Design, formulation and evalauation of liposomes co-loaded with human serum Albumin and Rifampicin
- Authors: Bapolisi, Alain Murhimalika
- Date: 2020
- Subjects: Liposomes , Serum albumin , Rifampin , Mycobacterium tuberculosis
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/161780 , vital:40670
- Description: Tuberculosis (TB) is a devastating infectious disease caused by Mycobacterium tuberculosis and is the leading cause of death from a single infectious agent. The high morbidity and mortality rates of TB are partly due to factors such as the lengthy regimen (of 6–24 months), the development of drug resistance, and the pathogen location within the macrophages. These, with poor physiochemical properties of existing drugs hamper the effectiveness of the treatment despite the existence of potent antibiotics such as Rifampicin (Rif). Hydrophobicity plagues many drugs, including Rif, which are then particularly affected due to inherently poor intracellular availability. Novel drug delivery approaches are therefore needed in order to optimize the cytotoxic potential of said antitubercular drugs. To improve the bioavailability of hydrophobic drugs, numerous delivery strategies have been developed. Amongst these, the coordination of cytotoxic drugs to therapeutic proteins have shown some success for improved efficacy in the management of illnesses including infectious diseases. Of therapeutic proteins, Human Serum Albumin (HSA) is an attractive drug carrier with interestingbenefits such as low immunogenicity, antioxidant properties and improving cellular uptake ofdrugs through HSA-specific binding sites which are expressed on most cells including macrophages, where M. tuberculosis often resides. Hence, combination of Rif to HSA (Rif-HSA)seems a promising approach for improved intracellular delivery of Rif. However, the in vivo stability of colloidal protein-based therapeutics is mostly challenging and an effective vehicle is needed to control the biological fate of such conjugates.Liposomes seem to be appropriate carriers for the Rif-HSA complex due to their reputable applicability for encapsulating diverse materials (i.e., hydrophobic and hydrophilic compounds or small and complex molecules) and preventing chemical and biological degradation of the cargo. Therefore, the main objective of this study was to simultaneously encapsulate Rif and HSA in liposomes, which, to the best of our knowledge, has not been done before. The dual liposomes (Rif-HSA-lip) were made by a modified “Reverse Phase Evaporation” method (REV), following a Design of Experiments (DOE) approach to determine which factors impact the formulation. In addition, liposomes were made from crude soybean lecithin (CSL), rather than expensive and highly purified lipids. The liposomes were fully characterised, and the encapsulation efficiency (î) was monitored using high-performance liquid chromatography (HPLC). The results were correlated with factors such as organic and aqueous phase composition, as well as the in vitro release profile of Rif. Transmission electron microscopy (TEM) results confirmed the formation of spherical dual liposomes nanoparticles of roughly 200 nm. Dynamic light scattering (DLS) and Zeta potential measurements showed a negative charge (<–45 mV) and with satisfactory polydispersity (PDI<0.5). HSA dramatically improved the aqueous solubility of Rif (from1.9 mg/ml in water to around 4.3 mg/ml in HSA 10% solution) mainly due to Rif-HSA hydrophobic interactions. This resulted in a good î of almost 60% for Rif, despite the presence of bulky HSA in the lipid bilayer. These details were confirmed using proton nuclear magnetic resonance (1H NMR) and Fourier-transform infrared spectroscopy (FTIR). Furthermore, energy dispersive X-ray (EDX) and DLS data suggested the presence of HSA poking out on the surface of liposomes, which is encouraging for potential targeted delivery in the future. The in vitro release studies also depicted a substantial improvement in the diffusion of Rif in dual liposomes versus free Rif, from 65% after 12 hours for free Rif to 95% after only 5 hours for Rif- HSA-lip. Finally, stability studies conducted over 30 days at room temperature, showed that the freeze-dried formulations of Rif-HSA-lip exhibited good shelf stability over liposomes with no HSA. This study represents an illustrative example of co-loading of antibiotics and proteins into liposomes, which could encourage further development of novel nanoparticulate tools for the effective management of both drug-susceptible and -resistant infectious diseases such as TB.
- Full Text:
- Date Issued: 2020
Design, formulation and evaluation of liposomes co-loaded with human serum albumin and rifampicin
- Authors: Bapolisi, Alain Murhimalika
- Date: 2020
- Subjects: Liposomes , Rifampin , Antitubercular agents , Serum albumin , Albumins , Tuberculosis -- Treatment
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/163179 , vital:41016
- Description: Tuberculosis (TB) is a devastating infectious disease caused by Mycobacterium tuberculosis and is the leading cause of death from a single infectious agent. The high morbidity and mortality rates of TB are partly due to factors such as the lengthy regimen (of 6–24 months), the development of drug resistance, and the pathogen location within the macrophages. These, with poor physiochemical properties of existing drugs hamper the effectiveness of the treatment despite the existence of potent antibiotics such as Rifampicin (Rif). Hydrophobicity plagues many drugs, including Rif, which are then particularly affected due to inherently poor intracellular availability. Novel drug delivery approaches are therefore needed in order to optimize the cytotoxic potential of said antitubercular drugs. To improve the bioavailability of hydrophobic drugs, numerous delivery strategies have been developed. Amongst these, the coordination of cytotoxic drugs to therapeutic proteins have shown some success for improved efficacy in the management of illnesses including infectious diseases. Of therapeutic proteins, Human Serum Albumin (HSA) is an attractive drug carrier with interesting benefits such as low immunogenicity, antioxidant properties and improving cellular uptake of drugs through HSA-specific binding sites which are expressed on most cells including macrophages, where M. tuberculosis often resides. Hence, combination of Rif to HSA (Rif-HSA) seems a promising approach for improved intracellular delivery of Rif. However, the in vivo stability of colloidal protein-based therapeutics is mostly challenging and an effective vehicle is needed to control the biological fate of such conjugates. Liposomes seem to be appropriate carriers for the Rif-HSA complex due to their reputable applicability for encapsulating diverse materials (i.e., hydrophobic and hydrophilic compounds or small and complex molecules) and preventing chemical and biological degradation of the cargo. Therefore, the main objective of this study was to simultaneously encapsulate Rif and HSA in liposomes, which, to the best of our knowledge, has not been done before. The dual liposomes (Rif-HSA-lip) were made by a modified “Reverse Phase Evaporation” method (REV), following a Design of Experiments (DOE) approach to determine which factors impact the formulation. In addition, liposomes were made from crude soybean lecithin (CSL), rather than expensive and highly purified lipids. iv The liposomes were fully characterised, and the encapsulation efficiency (î) was monitored using high-performance liquid chromatography (HPLC). The results were correlated with factors such as organic and aqueous phase composition, as well as the in vitro release profile of Rif. Transmission electron microscopy (TEM) results confirmed the formation of spherical dual liposomes nanoparticles of roughly 200 nm. Dynamic light scattering (DLS) and Zeta potential measurements showed a negative charge (<–45 mV) and with satisfactory polydispersity (PDI<0.5). HSA dramatically improved the aqueous solubility of Rif (from1.9 mg/ml in water to around 4.3 mg/ml in HSA 10% solution) mainly due to Rif-HSA hydrophobic interactions. This resulted in a good î of almost 60% for Rif, despite the presence of bulky HSA in the lipid bilayer. These details were confirmed using proton nuclear magnetic resonance (1H NMR) and Fourier-transform infrared spectroscopy (FTIR). Furthermore, energy dispersive X-ray (EDX) and DLS data suggested the presence of HSA poking out on the surface of liposomes, which is encouraging for potential targeted delivery in the future. The in vitro release studies also depicted a substantial improvement in the diffusion of Rif in dual liposomes versus free Rif, from 65% after 12 hours for free Rif to 95% after only 5 hours for Rif- HSA-lip. Finally, stability studies conducted over 30 days at room temperature, showed that the freeze-dried formulations of Rif-HSA-lip exhibited good shelf stability over liposomes with no HSA. This study represents an illustrative example of co-loading of antibiotics and proteins into liposomes, which could encourage further development of novel nanoparticulate tools for the effective management of both drug-susceptible and -resistant infectious diseases such as TB.
- Full Text:
- Date Issued: 2020
Categorising Network Telescope data using big data enrichment techniques
- Authors: Davis, Michael Reginald
- Date: 2019
- Subjects: Denial of service attacks , Big data , Computer networks -- Security measures
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/92941 , vital:30766
- Description: Network Telescopes, Internet backbone sampling, IDS and other forms of network-sourced Threat Intelligence provide researchers with insight into the methods and intent of remote entities by capturing network traffic and analysing the resulting data. This analysis and determination of intent is made difficult by the large amounts of potentially malicious traffic, coupled with limited amount of knowledge that can be attributed to the source of the incoming data, as the source is known only by its IP address. Due to the lack of commonly available tooling, many researchers start this analysis from the beginning and so repeat and re-iterate previous research as the bulk of their work. As a result new insight into methods and approaches of analysis is gained at a high cost. Our research approaches this problem by using additional knowledge about the source IP address such as open ports, reverse and forward DNS, BGP routing tables and more, to enhance the researcher's ability to understand the traffic source. The research is a BigData experiment, where large (hundreds of GB) datasets are merged with a two month section of Network Telescope data using a set of Python scripts. The result are written to a Google BigQuery database table. Analysis of the network data is greatly simplified, with questions about the nature of the source, such as its device class (home routing device or server), potential vulnerabilities (open telnet ports or databases) and location becoming relatively easy to answer. Using this approach, researchers can focus on the questions that need answering and efficiently address them. This research could be taken further by using additional data sources such as Geo-location, WHOIS lookups, Threat Intelligence feeds and many others. Other potential areas of research include real-time categorisation of incoming packets, in order to better inform alerting and reporting systems' configuration. In conclusion, categorising Network Telescope data in this way provides insight into the intent of the (apparent) originator and as such is a valuable tool for those seeking to understand the purpose and intent of arriving packets. In particular, the ability to remove packets categorised as non-malicious (e.g. those in the Research category) from the data eliminates a known source of `noise' from the data. This allows the researcher to focus their efforts in a more productive manner.
- Full Text:
- Date Issued: 2019
Popular politics in the rural Western Cape, South Africa: a case study of Ruiterbos
- Authors: Ghedi Alasow, Jonis
- Date: 2019
- Subjects: Political participation -- South Africa -- Cape Town , South Africa -- Politics and government -- 1994- , Land tenure -- Political aspects -- South Africa , Land use, Rural -- Political aspects -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/96165 , vital:31246
- Description: This thesis argues that the philosophical foundations upon which human beings have been engaged have, across various schools of thought, made the mistake of presuming that some people are more modern than others. This suggestion is refuted throughout this thesis. To do this, intellectual traditions that take the fundamental rationality of all human beings as an indispensable starting point are engaged to argue for the need to acknowledge that everyone in the ‘now’ is indeed, of the ‘now’. This thesis connects these debates about modernity, rationality and humanity to the contemporary discussions around rural politics with particular reference to Ruiterbos in the Western Cape province of South Africa. By means of detailed empirical and ethnographic research, this thesis illustrates the issues around which people in Ruiterbos are politicised. Via this case study, the a priori assumption that rural politics will necessarily manifest itself only with respect to questions of land and agrarian reform or labour relations is complicated. The two issues around which people in Ruiterbos, during the time of this research, seem to be politicised – housing and education – are surfaced throughout this thesis. The thesis argues that the findings in this case study call for an expansion of the issues that are traditionally considered when the question of rural politics is raised. The often historicist approach that limits the possibilities for politics in rural areas should be suspended for an approach that takes popular politics and political agents in rural areas seriously. The thesis finally argues that the conclusions that are reached with respect to questions of modernity and rural politics ought to be adopted to allow for more detailed and thorough explanations of popular politics in places like Ruiterbos.
- Full Text:
- Date Issued: 2019
“Like walking barefoot on the gravel road”: the experience of caring for a child with physical disabilities
- Authors: Ndlovu, Nokanyo
- Date: 2019
- Subjects: PhotoVoice , Photography in the social sciences , Action research , Children with disabilites -- Care -- South Africa , Children with disabilites -- Care -- South Africa -- Case studies , Caregivers -- South Africa -- Case studies , Caregivers -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/72479 , vital:30057
- Description: The aim of this study was to develop an understanding of the experiences of caregivers of children with physical disabilities and to explore ways of improving this experience. Although there is a considerable amount of international research on the experiences of caring for children with disabilities, the focus of the methods of enquiry has mainly been on knowledge production and there is limited research conducted using an approach like participatory action research. Secondly, in South Africa, there is still inadequate information regarding the experiences of caregivers who are from low socio-economic backgrounds. It is for these reasons that the current study, which employed PhotoVoice, a participatory research data collection tool, to explore the lived experiences of caregivers of children with physical disabilities from low socio-economic backgrounds was embarked upon. The research methodology comprised two main parts: firstly, a study of relevant literature on the subject matter, in order to gain in-depth understanding of the field; and secondly, qualitative data collection, using PhotoVoice. A sample of six participants between the ages of 22-57 years was selected through purposive and convenience sampling. Cameras were distributed to participants and after processing of images narratives were shared around selected photographs and this was later followed by focused group discussions. This analysis process provided two master themes, which are supported by subordinate themes. The master themes are: 1) The challenges associated with the caregiving experience, 2) The positive side of the caregiving experience. Participants experienced a lack of resources, challenges of mobility, the hopelessness of the situation, loneliness of the experience and the financial burden of caring for a child with physical disabilities as challenges associated with the caregiving role. Whereas the joy brought about by support from family, the health service providers and the Association for People with Physical Disabilities personnel; precious moments shared with the child; and personal growth were associated with the positive side of the caregiving experience. These findings support and expand on the growing knowledge of caring for children with physical disabilities. This research culminated in a sharing of the narratives with stakeholders by caregivers themselves as a way of seeking to influence policy, enhance their well-being and engage in a discussion of exploring ways of improving their experience.
- Full Text:
- Date Issued: 2019
A psychosocial reading of novice clinical psychologists’ talk about whiteness
- Authors: Kennedy, Brink
- Date: 2018
- Subjects: Clinical psychology Practice South Africa , White people Race identity South Africa , White privilege (Social structure) South Africa , White people Race identity Psychological aspects , Intercultural communication , Psychoanalysis and racism South Africa , Mentalization Based Therapy
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/60212 , vital:27751
- Description: This research presents a case study report of interview encounters with two novice white South African clinical psychologists. A psychosocial research methodology is employed to examine the discursive strategies that participants engage in when speaking about whiteness in the context of their professional identity and practice, as well as to examine the ways in which these discursive strategies support or constrain ‘mentalizing’ in relation to raced experience. One case study highlights an individualistic discourse of ‘racial innocence’, which constructs the speaker as being free of racial enculturation and consciousness, eliding a broader social context. I argue that this discourse closes down mentalizing in relation to more difficult, intractable aspects of raced experience in clinical work, relating to differences in positionality as well as issues of inequality. I also propose that this discourse may be understood in terms of a ‘pretend’ mode of thought, where aspects of the wider social context and of race in particular are experienced as being unrelated to intimate personal experience. The other case study highlights a discourse of ‘uneasy whiteness’ that involves awareness of white positionality, and that is grounded in a constructionist sensibility. This positions the speaker as being inevitably implicated in white privilege and racism in ways that she may be ignorant of. I argue that the discourse facilitates a particular type of mentalizing that is sensitive to the interpellation of intimate personal experience with a wider social context that encompasses a range of discourses and practices. It closes down mentalizing, however, in so far as it allows a reified construction of whiteness. I find the concept of psychic equivalence, which equates external (concrete, factual) reality and internal (subjective, symbolic) reality, useful in terms of understanding this reification. Overall the research highlights the tension between constructionist and individualistic modes of thinking within clinical psychology research and practice in the South African context. At the level of methodology, it presents an example of how these modes may be integrated within research. At the level of content, it explores differences between constructionist and individualistic talk in relation to race and psychological practice.
- Full Text:
- Date Issued: 2018
Quantification of water resources uncertainties in two sub-basins of the Limpopo River basin
- Authors: Oosthuizen, Nadia
- Date: 2018
- Subjects: Hydrologic models -- Limpopo River Watershed , Water-supply -- Limpopo River Watershed , Water-supply -- Management , Sustainable development , Rain and rainfall -- Mathematical models , Runoff -- Mathematical models , Reservoirs -- Limpopo River Watershed
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/63267 , vital:28388
- Description: The demand for water is rapidly growing, placing more strain on access to the resources and subsequently its management. For sustainable management, there is a need to accurately quantify the available water resources. Unfortunately, the data required for such assessments are frequently far from sufficient in terms of availability and quality, especially in southern Africa. In the absence of historical observed data, models are generally used to describe the different hydrological processes and generate data and information that will inform management and policy decision making. Ideally, any hydrological model should be based on a sound conceptual understanding of the processes in the basin and be backed by quantitative information for the parameterization of the model. Such data is however, often inadequate in many sub-basins necessitating the incorporation of the uncertainty related to the estimation process. Model parameter estimation and input data are significant sources of uncertainty that should be quantified. Also, in southern Africa water use data are unreliable because available databases consist of licensed information and actual use is generally unknown. In this study, the water resources of two sub-basins of the Limpopo River basin – the Mogalakwena in South Africa and the Shashe shared between Botswana and Zimbabwe – are estimated. The study assessed how uncertainties in the Pitman model parameterisation and input water use data affect the estimation of surface water resources of the selected sub-basins. Farm reservoirs and irrigated areas data from various sources were collected and used to run the Pitman model. Results indicate that the total model output uncertainty is higher for the Shashe sub-basin which is more data scarce than the Mogalakwena sub-basin. The study illustrates the importance of including uncertainty in the water resources assessment process to provide baseline data for decision making in resource management and planning. The study reviews existing information sources associated with the quantification of water balance components and gives an update of water resources of the sub-basin. The flows generated by the model at the outlet of the basin were between 22.6 Mm3 and 24.7 Mm3 per month when incorporating uncertainty to the main physical runoff generating parameters. The total predictive uncertainty of the model increased to between 22.2 Mm3 and 25.0 Mm3 when anthropogenic water use data such as small farm and large reservoirs and irrigation were included. The flows generated for Shashe was between 11.7 Mm3 and 14.5 Mm3 per month when incorporating uncertainty to the main physical runoff generating parameters. The predictive uncertainty of the model changed to 11.7 Mm3 and 17.7 Mm3 after the water use uncertainty was added. However, it is expected that the uncertainty could be reduced by using higher resolution remote sensing imagery.
- Full Text:
- Date Issued: 2018
Revising the distribution of mangrove forests in South Africa and changes in growth of mangrove species along a latitudinal gradient
- Authors: Bolosha, Uviwe
- Date: 2017
- Subjects: Mangrove ecology -- South Africa , Mangrove forests -- South Africa , Mangrove plants -- South Africa -- Effect of temperature on
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/7544 , vital:21271
- Description: Mangrove forests are a diverse assemblage of trees and shrubs that are adapted to a saline and tidally inundated environment. The global spread of mangrove species is affected by climate, with most confined to areas that are warmer and moist. At a global scale, temperature limits the distribution of mangrove forests but on a regional scale and local scale, rainfall, river flow and tidal exchange have a strong effect on the distribution and biomass of mangrove forests. Other factors that play a role in limiting growth and distribution of mangroves include accessibility of suitable habitats for growth and also conditions that are suitable for propagule dispersal. The objectives of this study were to review the distribution of mangroves in South Africa and determine the number of extreme temperature events that may limit further distribution and secondly to measure growth rates of mangrove species at Mngazana and Nahoon Estuary and the nutrient pools in the sediment of these forests. In 1982, Ward and Steinke published a list of estuaries where mangroves were present. The current study sampled the population structure, microclimate and level of expansion in two estuaries within and outside of the published range. The minimum, maximum temperature and number of extreme temperature events were measured using iButtons. Mangrove expansion will be limited by minimum temperatures (1.1 ° C) and an increase in extreme temperature events (830) (<5 ° C and 5- 10 ° C) at the latitudinal limits. Expansion of A. marina at Kwelera and Tyolomnqa Estuary was evident but sapling survival was low. Mangroves have expanded within and outside the range proposed by Ward and Steinke (1982), but are limited by physical factors, restricted by the presence of saltmarsh and other estuarine macrophytes and natural disturbance regimes. An increase in population growth was recorded over the years at both Mngazana and Nahoon Estuary. Nutrients, (ammonium, nitrates + nitrites and soluble reactive phosphorus) varied amongst sites and were related to seasonality. Nitrogen in both estuaries was available in the form of ammonium (NH4) and its concentration was generally higher (1.3-76.2 pm) than other forms of nitrogen (0.07-6.3 µm). Soluble reactive phosphorus (SRP) was higher during the wet seasons in both estuaries. An increase in porewater salinity since 2007 (41.3 practical salinity unit (PSU)) was measured at Mngazana and this is a result of freshwater abstraction and low rainfall. A. marina saplings and adults grew significantly faster at Nahoon Estuary (the distributional limit) (11.1 ± 1.1 cm year-¹) compared to Mngazana Estuary (5.3 ± 1.8 cm year-¹). Different mangrove species and forests respond differently to environmental factors and changes in mangrove distribution is expected in South Africa but changes are expected to happen slowly and opportunistically.
- Full Text:
- Date Issued: 2017
C3TO : a scalable architecture for mobile chat based tutoring
- Authors: Butgereit, Laura Lee
- Date: 2010
- Subjects: Intelligent tutoring systems , Instructional systems -- Design
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9746 , http://hdl.handle.net/10948/1511 , Intelligent tutoring systems , Instructional systems -- Design
- Description: C³TO (Chatter Call Centre/Tutoring Online) is a scalable architecture to support mobile online tutoring using chat protocols over cell phones. It is the scalability of this architecture which is the primary focus of this dissertation. Much has been written lamenting the state of mathematics education in South Africa. It is not a pretty story. In order to help solve this mathematical crisis, the “Dr Math” research project was started in January, 2007. “Dr Math” strove to assist school pupils with their mathematics homework by providing access to tutors from a nearby university to help them. The school pupils used MXit on their cell phones and the tutors used normal computer workstations. The original “Dr Math” research project expected no more than twenty to thirty school pupils to participate. Unexpectedly thousands of school pupils started asking “Dr Math” to assist them with their mathematics homework. The original software could not scale. The original software could not cater for the thousands of pupils needing help. The scalability problems which existed in the original “Dr Math” project included: hardware scalability issues, software scalability problems, lack of physical office space for tutors, and tutor time being wasted by trivial questions. C³TO tackled these scalability concerns using an innovative three level approach by implementing a technological feature level, a tactical feature level, and a strategic feature level in the C³TO architecture. The technological level included specific components, utilities, and platforms which promoted scalability. The technological level provided the basic building blocks with which to construct a scalable architecture. The tactical level arranged the basic building blocks of the technological level into a scalable architecture. The tactical level provided short term solutions to scalability concerns by providing easy configurability and decision making. The strategic level attempted to answer the pupils questions before they actually arrived at the tutor thereby reducing the load on the human tutors. C³TO was extensively tested and evaluated. C³TO supported thousands of school pupils with their mathematics homework over a period of ten months. C³TO was used to support a small conference. C³TO was used to encourage people to volunteer their time in participation of Mandela Day. C³TO was used to support “Winter School” during the winter school holiday. In all these cases, C³TO proved itself to be scalable.
- Full Text:
- Date Issued: 2010
The term structure of interest rates in South Africa
- Authors: Dollery, Brian
- Date: 1976
- Subjects: Interest rates -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:1083 , http://hdl.handle.net/10962/d1011180 , Interest rates -- South Africa
- Description: Since the late ' fifties the term structure of interest rates has attracted considerable attention from both theoretical and empirical economists. While potentially a very fruitful area for the application of the traditional methods of economic enquiry, the term structure has proved itself to be a potent testing ground for these tools, and consequently a wide range of sophisticated analytic devices have been introduced, Despite this, no general agreement has yet been reached and a number of crucial questions remain unanswered. It is our task in this dissertation to extend the enquiry into the South African context in an attempt to shed some light on the determination of the term structure of interest rates. Intro., p. 1.
- Full Text:
- Date Issued: 1976