Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors
- Faridoon, H, Edkins, Adrienne L, Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C, Kaye, Perry T
- Authors: Faridoon, H , Edkins, Adrienne L , Isaacs, Michelle , Mnkandhla, Dumisani , Hoppe, Heinrich C , Kaye, Perry T
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66289 , vital:28929 , https://doi.org/10.1016/j.bmcl.2016.05.023
- Description: publisher version , Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined.
- Full Text: false
- Date Issued: 2016
- Authors: Faridoon, H , Edkins, Adrienne L , Isaacs, Michelle , Mnkandhla, Dumisani , Hoppe, Heinrich C , Kaye, Perry T
- Date: 2016
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66289 , vital:28929 , https://doi.org/10.1016/j.bmcl.2016.05.023
- Description: publisher version , Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined.
- Full Text: false
- Date Issued: 2016
Teaching in higher education
- Authors: Quinn, Lynn
- Date: 2014
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/66557 , vital:28963 , https://doi.org/10.1080/1360144X.2014.908094
- Description: publisher version , As Becker and Denicolo point out in their introduction, traditionally most lecturers in higher education begin teaching with little or no formal training: ‘It is assumed if you were expert in your field you would be able, by some ill-defined means, to teach others’ (p. 1). This book aims to remedy that situation and does exactly what it sets out to do: it provides a useful, step-by-step training guide for teachers in higher education. It provides much needed advice for new academics for ways in which they can successfully combine their teaching and their research roles. It is written in an accessible style, draws on the experiences of people who have taught in higher education for some time, and provides practical advice for teaching in a range of contexts and for dealing with different challenges that may arise.
- Full Text: false
- Date Issued: 2014
- Authors: Quinn, Lynn
- Date: 2014
- Language: English
- Type: text , review
- Identifier: http://hdl.handle.net/10962/66557 , vital:28963 , https://doi.org/10.1080/1360144X.2014.908094
- Description: publisher version , As Becker and Denicolo point out in their introduction, traditionally most lecturers in higher education begin teaching with little or no formal training: ‘It is assumed if you were expert in your field you would be able, by some ill-defined means, to teach others’ (p. 1). This book aims to remedy that situation and does exactly what it sets out to do: it provides a useful, step-by-step training guide for teachers in higher education. It provides much needed advice for new academics for ways in which they can successfully combine their teaching and their research roles. It is written in an accessible style, draws on the experiences of people who have taught in higher education for some time, and provides practical advice for teaching in a range of contexts and for dealing with different challenges that may arise.
- Full Text: false
- Date Issued: 2014
The Johannesburg project
- Authors: Lewis, Colin A
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6167 , http://hdl.handle.net/10962/d1012355
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2006
- Authors: Lewis, Colin A
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6167 , http://hdl.handle.net/10962/d1012355
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2006
Glasbury muscle men
- Authors: Lewis, Colin A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6175 , http://hdl.handle.net/10962/d1012368
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text: false
- Date Issued: 2005
- Authors: Lewis, Colin A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6175 , http://hdl.handle.net/10962/d1012368
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text: false
- Date Issued: 2005
The bells of Jamestown, South Atlantic Ocean
- Authors: Lewis, Colin A
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6177 , http://hdl.handle.net/10962/d1012370 , http://www.ringingworld.co.uk
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2004
- Authors: Lewis, Colin A
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6177 , http://hdl.handle.net/10962/d1012370 , http://www.ringingworld.co.uk
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2004
Significance of 87Sr/86Sr ratios in the Merensky cyclic unit of the Bushveld Complex
- Kruger, Floris J, Marsh, Julian S
- Authors: Kruger, Floris J , Marsh, Julian S
- Date: 1982
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/133524 , vital:36986 , https://doi.org/10.1038/298053a0
- Description: In a number of mafic layered intrusions, layers with platinum group element (PGE) mineralization coincide with breaks in cumulus mineral composition and isotopic variation trends through the layered sequence1,2. For example, in the Bushveld Complex in South Africa, abrupt increases in initial 87Sr/86Sr ratios occur at the UG-2 and Merensky pegmatoid (or ‘reef’) horizons, both of which are exploited for PGEs. We report here the results of a detailed Sr-isotope study across the Merensky unit and its immediate foot- and hangingwall-rocks which, when considered together with new ideas on processes operating in magma chambers3–5, suggest that magma mixing and post-cumulus infiltration of liquids displaced from below were important during crystallization of the Merensky pegmatoid.
- Full Text: false
- Date Issued: 1982
- Authors: Kruger, Floris J , Marsh, Julian S
- Date: 1982
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/133524 , vital:36986 , https://doi.org/10.1038/298053a0
- Description: In a number of mafic layered intrusions, layers with platinum group element (PGE) mineralization coincide with breaks in cumulus mineral composition and isotopic variation trends through the layered sequence1,2. For example, in the Bushveld Complex in South Africa, abrupt increases in initial 87Sr/86Sr ratios occur at the UG-2 and Merensky pegmatoid (or ‘reef’) horizons, both of which are exploited for PGEs. We report here the results of a detailed Sr-isotope study across the Merensky unit and its immediate foot- and hangingwall-rocks which, when considered together with new ideas on processes operating in magma chambers3–5, suggest that magma mixing and post-cumulus infiltration of liquids displaced from below were important during crystallization of the Merensky pegmatoid.
- Full Text: false
- Date Issued: 1982
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