- Title
- Species distribution and antifungal susceptibility patterns of Candida isolates from a public tertiary teaching hospital in the Eastern Cape Province, South Africa
- Creator
- Mnge, P
- Creator
- Okeleye, B I
- Creator
- Vasaikar, S D
- Creator
- Apalata, T
- Subject
- Candida Candida species
- Subject
- Antifungal agents Antifungal susceptibility
- Date Issued
- 2017-03-14
- Date
- 2017-03-14
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/11260/6817
- Identifier
- vital:49389
- Identifier
- http://dx.doi.org/10.1590/1414-431X20175797
- Description
- Candida species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant Candida species. This study aimed to identify the species distribution of Candida isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209 Candida isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar Candida. The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine. Four species of Candida were isolated, of which C. albicans was the most frequent, isolated in 45.4 percent (95/209) of the isolates, followed by C. glabrata: 31.1 percent (65/209). The MICs of the different antifungal drugs varied amongst the species of Candida. From the 130 isolates tested for MICs, 90.77 percent (112/130) were susceptible to all antifungal drugs and 6.9 percent (9/130) of the isolates were multi-drug resistant. C. dubliniensis (n=2) isolates were susceptible to all the above mentioned antifungal drugs. There was no significant difference in species distribution amongst clinical specimens and between patients’ genders (P40.05). An increase in MIC values for fluconazole and flucytosine towards the resistance range was observed. To our knowledge, this is the first report on surveillance of Candida species distribution and antifungal susceptibility at a public tertiary teaching hospital in Eastern Cape, South Africa.
- Format
- 7 pages
- Format
- Publisher
- Scielo Brazil
- Language
- English
- Relation
- Brazilian Journal of Medical and Biological Research
- Relation
- Mnge P, Okeleye BI, Vasaikar SD, Apalata T. Species distribution and antifungal susceptibility patterns of Candida isolates from a public tertiary teaching hospital in the Eastern Cape Province, South Africa. Braz J Med Biol Res. 2017 May 15;50(6):e5797. doi: 10.1590/1414-431X20175797. PMID: 28513771; PMCID: PMC5479383.
- Relation
- Brazilian Journal of Medical and Biological Research volume 50 number 6 1 7 2017-00
- Rights
- © 2017. The Authors
- Rights
- Scielo Brazil
- Rights
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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