Molecular Detection of Antibiotic-Resistant Genes in Pseudomonas aeruginosa from Nonclinical Environment: Public Health Implications in Mthatha, Eastern Cape Province, South Africa
- Mojisola Clara Hosu, Sandeep Vasaikar, Grace Emily Okuthe, Teke Apalata
- Authors: Mojisola Clara Hosu , Sandeep Vasaikar , Grace Emily Okuthe , Teke Apalata
- Date: 5 January 2021
- Subjects: Microbiology
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2417 , vital:41877
- Description: Evaluation of resistant profiles and detection of antimicrobial-resistant genes of bacterial pathogens in the nonclinical milieu is imperative to assess the probable risk of dissemination of resistant genes in the environment. .is paper sought to identify antibiotic-resistant genes in Pseudomonas aeruginosa from nonclinical sources in Mthatha, Eastern Cape, and evaluate its public health implications. Samples collected from abattoir wastewater and aquatic environment were processed by membrane filtration and cultured on CHROMagarTM Pseudomonas medium. Species identification was performed by autoSCAN-4 (Dade Behring Inc., IL). Molecular characterization of the isolates was confirmed using real-time polymerase chain reaction (rPCR) and selected isolates were further screened for the possibility of harboring antimicrobial resistance genes. Fifty-one Pseudomonas species were recovered from abattoir wastewater and surface water samples, out of which thirty-six strains were Pseudomonas aeruginosa (70.6%). .e P. aeruginosa isolates demonstrated resistance to aztreonam (86.1%), ceftazidime (63.9%), piperacillin (58.3%), cefepime (55.6%), imipenem (50%), piperacillin/tazobactam (47.2%), meropenem (41.7%), and levofloxacin (30.6%). Twenty out of thirty-six P. aeruginosa displayed multidrug resistance profiles and were classified as multidrug-resistant (MDR) (55.6%). Most of the bacterial isolates exhibited a high Multiple Antibiotic Resistance (MAR) Index ranging from 0.08 to 0.69 with a mean MAR index of 0.38. In the rPCR analysis of fifteen P. aeruginosa isolates, 14 isolates (93.3%) were detected harboring blaSHV, six isolates (40%) harbored blaTEM, and three isolates (20%) harbored blaCTX-M, being the least occurring ESBL. Results of the current study revealed that P. aeruginosa isolates recovered from nonclinical milieu are resistant to frontline clinically relevant antipseudomonal drugs. .is is concerning as it poses a risk to the environment and constitutes a public health threat. Given the public health relevance, the paper recommends monitoring of multidrug-resistant pathogens in effluent environments.
- Full Text:
- Authors: Mojisola Clara Hosu , Sandeep Vasaikar , Grace Emily Okuthe , Teke Apalata
- Date: 5 January 2021
- Subjects: Microbiology
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2417 , vital:41877
- Description: Evaluation of resistant profiles and detection of antimicrobial-resistant genes of bacterial pathogens in the nonclinical milieu is imperative to assess the probable risk of dissemination of resistant genes in the environment. .is paper sought to identify antibiotic-resistant genes in Pseudomonas aeruginosa from nonclinical sources in Mthatha, Eastern Cape, and evaluate its public health implications. Samples collected from abattoir wastewater and aquatic environment were processed by membrane filtration and cultured on CHROMagarTM Pseudomonas medium. Species identification was performed by autoSCAN-4 (Dade Behring Inc., IL). Molecular characterization of the isolates was confirmed using real-time polymerase chain reaction (rPCR) and selected isolates were further screened for the possibility of harboring antimicrobial resistance genes. Fifty-one Pseudomonas species were recovered from abattoir wastewater and surface water samples, out of which thirty-six strains were Pseudomonas aeruginosa (70.6%). .e P. aeruginosa isolates demonstrated resistance to aztreonam (86.1%), ceftazidime (63.9%), piperacillin (58.3%), cefepime (55.6%), imipenem (50%), piperacillin/tazobactam (47.2%), meropenem (41.7%), and levofloxacin (30.6%). Twenty out of thirty-six P. aeruginosa displayed multidrug resistance profiles and were classified as multidrug-resistant (MDR) (55.6%). Most of the bacterial isolates exhibited a high Multiple Antibiotic Resistance (MAR) Index ranging from 0.08 to 0.69 with a mean MAR index of 0.38. In the rPCR analysis of fifteen P. aeruginosa isolates, 14 isolates (93.3%) were detected harboring blaSHV, six isolates (40%) harbored blaTEM, and three isolates (20%) harbored blaCTX-M, being the least occurring ESBL. Results of the current study revealed that P. aeruginosa isolates recovered from nonclinical milieu are resistant to frontline clinically relevant antipseudomonal drugs. .is is concerning as it poses a risk to the environment and constitutes a public health threat. Given the public health relevance, the paper recommends monitoring of multidrug-resistant pathogens in effluent environments.
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Morphology, histology and histochemistry of the digestive tract of the Banded tilapia, Tilapia sparrmanii (Perciformes: Cichlidae)
- Grace E. Okuthe, Bongile Bhomela
- Authors: Grace E. Okuthe , Bongile Bhomela
- Date: December 23, 2020
- Subjects: Fish, gastrointestinal tract, histo-architecture
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2425 , vital:41881
- Description: ABSTRACT. This study described anatomical, histological and histochemical features of the mucosal layer of the digestive tract of Tilapia sparrmanii Smith, 1840, an omnivorous freshwater fish endemic to Southern Africa. This species exhibited a short thick oesophagus with long deep longitudinal folds (466.68 ± 16.91 µm), and a thick (173.50 ± 10.92 µm) muscular layer that allow the passage of large food items. The mucosa was lined with stratified secretory epithelium rich in goblet cells that secreted neutral and acid mucins. The stomach was a sac-like structure with simple tubular glands surrounded by connective tissue. The mucosa was lined with simple columnar epithelium and the lamina propria exhibited a well-developed layer of gastric glands that occupied the entire length of the cardio-fundic region. The stomach mucosa consisted of epithelial cells with intense neutral mucin secretion which protects against gastric juice. Neck cells of gastric glands synthesized neutral and acid mucins. The intestine was highly coiled and presented a complex pattern of transversal folds internally (villi). Villi length decreased progressively from the anterior to the posterior intestine (p < 0.0001). Tunica muscularis of the mid-intestine had the thinnest thickness among all parts of the intestine (p < 0.0001). Goblet cells whose numbers increased towards the rectum secreted both acid and neutral mucins. The results indicate structural similarities of T. sparrmanii GIT with other tilapia species and will be useful for understanding the physiology of the digestive systems as well as functional components of the GIT.
- Full Text:
- Authors: Grace E. Okuthe , Bongile Bhomela
- Date: December 23, 2020
- Subjects: Fish, gastrointestinal tract, histo-architecture
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2425 , vital:41881
- Description: ABSTRACT. This study described anatomical, histological and histochemical features of the mucosal layer of the digestive tract of Tilapia sparrmanii Smith, 1840, an omnivorous freshwater fish endemic to Southern Africa. This species exhibited a short thick oesophagus with long deep longitudinal folds (466.68 ± 16.91 µm), and a thick (173.50 ± 10.92 µm) muscular layer that allow the passage of large food items. The mucosa was lined with stratified secretory epithelium rich in goblet cells that secreted neutral and acid mucins. The stomach was a sac-like structure with simple tubular glands surrounded by connective tissue. The mucosa was lined with simple columnar epithelium and the lamina propria exhibited a well-developed layer of gastric glands that occupied the entire length of the cardio-fundic region. The stomach mucosa consisted of epithelial cells with intense neutral mucin secretion which protects against gastric juice. Neck cells of gastric glands synthesized neutral and acid mucins. The intestine was highly coiled and presented a complex pattern of transversal folds internally (villi). Villi length decreased progressively from the anterior to the posterior intestine (p < 0.0001). Tunica muscularis of the mid-intestine had the thinnest thickness among all parts of the intestine (p < 0.0001). Goblet cells whose numbers increased towards the rectum secreted both acid and neutral mucins. The results indicate structural similarities of T. sparrmanii GIT with other tilapia species and will be useful for understanding the physiology of the digestive systems as well as functional components of the GIT.
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Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents
- Letswalo, Boitumelo Prescilla, Schmid-Zalaudek, Karin, Brix, Bianca, Matjuda, Edna Ngoakoana, Klosz, Fabian, Obernhumer, Natalie, Gaisl, Michael, Engwa, Godwill Azeh, Sewani-Rusike, Constance, Fredriksen, Per Morten, Nkeh-Chungag, Benedicta, Goswami, Nandu
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
- Full Text:
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
- Full Text:
Detection of a SARS-CoV-2 variant of concern in South Africa
- Authors: Oluwakemi Laguda-Akingba
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4505 , vital:44127
- Description: Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3–5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu– Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6–8.
- Full Text:
- Authors: Oluwakemi Laguda-Akingba
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4505 , vital:44127
- Description: Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3–5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu– Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6–8.
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Detection of extended spectrum beta‑lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa
- Mojisola C. Hosu, Sandeep D. Vasaikar,, Grace E. Okuthe, Teke Apalata
- Authors: Mojisola C. Hosu , Sandeep D. Vasaikar, , Grace E. Okuthe , Teke Apalata
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4509 , vital:44128
- Description: The proliferation of extended spectrum beta-lactamase (ESBL) producing Pseudomonas aeruginosa represent a major public health threat. In this study, we evaluated the antimicrobial resistance patterns of P. aeruginosa strains and characterized the ESBLs and Metallo- β-lactamases (MBL) produced. Strains of P. aeruginosa cultured from patients who attended Nelson Mandela Academic Hospital and other clinics in the four district municipalities of the Eastern Cape between August 2017 and May 2019 were identified; antimicrobial susceptibility testing was carried out against thirteen clinically relevant antibiotics using the BioMérieux VITEK 2 and confirmed by Beckman autoSCAN-4 System. Real-time PCR was done using Roche Light Cycler 2.0 to detect the presence of ESBLs; blaSHV, blaTEM and blaCTX-M genes; and MBLs; blaIMP, blaVIM. Strains of P. aeruginosa demonstrated resistance to wide-ranging clinically relevant antibiotics including piperacillin (64.2%), followed by aztreonam (57.8%), cefepime (51.5%), ceftazidime (51.0%), piperacillin/tazobactam (50.5%), and imipenem (46.6%). A total of 75 (36.8%) multidrug-resistant (MDR) strains were observed of the total pool of isolates. The blaTEM, blaSHV and blaCTX-M was detected in 79.3%, 69.5% and 31.7% isolates (n = 82), respectively. The blaIMP was detected in 1.25% while no blaVIM was detected in any of the strains tested. The study showed a high rate of MDR P. aeruginosa in our setting. The vast majority of these resistant strains carried blaTEM and blaSHV genes. Continuous monitoring of antimicrobial resistance and strict compliance towards infection prevention and control practices are the best defence against spread of MDR P. aeruginosa.
- Full Text:
- Authors: Mojisola C. Hosu , Sandeep D. Vasaikar, , Grace E. Okuthe , Teke Apalata
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4509 , vital:44128
- Description: The proliferation of extended spectrum beta-lactamase (ESBL) producing Pseudomonas aeruginosa represent a major public health threat. In this study, we evaluated the antimicrobial resistance patterns of P. aeruginosa strains and characterized the ESBLs and Metallo- β-lactamases (MBL) produced. Strains of P. aeruginosa cultured from patients who attended Nelson Mandela Academic Hospital and other clinics in the four district municipalities of the Eastern Cape between August 2017 and May 2019 were identified; antimicrobial susceptibility testing was carried out against thirteen clinically relevant antibiotics using the BioMérieux VITEK 2 and confirmed by Beckman autoSCAN-4 System. Real-time PCR was done using Roche Light Cycler 2.0 to detect the presence of ESBLs; blaSHV, blaTEM and blaCTX-M genes; and MBLs; blaIMP, blaVIM. Strains of P. aeruginosa demonstrated resistance to wide-ranging clinically relevant antibiotics including piperacillin (64.2%), followed by aztreonam (57.8%), cefepime (51.5%), ceftazidime (51.0%), piperacillin/tazobactam (50.5%), and imipenem (46.6%). A total of 75 (36.8%) multidrug-resistant (MDR) strains were observed of the total pool of isolates. The blaTEM, blaSHV and blaCTX-M was detected in 79.3%, 69.5% and 31.7% isolates (n = 82), respectively. The blaIMP was detected in 1.25% while no blaVIM was detected in any of the strains tested. The study showed a high rate of MDR P. aeruginosa in our setting. The vast majority of these resistant strains carried blaTEM and blaSHV genes. Continuous monitoring of antimicrobial resistance and strict compliance towards infection prevention and control practices are the best defence against spread of MDR P. aeruginosa.
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Detection of sexually transmitted pathogens and co-infection with human papillomavirus in women residing in rural Eastern Cape, South Africa
- Taku, Ongeziwe, Brink, Adrian, Meiring, Tracy L, Phohlo, Keletso, Businge, Charles B, Mbulawa, Zizipho Z A, Williamson, Anna-Lise
- Authors: Taku, Ongeziwe , Brink, Adrian , Meiring, Tracy L , Phohlo, Keletso , Businge, Charles B , Mbulawa, Zizipho Z A , Williamson, Anna-Lise
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4064 , vital:44019
- Full Text:
- Authors: Taku, Ongeziwe , Brink, Adrian , Meiring, Tracy L , Phohlo, Keletso , Businge, Charles B , Mbulawa, Zizipho Z A , Williamson, Anna-Lise
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4064 , vital:44019
- Full Text:
Eastern Cape Healthcare Workers Acquisition of SARS-CoV-2 (ECHAS): Cross-Sectional (Nested Cohort) Study Protocol
- Oladele Vincent Adeniyi, David Stead, Mandisa Singata-Madliki 4, Joanne Batting, Leo Hyera, Eloise Jelliman, Shareef Abrahams, Andrew Parrish
- Authors: Oladele Vincent Adeniyi , David Stead , Mandisa Singata-Madliki 4 , Joanne Batting , Leo Hyera , Eloise Jelliman , Shareef Abrahams , Andrew Parrish
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3972 , vital:43978
- Full Text:
- Authors: Oladele Vincent Adeniyi , David Stead , Mandisa Singata-Madliki 4 , Joanne Batting , Leo Hyera , Eloise Jelliman , Shareef Abrahams , Andrew Parrish
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3972 , vital:43978
- Full Text:
Evaluation of Intussusception After Oral Monovalent Rotavirus Vaccination in South Africa
- Michelle J. Groome, Nick Andrews, Jacqueline E. Tate, Marion Arnold, Milind Chitnis, Sharon Cox, Corné de Vos, Mari Kirsten, Susanna M. le Grange, Jerome Loveland, Sello Machaea, Ashwini Maharaj, Shabir A. Madhi, Umesh D. Parashar
- Authors: Michelle J. Groome , Nick Andrews , Jacqueline E. Tate , Marion Arnold , Milind Chitnis , Sharon Cox , Corné de Vos , Mari Kirsten , Susanna M. le Grange , Jerome Loveland , Sello Machaea , Ashwini Maharaj , Shabir A. Madhi , Umesh D. Parashar
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4543 , vital:44131
- Full Text:
- Authors: Michelle J. Groome , Nick Andrews , Jacqueline E. Tate , Marion Arnold , Milind Chitnis , Sharon Cox , Corné de Vos , Mari Kirsten , Susanna M. le Grange , Jerome Loveland , Sello Machaea , Ashwini Maharaj , Shabir A. Madhi , Umesh D. Parashar
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4543 , vital:44131
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Factors affecting specialist psychiatry training in South Africa: Bullying during specialist psychiatric training?
- Beath, Natalie, Moxley, Karis, Subramaney, Ugasvaree, Zingela, Zukiswa, Chiliza, Bonginkosi, Joska, John, Kotzé, Carla, Seedat, Soraya
- Authors: Beath, Natalie , Moxley, Karis , Subramaney, Ugasvaree , Zingela, Zukiswa , Chiliza, Bonginkosi , Joska, John , Kotzé, Carla , Seedat, Soraya
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3839 , vital:43955
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- Authors: Beath, Natalie , Moxley, Karis , Subramaney, Ugasvaree , Zingela, Zukiswa , Chiliza, Bonginkosi , Joska, John , Kotzé, Carla , Seedat, Soraya
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3839 , vital:43955
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Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis
- Charles Bitamazire Businge, Namhla Madini, Benjamin Longo-Mbenza, A P Kengne
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
- Authors: Charles Bitamazire Businge , Namhla Madini , Benjamin Longo-Mbenza , A P Kengne
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4602 , vital:44141
- Full Text:
Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis
- Charles Bitamazire Businge, Anthony Usenbo, Benjamin Longo-Mbenza, AP Kengne
- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
- Full Text:
- Authors: Charles Bitamazire Businge , Anthony Usenbo , Benjamin Longo-Mbenza , AP Kengne
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3876 , vital:43961
- Full Text:
Knowledge Policing: Re-conceptualizing Ogun in Peter Omoko’s Battles of Pleasure and Roy-Omoni’s Morontonu
- Olutoba Gboyega Oluwasuji,, Sone Mirabeau Enongene
- Authors: Olutoba Gboyega Oluwasuji, , Sone Mirabeau Enongene
- Date: 2021
- Subjects: Coloniality, Decolonial Epistemic Perspective, Knowledge Policing, Ogun, Yoruba
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2688 , vital:42323
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- Authors: Olutoba Gboyega Oluwasuji, , Sone Mirabeau Enongene
- Date: 2021
- Subjects: Coloniality, Decolonial Epistemic Perspective, Knowledge Policing, Ogun, Yoruba
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2688 , vital:42323
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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAPPsychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda
- Stevenson, Anne, Zingela, Zukiswa, Akena, Dickens, Stroud, Rocky E, Atwoli, Lukoye, Campbell, Megan M, Chibnik, Lori B, Kwobah, Edith, Kariuki, Symon M, Martin, Alicia R, de Menil, Victoria, Newton, Charles R J C, Sibeko, Goodman, Stein, Dan J, Teferra, Solomon, Koenen, Karestan C
- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
- Full Text:
- Authors: Stevenson, Anne , Zingela, Zukiswa , Akena, Dickens , Stroud, Rocky E , Atwoli, Lukoye , Campbell, Megan M , Chibnik, Lori B , Kwobah, Edith , Kariuki, Symon M , Martin, Alicia R , de Menil, Victoria , Newton, Charles R J C , Sibeko, Goodman , Stein, Dan J , Teferra, Solomon , Koenen, Karestan C
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4594 , vital:44137
- Full Text:
Predictors of institutional delivery service utilization among women of reproductive age in Senegal: a population-based study
- Betregiorgis Zegeye, Bright Opoku Ahinkorah, Dina Idriss-Wheelr, Olanrewaju Oladimeji, Comfort Z. Olorunsaiye, Sanni Yaya
- Authors: Betregiorgis Zegeye , Bright Opoku Ahinkorah , Dina Idriss-Wheelr , Olanrewaju Oladimeji , Comfort Z. Olorunsaiye , Sanni Yaya
- Date: 2021
- Subjects: Institutional delivery, Women, Reproductive age, Senegal, Maternal health, Global health, Sub-Saharan Africa
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4496 , vital:44126
- Description: Background: In Senegal, sub-Saharan Africa, many women continue to die from pregnancy and childbirth complications. Even though health facility delivery is a key intervention to reducing maternal death, utilization is low. There is a dearth of evidence on determinants of health facility delivery in Senegal. Therefore, this study investigated the predictors of health facility-based delivery utilization in Senegal. Methods: Data from the 2017 Senegal Continuous Survey were extracted for this study, and approximately 11,487 ever-married women aged 15–49 years participated. Chi-square test was used to select significant variables and multivariable logistic regression analysis was performed to identify statistically significant predictors at a 95% confidence interval with a 0.05 p-value using Stata version 14 software. Results: Facility-based delivery utilization was 77.7% and the main predictors were maternal educational status (primary school Adjusted Odds Ratio [aOR] = 1.44, 95% CI; 1.14–1.83; secondary school aOR = 1.62, 95% CI; 1.17– 2.25), husband’s educational status (primary school aOR = 1.65, 95% CI; 1.24–2.20, secondary school aOR = 2.17, 95% CI; 1.52–3.10), maternal occupation (agricultural-self-employed aOR = 0.77, 95% CI; 0.62–0.96), ethnicity (Poular aOR = 0.74, 95% CI; 0.56–0.97), place of residence (rural aOR = 0.57, 95% CI; 0.43, 0.74), media exposure (yes aOR = 1.26, 95% CI; 1.02–1.57), economic status (richest aOR = 5.27, 95% CI; 2.85–9.73), parity (seven and above aOR =0.46, 95% CI; 0.34–0.62), wife beating attitude (refuse aOR =1.23, 95% CI; 1.05–1.44) and skilled antenatal care (ANC) (yes aOR = 4.34, 95% CI; 3.10–6.08). Conclusion: Uptake of health facility delivery services was seen among women who were educated, exposed to media, wealthy, against wife-beating, attended ANC by skilled attendants and had educated husbands. On the other hand, women from ethnic groups like Poular, those working in agricultural activities, living in rural setting, and those who had more delivery history were less likely to deliver at a health facility. Therefore, there is the need to empower women by encouraging them to use skilled ANC services in order for them to gain the requisite knowledge they need to enhance their utilization of health facility delivery, whiles at the same time, removing socio-economic barriers to access to health facility delivery that occur from low education, poverty and rural dwelling.
- Full Text:
- Authors: Betregiorgis Zegeye , Bright Opoku Ahinkorah , Dina Idriss-Wheelr , Olanrewaju Oladimeji , Comfort Z. Olorunsaiye , Sanni Yaya
- Date: 2021
- Subjects: Institutional delivery, Women, Reproductive age, Senegal, Maternal health, Global health, Sub-Saharan Africa
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4496 , vital:44126
- Description: Background: In Senegal, sub-Saharan Africa, many women continue to die from pregnancy and childbirth complications. Even though health facility delivery is a key intervention to reducing maternal death, utilization is low. There is a dearth of evidence on determinants of health facility delivery in Senegal. Therefore, this study investigated the predictors of health facility-based delivery utilization in Senegal. Methods: Data from the 2017 Senegal Continuous Survey were extracted for this study, and approximately 11,487 ever-married women aged 15–49 years participated. Chi-square test was used to select significant variables and multivariable logistic regression analysis was performed to identify statistically significant predictors at a 95% confidence interval with a 0.05 p-value using Stata version 14 software. Results: Facility-based delivery utilization was 77.7% and the main predictors were maternal educational status (primary school Adjusted Odds Ratio [aOR] = 1.44, 95% CI; 1.14–1.83; secondary school aOR = 1.62, 95% CI; 1.17– 2.25), husband’s educational status (primary school aOR = 1.65, 95% CI; 1.24–2.20, secondary school aOR = 2.17, 95% CI; 1.52–3.10), maternal occupation (agricultural-self-employed aOR = 0.77, 95% CI; 0.62–0.96), ethnicity (Poular aOR = 0.74, 95% CI; 0.56–0.97), place of residence (rural aOR = 0.57, 95% CI; 0.43, 0.74), media exposure (yes aOR = 1.26, 95% CI; 1.02–1.57), economic status (richest aOR = 5.27, 95% CI; 2.85–9.73), parity (seven and above aOR =0.46, 95% CI; 0.34–0.62), wife beating attitude (refuse aOR =1.23, 95% CI; 1.05–1.44) and skilled antenatal care (ANC) (yes aOR = 4.34, 95% CI; 3.10–6.08). Conclusion: Uptake of health facility delivery services was seen among women who were educated, exposed to media, wealthy, against wife-beating, attended ANC by skilled attendants and had educated husbands. On the other hand, women from ethnic groups like Poular, those working in agricultural activities, living in rural setting, and those who had more delivery history were less likely to deliver at a health facility. Therefore, there is the need to empower women by encouraging them to use skilled ANC services in order for them to gain the requisite knowledge they need to enhance their utilization of health facility delivery, whiles at the same time, removing socio-economic barriers to access to health facility delivery that occur from low education, poverty and rural dwelling.
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Prevalence of Helicobacter pylori infection and the incidence of the associated malignant and peptic ulcer disease PUD at Nelson Mandela Academic.pdf
- Authors: Stephen Z. Molaoa
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4104 , vital:44024
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- Authors: Stephen Z. Molaoa
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4104 , vital:44024
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Prevalence of Hypertension and Its Associated Risk Factors in a Rural Black Population of Mthatha Town, South Africa
- Jyoti Rajan Sharma, Sihle E. Mabhida, Bronwyn Myers 3, Teke Apalata, Edward Nicol, Mongi Benjeddou, Christo Muller, Rabia Johnson
- Authors: Jyoti Rajan Sharma , Sihle E. Mabhida , Bronwyn Myers 3 , Teke Apalata , Edward Nicol , Mongi Benjeddou , Christo Muller , Rabia Johnson
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3980 , vital:43979
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- Authors: Jyoti Rajan Sharma , Sihle E. Mabhida , Bronwyn Myers 3 , Teke Apalata , Edward Nicol , Mongi Benjeddou , Christo Muller , Rabia Johnson
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3980 , vital:43979
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Protocol for a prospective descriptive prevalence study of catatonia in an acute mental health unit in urban South Africa
- Zingela, Zukiswa, Cronje, Johan, Fink, Max, van Wyk, Stephanus, Stroud, Louise
- Authors: Zingela, Zukiswa , Cronje, Johan , Fink, Max , van Wyk, Stephanus , Stroud, Louise
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4610 , vital:44142
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- Authors: Zingela, Zukiswa , Cronje, Johan , Fink, Max , van Wyk, Stephanus , Stroud, Louise
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4610 , vital:44142
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Relationship between Endothelial Function, Antiretroviral Treatment and Cardiovascular Risk Factors in HIV Patients of African Descent in South Africa: A Cross-Sectional Study
- Benedicta N. Nkeh-Chungag, Goswami, Nandu, Engwa, Godwill Azeh, Sewani-Rusike, Constance R, Mbombela, Vuyolwethu, Ingrid WebsterPatrick De Boever, Kessler, Harald H, Stelzl, Evelyn
- Authors: Benedicta N. Nkeh-Chungag , Goswami, Nandu , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mbombela, Vuyolwethu , Ingrid WebsterPatrick De Boever , Kessler, Harald H , Stelzl, Evelyn
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3998 , vital:43982
- Full Text:
- Authors: Benedicta N. Nkeh-Chungag , Goswami, Nandu , Engwa, Godwill Azeh , Sewani-Rusike, Constance R , Mbombela, Vuyolwethu , Ingrid WebsterPatrick De Boever , Kessler, Harald H , Stelzl, Evelyn
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3998 , vital:43982
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RNA – Sustainable Marine & Freshwater Economic Development (SMAFED)
- Authors: Okuthe, Grace
- Date: 2021
- Language: English
- Type: Poster
- Identifier: http://hdl.handle.net/11260/6415 , vital:45479
- Description: In a knowledge-based economy, the capacity to compete in the global market is highly dependent on the ability to innovate and apply the relevant technologies to industries and productive sectors. Investment in Science, Technology & Innovation (STI) and its integration into the social, economic and governance policies can increase global market competiveness, create employment and increase productivity, which are key components for achieving S. African Vision 2030. It is against this National background that Walter Sisulu University (WSU) has established RNAs. The general theme of the RNA is; Marine & Freshwater Resource Management & Economic Development. Hence, the name the proposed name (SMAFED)
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- Authors: Okuthe, Grace
- Date: 2021
- Language: English
- Type: Poster
- Identifier: http://hdl.handle.net/11260/6415 , vital:45479
- Description: In a knowledge-based economy, the capacity to compete in the global market is highly dependent on the ability to innovate and apply the relevant technologies to industries and productive sectors. Investment in Science, Technology & Innovation (STI) and its integration into the social, economic and governance policies can increase global market competiveness, create employment and increase productivity, which are key components for achieving S. African Vision 2030. It is against this National background that Walter Sisulu University (WSU) has established RNAs. The general theme of the RNA is; Marine & Freshwater Resource Management & Economic Development. Hence, the name the proposed name (SMAFED)
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Socio-demographic associations of HIV among women attending antenatal care in selected rural primary care facilities in South Africa’s Eastern Cape province
- Sikhumbuzo A. Mabunda, Khuthala Sigovana, Wezile Chitha, Teke Apalata, Sibusiso Nomatshila
- Authors: Sikhumbuzo A. Mabunda , Khuthala Sigovana , Wezile Chitha , Teke Apalata , Sibusiso Nomatshila
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4112 , vital:44025
- Full Text:
- Authors: Sikhumbuzo A. Mabunda , Khuthala Sigovana , Wezile Chitha , Teke Apalata , Sibusiso Nomatshila
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/4112 , vital:44025
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