Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives

Odame, Felix; Krause, Jason; Hosten, Eric C; Betz, Richard; Lobb, Kevin A; Tshentu, Zenixole R; Frost, Carminita L

Title: Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives
Creator: Odame, Felix
Creator: Krause, Jason
Creator: Hosten, Eric C
Creator: Betz, Richard
Creator: Lobb, Kevin A
Creator: Tshentu, Zenixole R
Creator: Frost, Carminita L
Subject: To be catalogued
Date Issued: 2018
Date: 2018
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/447209
Identifier: vital:74592
Identifier: xlink:href="https://dx.doi.org/10.4314/bcse.v32i2.8 "
Description: A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with 1 H NMR and IR. The crystal structures of two derivatives, 2-(2- chlorophenyl)-1H-benzimidazole and 2-(1H-benzimidazol-2-yl)-4-nitrophenol, are presented. A study of the DPPH scavenging activity of these compounds showed that 2-(1H-benzimidazol-2-yl)phenol (2), 2-p-tolyl-1Hbenzimidazole (3) and 2-(4-methoxyphenyl)-1H-benzimidazole (7) gave IC50 values 1974, 773 and 800 µM.
Format: computer
Format: online resource
Format: application/pdf
Format: 1 online resource (14 pages)
Format: pdf
Publisher: Bulletin of the Chemical Society of Ethiopia
Language: English
Relation: Bulletin of the Chemical Society of Ethiopia
Relation: Odame, F., Krause, J., Hosten, E.C., Betz, R., Lobb, K., Tshentu, Z.R. and Frost, C.L., 2018. Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives. Bulletin of the Chemical Society of Ethiopia, 32(2), pp.271-284
Relation: Bulletin of the Chemical Society of Ethiopia volume 32 number 2 p. 271 2018 1726-801X
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Bulletin of the Chemical Society of Ethiopia Open Access Terms and Conditions Statement (https://www.ajol.info/index.php/bcse/about)
Rights: Closed Access

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