- Title
- Assessment of antibiotic production by some marine actinomycetes belonging to the genera norcadia, saccharopolyspora and kibdellosporangium.
- Creator
- Koba, Siziwe (https://orcid.org/0000-0002-6761-6403)
- Subject
- Actinobacteria
- Subject
- Bacteria
- Subject
- Actinomycetales
- Date Issued
- 2010
- Date
- 2010
- Type
- Master's theses
- Type
- text
- Identifier
- http://hdl.handle.net/10353/25811
- Identifier
- vital:64488
- Description
- Antibacterial potency of the extracts of the three marine actinomycetes strains which were isolated in the Nahoon Beach and tentatively identified as the genera Norcadia, Kibdellosporingium and Saccharopolyspora were investigated in this study against a panel of referenced, environmental and clinical bacterial strains. The ethyl acetate extracts of these marine actinomycetes were screened for activity against 32 bacterial isolates. Out of the 32 organisms, 10 were susceptible to one or all the extracts used. Antibacterial activity was mainly observed against Gram-negative organisms with Minimum inhibitory concentration (MIC) values ranging from 0.078 mg/ml to >10mg/ml. The killing rates of the active extracts were also elucidated using standard procedures. The two extracts NO64 and NO53 showed rapid bactericidal activity against B. pumilus ATCC 14884 and Serratia marcens with a 3Log10 reduction in counts within 6 hours at 3.75 mg/ml and 5 mg/ml respectively. In conclusion, the ethyl acetate extract of these marine actinomycetes strains possess strong bactericidal and bacteriostatic activities against Gram negative organisms and can be therapeutically useful in the treatment of bacterial infections which are mainly caused by Gram negative bacteria.
- Description
- Thesis (MA) -- Faculty of Science and Agriculture, 2010
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (67 leaves)
- Format
- Publisher
- University of Fort Hare
- Publisher
- Faculty of Science and Agriculture
- Language
- English
- Rights
- University of Fort Hare
- Rights
- All Rights Reserved
- Rights
- Open Access
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UFH Department of Biochemistry & Microbiology
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Koba, S (M dissertation).pdf | 317 KB | Adobe Acrobat PDF | View Details Download |