Antibiotic stewardship: the role of clinical pharmacist
- Authors: Ramkhalawon, Shabeerah
- Date: 2015
- Subjects: Hospital pharmacies -- South Africa Pharmacists -- South Africa
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10948/10858 , vital:26830
- Description: South Africa has a high prevalence of infectious diseases; the major ones being the Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome epidemic, and tuberculosis. South Africa’s burden of resistant bacteria is also increasing. Antibiotic resistance in hospitalised patients leads to an increase in morbidity and mortality, resulting in longer hospital stays, and an increase in hospital costs. In order to counteract the problem of antibiotic resistance in hospitals and other healthcare facilities and preserve the efficacy of currently available antibiotics, there is a need for serious antibiotic management. Antibiotic stewardship initiatives have thus been put in place to guide healthcare professionals on the correct use of antibiotics. Clinical pharmacists can intervene and contribute to antibiotic stewardship owing to comprehensive knowledge of antibiotics, including the properties, uses, safety and efficacy of individual agents. There is a paucity of research to support the role of the clinical pharmacist in antibiotic stewardship in public sector hospitals. The current pharmacist staffing system within public sector hospitals does not adequately support pharmacists, in particular clinical pharmacists, to participate actively in antibiotic stewardship. The primary aim of the study was to evaluate the role of the clinical pharmacist in antibiotic stewardship in a public hospital setting. A secondary aim was to contribute towards more rational inpatient use of antibiotics in the general medical ward. The hypothesis for the study was that clinical pharmacists can make a positive contribution to the correct use of antibiotics in a public hospital setting. The study showed that the introduction of a pharmacist-driven antibiotic stewardship in the ward, using a prospective audit and feedback strategy, had a positive effect on overall appropriateness of antibiotic prescribing (Chi2=7.89; df=3; p=0.04815, Cramer’s V=0.13). However, this finding did not show any reduction in the volume of antibiotic use. Positive patient outcomes were achieved and shown through a reduction in the length of hospital stay (p=0.00487; one-way ANOVA). Although patients were not followed up on discharge to assess re-admission rates, the results are relevant in order to inform the hospital staff about the implementation of antibiotic stewardship at the public hospital setting with the aims of reducing inappropriate antibiotic prescribing and improving patient outcomes. From the results of the study, it can be concluded that the hypothesis was achieved and that the clinical pharmacist did play an integral role in antibiotic prescribing at the public hospital setting. Thus, it can be concluded that the study, though limited in its scope, achieved its aims and objectives, and showed that the clinical pharmacist does play an integral role in the rational use of antibiotics in a public hospital setting.
- Full Text:
- Date Issued: 2015
- Authors: Ramkhalawon, Shabeerah
- Date: 2015
- Subjects: Hospital pharmacies -- South Africa Pharmacists -- South Africa
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10948/10858 , vital:26830
- Description: South Africa has a high prevalence of infectious diseases; the major ones being the Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome epidemic, and tuberculosis. South Africa’s burden of resistant bacteria is also increasing. Antibiotic resistance in hospitalised patients leads to an increase in morbidity and mortality, resulting in longer hospital stays, and an increase in hospital costs. In order to counteract the problem of antibiotic resistance in hospitals and other healthcare facilities and preserve the efficacy of currently available antibiotics, there is a need for serious antibiotic management. Antibiotic stewardship initiatives have thus been put in place to guide healthcare professionals on the correct use of antibiotics. Clinical pharmacists can intervene and contribute to antibiotic stewardship owing to comprehensive knowledge of antibiotics, including the properties, uses, safety and efficacy of individual agents. There is a paucity of research to support the role of the clinical pharmacist in antibiotic stewardship in public sector hospitals. The current pharmacist staffing system within public sector hospitals does not adequately support pharmacists, in particular clinical pharmacists, to participate actively in antibiotic stewardship. The primary aim of the study was to evaluate the role of the clinical pharmacist in antibiotic stewardship in a public hospital setting. A secondary aim was to contribute towards more rational inpatient use of antibiotics in the general medical ward. The hypothesis for the study was that clinical pharmacists can make a positive contribution to the correct use of antibiotics in a public hospital setting. The study showed that the introduction of a pharmacist-driven antibiotic stewardship in the ward, using a prospective audit and feedback strategy, had a positive effect on overall appropriateness of antibiotic prescribing (Chi2=7.89; df=3; p=0.04815, Cramer’s V=0.13). However, this finding did not show any reduction in the volume of antibiotic use. Positive patient outcomes were achieved and shown through a reduction in the length of hospital stay (p=0.00487; one-way ANOVA). Although patients were not followed up on discharge to assess re-admission rates, the results are relevant in order to inform the hospital staff about the implementation of antibiotic stewardship at the public hospital setting with the aims of reducing inappropriate antibiotic prescribing and improving patient outcomes. From the results of the study, it can be concluded that the hypothesis was achieved and that the clinical pharmacist did play an integral role in antibiotic prescribing at the public hospital setting. Thus, it can be concluded that the study, though limited in its scope, achieved its aims and objectives, and showed that the clinical pharmacist does play an integral role in the rational use of antibiotics in a public hospital setting.
- Full Text:
- Date Issued: 2015
Design, development and analysis of the friction stir welding process
- Authors: Blignault, Calvin
- Date: 2002
- Subjects: Friction welding
- Language: English
- Type: Thesis , Masters , MTech (Mechanical Engineering)
- Identifier: vital:10809 , http://hdl.handle.net/10948/1350 , Friction welding
- Description: The development of a CNC-based technology FSW machine to accurately produce friction stir weld samples that can be analyzed for research purposes is implemented and discussed. A process diagnosis and control scheme to improve the process monitoring and weld evaluation capabilities of an FSW machine are proposed and implemented. Basic CNC-based hardware implementation such as optical encoders and inverters for process control are explained and verified. The control scheme and framework of interfaces to the digital I/O cards for PC user interface are explained. An advanced monitoring system which senses process performance parameters such as tool temperature, 3-axis tool forces, torque and spindle speed are explained. Mechanical designs and manufacturing techniques such as tool, clamp and backing plate designs are explained and verified. The process parameters for quality optimization are investigated and optimized by making use of Correlation and Regression Analysis. The statistical data and analytical relationships between welding parameters (independent) and each of the performance parameters (dependent) are obtained and used to simulate the machining process. The weld research samples are tested for strength and integrity making use of various scientific testing techniques. The reliability of the samples are also evaluated and compared to that of other institutions. Process variables and the optimum operating range of the Friction Stir Welding machine is determined and a framework for further research into weld quality optimization is set.
- Full Text:
- Date Issued: 2002
- Authors: Blignault, Calvin
- Date: 2002
- Subjects: Friction welding
- Language: English
- Type: Thesis , Masters , MTech (Mechanical Engineering)
- Identifier: vital:10809 , http://hdl.handle.net/10948/1350 , Friction welding
- Description: The development of a CNC-based technology FSW machine to accurately produce friction stir weld samples that can be analyzed for research purposes is implemented and discussed. A process diagnosis and control scheme to improve the process monitoring and weld evaluation capabilities of an FSW machine are proposed and implemented. Basic CNC-based hardware implementation such as optical encoders and inverters for process control are explained and verified. The control scheme and framework of interfaces to the digital I/O cards for PC user interface are explained. An advanced monitoring system which senses process performance parameters such as tool temperature, 3-axis tool forces, torque and spindle speed are explained. Mechanical designs and manufacturing techniques such as tool, clamp and backing plate designs are explained and verified. The process parameters for quality optimization are investigated and optimized by making use of Correlation and Regression Analysis. The statistical data and analytical relationships between welding parameters (independent) and each of the performance parameters (dependent) are obtained and used to simulate the machining process. The weld research samples are tested for strength and integrity making use of various scientific testing techniques. The reliability of the samples are also evaluated and compared to that of other institutions. Process variables and the optimum operating range of the Friction Stir Welding machine is determined and a framework for further research into weld quality optimization is set.
- Full Text:
- Date Issued: 2002
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