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A conceptual IT governance framework to guide the development of interoperable health information systems

  • Authors: Matshaba, Lebogang
  • Date: 2022-04-06
  • Subjects: Information technology Management , Information technology Management Standards , Information technology Security measures , Medical informatics South Africa , Medical records Data processing , Internetworking (Telecommunication) , National health insurance South Africa , Design Science Research (DSR)‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/284570 , vital:56075
  • Description: In light of changing health needs, health information systems are presented with a plethora of challenges. For instance, the rise of COVID-19 in the past year has led to the discourse on the strength of current health systems to support health needs and the readiness for the National Health Insurance in South Africa. In addition to operating in resource-constrained environments, the lack of synchrony between health information systems across health facilities led to the fragmentation of health information and diminished access to quality healthcare. This research, following the Design Science Research Methodology (DSRM) process, developed an IT governance conceptual framework (HISIG-CF), to inform the interoperability of health information systems. The HISIG-CF is developed from literature and qualitative data collected using an expert reviews method from practitioners in the healthcare sector who evaluated the constructs of the HISIG-CF. Thematic analysis and hermeneutics were used to analyse and interpret the data. The results revealed a need for more guidance to inform interoperability interventions and strengthen current health information systems. The contribution of this study is the HISIG-CF which is deemed relevant and potentially fit-for-purpose to improve health information systems interoperability within the healthcare sector in South Africa. , Thesis (MCom) -- Faculty of Commerce, Department of Information Systems, 2022
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  • Date Issued: 2022-04-06

A framework for guiding the interdisciplinary design of mHealth intervention apps for physical activity behaviour change

  • Authors: Thomson, Callie Deborah
  • Date: 2022-04-06
  • Subjects: Wireless communication systems in medical care , Exercise Health aspects , Behavior modification , Mobile apps , Medical care Technological innovations , Medical informatics , Health promotion Technological innovations , Application software Development , Design Science Research‎ (DSR)
  • Language: English
  • Type: Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/232193 , vital:49970 , DOI http://doi.org/10.21504/10962/232193
  • Description: The global pandemic of noncommunicable diseases and its associated premature mortality rates and socioeconomic burden have led to increasingly intensified efforts towards designing and delivering health promotion interventions aimed at addressing the leading modifiable health risk behaviours, such as physical inactivity. Developing physical activity behaviour change interventions that target individuals at the dual intra-interpersonal socioecological levels of health promotion has become a key objective worldwide. Digital and mobile technology is revolutionising the ways in which health behaviour change interventions are delivered to individuals across the world, with mobile health applications (mHealth apps) increasingly recognised as a powerful means of promoting physical activity behaviour change. However, with the growth and opportunities of mHealth apps, come several design challenges. Key design challenges concern the integration of theory, the incorporation of evidence-based behaviour change techniques, the application of persuasive systems design principles, and the importance of multi- and interdisciplinary collaborative design, development and evaluation approaches. These key challenges influence the output product design and effectiveness of mHealth physical activity behaviour change intervention apps. There exists a paucity of approaches for guiding and supporting the multi- and interdisciplinary collaborative design, development and evaluation of mHealth physical activity behaviour change intervention apps. To address this gap, this research study proposes an Interdisciplinary mHealth App Design Framework, framed by a novel boundary object view. This view considers the diverse communities of practice, boundary objects and supporting artefacts, process activities, and knowledge sharing practices necessary and relevant to the design of effective mHealth physical activity behaviour change intervention apps. The framework’s development is guided by a Design Science Research (DSR) approach. Its core components are based on the findings of a critical theoretical analysis of twenty existing multi- and interdisciplinary digital health development approaches. Once developed, the framework is evaluated using a qualitative DSR linguistic interpretivist approach, with semi-structured interviews as the research instrument. The thematic analysis findings from interviews with thirty-one international academic researchers and industry practitioners informs the iterative modification and revision of an enhanced Interdisciplinary mHealth App Design Framework, constituting the main DSR artefact contribution of the research study. In addition, four theoretical contributions are made to the mHealth intervention app design body of knowledge, and a practical contribution is made through the provision of guideline recommendations for academics and industry practitioners. Methodological contributions are also made in terms of applying DSR, adopting a hybrid cognitive reasoning strategy, and employing a qualitative linguistic interpretivist approach to evaluation within a DSR project. , Thesis (PhD) -- Faculty of Commerce, Information Systems, 2022
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  • Date Issued: 2022-04-06

A framework for the economic valuation of wetland rehabilitation: case studies from South Africa

  • Authors: Browne, Michelle
  • Date: 2022-04-06
  • Subjects: Wetland restoration South Africa , Wetland management South Africa , Ecosystem management South Africa , Ecosystem services South Africa , Ecosystem management Economic aspects South Africa , Wetland restoration Cost effectiveness South Africa
  • Language: English
  • Type: Academic theses , Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/263560 , vital:53638 , DOI 10.21504/10962/263561
  • Description: Wetlands are recognised as having the potential to contribute long-term benefits to society; wetland rehabilitation is undertaken to recover these benefits in response to widespread wetland degradation. Increasingly, there have been calls to value the benefits of wetland rehabilitation to justify further investment. Such is the case in South Africa. Furthermore, recent global agendas and targets for ecosystem restoration, such as the declaration of the Decade of Restoration 2021-2030, suggest increasing pressure on governments to implement rehabilitation and imply a concomitant increase in decision-making regarding where and how to rehabilitate. In response to these information needs, this thesis explores the economic valuation of wetland rehabilitation through a narrative review of the foundational theory of values and valuation, a quantitative review of applied wetland rehabilitation economic valuation studies, and the evaluation of five wetland rehabilitation projects from South Africa. Projects were selected as case studies to represent various rehabilitation goals and explore different contexts (urban-rural; beneficiary groups), the timing of the evaluation (ex ante, ex post) and value types and valuation methods. The final chapter of the thesis integrates the case study experiences with the findings of the theoretical research components to propose a framework for the valuation of wetland rehabilitation, which can be applied in South Africa, and more generally, to further demonstrate the values of wetland rehabilitation, and as a tool to guide wetland rehabilitation decision-making. While initially grounded in mainstream economics, the research led into a number of fields including philosophy, social-ecological systems and social-ecological relations thinking, several environmental science areas and livelihood and human well-being frameworks. A deeper look into economic theory and history revealed an evolution of thinking on the meaning of ‘value’ and view of ‘nature’ and numerous critiques of standard neoclassical economics. From the insights gained and the case study experiences, this thesis argues that the neoclassical economic perspective, especially combined with a monetary metric, is too restrictive, and arguably too abstract in its assumptions of human behaviour and reliance on mathematical models, as an overarching framework for the valuation of wetland rehabilition. This is not to suggest that standard economic valuation concepts and methods cannot be useful, as the research case studies illustrated, but rather that wetland valuation must be approached from a value pluralism perspective. To this end, the proposed framework offers a way to think beyond, or in addition to, standard economic approaches in articulating the values of wetland rehabilitation. , Thesis (PhD) -- Faculty of Commerce, Economics and Economic History, 2022
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  • Date Issued: 2022-04-06

A laboratory simulation investigating the impact of sunglass tint on the catching performance of cricket fielders

  • Authors: Nellemann, Stacy Amanda
  • Date: 2022-04-06
  • Subjects: Sunglasses , Cricket Physiological aspects , Cricket players , Glare , Vision , Contrast sensitivity (Vision) , Fielders (Cricket)‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/291281 , vital:56839
  • Description: Background: Sunglasses are popularly worn by outdoor athletes such as cricketers. They are primarily worn to preserve ocular health due to the length of time exposed to the sun’s glare on the field. More recently, sunglasses are now worn for their purported performance-enhancing benefits supposedly allowing athletes to “see clearly, react faster and perform with confidence”. Fielders typically wear sunglasses, but it is rare to see the bowler or the batter wearing sunglasses although they are exposed to the same conditions. If sunglasses provide visual clarity for better reaction time, it is assumed this would also be beneficial for both batsmen and bowlers alike. It is interesting that although fielding plays a key role in the winning of a match, it has received very little research in comparison to the areas of batting and bowling. Research concerning sunglasses in the past has been concerned with its effect on ocular parameters such as colour vision and contrast sensitivity, with minimal research on their effect on performance, specifically on how different colour tints may affect performance such as catching in fielding. Objective: The purpose of this study was to compare the catching performance of fielders when wearing three different colour tints of sunglasses. Methods: Thirty male cricketers currently playing for Rhodes University or country districts sides in Makhanda, South Africa, who were non-habitual sunglass wearers were recruited for this study. An optician administered a pre-screening test to ensure participants did not have any visual defects that would affect the results, determining who was eligible to continue with the research project. Twenty-five participants qualified with a further four withdrawing during the experimentation phase due to personal reasons. Eligible participants were required to complete four testing sessions on separate days thereafter in which they wore a different colour tint at each session (clear, blue, G30 and red). These tints were randomised among participants. Participants were required to catch 18 balls projected from a bowling machine in each session. The number of balls caught as well as the quality of catch was recorded. At the end of the fourth session, participants were presented with a questionnaire investigating their subjective experience of the protocol and preference for any particular colour of lens. Results: Statistically significant results were found between the different colour lenses for the ocular parameters of contrast sensitivity and stereopsis tested by the optician. The red lens was found to be the best for contrast sensitivity with the blue lens performing the worst on this test. With regard to stereopsis, the G30 lens was the worst, with the red lens performing the best. The performance measures resulted in no significant difference between the different colour lenses both concerning the total number of catches taken as well as the quality of catch taken. The same result was found irrespective of the colour of lens used in each session. Data gathered from the questionnaire regarding visual comfort and target visibility resulted in the red lens being rated statistically worse than the other three conditions. In terms of personal preference, the G30 lens was rated statistically as the best coloured lens. Conclusion: It can be concluded that objectively there is no difference in performance between the three coloured lenses. Although from an ocular perspective, the red lens was expected to perform the best in terms of catching performance, there was no difference. Subjectively there was a strong preference among the players for the G30 lens with players strongly disliking the red lens. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
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  • Date Issued: 2022-04-06

A multispectral and machine learning approach to early stress classification in plants

  • Authors: Poole, Louise Carmen
  • Date: 2022-04-06
  • Subjects: Machine learning , Neural networks (Computer science) , Multispectral imaging , Image processing , Plant stress detection‎
  • Language: English
  • Type: Master's thesis , text
  • Identifier: http://hdl.handle.net/10962/232410 , vital:49989
  • Description: Crop loss and failure can impact both a country’s economy and food security, often to devastating effects. As such, the importance of successfully detecting plant stresses early in their development is essential to minimize spread and damage to crop production. Identification of the stress and the stress-causing agent is the most critical and challenging step in plant and crop protection. With the development of and increase in ease of access to new equipment and technology in recent years, the use of spectroscopy in the early detection of plant diseases has become notably popular. This thesis narrows down the most suitable multispectral imaging techniques and machine learning algorithms for early stress detection. Datasets were collected of visible images and multispectral images. Dehydration was selected as the plant stress type for the main experiments, and data was collected from six plant species typically used in agriculture. Key contributions of this thesis include multispectral and visible datasets showing plant dehydration as well as a separate preliminary dataset on plant disease. Promising results on dehydration showed statistically significant accuracy improvements in the multispectral imaging compared to visible imaging for early stress detection, with multispectral input obtaining a 92.50% accuracy over visible input’s 77.50% on general plant species. The system was effective at stress detection on known plant species, with multispectral imaging introducing greater improvement to early stress detection than advanced stress detection. Furthermore, strong species discrimination was achieved when exclusively testing either early or advanced dehydration against healthy species. , Thesis (MSc) -- Faculty of Science, Ichthyology & Fisheries Sciences, 2022
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  • Date Issued: 2022-04-06

A novel o/w microemulsion fixed dose combination of efavirenz, emtricitabine and tenofovir disoproxil fumarate: development and characterisation

  • Authors: Mabvira, Samantha
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/232925 , vital:50038
  • Description: Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2022
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  • Date Issued: 2022-04-06

A retrospective study of antimicrobial prescribing practices in paediatric patients at the Mahalapye District Hospital, Central Botswana

  • Authors: Nyawera, Angella
  • Date: 2022-04-06
  • Subjects: Anti-infective agents Botswana Mahalapye , Drug resistance , Pediatrics Botswana Mahalapye , Pediatrics Formulae, receipts, prescriptions , Drugs Prescribing Moral and ethical aspects
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/290682 , vital:56774
  • Description: Background: The development of antimicrobial resistance (AMR) has been linked to the increased and irrational use of antimicrobial medicines. The aim of this study was to investigate the antimicrobial prescribing practices in the paediatric medical ward at Mahalapye District Hospital (MDH) in Botswana and to determine whether antimicrobial stewardship (AMS) measures were being implemented at the hospital. Methods A cross-sectional, descriptive, mixed methods, observational approach was taken in this study. The study site was the paediatric medical ward (PMW) at MDH. Information about the antimicrobials prescribed for paediatric patients from January 2018 to December 2018 was collected from patients’ information files and compared to national antimicrobial prescribing guidelines to determine prescribers’ adherence. Qualitative semi-structured interviews were conducted with members of staff at MDH to determine whether antimicrobial stewardship (AMS) measures were adopted at the hospital. Results A total of 278 patients were included in this study, 12 of these were admitted twice during the study period. In total 290 admissions were analysed, with 659 antimicrobial medicines prescribed. The most common diagnoses were pneumonia (36.9%), acute gastroenteritis (20.7%), upper respiratory tract infections (3.4%), and bronchiolitis (3.1%). The most prescribed antimicrobials were ampicillin (21.4%), gentamicin (21.2%), and cefotaxime (8.3%). Adherence to guidelines was relatively good, with 82.7% of antimicrobials prescribed for the patients in the study having been prescribed in compliance with the national prescribing guidelines. The semi-structured interviews highlighted the fact that staff knew about AMS and AMR in general, however awareness of an AMS committee at MDH varied. The AMS committee was a multidisciplinary committee, which was a subcommittee of the Drugs and Therapeutics Committee (DTC). Discussion and Conclusion The results suggest that adherence to prescribing guidelines was relatively high compared to other paediatric antimicrobial utilisation studies in African countries. Prescribing of antimicrobial medicines was consistent with other African countries. The long period of time that it takes for microbiological test results to become available means that most prescribers rely on empirical prescribing. The antimicrobial committee is a multidisciplinary committee with defined roles for its members, consistent with international guidelines for implementing an AMS committee at a hospital. , Thesis (MPharm) -- Faculty of Pharmacy, Pharmacy, 2022
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  • Date Issued: 2022-04-06

Academic or ‘zoombie’? Characterizing sleep quality, work and lifestyle behaviours among a cohort of South African academic staff during the Covid-19 pandemic

  • Authors: Le Grange, Sarah-Ann
  • Date: 2022-04-06
  • Subjects: Sleep-wake cycle South Africa Eastern Cape , Sleep Physiological aspects , Lifestyles Health aspects South Africa Eastern Cape , COVID-19 Pandemic, 2020- Influence , Work environment Psychological aspects , Work environment Physiological aspects , College teachers Workload South Africa Eastern Cape , Pittsburgh Sleep Quality Index (PSQI)‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/291099 , vital:56818
  • Description: Working in academe is characterized by high work demands, long and late working hours and balancing multiple roles. This often leaves academic staff (interchangeably referred to as ‘academics’ and ‘staff’) with limited time to prioritize adequate rest and sleep. While sufficient sleep is important for general well-being and work performance, it may be important for academics given the cognitive and interactive nature of their work. However, limited research has characterized sleep behaviours and sleep quality in academic staff globally and specifically in South Africa (SA). Further, research shows that academics from different academic ranks and genders differ in their work experiences but less is known about whether these factors affect their sleep and lifestyle factors. Over and above the demands of academic work, the current study was conducted during COVID-19, which saw unprecedented change in workloads for academic staff due to online teaching and learning. Additionally, the pandemic has been associated with poorer sleep quality and lifestyle behaviours in the general population, but very few studies have explored this in the context of academics. Thus, this study aimed to characterize the sleep quality, work and lifestyle factors among academics from a university in the Eastern Cape province of SA and determine the effects of gender and academic rank on these measures. Additionally, the study aimed to determine the impact of COVID-19 on sleep and work-related factors of this group. This study adopted a cross-sectional design and made use of an online questionnaire that was distributed to all academics employed at the institution via email. The data collection occurred over an 8-week testing period between August and September of 2020. The questionnaire explored sociodemographic, work and lifestyle characteristics, while the characteristics of sleep and sleep quality were explored with the Pittsburgh Sleep Quality Index (PSQI). Additionally, an open-ended section was included to determine the impact of COVID-19-related changes on sleep and work. The questionnaire responses were analyzed with descriptive and inferential statistics and the open-ended questions were analyzed with thematic analyses. A total of 84 respondents completed the questionnaire. On average, sleep quality was poor (global score of 7.09 ± 3.8), the reported sleep duration was short (6.41 ± 1.06 hrs) and the group was classified as overweight according to median BMI (26.67 [23.8-2 29.45] kg/m2). Over a third (35.71%) of academic staff reported not meeting physical activity guidelines and reported using screens one hour prior to bed every night during the week (76.19%) and the weekend (67.88%). Staff also worked long total weekly work hours (54.25 ± 11). Female academics had a poorer sleep quality (p = 0.035), spent a longer time in bed (p = 0.04), experienced more bad dreams (p = <0.01), had their last serving of alcohol earlier (p = 0.04) and worked less weekday (p = 0.04) and less total weekly (p = 0.02) hours compared to male academics. Professorship-level academics were significantly older than junior- and senior-level academics (p = <0.01) while senior-level academics had a poorer PSQI compared to professorship-level academics (p = 0.03). The thematic analysis showed that home environment, neighbourhood noise, work and mental health were the main emerging factors that disturbed sleep. The thematic analysis showed that, in relation to the impact of COVID19, sleep schedules changed and sleep duration and sleep quality improved or got worse. Respondents reported their work hours increasing, work schedules becoming less routine while working from home, dealing with the challenges of working online and experiencing worry, stress and anxiety due to the pandemic. The study highlights that, in the context of lockdown and having to work and teach online from home, academics reported poor quality sleep and short sleep duration. Further, on average, the sample reported working extensive hours and unhealthy lifestyle behaviours. The sleep health, nature of work and overall lifestyles of academic staff deserves more research attention, given the importance of their work and the impact that inadequate sleep could have on academics’ health and work performance. Sleep quality was worse for females and mid-career academics, suggesting that their sleep quality may be at greater risk than other sub-groups. However, the reasons for these differences need to be explored in future studies. The findings contribute to the narrative that academe involves numerous demands and supports previous research that has suggested that academics’ sleep is insufficient. Furthermore, COVID-19 had an impact on staff’s sleep, with staff reporting changes in their sleep quality and duration. The pandemic impacted work of academics by presenting novel demands related to online teaching, intensifying demands overall and disrupting work routines. However, future research is needed to understand academics’ sleep behaviours, work and lifestyles, especially in South Africa. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
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  • Date Issued: 2022-04-06

Adolescents and coaches/trainers perspectives of ergogenic sports supplement use within South African private high schools

  • Authors: Butler, Nicholas John
  • Date: 2022-04-06
  • Subjects: Dietary supplements , Energy metabolism , Teenagers South Africa , Teenagers Physiology South Africa , Teenagers Substance use South Africa , Coaches (Athletics) South Africa , Athletic trainers South Africa , Private schools South Africa , Ergogenic aids‎
  • Language: English
  • Type: Master's thesis , text
  • Identifier: http://hdl.handle.net/10962/232443 , vital:49992
  • Description: Sports supplements, also referred to as ergogenic aids, are used because of the assertion that they can enhance physical or athletic performance and/or physical appearance. Commonly used sports supplements include creatines, proteins, amino acids, stimulants, and in some cases pro-hormones. There is a relatively high and increasing prevalence of sports supplement use by the general population globally and in South Africa, particularly among adolescents and young adults due to various factors. While some research has explored supplement use among adolescents in a school setting, no study has explored this across the private school system in South Africa. Additionally, given the important role that coaches/trainers play in adolescent development, it is critical to also understand the role that they play regarding adolescent supplement use, given that there has been limited research around this topic in South Africa. Therefore, there were two aims of this study; Firstly, this study explored the prevalence and perceptions (knowledge; attitudes; beliefs) of sports supplements among South African private high school adolescents. Secondly, this study explored the perceptions (knowledge; attitudes; application of knowledge) towards sports supplements among adolescent coaches/trainers in South African private high schools. Considering the dual aim of this study, this thesis was structured as a two-part research study. Both parts took the form of a cross-sectional design, using an online questionnaire to collect qualitative and quantitative data. In total, a cohort of n=50 adolescents and n=49 coaches/trainers participated. Adolescent participants reported a high prevalence of sports supplement use (62%) with their main reasons for using them being recovery and performance. Adolescents were primarily influenced/advised by friends and coaches/trainers to start using sports supplements. Coaches/trainers primarily relied on other coaches/trainers and internet advertising/sites as a main source of information. Less than half of the participants from both groups reported having any formal education or training related to sports nutrition or sports supplements. Both groups thought that these products are being misused by adolescents, which may account for why a portion of the adolescent participants reported experiencing adverse side-effects from using sports supplements, and a few coach/trainer participants reported witnessing this in their practice. This may be a result of the professionalisation of school sport which places pressure on athletes and their coaches/trainers to perform and may in turn be the reason why some adolescents reported that they would use, and some coaches/trainers reported they would recommend the use of sports supplements even if they were aware of risk/dangers involved. Thus, there is a need for education/training among South African high school adolescents and their coaches/trainers with respect to the use of sports supplements, so that they can make informed decisions from reliable sources of information or advice in order to use these products safely and effectively. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
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  • Date Issued: 2022-04-06

An investigation into stakeholder inclusivity and the board’s ability to create competitive advantage at South Africa’s “big five” retail banks

  • Authors: Wolhuter, Darren Wilfred
  • Date: 2022-04-06
  • Subjects: Stakeholder management South Africa , Strategic planning South Africa , Banks and banking South Africa , Corporate governance South Africa , Competition , Resource-based theory‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/284548 , vital:56073
  • Description: Stakeholder theory has long put forth the concept that managerial attention must be given to all stakeholders towards the realisation of value creation opportunities. Through the process of stakeholder engagement, and through the adoption of stakeholder inclusivity principles, an organisation can position itself to reap the benefits of understanding the legitimate needs and interests of all its stakeholders by seeking to satisfy all its stakeholders in turn. This study analysed the integrated reports of five retail banks, whose main base of operations were in South Africa, to assess the board’s ability to create value for its stakeholders through adopting a stakeholder inclusive approach to corporate governance as advocated for by the King Code on Corporate Governance in South Africa – King IV™. This assessment was done through an examination of a selection of outcomes relevant to the banking industry and related to each of the six capitals that form part of the value creation process as indicated for in the Integrated Reporting Framework (IIRC, 2013): 1) Financial Capital, 2) Manufactured Capital; 3) Intellectual Capital; 4) Human Capital; 5) Social and Relationship Capital, and; 6) Natural Capital. The results obtained, over a three-year period – 2018 to 2020, revealed that while the directors had a firm understanding of who their material stakeholders were, they struggled to create value that catered to all their stakeholders collectively. In addition, the directors were also unable to create sustainable value over the assessment period. As a result of this, most banks, with the exception of one, were unable to realise the value creation opportunities that could have led to a potential source of competitive advantage. The study concludes that while no observable sustainable competitive advantage was evident over the period of assessment, the concept of stakeholder inclusivity is an important corporate governance principle that drives value creation and, as such, warrants more attention from the director’s point of view. This research is intended to contribute to the growing knowledge on the importance of stakeholder inclusivity in corporate governance execution. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2022
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  • Date Issued: 2022-04-06

An investigation into the force-EMG relationship for static and dynamic exertions

  • Authors: Koekemoer, Wesley Agosthinho
  • Date: 2022-04-06
  • Subjects: Electromyography , Force and energy , Muscles Physiology , Biomechanics , Muscle contraction , Isometric exercise , Isotonic exercise , ‎Static and dynamic exertions
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/291076 , vital:56816
  • Description: The force-EMG relationship has multiple applications in varying fields of study and practice. One such application is the development of safety guidelines and regulations. Current guidelines are based on static muscle actions even though the majority of tasks encountered in industry are dynamic in nature. This may have negative implications for the health, safety, and productivity of workers as regulations based on static muscle actions may place higher force demands on manual labourers compared to what would be expected if regulations were based on dynamic muscle actions. Regulations based on dynamic muscle actions may be more effective in worker safety as the nature of the regulation matches that of the demand. Few studies have investigated the force-EMG relationship during dynamic muscle actions and the few that do exist have reported contradictory / mixed results. Therefore, the purpose of this study was to: 1) gain an understanding of EMG responses at different load levels, and 2) show how the relationship differs between static and dynamic muscle actions. A two-factorial repeated-measures experiment was developed for this study. Eighteen experimental conditions, utilizing six load levels (0%, 20%, 40%, 60%, 80%, and 100% of maximum voluntary force) for each of the three muscle actions (isometric, concentric and eccentric). Surface EMG responses were obtained under these conditions by repeatedly dorsiflexing and plantarflexing the foot, thus activating the soleus muscle. A maximum voluntary exertion on an isokinetic dynamometer determined the maximum force level, based on which the sub-maximal loads were calculated and added to a pulley system. 31 student participants were recruited for this experiment which was conducted over two sessions – one information and habituation session, and one experimental session. The EMG data recorded were processed and checked for normality and outliers. The data was then analysed via a General Linear Model analysis to determine the effect of exertion type and of load level on the muscle activity. Significant differences were identified at p<0.05 and followed by a Tukey post-hoc test. Correlation analyses were also conducted to determine the relationship between the force and EMG at all three exertion types. All dependent measures showed that as the load level increased so did the sEMG amplitude for all muscle actions. Muscle actions differed significantly between majority of six force levels. Correlations between the load levels and sEMG amplitude for each muscle action indicated a significant correlation with a moderate strength. The conclusion draws from this study that there is a positive correlation between force and sEMG amplitude, at all load levels, with a moderate strength. However, the muscle actions differed significantly from each other. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2022
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  • Date Issued: 2022-04-06

Antimalarial activity of quinoline thiosemicarbazones: synthesis and antiplasmodial evaluation

  • Authors: Nqeno, Lukhanyiso Khanyisile
  • Date: 2022-04-06
  • Subjects: Antimalarials , Quinoline , Thiosemicarbazones , Malaria Chemotherapy , Plasmodium falciparum , Malaria Africa, Sub-Saharan , Iron chelates Therapeutic use
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/291292 , vital:56841
  • Description: Africa is one of the regions that is most affected by malaria, as 90% of all malaria deaths occur in sub-saharan Africa. Malaria is a life threatening disease responsible for an estimated 800000 deaths each year, the majority of these deaths occurred in children under the age of five. The disease is a mosquito-borne, and it is transmitted to humans by the female Anopheles mosquito. The parasite responsible for this disease belong to the Plasmodium genus with Plasmodium falciparum causing the most severe cases of the disease in humans. The most widely available anti-malarials were designed to specifically target the pathogenic blood stage in humans, however, in order to completely eradicate malaria there is a need for the development of medicines that not only target the pathogenic blood stage of the parasite but also block parasite transmission and eliminate asymptomatic and cryptic hepatic forms of the parasite. Iron chelators have recently gained importance as potent antimalarials, to cause infection nearly all protozoa obtain growth essential iron from their hosts. Iron is required for the development of the parasite. Deprivation of utilizable iron by chelation is a proficient approach to arrest parasite growth and associated infection. Thiosemicarbazones are known iron chelating agents by bonding through the sulfur and azomethine nitrogen atoms. This study is aimed at the identification of thiosemicarbazone based derivatives as possible antimalarial agents. Due to their iron chelation abilities there has been increasing interest in the investigation of thiosemicarbazones as possible antimalarials. During the course of this project, several thiosemicarbazone derivatives were synthesized and their structure confirmed using routine analytical techniques (NMR, FTIR, and HRMS). The synthesized compounds were evaluated in vitro against the chloroquine sensitive strain (3D7) of P. falciparum for antimarial activity. The compounds were also evaluated agsinst Hela cells for overt cytotoxicity. The compounds generally showed poor antimalarial activity. One compound (LKN11) was identified to possess intrinsic and moderate antimalarial activity of 6.6 μM. The compounds were generally not cytotoxic against Hela cell at concentrations of up to 20 μM, with only compound LKN10 showing modest cytotoxic activity of 9.5 μM. This research went on to identify two thiosemicarbazone based derivatives which had a significant effect on HeLa and pLDH cells. , Thesis (MSc) -- Faculty of Science, Chemistry, 2022
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  • Date Issued: 2022-04-06

Assessing the density and distribution of spotted hyaenas (Crocuta crocuta) in Hluhluwe–iMfolozi Park, KwaZulu-Natal, South Africa

  • Authors: Roberts, Peter Jean
  • Date: 2022-04-06
  • Subjects: Spotted hyena Home range South Africa Hluhluwe Game Reserve , Spotted hyena Habitat South Africa Hluhluwe Game Reserve , Animal population density South Africa Hluhluwe Game Reserve , Scouting cameras , Home range (Animal geography) , Spatially-explicit mark recapture (SECR)‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/292681 , vital:57006
  • Description: Protected areas are becoming increasingly isolated refugia for large carnivores and are critical for their survival. Spotted hyaenas (Crocuta crocuta) have, for centuries, been ‘managed’ as problem causing animals and their conservation has been largely overlooked. To preserve a population, it is paramount to understand its distribution and abundance through reliable and cost-effective monitoring techniques. My study estimated the density of spotted hyaenas and their use of space in Hluhluwe–iMfolozi Park (HiP), South Africa. I compared camera trap by-catch data and call-up surveys between 2013–2018 to assess spotted hyaena densities. The camera trap data estimated an average of 16.72 (SD: ±2.22) hyaenas per 100 km2 between 2013–2018, with an annual estimated high of 19.01 in 2018 and a low of 12.77 in 2015. The call-up surveys consistently produced lower estimates than those obtained from the camera trap data. These results highlight the importance of calibrating the response probability factor for call-up surveys to maintain precision. The space use of spotted hyaenas was analysed using the photo-capture data obtained during the same six-year period, to produce individual 100% Minimum Convex Polygon’s (MCPs). Seven clan territories were identified from individual female home ranges that overlapped by more than 66% of their MCPs. Territory sizes were similar to historical estimates for the park, with averages of 13.96 (SD: ±6.48) km2 in Hluhluwe and 34.61 (SD: ±23.87) km2 in iMfolozi. My study successfully used by-catch camera data to calculate annual density estimates and investigate the spatial use patterns for spotted hyaenas in HiP. I demonstrate that this approach is cost-effective and reliable for calculating density estimates. Conservation practitioners should take heed of the advancements in technology and analytical capacity now available to them to improve monitoring efforts. My study specifically calls for collaborative efforts to use existing camera trap data to improve regional estimates and population trends of spotted hyaenas across their range. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2022
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  • Date Issued: 2022-04-06

Bioethical analysis of COVID19, WASH/waste and related disaster management implications

  • Authors: Iheanetu, Chidinma Uchenna
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/232250 , vital:49975
  • Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2022
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  • Date Issued: 2022-04-06

Bond market integration in the Common Monetary Area (CMA)

  • Authors: Ramoriting, Retšelisitsoe Silvia
  • Date: 2022-04-06
  • Subjects: Globalization , Globalization Economic aspects , Bond market , Rand area , Africa, Southern Economic integration , ‎Autoregressive distributed lag (ARDL) model
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/284592 , vital:56077
  • Description: The study reviews the phenomenon of financial integration. During the late 1980s and 1990s, financial market integration around the world increased due to globalisation of investments and the need for higher returns and international risk diversification. The increase was accompanied by a significant increase in private capital flows into developing countries from developed countries. The main goal of the study is to examine bond market integration in the common monetary area The study therefore investigates the co-movement of government bond returns within the CMA using data from Eswatini, Namibia, and South Africa. The study attempts to find the short-run and long-run relationship of these government bond returns using the ARDL cointegration technique. The study uses daily data of 10-year government bond yields spanning from August 2014 to September 2019. The empirical results reveal that there exists a short-run and long-run relationship between South Africa and Eswatini. Between South Africa and Namibia, there only exist a short-run relationship. Just like the previously mentioned studies, the short-run relationship is a result of policy convergence. The lack of long-run relationship between South and Namibia was due to poor institutional developments and limited investment opportunities. In this case, policy measures (or reforms) and a review of the union are necessary to increase integration of these bond markets. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2022
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  • Date Issued: 2022-04-06

Cloning, expression, partial characterisation and application of a recombinant GH10 xylanase, XT6, from Geobacillus stearothermophilus T6 as an additive to chicken feeds

  • Authors: Sithole, Tariro
  • Date: 2022-04-06
  • Subjects: Chicken feed industry , Chickens Feeding and feeds , Bacillus (Bacteria) , Xylanases , Polysaccharides , Geobacillus stearothermophilus‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/292693 , vital:57007
  • Description: Monogastric animal farming has largely been sustained by feeding animals with grain feedstocks containing non-starch polysaccharides (NSPs) and anti-nutritive factors, which cause adverse effects, such as increased digesta viscosity and entrapment of nutrients, which leads to the inaccessibility of nutrients. These effects have been linked to a reduction in nutrient digestion and absorption, which results in a decreased feed conversion ratio, energy metabolism and animal growth. Monogastric animals do not produce enzymes that can hydrolyse these NSPs. The application of exogenous enzymes as supplements to animal feeds has been implemented to reduce viscosity and increase nutrient absorption in poultry and pigs over the past few decades. The aim of this study was to clone, express, partially characterise and apply a glycoside hydrolase (GH) family 10 xylanase (XT6), derived from Geobacillus stearothermophilus T6, as an additive to locally produced chicken feeds. The xt6 gene (1,236 bp) was subcloned and expressed in Escherichia coli DH5α and BL21(DE3) cells, respectively. Upon expression, XT6 had a molecular weight of 42 kDa and was partially purified by Ni-NTA chromatography and ultrafiltration. The purification step resulted in a yield of 66.7% with a 16.8-fold increase in purification. XT6 exhibited maximal activity when incubated at a pH and temperature of pH 6.0 and 70°C, respectively, with a high thermostability over a broad range of pH (2–9) and temperature (30–90 °C). The specific activities of XT6 on extracted soluble and insoluble wheat flour arabinoxylans were 110.9 U/mg and 63.98 U/mg, respectively. Kinetic data showed that XT6 displayed a higher catalytic activity and affinity (Vmax = 231.60 μmol/min/mg and KM = 2.759 mg/ml) for soluble wheat arabinoxylan, compared to insoluble wheat arabinoxylan (Vmax = 99.02 μmol/min/mg and KM = 5.058 mg/ml). High-performance liquid chromatography (HPLC) analysis showed that the enzyme hydrolysed wheat flour, arabinoxylan and chicken feeds, producing a range of xylooligosaccharides (XOS), with xylotetraose and xylopentaose being the predominant XOS species. Hydrolysis of both soluble and insoluble wheat flour arabinoxylans by XT6 led to a significant reduction in substrate viscosity. The effects of simulated gastrointestinal fluid contents, such as proteases, bile salts and mucins, on XT6 stability were also studied. Exposure of XT6 to pepsin did not significantly reduce its activity; however, the inhibitory effect of trypsin and mucin on XT6 was much greater. The presence of gut-derived bile salts had no iii | P a g e significant effect on XT6 activity. Finally, it was shown that the XOS produced from the hydrolysis of chicken feeds (starter and grower feeds) by XT6 significantly enhanced the growth of the probiotic bacteria B. subtilis, while there was no significant improvement in the growth of S. thermophilus and L. bulgaricus. In conclusion, the recombinantly produced XT6 demonstrated efficient hydrolysis of starter and grower feeds, and produced XOS that showed prebiotic activity on selected probiotic bacteria. In addition, the pH, temperature and simulated gastric juice content stability of XT6 renders it an attractive candidate as an additive for chicken feeds. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2022
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  • Date Issued: 2022-04-06

Comparison of a novel HPLC method and conventional protein assays for the quantitation of insulin aspart in Novorapid®

  • Authors: Dickson, Courtney Rae
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/290704 , vital:56776
  • Description: Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2022
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  • Date Issued: 2022-04-06

Effects of hydraulic fracking fluid on soil microbial composition and diversity

  • Authors: Sianyuka, Nicolette
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/232366 , vital:49985
  • Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2022
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  • Date Issued: 2022-04-06

Exchange rate volatility and the returns on diversified South African investment portfolios

  • Authors: Mulamu, Murendeni
  • Date: 2022-04-06
  • Subjects: Foreign exchange rates South Africa , Rate of return , Investments , GARCH model , Regression analysis , ‎Autoregressive distributed lag (ARDL) model
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/284581 , vital:56076
  • Description: Globalisation has made it much easier to invest in foreign countries. This creates endless options accessible to investors, including exploiting opportunities for investment in international economies. Although foreign investment portfolio diversification provides significant opportunities for financial returns, exchange rate volatility may play a prominent role when investing in foreign markets. Since the introduction of a floating exchange rate system, together with the inflation-targeting monetary policy framework in South Africa, there has been significant volatility in the exchange rate, far more than during the previous dispensations. This, however, creates a strong need to consider how the unpredictable nature of the exchange rate affects these investments. The purpose of this study is to analyse the effect of exchange rate volatility on the returns on diversified South African investment portfolios. This research examined whether there is a homogenous relationship between South African (domestic) portfolios and the internationally diversified portfolios. In addition, the study investigated the long-run relationship between the exchange rate volatility and both domestic portfolios and the internationally diversified portfolios for the period 2007-2019. To achieve these goals, a panel ARDL model was employed. This study found that exchange rate volatility does not account for a significant portion of returns on investment portfolios fluctuations. Moreover, the relationship is not homogenous because returns on domestic investment portfolios react positively to the exchange rate volatility, whereas returns international investment portfolios respond negatively/positively to the exchange rate volatility depending on whether the relationship is short or long run. This study will contribute to the existing literature, and it is important for investors intending to diversify their investment portfolios both domestically and internationally using different mutual funds in South Africa. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2022
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  • Date Issued: 2022-04-06

Exploring the entrepreneurial intention of students in one Higher Education Institution (HEI)

  • Authors: Kenye-Duma, Ayanda Rachel
  • Date: 2022-04-06
  • Subjects: Entrepreneurship South Africa , Intention , Entrepreneurship Study and teaching (Higher) South Africa , Students Attitudes , Social entrepreneurship , Social capital (Sociology) , Unemployment South Africa , Entrepreneurship Development in Higher Education (EDHE)‎
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/284514 , vital:56070
  • Description: This study was interpretive and qualitatively explored students' entrepreneurial intentions at Rhodes University. It was conducted to understand entrepreneurship among students. Understanding students' entrepreneurship is critical as entrepreneurship is touted as a reasonable response to alleviate the high unemployment in South Africa. The study explored how students became entrepreneurs (or how their entrepreneurship intentions were formed) and the factors that enhanced (enablers and barriers) and inhibited them. The significance of living with and after COVID-19, youth and graduate unemployment alleviation places entrepreneurship development by institutions of higher learning, governments and private sector in the centre of economic recovery. The establishment of the Entrepreneurship Development in Higher Education (EDHE) in 2016, highlights the commitment of the South African government, for Higher Education Institutions (HEI) to engage more in entrepreneurship and do more research to understand how students become entrepreneurs and unravel the challenges. Understanding students' entrepreneurship intentions can facilitate a supportive environment for students entrepreneurship. With “very little research about student entrepreneurship at this university” being the guiding research problem, the aim was to gain insight into the entrepreneurship intention of university students by exploring factors that influence students to become entrepreneurs. The study employed Ajzen’s Theory of Planned Behaviour to explore the entrepreneurial intentions of university students in terms of the underlying attitudes, subjective norms, and perceived behavioural control. The students who participated in the study fell into three categories of entrepreneurial intention: (i) Intending to start a business, (ii) starting a business, and (ii) those who were already operating a business. All the participants, irrespective of their stage of entrepreneurial intention, demonstrated a positive attitude and self-efficacy. All participants showed self-efficacy by identifying barriers and taking positive steps to overcome them. The main barriers were access to funding, capital, training, business opportunities with the university and lack of interaction with established entrepreneurs. The results demonstrated the close interplay of attitudes, social norms and perceived behavioural control in students’ entrepreneurial intentions. Social recognition of entrepreneurship, social capital, education and role models contributed to positive attitudes, and social norms influenced students’ entrepreneurial intentions. A supportive environment was found to be critical for nurturing entrepreneurship intentions. The study recommends a supportive climate cultivated by Rhodes University to promote entrepreneurship. The supportive environment must include the elevation of entrepreneurship in prominent offices of the university, strengthening entrepreneurship societies and interactions with established entrepreneurs, and engagement with the private sector to contribute and promote entrepreneurship among students. , Thesis (MBA) -- Faculty of Commerce, Rhodes Business School, 2022
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  • Date Issued: 2022-04-06
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