possible further research in strengthening learner support so as to increase the numbers of learners who qualify for higher education and to enable the learners from disadvantaged communities to realise their aspirations, are suggested.
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  • Date Issued: 2005

An investigation of the factors that influence the decision-making of Chinese tourist travelling to South Africa

  • Authors: Wan, Jiangtao
  • Date: 2005
  • Subjects: Tourism -- South Africa -- Decision making , Chinese -- Travel -- South Africa -- Attitudes
  • Language: English
  • Type: Thesis , Masters , MTech
  • Identifier: vital:9340 , http://hdl.handle.net/10948/411 , Tourism -- South Africa -- Decision making , Chinese -- Travel -- South Africa -- Attitudes
  • Description: The growth of the Chinese economy represents a significant opportunity for global travel and tourism and it has raised the expectation that the South African tourism industry will explore and benefit from the Chinese outbound market growth. Since international travel and tourism is becoming a significant component of the South African economy, it is important to understand the factors that influence consumer decision-making in tourism. The main objective of this study was to determine the factors that influence the decision-making of Chinese tourists that travel to South Africa. The research gives a systemic review of the Chinese outbound market, starting with the Chinese outbound travel history, and the impact of the social-economic issues on Chinese travel and tourism. An overview is provided of the size, growth and the regulation of the Chinese outbound market, as well as the main characteristics of Chinese outbound tourists. The factors that influence decision-making are compartmentalised into two categories: internal and external factors. Internal and external factors relate to the concept that people travel due to the fact that they are pushed by their own internal forces and pulled by the external forces such as the social environment, reference groups, social class, the restrictions from government regulations and the attraction of travel destination countries. The empirical findings reflect that the factors that have the most significant impact on the decision-making process of Chinese outbound tourists travelling to South Africa are perception about safety, lack of knowledge about South Africa and a growth in the use of the Internet as a source of tourist information. The study also reflects a tendency towards individualism and a shift away from traditional group decision-making. Based on the findings of the empirical study, South Africa tourism needs to offer a safe travel environment, provide greater access to information featuring South Africa as a tourist destination, and offer discounted travel packages
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  • Date Issued: 2005

An investigation of the role of news values in the selection of news sources in a contemporary third world newspaper: a case study of the Daily Nation newspaper

  • Authors: Kisuke, Connie Syomiti
  • Date: 2005
  • Subjects: Daily Nation (Nairobi, Kenya) , Government and the press -- Africa , Reporters and reporting , Mass media -- Political aspects -- Africa , Newspapers -- Africa , Journalism -- Social aspects
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:3446 , http://hdl.handle.net/10962/d1002900 , Daily Nation (Nairobi, Kenya) , Government and the press -- Africa , Reporters and reporting , Mass media -- Political aspects -- Africa , Newspapers -- Africa , Journalism -- Social aspects
  • Description: News in our contemporary newspapers has come to be associated more and more with what the elites do and say. Both their deeds and misdeeds are treated as newsworthy events and in the process they become newsmakers, both actors and sources of news. Even when they are not directly involved in news events they are sought out by journalists to validate those events and to interpret the social reality to the readers as news sources. This study is about the selection of news sources in the Daily Nation, a contemporary, independent newspaper based in Nairobi, Kenya. In this study, I set out to unravel the complex processes that underlie newsmaking and source selection. This study is informed by the theory of news values and the paradigm of the role of media in democracy. Based on qualitative interviews, observations and content analysis of the front-page stories, it investigates the process of news and source selection in front-page stories. Through these approaches, I established that news values are significant criteria that inform journalists in both the selection of front-page news stories and the sources of these stories. I also established that social values of the society in which this newspaper operates are heavily embedded in the news. For example, the journalists preferred male politicians as sources of news in the front-page stories to women, and the elites to ordinary people, and this reflected on the social structures and cultural norms that are prevalent in this society. This study, further, established that the news values of this newspaper share commonly with the Western news media in terms of journalistic conventions and ways of interpreting the social reality in the news. Ideally, the newspaper embraces the principles of democracy in news reporting, but in practice it does not satisfactorily adhere to the full requirements of its democratic role in terms of source selection. The democratic principles in news reporting require, among other things, that the newspaper should allow a diversity of views in the news, representing various groups that are found in real society including the elites, non-elites, women, ordinary people and minorities. In the case of the Daily Nation, a tiny group of elite male professional politicians made up the largest majority of its front-page news sources.
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  • Date Issued: 2005

An LC-MS-MS method for the determination of cyclizine in human serum

  • Authors: Mohammadi, Ali , Kanfer, Isadore , Sewram, V , Walker, Roderick B
  • Date: 2005
  • Language: English
  • Type: Article
  • Identifier: vital:6408 , http://hdl.handle.net/10962/d1006481
  • Description: Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method is presented for the quantitation of cyclizine in serum. Sample pretreatment involved liquid-liquid extraction of 200 μl of serum with dichloromethane after the addition of 100 μl each of ammonium hydroxide and internal standard solutions. The extracts were analyzed by HPLC on a Luna ® C18 reversed-phase column and an ion-trap mass spectrometer with an electrospray interface. A limit of detection of 1 ng/ml was determined which allowed for the reliable measurement of cyclizine in the serum of human subjects. The method was found to be linear over the calibration range of 2.5-100 ng/ml. The applicability of this method was demonstrated by the analysis of serum obtained from a human volunteer following administration of a single 50 mg cyclizine hydrochloride tablet. The reported method was observed to have the necessary sensitivity, selectivity, precision and accuracy for monitoring cyclizine concentrations in human subjects following oral administration.
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  • Date Issued: 2005

An Open Design and Implementation for the Enabler Component of the Plural Node Architecture of Professional Audio Devices

  • Authors: Foss, Richard , Fujimori, J I , Okai-Tettey, Harold
  • Date: 2005
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/427225 , vital:72423 , https://www.aes.org/e-lib/browse.cfm?elib=13327
  • Description: The Plural Node architecture is an implementation architecture for professional audio devices that adhere to the “Audio and Music (A/M)” protocol. The Plural-Node implementation architecture comprises two components on separate IEEE 1394 nodes – a “Transporter” component dedicated to A/M protocol handling, and an “Enabler” component that controls the Transporter and provides high level plug abstractions. An Open Generic Transporter specification has been developed for the Transporter component. This paper details an open design and implementation for the Enabler component that allows for connection management via abstract, mLAN plugs.
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  • Date Issued: 2005

An Open Generic Transporter Specification for the Plural Node Architecture of Professional Audio Devices

  • Authors: Foss, Richard , Fujimori, J I , Kounosu, Ken , Laubscher, Ron
  • Date: 2005
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/427239 , vital:72424 , https://www.aes.org/e-lib/browse.cfm?elib=13191
  • Description: The Plural Node architecture is an implementation architecture for professional audio devices that adhere to the “Audio and Music (A/M)” protocol. The A/M protocol determines how audio and MIDI data are transported over IEEE 1394 (firewire). The Plural-Node implementation architecture comprises two components on separate IEEE 1394 nodes – a “Transporter” component dedicated to A/M protocol handling, and an “Enabler” component that controls the Transporter and provides high level plug abstractions. Low level control of individual Transporters occurs within the “Hardware Abstraction Layer” (HAL) of the Enabler. Device manufacturers write their own plug-ins for the HAL to interact with their Transporters. The Open Generic Transporter specification provides an open interface between the HAL and Transporter for the convenience of device manufacturers.
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  • Date Issued: 2005

An organisation development intervention in a previously disadvantaged school in the Eastern Cape

  • Authors: Mitchell, Pauline
  • Date: 2005
  • Subjects: Educational change -- South Africa -- Eastern Cape Education and state -- South Africa -- Eastern Cape Education -- Social aspects -- South Africa -- Eastern Cape Education -- South Africa -- Eastern Cape School improvement programs -- South Africa -- Eastern Cape -- Case studies Education -- Aims and objectives -- South Africa -- Eastern Cape
  • Language: English
  • Type: Thesis , Masters , MEd
  • Identifier: vital:1682 , http://hdl.handle.net/10962/d1003565
  • Description: “We often spend too much time coping with problems along our path that we forget why we are on that path” Peter Senge This study describes and analyses the implementation of Organisation Development (OD) to a previously disadvantaged school. OD is a relatively new method of planned change in South Africa. Unlike more traditional change initiatives, OD promotes collaboration; it tries to involve all members of an organisation in problem solving and decision-making. It is an applied behavioural science discipline dedicated to improving organisations and the people in them. Previously disadvantaged schools in South Africa continue to be disadvantaged. Ten years after the introduction of democracy there have been few changes in some of these schools and some seem to be getting worse. This study was an attempt to introduce a process of planned change to one such school. Since 1994 many changes have been imposed on our schools with new curricula, increased class sizes, changes in systems of assessment and teaching methods and the abolishment of past procedures such as corporal punishment. Teachers have had little say in any of these changes and this has resulted in resistance, resignation, frustration and in many cases a lack of ability to cope. OD was introduced to Acacia High School in the form of a Survey Data Feedback (SDF). An action research process followed and a diagnosis was made followed by action planning and then the execution of a plan. My study follows this process and the implementation of the plan describing its successes. Sadly change was not sustained and I highlight some of the challenges that face the school in order to bring about real long-term improvement in the culture of learning and teaching.
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  • Date Issued: 2005

Animal suffering in factory farming and the best way to prevent it

  • Authors: Watkins, Gareth
  • Date: 2005
  • Subjects: Vegetarianism -- Moral and ethical aspects Food animals -- Moral and ethical aspects Animal rights Animal welfare Animal welfare -- Moral and ethical aspects Vegetarianism
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:2728 , http://hdl.handle.net/10962/d1003736
  • Description: This thesis moves beyond the traditional approaches of how we ought to treat animals, and instead concentrates on the best strategy for preventing animal suffering in the farming industry. Chapter 1 considers the question of how we can know that animals feel pain, and concludes not only that it is rational to believe that they can, but also that this is a significant fact. Chapter 2 then analyses one possible strategy for helping to prevent animal suffering, namely demi-vegetarianism. For a number of reasons, however, this strategy is found to be flawed, therefore Chapter 3 analyses a second possible strategy, namely vegetarianism, and concludes that this is, in fact, the best strategy for helping to prevent animal suffering in the farming industry.
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  • Date Issued: 2005
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