The intersection between social development and the internationalisation of higher education in Colombia
- Authors: Anzola-Pardo, Giovanni
- Date: 2018
- Subjects: Education, Higher -- Colombia , Education and globalization International education -- Colombia Education, Higher -- International cooperation -- Colombia
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/23371 , vital:30536
- Description: The study addresses the nature of Colombian sustainable social development and the internationalisation of higher education (iHE). This intersection is analysed within various theoretical paradigms surrounding social sustainable development and the internationalisation of higher education. This study aims at reviewing the activities of Higher Education Institutions (HEIs) which focus on internationalisation. The analysis focuses on the manner in which HEIs in Colombia approach internationalisation vis-à-vis social sustainable development, and emphasis is made on knowledge transfer, research and community engagement. Using the theories of sustainable development, the iHE, in terms of practises and policies, are assessed. Within a mixed-methods approach, data gathered from Colombian university heads (16 presidents and vice-presidents) and 133 individuals responsible for internationalisation affairs is analysed. Concurrent triangulation is used to help introduce a series of themes and sub-themes derived from the qualitative and quantitative information. Within a social constructionist framework, this study has a twofold purpose. On the one hand, it is sought to identify and understand the challenges for Colombia’s academic internationalisation; on the other, an in-depth approach is presented in relation to the way different stakeholders perceive the society-HE internationalisation nexus. The major findings of the study indicate that there is a need to clarify and revise Colombia’s Higher Education policy to address both the education needs of the society and its social development requirements. It was also found that higher education internationalisation could act as an important agent of social change.
- Full Text:
- Date Issued: 2018
Chang liver cell line as a model for Type II Diabetes in the liver and possible reversal of this condition by an indigenous medicinal plant
- Authors: Williams, Saralene Iona
- Date: 2009
- Subjects: Diabetes -- Alternative treatment , Medicinal plants , Traditional medicine , Liver -- Diseases
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10339 , http://hdl.handle.net/10948/d1016179
- Description: The incidence of Type 2 Diabetes Mellittus (T2DM) is increasing world wide. In Africa the limited access to health care and the insidious course of the disease lead to more severe illness and diabetic complications. There is a need to find alternative approaches to treatment and prevention that address the problems and needs of Africa. Sutherlandia frutescens (S.frutescens) is a traditional herbal plant with known anti-diabetic properties, the precise mechanism of action of S.frutescens is not known. In order to develop new approaches for treatment and prevention of T2DM the pathophysiology of T2DM must be understood. T2DM is the final outcome of a multi-organ disease characterized by early defects in muscle, adipocytes, hepatocytes and pancreatic β-cells. In this study the role of the liver was investigated because of its central role in glucose and lipid metabolism. It is hard to differentiate between all the influences in an in vivo model, so the aim of this study was to develop an in vitro model of T2DM in Chang liver cells and to determine if S.frutescens can reverse the state of insulin resistance in this model. Different culture media conditions were screened to identify a method that can be used as the T2DM model in Chang liver cells. Serum free medium (MCBD-201) supplemented with human diabetic serum, (2.5%-10%), high insulin concentrations (0.1μM-1μM), high fructose concentrations (1-10mM). and a combination of high insulin and high fructose was used for this screening. Chang liver cells cultured in MCBD-201 medium supplemented with 1mM fructose and 0.1μM insulin showed reduced glucose uptake and increased lipid accumulation. The effect of two S.frutescens extracts, two anti-diabetic drugs, metformin and ciglitazone, and a hypolipidemic drug ciprofibrate were determined and shown to increase glucose uptake and reduce lipid accumulation. It was postulated that exposing the cells to excess nutrients in the form of high fructose would stimulate the cells to become adipogenic and accumulate lipids, which would interfere with the glucose uptake and induce insulin resistance. Gene expression of PPARγ, PPARα, and SREBP-1 transcription factors regulating lipid metabolism was determined in Chang liver cells cultured in insulin resistance inducing medium over a 48 hour time course. The expression of PPARγ, known to stimulate adipogenesis was increased after 6, 24 and 48 hours of exposure (P(H1)<0.0001). The expression of PPARα, known to stimulate β-oxidation expression, was significantly decreased after 24 hours of exposure (P(H1)<0.0001). The presence of the plant extracts in the insulin resistance inducing media protect against this increase in adipogenesis and decrease in β-oxidation after 48 hours of exposure by increasing PPARα expression and decreasing PPARγ expression. A PCR Array was performed which identified 32 more potential molecular targets of S.frutescens. Five of the 32 targets identified with the PCR Array were validated using qRT-PCR. These genes play a role in lipid and glucose metabolism and protection against oxidative stress and inflammation. In summary a cellular model of insulin resistace in hepatocytes has been established and the capacity of S.frutescens to reverse this process has been demonstrated by acting as a dual PPARγ/α agonist. New genes have been identified in the development of insulin resistance and as targets of S.frutescens.
- Full Text:
- Date Issued: 2009