A geoscientific framework for the proposed site of South Africa's second nuclear power plant: Thyspunt, Eastern Cape
- Authors: Claassen, Debbie
- Date: 2015
- Subjects: Geology, Structural -- South Africa -- Eastern Cape , Geology, Stratigraphic , Geochemistry , Rock mechanics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10678 , http://hdl.handle.net/10948/d1021182
- Description: This study describes the bedrock lithologies and structure of the Ordovician to early Devonian (485-419 Ma) Table Mountain Group (TMG), the Devonian (419-358 Ma) lower Bokkeveld Group, and the Miocene to Holocene (<23 Ma) overburden sediments of the Algoa Group within an area identified by Eskom for the potential construction of South Africa’s second proposed nuclear power plant (NPP), ‘Nuclear-1’. The study area is located along the southern coastal margin of the Eastern Cape Province, South Africa, between Oyster Bay and St. Francis (approximately 88 km west of Port Elizabeth), and encompasses the Thyspunt site where the proposed NPP will be built. The study aims to supplement existing information about the Thyspunt area, related to the geoscientific topic ‘Geological Setting’, as outlined in section 2.5.1.1 of the US Nuclear Regulatory Commission (USNRC) Standard Review Plan NUREG-800, which details the geological information required for review of a proposed NPP. The results obtained from geoscientific studies are used to determine geological factors that may potentially affect site specific design. Factors considered include: bedrock lithology, stratigraphic bedrock contacts, bedrock palaeotopography, thickness of overburden sediments and structural geology. Work by previous authors is combined with new data to create a GIS based 2½D model of the study area’s geology (geomodel) and on which future research or interpretations can be based. Field mapping and petrographic analyses of the TMG, comprising the Peninsula, Cedarberg, Goudini, Skurweberg and Baviaanskloof Formations as well as the lower undifferentiated Bokkeveld Group were undertaken to define the study area’s lithologies and structure. Interpretation of geophysical results and the integration of existing borehole data aided in defining the variability in overburden sediments, the identification of contacts between TMG formations beneath overburden, and the palaeotopography of bedrock. Borehole data indicates a clear N-S trend in the thickness distribution of Algoa Group aeolian and marine related sediments. Four coast-parallel trending thickness zones (zones A – D) are recognized within the study area. At Thyspunt overburden thickness reaches a maximum of 61 m, approximately 1200 m from the coastline, in areas underlain by the argillaceous Goudini and Cedarberg Formations. Overburden thickness is influenced by a combination of dune relief, bedrock lithology, palaeotopography and the area’s sediment supply. Interpolation of bedrock elevation points and detailed cross sections across bedrock reveals four NW-SE trending palaeovalleys at Thyspunt, Tony’s Bay, Cape St. Francis and St. Francis, where bedrock relief (beneath overburden) is formed to be below present day sea-level. Approximately 450 m NW of Thys Bay, a 1050 m2 (area below sea-level) palaeovalley, gently sloping SE to a depth of -15.5 m asl, is cut into strata of the Goudini Formation resulting in thicker overburden fill in that area. Structural analysis of the TMG confirms that NE-SW striking strata form part of the regional SE plunging, north verging Cape St. Francis anticline. Bedding inclination is controlled by the distance away from the fold axis, varying from a 5° SE dip along the broad fold hinge to 65° along its moderately steeper SE limb. Folds within the study area plunge gently southeastward at shallow angles, with axial planes dipping steeply SW or NE. Fold axes orientated perpendicular to the fold axis of the Cape St. Francis anticline indicate a secondary stress orientation oblique to the main palaeostress direction. The previously identified 40 km long, NW-SE trending Cape St. Francis fault occurring offshore within 17.5 km of Thyspunt show no onshore continuation within the bounds of the study area. Late jointing is pervasive within the study area and four joint systems are identified. The dominant joint set J1, trends N-S to NNE - SSW; perpendicular to bedding and has a subvertical dip. Normal right-lateral and left-lateral micro-faults dip subvertically, with a displacement that ranges from a few centimetres to <3 m. Micro-faults trend parallel to joints sets J1 and J4 (ESE-WSW). Inferred faults, identified by the Atomic Energy Co-operation (AEC), are interpreted as zones of closely spaced jointing (shatter zones), and show little to no recognizable displacement. Faults and joints do not extend into the younger cover deposits of the Algoa Group and are therefore older than 23 Ma years.
- Full Text:
- Date Issued: 2015
- Authors: Claassen, Debbie
- Date: 2015
- Subjects: Geology, Structural -- South Africa -- Eastern Cape , Geology, Stratigraphic , Geochemistry , Rock mechanics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10678 , http://hdl.handle.net/10948/d1021182
- Description: This study describes the bedrock lithologies and structure of the Ordovician to early Devonian (485-419 Ma) Table Mountain Group (TMG), the Devonian (419-358 Ma) lower Bokkeveld Group, and the Miocene to Holocene (<23 Ma) overburden sediments of the Algoa Group within an area identified by Eskom for the potential construction of South Africa’s second proposed nuclear power plant (NPP), ‘Nuclear-1’. The study area is located along the southern coastal margin of the Eastern Cape Province, South Africa, between Oyster Bay and St. Francis (approximately 88 km west of Port Elizabeth), and encompasses the Thyspunt site where the proposed NPP will be built. The study aims to supplement existing information about the Thyspunt area, related to the geoscientific topic ‘Geological Setting’, as outlined in section 2.5.1.1 of the US Nuclear Regulatory Commission (USNRC) Standard Review Plan NUREG-800, which details the geological information required for review of a proposed NPP. The results obtained from geoscientific studies are used to determine geological factors that may potentially affect site specific design. Factors considered include: bedrock lithology, stratigraphic bedrock contacts, bedrock palaeotopography, thickness of overburden sediments and structural geology. Work by previous authors is combined with new data to create a GIS based 2½D model of the study area’s geology (geomodel) and on which future research or interpretations can be based. Field mapping and petrographic analyses of the TMG, comprising the Peninsula, Cedarberg, Goudini, Skurweberg and Baviaanskloof Formations as well as the lower undifferentiated Bokkeveld Group were undertaken to define the study area’s lithologies and structure. Interpretation of geophysical results and the integration of existing borehole data aided in defining the variability in overburden sediments, the identification of contacts between TMG formations beneath overburden, and the palaeotopography of bedrock. Borehole data indicates a clear N-S trend in the thickness distribution of Algoa Group aeolian and marine related sediments. Four coast-parallel trending thickness zones (zones A – D) are recognized within the study area. At Thyspunt overburden thickness reaches a maximum of 61 m, approximately 1200 m from the coastline, in areas underlain by the argillaceous Goudini and Cedarberg Formations. Overburden thickness is influenced by a combination of dune relief, bedrock lithology, palaeotopography and the area’s sediment supply. Interpolation of bedrock elevation points and detailed cross sections across bedrock reveals four NW-SE trending palaeovalleys at Thyspunt, Tony’s Bay, Cape St. Francis and St. Francis, where bedrock relief (beneath overburden) is formed to be below present day sea-level. Approximately 450 m NW of Thys Bay, a 1050 m2 (area below sea-level) palaeovalley, gently sloping SE to a depth of -15.5 m asl, is cut into strata of the Goudini Formation resulting in thicker overburden fill in that area. Structural analysis of the TMG confirms that NE-SW striking strata form part of the regional SE plunging, north verging Cape St. Francis anticline. Bedding inclination is controlled by the distance away from the fold axis, varying from a 5° SE dip along the broad fold hinge to 65° along its moderately steeper SE limb. Folds within the study area plunge gently southeastward at shallow angles, with axial planes dipping steeply SW or NE. Fold axes orientated perpendicular to the fold axis of the Cape St. Francis anticline indicate a secondary stress orientation oblique to the main palaeostress direction. The previously identified 40 km long, NW-SE trending Cape St. Francis fault occurring offshore within 17.5 km of Thyspunt show no onshore continuation within the bounds of the study area. Late jointing is pervasive within the study area and four joint systems are identified. The dominant joint set J1, trends N-S to NNE - SSW; perpendicular to bedding and has a subvertical dip. Normal right-lateral and left-lateral micro-faults dip subvertically, with a displacement that ranges from a few centimetres to <3 m. Micro-faults trend parallel to joints sets J1 and J4 (ESE-WSW). Inferred faults, identified by the Atomic Energy Co-operation (AEC), are interpreted as zones of closely spaced jointing (shatter zones), and show little to no recognizable displacement. Faults and joints do not extend into the younger cover deposits of the Algoa Group and are therefore older than 23 Ma years.
- Full Text:
- Date Issued: 2015
A natural user interface architecture using gestures to facilitate the detection of fundamental movement skills
- Authors: Amanzi, Richard
- Date: 2015
- Subjects: Human activity recognition , Human-computer interaction
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/6204 , vital:21055
- Description: Fundamental movement skills (FMSs) are considered to be one of the essential phases of motor skill development. The proper development of FMSs allows children to participate in more advanced forms of movements and sports. To be able to perform an FMS correctly, children need to learn the right way of performing it. By making use of technology, a system can be developed that can help facilitate the learning of FMSs. The objective of the research was to propose an effective natural user interface (NUI) architecture for detecting FMSs using the Kinect. In order to achieve the stated objective, an investigation into FMSs and the challenges faced when teaching them was presented. An investigation into NUIs was also presented including the merits of the Kinect as the most appropriate device to be used to facilitate the detection of an FMS. An NUI architecture was proposed that uses the Kinect to facilitate the detection of an FMS. A framework was implemented from the design of the architecture. The successful implementation of the framework provides evidence that the design of the proposed architecture is feasible. An instance of the framework incorporating the jump FMS was used as a case study in the development of a prototype that detects the correct and incorrect performance of a jump. The evaluation of the prototype proved the following: - The developed prototype was effective in detecting the correct and incorrect performance of the jump FMS; and - The implemented framework was robust for the incorporation of an FMS. The successful implementation of the prototype shows that an effective NUI architecture using the Kinect can be used to facilitate the detection of FMSs. The proposed architecture provides a structured way of developing a system using the Kinect to facilitate the detection of FMSs. This allows developers to add future FMSs to the system. This dissertation therefore makes the following contributions: - An experimental design to evaluate the effectiveness of a prototype that detects FMSs - A robust framework that incorporates FMSs; and - An effective NUI architecture to facilitate the detection of fundamental movement skills using the Kinect.
- Full Text:
- Date Issued: 2015
- Authors: Amanzi, Richard
- Date: 2015
- Subjects: Human activity recognition , Human-computer interaction
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/6204 , vital:21055
- Description: Fundamental movement skills (FMSs) are considered to be one of the essential phases of motor skill development. The proper development of FMSs allows children to participate in more advanced forms of movements and sports. To be able to perform an FMS correctly, children need to learn the right way of performing it. By making use of technology, a system can be developed that can help facilitate the learning of FMSs. The objective of the research was to propose an effective natural user interface (NUI) architecture for detecting FMSs using the Kinect. In order to achieve the stated objective, an investigation into FMSs and the challenges faced when teaching them was presented. An investigation into NUIs was also presented including the merits of the Kinect as the most appropriate device to be used to facilitate the detection of an FMS. An NUI architecture was proposed that uses the Kinect to facilitate the detection of an FMS. A framework was implemented from the design of the architecture. The successful implementation of the framework provides evidence that the design of the proposed architecture is feasible. An instance of the framework incorporating the jump FMS was used as a case study in the development of a prototype that detects the correct and incorrect performance of a jump. The evaluation of the prototype proved the following: - The developed prototype was effective in detecting the correct and incorrect performance of the jump FMS; and - The implemented framework was robust for the incorporation of an FMS. The successful implementation of the prototype shows that an effective NUI architecture using the Kinect can be used to facilitate the detection of FMSs. The proposed architecture provides a structured way of developing a system using the Kinect to facilitate the detection of FMSs. This allows developers to add future FMSs to the system. This dissertation therefore makes the following contributions: - An experimental design to evaluate the effectiveness of a prototype that detects FMSs - A robust framework that incorporates FMSs; and - An effective NUI architecture to facilitate the detection of fundamental movement skills using the Kinect.
- Full Text:
- Date Issued: 2015
A sustainable water quality framework for South Africa towards 2050
- Authors: Osmond, Christopher John
- Date: 2015
- Subjects: Construction industry -- South Africa , Sustainable development -- South Africa , Water resources development -- South Africa , Water quality management -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3255 , vital:20417
- Description: There are a wide range of issues that stem from inadequate access to, and the unsustainable management of water resources, which can lead to ecological and human crises (Gleik, 1998: 571). With the increasing demand for clean water for drinking and sanitation, coupled with population growth, aging infrastructure, and climate change, many countries face a complex set of threats when dealing with their water resources and the management thereof (Environmental Protection Agency, 2012: 4). South Africa‟s challenges are no different, if current trends in water management continue and government does not intervene with what has been an unequal society even in terms of the division of water, it will continue to lose ground in its development and sustaining of water resources (Ukwandu, 2009: 24 - 30). “The objective of managing the quantity, quality and reliability of the nation‟s water resources is to achieve optimum, long-term, environmentally sustainable social and economic benefit for society from their use.” (Principle 7 of the National Water Policy, Department of Water Affairs and Forestry, 1997: 20). The primary objective of this research is to develop a framework for water management and sustainable development by utilising a Causal Layered Analysis (CLA) to develop strategies for innovation in South Africa towards 2050. New rules and regulations have been adopted by local municipal divisions in South Africa to promote sustainable, environmentally friendly buildings and methods. It is therefore the aim of the research to establish ways in which water can be harvested and saved in a simple and innovative yet sustainable manner. The complexity of erecting structures has also increased with some sustainable measures in water management taking place, however the water issues in South Africa continue to grow and cause concern. Government therefore plays a pivotal role in ensuring that water is managed sustainably at not only harvesting and infrastructure level but also re-cycling level, where simple innovative strategies can be adopted. This paper further seeks to highlight the positive and negative impacts of implementing water management methods and strategies that can be adopted.
- Full Text:
- Date Issued: 2015
- Authors: Osmond, Christopher John
- Date: 2015
- Subjects: Construction industry -- South Africa , Sustainable development -- South Africa , Water resources development -- South Africa , Water quality management -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3255 , vital:20417
- Description: There are a wide range of issues that stem from inadequate access to, and the unsustainable management of water resources, which can lead to ecological and human crises (Gleik, 1998: 571). With the increasing demand for clean water for drinking and sanitation, coupled with population growth, aging infrastructure, and climate change, many countries face a complex set of threats when dealing with their water resources and the management thereof (Environmental Protection Agency, 2012: 4). South Africa‟s challenges are no different, if current trends in water management continue and government does not intervene with what has been an unequal society even in terms of the division of water, it will continue to lose ground in its development and sustaining of water resources (Ukwandu, 2009: 24 - 30). “The objective of managing the quantity, quality and reliability of the nation‟s water resources is to achieve optimum, long-term, environmentally sustainable social and economic benefit for society from their use.” (Principle 7 of the National Water Policy, Department of Water Affairs and Forestry, 1997: 20). The primary objective of this research is to develop a framework for water management and sustainable development by utilising a Causal Layered Analysis (CLA) to develop strategies for innovation in South Africa towards 2050. New rules and regulations have been adopted by local municipal divisions in South Africa to promote sustainable, environmentally friendly buildings and methods. It is therefore the aim of the research to establish ways in which water can be harvested and saved in a simple and innovative yet sustainable manner. The complexity of erecting structures has also increased with some sustainable measures in water management taking place, however the water issues in South Africa continue to grow and cause concern. Government therefore plays a pivotal role in ensuring that water is managed sustainably at not only harvesting and infrastructure level but also re-cycling level, where simple innovative strategies can be adopted. This paper further seeks to highlight the positive and negative impacts of implementing water management methods and strategies that can be adopted.
- Full Text:
- Date Issued: 2015
An analysis of soil properties associated with badland and gully erosion in rural catchments of the Ngqushwa District, Eastern Cape Province
- Authors: De Jager, Megan Joan
- Date: 2015
- Subjects: Soil mechanics -- South Africa -- Eastern Cape , Soils -- South Africa -- Eastern Cape -- Testing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3519 , vital:20438
- Description: Accelerated soil erosion holds strong links to excessive land degradation, socioeconomic problems and accelerated climate change, particularly in developing countries such as South Africa. An analysis of the properties of severely eroded soils is undertaken to determine which characteristic properties influence the erodibility of the soils at several gully and badland sites in three catchments of the Ngqushwa rural municipality, which is tagged as one of the area’s most severely affected by soil erosion and degradation in the Eastern Cape. Physical, biological and chemical properties of the soils were analysed, including aggregate stability, soil texture, organic matter- and carbon content, clay mineralogy, sesquioxide content as Fe2O3 and cation composition. The distribution of a number of these properties was also determined, particularly between erosion sites, along hillslope profiles and with depth. The study area comprises three catchments, namely Mgwalana, Bira and Gqora which share common soil parent materials, land use history, exhibit similar topography and advanced degree of erosion. A total of 63 soil samples were strategically collected from identified erosion zones and site controls devoid of active erosion; where stability was evident by means of vegetation cover and soil surface condition. Surface samples were collected above 30cm depth and subsurface samples at depths greater than 30cm. To determine the fate of carbon additional samples were collected from runon and sink zones at the Mgwalana catchment along a transect from top to bottom slope. Laboratory analyses was performed to determine the soil properties, whereby C content was measured by the dry combustion method, Fe2O3- and cation content by Atomic Absorption (AA) Spectrometer, texture by the separation method described by Schlichting, Blume & Stahr (1995), clay mineralogy by X-Ray Diffraction and organic matter content by conversion of total C. In addition to these properties being used to infer aggregate stability, the wet sieving method was also used for this purpose and for validation of the other soil properties. The results revealed that no one soil property has a greater influence on aggregate stability than the others, but rather that the stability of the soil is dependent on the combinations of these properties in the soil and the interactions that occur between them. Based on this, the results indicated greater stability for runon, sink and control samples, mainly in the topsoil, which were characterised by a relatively higher C- and organic matter content, loam texture and higher concentrations of Ca2+. Furthermore, the less stable eroded samples were characterised by a more clay rich texture particularly in the subsoil, relatively lower C- and organic matter contents and a greater sodicity due to higher concentrations of Na+. The least stable soils belonged to the Gqora catchment, which were found to consist of higher silt content in the topsoil and a higher Fe2O3 content in the subsoil. The clay mineralogy was relatively uniform across all catchments, comprising of primarily illite and secondly kaolinite. The sample with the highest sodicity in terms of ESP contained smectite clay in addition to illite and kaolinite which is assumed to contribute to this increased Na+ concentration. These findings aid in the conclusion that the chemical characteristics of the soils, in association with biological and, to a less extent, physical properties of the soil exacerbate the erosion problem initiated by the extrinsic contributors, such as climate and topography. Investigation into the fate of carbon on eroded lands revealed a topographically driven dynamic whereby the total carbon content was found to be greater at the top and middle slope positions as well as in the sink zone. These hillslope sections were found to have a lower slope gradient and slightly more pronounced concave shape to those sections with lower C values. These topographic variables influence the degree of gully erosion taking place at different hillslope sections, which tends to be greater where slope angle is increased and convexity exists, resulting in the removal of soil C at these positions and its deposition in areas of accumulation, namely the runon and sink zones of low angle concave slope sections. The findings of this research may be used to develop restoration and management strategies with the ultimate goal to reduce the soils vulnerability to erosion by enhancing those soil properties conducive to greater aggregate stability as determined in the present study.
- Full Text:
- Date Issued: 2015
- Authors: De Jager, Megan Joan
- Date: 2015
- Subjects: Soil mechanics -- South Africa -- Eastern Cape , Soils -- South Africa -- Eastern Cape -- Testing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3519 , vital:20438
- Description: Accelerated soil erosion holds strong links to excessive land degradation, socioeconomic problems and accelerated climate change, particularly in developing countries such as South Africa. An analysis of the properties of severely eroded soils is undertaken to determine which characteristic properties influence the erodibility of the soils at several gully and badland sites in three catchments of the Ngqushwa rural municipality, which is tagged as one of the area’s most severely affected by soil erosion and degradation in the Eastern Cape. Physical, biological and chemical properties of the soils were analysed, including aggregate stability, soil texture, organic matter- and carbon content, clay mineralogy, sesquioxide content as Fe2O3 and cation composition. The distribution of a number of these properties was also determined, particularly between erosion sites, along hillslope profiles and with depth. The study area comprises three catchments, namely Mgwalana, Bira and Gqora which share common soil parent materials, land use history, exhibit similar topography and advanced degree of erosion. A total of 63 soil samples were strategically collected from identified erosion zones and site controls devoid of active erosion; where stability was evident by means of vegetation cover and soil surface condition. Surface samples were collected above 30cm depth and subsurface samples at depths greater than 30cm. To determine the fate of carbon additional samples were collected from runon and sink zones at the Mgwalana catchment along a transect from top to bottom slope. Laboratory analyses was performed to determine the soil properties, whereby C content was measured by the dry combustion method, Fe2O3- and cation content by Atomic Absorption (AA) Spectrometer, texture by the separation method described by Schlichting, Blume & Stahr (1995), clay mineralogy by X-Ray Diffraction and organic matter content by conversion of total C. In addition to these properties being used to infer aggregate stability, the wet sieving method was also used for this purpose and for validation of the other soil properties. The results revealed that no one soil property has a greater influence on aggregate stability than the others, but rather that the stability of the soil is dependent on the combinations of these properties in the soil and the interactions that occur between them. Based on this, the results indicated greater stability for runon, sink and control samples, mainly in the topsoil, which were characterised by a relatively higher C- and organic matter content, loam texture and higher concentrations of Ca2+. Furthermore, the less stable eroded samples were characterised by a more clay rich texture particularly in the subsoil, relatively lower C- and organic matter contents and a greater sodicity due to higher concentrations of Na+. The least stable soils belonged to the Gqora catchment, which were found to consist of higher silt content in the topsoil and a higher Fe2O3 content in the subsoil. The clay mineralogy was relatively uniform across all catchments, comprising of primarily illite and secondly kaolinite. The sample with the highest sodicity in terms of ESP contained smectite clay in addition to illite and kaolinite which is assumed to contribute to this increased Na+ concentration. These findings aid in the conclusion that the chemical characteristics of the soils, in association with biological and, to a less extent, physical properties of the soil exacerbate the erosion problem initiated by the extrinsic contributors, such as climate and topography. Investigation into the fate of carbon on eroded lands revealed a topographically driven dynamic whereby the total carbon content was found to be greater at the top and middle slope positions as well as in the sink zone. These hillslope sections were found to have a lower slope gradient and slightly more pronounced concave shape to those sections with lower C values. These topographic variables influence the degree of gully erosion taking place at different hillslope sections, which tends to be greater where slope angle is increased and convexity exists, resulting in the removal of soil C at these positions and its deposition in areas of accumulation, namely the runon and sink zones of low angle concave slope sections. The findings of this research may be used to develop restoration and management strategies with the ultimate goal to reduce the soils vulnerability to erosion by enhancing those soil properties conducive to greater aggregate stability as determined in the present study.
- Full Text:
- Date Issued: 2015
An assessment of the in vitro neuroprotective potential of selected Algerian and South African medicinal plant extracts
- Authors: Fewell, William
- Date: 2015
- Subjects: Medicinal plants -- South Africa , Nervous system -- Alternative treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/8608 , vital:26411
- Description: It is estimated by the World Health Organization (WHO) that by 2040 neurodegenerative disorders will collectively surpass cancer as the primary cause of death in industrialised countries (WHO,2006). Natural flora represents one of the most important therapeutic sources in modern drug discovery, however only a limited number of plant species have been screened for their neuroprotective value. The neuroprotective potential of eleven Algerian and two South African medicinal plant extracts were assessed in this study, aiming to identify promising candidates for future research. Neurodegenerative disorders such as Parkinson’s disease are characterised by distinct biochemical features, including protein misfolding/-aggregation, excessive oxidative stress and apoptotic cell death. As such, medicinal plant extracts were screened for biological properties directly relevant to neurodegeneration. The capacity to induce autophagy was also investigated as mounting evidence suggests that activation of this pathway may reduce abnormal protein aggregation and promote neuronal survival.
- Full Text: false
- Date Issued: 2015
- Authors: Fewell, William
- Date: 2015
- Subjects: Medicinal plants -- South Africa , Nervous system -- Alternative treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/8608 , vital:26411
- Description: It is estimated by the World Health Organization (WHO) that by 2040 neurodegenerative disorders will collectively surpass cancer as the primary cause of death in industrialised countries (WHO,2006). Natural flora represents one of the most important therapeutic sources in modern drug discovery, however only a limited number of plant species have been screened for their neuroprotective value. The neuroprotective potential of eleven Algerian and two South African medicinal plant extracts were assessed in this study, aiming to identify promising candidates for future research. Neurodegenerative disorders such as Parkinson’s disease are characterised by distinct biochemical features, including protein misfolding/-aggregation, excessive oxidative stress and apoptotic cell death. As such, medicinal plant extracts were screened for biological properties directly relevant to neurodegeneration. The capacity to induce autophagy was also investigated as mounting evidence suggests that activation of this pathway may reduce abnormal protein aggregation and promote neuronal survival.
- Full Text: false
- Date Issued: 2015
An assessment of vegetation condition of small, ephemeral wetlands ecosystem in a conserved and non-conserved area of the Nelson Mandela Bay Metropole
- Authors: Dlamini, Mandla E
- Date: 2015
- Subjects: Wetland conservation -- South Africa -- Nelson Mandela Bay Municipality , Wetland ecology -- South Africa -- Nelson Mandela Bay Municipality , Remote sensing -- South Africa -- Nelson Mandela Bay Municipality
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4653 , vital:20626
- Description: Wetlands in South Africa are increasingly coming under threat from agriculture and urban development and rapidly disappearing, especially small, ephemeral wetlands. In response to the many threats to wetlands, South Africa has seen an increased interest in wetland research, which has introduced many methods to help standardize the approach to research, management and conservation of wetlands. Remote sensing can be a powerful tool to monitor changes in wetland vegetation and degradation leading to losses in wetlands. However, research into wetland ecosystems has focused on large systems (> 8 ha). Small wetlands (< 2 ha), by contrast, are often overlooked and unprotected due to the lack of detailed inventories at a scale that is appropriate for their inclusion. The main aim of this study was to determine if remote sensing (RS) and Geographical Information System (GIS) techniques could detect changes in small, ephemeral wetlands within areas under different management regimes in the Nelson Mandela Bay Metropole (NMBM) at different time intervals. Further, to explore the potential of hyperspectral remote sensing for the discrimination between plant species and to see if differences could be detected in the same species within two areas different management regimes. Four SPOT satellite images taken within a 6-year period (2006-2012) were analysed to detect land cover land changes. Supervised classification to classify land cover classes and post-classification change detection was used. Proportions of dense vegetation were higher in the conservation area and bare surface was higher outside that conservation area in the metropolitan open space area. Statistical tests were performed to compare the spectral responses of the four individual wetland sites using Normalized Difference Vegetation Index (NDVI) and red edge position (REP) .REP results for conserved sites showed significant differences (P < 0.05), as opposed to non-conserved ones. By implication, wetland vegetation that is in less degraded condition can be spectrally discriminated, than the one that is most degraded. Field spectroscopy and multi-temporal imagery can be useful in studying small wetlands.
- Full Text:
- Date Issued: 2015
- Authors: Dlamini, Mandla E
- Date: 2015
- Subjects: Wetland conservation -- South Africa -- Nelson Mandela Bay Municipality , Wetland ecology -- South Africa -- Nelson Mandela Bay Municipality , Remote sensing -- South Africa -- Nelson Mandela Bay Municipality
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4653 , vital:20626
- Description: Wetlands in South Africa are increasingly coming under threat from agriculture and urban development and rapidly disappearing, especially small, ephemeral wetlands. In response to the many threats to wetlands, South Africa has seen an increased interest in wetland research, which has introduced many methods to help standardize the approach to research, management and conservation of wetlands. Remote sensing can be a powerful tool to monitor changes in wetland vegetation and degradation leading to losses in wetlands. However, research into wetland ecosystems has focused on large systems (> 8 ha). Small wetlands (< 2 ha), by contrast, are often overlooked and unprotected due to the lack of detailed inventories at a scale that is appropriate for their inclusion. The main aim of this study was to determine if remote sensing (RS) and Geographical Information System (GIS) techniques could detect changes in small, ephemeral wetlands within areas under different management regimes in the Nelson Mandela Bay Metropole (NMBM) at different time intervals. Further, to explore the potential of hyperspectral remote sensing for the discrimination between plant species and to see if differences could be detected in the same species within two areas different management regimes. Four SPOT satellite images taken within a 6-year period (2006-2012) were analysed to detect land cover land changes. Supervised classification to classify land cover classes and post-classification change detection was used. Proportions of dense vegetation were higher in the conservation area and bare surface was higher outside that conservation area in the metropolitan open space area. Statistical tests were performed to compare the spectral responses of the four individual wetland sites using Normalized Difference Vegetation Index (NDVI) and red edge position (REP) .REP results for conserved sites showed significant differences (P < 0.05), as opposed to non-conserved ones. By implication, wetland vegetation that is in less degraded condition can be spectrally discriminated, than the one that is most degraded. Field spectroscopy and multi-temporal imagery can be useful in studying small wetlands.
- Full Text:
- Date Issued: 2015
An entrepreneurial framework for new venture property development projects
- Authors: Abrey, Mark Henry Shaw
- Date: 2015
- Subjects: Real estate development -- South Africa , Entrepreneurship -- South Africa , Land subdivision -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:9709 , http://hdl.handle.net/10948/d1020162
- Description: The business of real estate is one of the largest suppliers of employment, and contributes significantly to the gross domestic product of numerous countries worldwide. It is, therefore, imperative that new real estate development entrepreneurs entering the market identify key competitiveness indicators in order to survive and ensure their success within an ever-changing market. However, property development is a complex process and considered to be 'too risky' Consequently, property development entrepreneurs lack the skills and expertise to effectively manage their business enterprises and the associated risks from project inception to completion, and commissioning. The study was conducted by means of a review of the related literature and by conducting an empirical study. The empirical study was conducted using a quantitative statistical approach by distributing research questionnaires to members falling within the sample population. The primary objective of the study was to develop an entrepreneurial framework for perceived success of new venture property development projects. A descriptive survey was conducted among professionals registered with the South African Property Owners Association (SAPOA) and property development practitioners within South Africa. The salient findings suggest that the following variables positively influence the perceived success of new venture property development projects: Entrepreneurial vision; Strategic management; Stakeholders‘ interests; Professional feasibility and viability reporting; Procurement; Communication; Consumer confidence; Risk management; Governance structures; Specialist advice; The entrepreneurial framework, and The project management body of knowledge (PMBOK). Furthermore, the following variables were identified in the empirical framework affecting the perceived success of new venture property development projects: Entrepreneurial Vision; Strategic Management; Stakeholders‘ Interest; Professional Feasibility and Viability Reporting; Procurement; Communication; Consumer Confidence; Risk Management; Governance Structures; Specialist Advice, and The Project Management Body of Knowledge (PMBOK). This study contributed to the South African property development body of knowledge by addressing the challenges faced by inexperienced entrepreneurs entering the property development market. Furthermore, this study aimed to improve the framework utilised by emerging property developers.
- Full Text:
- Date Issued: 2015
- Authors: Abrey, Mark Henry Shaw
- Date: 2015
- Subjects: Real estate development -- South Africa , Entrepreneurship -- South Africa , Land subdivision -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:9709 , http://hdl.handle.net/10948/d1020162
- Description: The business of real estate is one of the largest suppliers of employment, and contributes significantly to the gross domestic product of numerous countries worldwide. It is, therefore, imperative that new real estate development entrepreneurs entering the market identify key competitiveness indicators in order to survive and ensure their success within an ever-changing market. However, property development is a complex process and considered to be 'too risky' Consequently, property development entrepreneurs lack the skills and expertise to effectively manage their business enterprises and the associated risks from project inception to completion, and commissioning. The study was conducted by means of a review of the related literature and by conducting an empirical study. The empirical study was conducted using a quantitative statistical approach by distributing research questionnaires to members falling within the sample population. The primary objective of the study was to develop an entrepreneurial framework for perceived success of new venture property development projects. A descriptive survey was conducted among professionals registered with the South African Property Owners Association (SAPOA) and property development practitioners within South Africa. The salient findings suggest that the following variables positively influence the perceived success of new venture property development projects: Entrepreneurial vision; Strategic management; Stakeholders‘ interests; Professional feasibility and viability reporting; Procurement; Communication; Consumer confidence; Risk management; Governance structures; Specialist advice; The entrepreneurial framework, and The project management body of knowledge (PMBOK). Furthermore, the following variables were identified in the empirical framework affecting the perceived success of new venture property development projects: Entrepreneurial Vision; Strategic Management; Stakeholders‘ Interest; Professional Feasibility and Viability Reporting; Procurement; Communication; Consumer Confidence; Risk Management; Governance Structures; Specialist Advice, and The Project Management Body of Knowledge (PMBOK). This study contributed to the South African property development body of knowledge by addressing the challenges faced by inexperienced entrepreneurs entering the property development market. Furthermore, this study aimed to improve the framework utilised by emerging property developers.
- Full Text:
- Date Issued: 2015
An exposition of Hilbert C-modules
- Authors: Sokopo, Bulelani Joab
- Date: 2015
- Subjects: Mathematics Algebra , Functions, Continuous Mathematical analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/50008 , vital:41974
- Description: In trying to prove that derivations of type I AW -algebras are inner, I. Kaplansky introduced and developed the basics of the concept of Hilbert C- modules. He sought to generalize the idea of a Hilbert space by replacing the field C of all complex numbers with a general (commutative and unital) C-algebra. Twenty years later, the concept was broadened and expanded to non-commutative C-algebras by W. L. Paschke and M. A. Rieffel in their papers on inner product modules over B-algebras and induced representations of C-algebras, respectively. Since then, the theory of Hilbert C-modules has grown rapidly. It was used by G. G. Kasparov as the framework for his bivariant K-theory. More recently, Hilbert C-modules have formed the technical basis for the C*-algebraic approach to quantum group theory. The aim of this dissertation is to provide as detailed an account as possible of the theory of Hilbert C-modules, as given in a book of E. C. Lance, up to and including the KSGNS construction. The KSGNS construction, named after Kasparov, Stinespring, Gelfand, Naimark and Segal, is a generalization to Hilbert C-modules of the familiar GNS construction for C-algebras. The result by Kaplansky that all derivations of a type I AW-algebra are inner is given as an application in the final chapter of the dissertation.
- Full Text:
- Date Issued: 2015
- Authors: Sokopo, Bulelani Joab
- Date: 2015
- Subjects: Mathematics Algebra , Functions, Continuous Mathematical analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/50008 , vital:41974
- Description: In trying to prove that derivations of type I AW -algebras are inner, I. Kaplansky introduced and developed the basics of the concept of Hilbert C- modules. He sought to generalize the idea of a Hilbert space by replacing the field C of all complex numbers with a general (commutative and unital) C-algebra. Twenty years later, the concept was broadened and expanded to non-commutative C-algebras by W. L. Paschke and M. A. Rieffel in their papers on inner product modules over B-algebras and induced representations of C-algebras, respectively. Since then, the theory of Hilbert C-modules has grown rapidly. It was used by G. G. Kasparov as the framework for his bivariant K-theory. More recently, Hilbert C-modules have formed the technical basis for the C*-algebraic approach to quantum group theory. The aim of this dissertation is to provide as detailed an account as possible of the theory of Hilbert C-modules, as given in a book of E. C. Lance, up to and including the KSGNS construction. The KSGNS construction, named after Kasparov, Stinespring, Gelfand, Naimark and Segal, is a generalization to Hilbert C-modules of the familiar GNS construction for C-algebras. The result by Kaplansky that all derivations of a type I AW-algebra are inner is given as an application in the final chapter of the dissertation.
- Full Text:
- Date Issued: 2015
Approaches in the prioritisation of areas for biodiversity conservation: a case study from the Western Cape pf South Africa
- Authors: Southey, Phillippa Kate
- Date: 2015
- Subjects: Biodiversity conservation -- South Africa -- Western Cape , Conservation of natural resources -- South Africa -- Western Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4122 , vital:20548
- Description: Historical ad hoc allocations of land for biodiversity conservation have led to a biased representation of habitat within the Cape Floristic Region, with Protected Areas concentrated in upland areas at high altitudes and on steep slopes. The field of Conservation Planning developed to ensure that allocations of areas to Protected status no longer result in such bias and rather promotes the persistence of biodiversity. This study reviewed a recent allocation of land to biodiversity conservation within Western Cape of South Africa, using both a quantitative and qualitative approach, to determine their value to biodiversity conservation. The area was previously used for commercial forestry but now has been allocated to conservation land-uses. The allocation was based on the area’s value to the forestry industry. The qualitative approach in this study engaged with relevant stakeholder groups to map priority areas, while the quantitative approach used available data on biodiversity features to map priority areas. Neither approach determined that the area allocated is in its full extent a priority for biodiversity conservation. This indicated that in the current era of Conservation Planning, Protected Areas are still being allocated in an ad hoc manner, as a result of their limited perceived benefit to anthropocentric needs. The future allocation of land to biodiversity conservation should rather integrate expert knowledge and available quantifiable data to ensure that priority areas for biodiversity conservation are being protected.
- Full Text:
- Date Issued: 2015
- Authors: Southey, Phillippa Kate
- Date: 2015
- Subjects: Biodiversity conservation -- South Africa -- Western Cape , Conservation of natural resources -- South Africa -- Western Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4122 , vital:20548
- Description: Historical ad hoc allocations of land for biodiversity conservation have led to a biased representation of habitat within the Cape Floristic Region, with Protected Areas concentrated in upland areas at high altitudes and on steep slopes. The field of Conservation Planning developed to ensure that allocations of areas to Protected status no longer result in such bias and rather promotes the persistence of biodiversity. This study reviewed a recent allocation of land to biodiversity conservation within Western Cape of South Africa, using both a quantitative and qualitative approach, to determine their value to biodiversity conservation. The area was previously used for commercial forestry but now has been allocated to conservation land-uses. The allocation was based on the area’s value to the forestry industry. The qualitative approach in this study engaged with relevant stakeholder groups to map priority areas, while the quantitative approach used available data on biodiversity features to map priority areas. Neither approach determined that the area allocated is in its full extent a priority for biodiversity conservation. This indicated that in the current era of Conservation Planning, Protected Areas are still being allocated in an ad hoc manner, as a result of their limited perceived benefit to anthropocentric needs. The future allocation of land to biodiversity conservation should rather integrate expert knowledge and available quantifiable data to ensure that priority areas for biodiversity conservation are being protected.
- Full Text:
- Date Issued: 2015
Assessing symptoms of eutrophication in estuaries
- Authors: Lemley, Daniel Alan
- Date: 2015
- Subjects: Estuarine eutrophication -- South Africa , Water quality -- South Africa , Ecological integrity -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3427 , vital:20429
- Description: Water quality and ecological integrity of estuaries reflect activities within the entire upstream catchment. Much emphasis has been placed on the response of estuaries to anthropogenic stressors through the use of monitoring programmes. Key to the success of these programmes is the use of indicators as they transform data into useful information. The ultimate aim of this study was to identify eutrophic symptoms in selected estuaries in the Gouritz Water Management Area (WMA) using a multi-metric classification method. The study sites included the permanently open Duiwenhoks, Goukou, Gouritz, and Kaaimans estuaries, as well as the temporarily open/closed Hartenbos, Klein Brak, Great Brak, Gwaing, and Goukamma estuaries. Initially, the “pressure” associated with all the estuaries in the Gouritz WMA was determined (e.g. total daily nutrient loads and changes in river inflow affecting flushing time) using long-term flow and water quality monitoring data provided by the Department of Water Affairs (DWA). Subsequently, the “state” of the selected estuaries was assessed using a variety of indicators, including: inorganic nutrients (~ N and P), phytoplankton, epiphytes and microphytobenthos. Estuaries with longer flushing time suggested greater vulnerability to eutrophication. For example, the Gwaing (281.11 kg DIN d-1; 78.85 kg DIP d-1) and Hartenbos (38.33 kg DIN d-1; 21.51 kg DIP d-1) estuaries generally received the highest daily inorganic nutrient loads. However, at the time of sampling, the Hartenbos Estuary had a longer flushing time (i.e. weeks) compared to the Gwaing Estuary (i.e. couple of days). Field data confirmed the greater vulnerability to eutrophication associated with longer flushing times, as the indicators measured in the Hartenbos Estuary exceeded all the proposed ‘thresholds’ of a eutrophic system (~ overall ‘Poor’ condition). The Great Brak Estuary (~ overall ‘Fair’ condition) provided an interesting example where eutrophic symptoms were only detected when assessing the microalgal primary producers (i.e. high biomass and low diversity). Furthermore, the need to distinguish between naturally and anthropogenically induced symptoms was highlighted. One such scenario was noted in the Kaaimans Estuary, where its natural hydro-morphological characteristics (i.e. steep banks, low river inflow, and deep/narrow channel) led to the possible exaggeration of its overall eutrophic condition, i.e. received a ‘Fair’ rather than ‘Good’ rating, arising from ‘Poor’ ratings for dissolved oxygen and benthic diatom diversity. Overall, this study demonstrated the importance of adopting a holistic approach when assessing the condition and trophic status of estuaries. Studies such as these allow for the detection of vulnerable and degraded systems, which can provide important information with regards to the identification of management priorities.
- Full Text:
- Date Issued: 2015
- Authors: Lemley, Daniel Alan
- Date: 2015
- Subjects: Estuarine eutrophication -- South Africa , Water quality -- South Africa , Ecological integrity -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3427 , vital:20429
- Description: Water quality and ecological integrity of estuaries reflect activities within the entire upstream catchment. Much emphasis has been placed on the response of estuaries to anthropogenic stressors through the use of monitoring programmes. Key to the success of these programmes is the use of indicators as they transform data into useful information. The ultimate aim of this study was to identify eutrophic symptoms in selected estuaries in the Gouritz Water Management Area (WMA) using a multi-metric classification method. The study sites included the permanently open Duiwenhoks, Goukou, Gouritz, and Kaaimans estuaries, as well as the temporarily open/closed Hartenbos, Klein Brak, Great Brak, Gwaing, and Goukamma estuaries. Initially, the “pressure” associated with all the estuaries in the Gouritz WMA was determined (e.g. total daily nutrient loads and changes in river inflow affecting flushing time) using long-term flow and water quality monitoring data provided by the Department of Water Affairs (DWA). Subsequently, the “state” of the selected estuaries was assessed using a variety of indicators, including: inorganic nutrients (~ N and P), phytoplankton, epiphytes and microphytobenthos. Estuaries with longer flushing time suggested greater vulnerability to eutrophication. For example, the Gwaing (281.11 kg DIN d-1; 78.85 kg DIP d-1) and Hartenbos (38.33 kg DIN d-1; 21.51 kg DIP d-1) estuaries generally received the highest daily inorganic nutrient loads. However, at the time of sampling, the Hartenbos Estuary had a longer flushing time (i.e. weeks) compared to the Gwaing Estuary (i.e. couple of days). Field data confirmed the greater vulnerability to eutrophication associated with longer flushing times, as the indicators measured in the Hartenbos Estuary exceeded all the proposed ‘thresholds’ of a eutrophic system (~ overall ‘Poor’ condition). The Great Brak Estuary (~ overall ‘Fair’ condition) provided an interesting example where eutrophic symptoms were only detected when assessing the microalgal primary producers (i.e. high biomass and low diversity). Furthermore, the need to distinguish between naturally and anthropogenically induced symptoms was highlighted. One such scenario was noted in the Kaaimans Estuary, where its natural hydro-morphological characteristics (i.e. steep banks, low river inflow, and deep/narrow channel) led to the possible exaggeration of its overall eutrophic condition, i.e. received a ‘Fair’ rather than ‘Good’ rating, arising from ‘Poor’ ratings for dissolved oxygen and benthic diatom diversity. Overall, this study demonstrated the importance of adopting a holistic approach when assessing the condition and trophic status of estuaries. Studies such as these allow for the detection of vulnerable and degraded systems, which can provide important information with regards to the identification of management priorities.
- Full Text:
- Date Issued: 2015
Changes in diet resource use by elephants, Loxodonta Africana, due to changes in resource availability in the Addo National Park
- Authors: Du Toit, Jana
- Date: 2015
- Subjects: Elephants -- Nutrition -- South Africa -- Eastern Cape , Elephants -- Habitat -- South Africa -- Eastern Cape , Wildlife conservation , Addo Elephant National Park (South Africa)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10731 , ISSN http://hdl.handle.net/10948/d1021194
- Description: Animals are restricted in their diets by several factors, most notably the availability and quality of resources. Variation in resource availability causes herbivores to shift their diets seasonally and spatially. Elephants (Loxodonta africana), are known to have extensive impacts on plant communities, altering ecosystem functioning and causing a decline in biodiversity. In enclosed areas, these impacts are increased leading to a decline in resource availability and presumably resource quality. In the Addo Elephant National Park, the Main Camp section has a history of high elephant impacts and therefore reduced resource availability. Whereas, the recently added Colchester section has greater resource availability, due to the absence of elephants in this section since the fencing of the Park. This study investigated the changes in diet (diet breadth, preference and diet quality) of elephants due to an increase in resource availability. Three alternative hypotheses were contrasted: 1) elephants as generalist foragers, 2) elephants as optimal foragers, or 3) elephants learning foraging behaviour. Using microhistological analysis, the diets of elephants were described over five sampling periods (August 2010 – February 2014) in both sections. Forage availability was estimated using a modified line-intercept method, and was used to determine changes in preference by relating forage availability to use. In the Colchester section the diet breadth of elephants increased, and was coupled with a high initial variation between the diets of elephants, which decreased in subsequent sampling periods. This supported the elephants learning foraging behaviour hypothesis. However, there was no increase in diet preference by elephants in the Colchester section, which supported the elephants as generalist foragers hypothesis. There was also no difference in the diet quality of elephants in the Main Camp and Colchester sections, which did not support any of the three hypotheses. The elephants learning foraging behaviour hypothesis is proposed to be the link between the alternate two hypotheses, and given enough time, either of the two could be supported. The lack of difference in preference and diet quality between elephants in the Main Camp and Colchester sections is hypothesised to be due to the population level (not measured for individuals) at which these were measured. Microhistological analysis of faeces was used to describe the diet of elephants, which was compared to the diet described by DNA metabarcoding. Microhistological analysis is a traditional, favoured technique used in describing the diet of wild herbivores, whereas DNA metabarcoding is a relatively new and untested technique. These two techniques have not yet been compared in the diet of megaherbivores. Results indicated that microhistological analysis identified significantly more grass in the diet of elephants, than DNA metabarcoding did, which was expected as previous studies also found overestimation of grasses. Microhistological analysis identified more plant families in the diet of elephants, than DNA metabarcoding. Most of the differences between the two techniques can be attributed to the difference in taxonomic resolution, which was due to the lack of a complete reference collection for DNA metabarcoding. Although either of the two techniques can be used to describe the diet of elephants, the most reliable results would be obtained when using both techniques. The findings of this study suggest that due to the high initial variation between the diets of elephants, with an increase in resource availability, the impacts will also initially be highly varied. This suggests that identifying plant species to monitor elephants impacts initially will be difficult. However, important plant species, or those known to be vulnerable to elephants impacts should be carefully monitored initially and monitoring should not only occur annually, but also seasonally.
- Full Text:
- Date Issued: 2015
- Authors: Du Toit, Jana
- Date: 2015
- Subjects: Elephants -- Nutrition -- South Africa -- Eastern Cape , Elephants -- Habitat -- South Africa -- Eastern Cape , Wildlife conservation , Addo Elephant National Park (South Africa)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10731 , ISSN http://hdl.handle.net/10948/d1021194
- Description: Animals are restricted in their diets by several factors, most notably the availability and quality of resources. Variation in resource availability causes herbivores to shift their diets seasonally and spatially. Elephants (Loxodonta africana), are known to have extensive impacts on plant communities, altering ecosystem functioning and causing a decline in biodiversity. In enclosed areas, these impacts are increased leading to a decline in resource availability and presumably resource quality. In the Addo Elephant National Park, the Main Camp section has a history of high elephant impacts and therefore reduced resource availability. Whereas, the recently added Colchester section has greater resource availability, due to the absence of elephants in this section since the fencing of the Park. This study investigated the changes in diet (diet breadth, preference and diet quality) of elephants due to an increase in resource availability. Three alternative hypotheses were contrasted: 1) elephants as generalist foragers, 2) elephants as optimal foragers, or 3) elephants learning foraging behaviour. Using microhistological analysis, the diets of elephants were described over five sampling periods (August 2010 – February 2014) in both sections. Forage availability was estimated using a modified line-intercept method, and was used to determine changes in preference by relating forage availability to use. In the Colchester section the diet breadth of elephants increased, and was coupled with a high initial variation between the diets of elephants, which decreased in subsequent sampling periods. This supported the elephants learning foraging behaviour hypothesis. However, there was no increase in diet preference by elephants in the Colchester section, which supported the elephants as generalist foragers hypothesis. There was also no difference in the diet quality of elephants in the Main Camp and Colchester sections, which did not support any of the three hypotheses. The elephants learning foraging behaviour hypothesis is proposed to be the link between the alternate two hypotheses, and given enough time, either of the two could be supported. The lack of difference in preference and diet quality between elephants in the Main Camp and Colchester sections is hypothesised to be due to the population level (not measured for individuals) at which these were measured. Microhistological analysis of faeces was used to describe the diet of elephants, which was compared to the diet described by DNA metabarcoding. Microhistological analysis is a traditional, favoured technique used in describing the diet of wild herbivores, whereas DNA metabarcoding is a relatively new and untested technique. These two techniques have not yet been compared in the diet of megaherbivores. Results indicated that microhistological analysis identified significantly more grass in the diet of elephants, than DNA metabarcoding did, which was expected as previous studies also found overestimation of grasses. Microhistological analysis identified more plant families in the diet of elephants, than DNA metabarcoding. Most of the differences between the two techniques can be attributed to the difference in taxonomic resolution, which was due to the lack of a complete reference collection for DNA metabarcoding. Although either of the two techniques can be used to describe the diet of elephants, the most reliable results would be obtained when using both techniques. The findings of this study suggest that due to the high initial variation between the diets of elephants, with an increase in resource availability, the impacts will also initially be highly varied. This suggests that identifying plant species to monitor elephants impacts initially will be difficult. However, important plant species, or those known to be vulnerable to elephants impacts should be carefully monitored initially and monitoring should not only occur annually, but also seasonally.
- Full Text:
- Date Issued: 2015
Decision making for investment in residential real estate
- Authors: James, Matthew Gary Robert
- Date: 2015
- Subjects: Real estate investment -- Decision making Investment analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/10868 , vital:26831
- Description: Investment in residential real estate involves almost all members of the public at some stage of their lives, whether this be one's first home or the purchasing of one‟s first investment property. Understanding how to maximise the return on one's investment is something that can benefit the investor from before the investment is made until after the property has been sold, if it is sold at all. Literature surveys have concluded that there are a number of variables to consider when maximising the return on investment. As residential real estate is not a perfect science, there are guidelines and routes that are more beneficial to the investor depending on the current market, environment and economic standing. A survey was undertaken by members of the public that are involved in residential real estate investment, relative to the maximisation of the return on investment in residential real estate. The salient findings include: Investors in residential real estate spend more than average to extensive time prior, to investment researching the chosen residential real estate property; Investors in residential real estate perform a feasibility study before committing to the development whereas; Investors in residential real estate make use of financial advisors/valuers/estate agents or other investors' knowledge bases in deciding whether to invest in a residential property development; Investors in residential real estate believe that their degree of knowledge about the residential property market and residential property investments are average to very high. Investors in residential real estate somewhat agree that residential real estate investors do not effectively manage their investments. It was recommended that investors make use of help and guidance when investing in residential real estate, perform a feasibility study and ensure that they know their market before investing in a project. It was also noted that location plays a large role when deciding on an investment opportunity worth investing into. By creating awareness and ensuring that all methods and guidelines have been used to maximise the returns that their proposed residential real estate investment, investors can ensure a stronger, healthier cash flow and reap the highest possible benefits from their residential real estate portfolio.
- Full Text:
- Date Issued: 2015
- Authors: James, Matthew Gary Robert
- Date: 2015
- Subjects: Real estate investment -- Decision making Investment analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/10868 , vital:26831
- Description: Investment in residential real estate involves almost all members of the public at some stage of their lives, whether this be one's first home or the purchasing of one‟s first investment property. Understanding how to maximise the return on one's investment is something that can benefit the investor from before the investment is made until after the property has been sold, if it is sold at all. Literature surveys have concluded that there are a number of variables to consider when maximising the return on investment. As residential real estate is not a perfect science, there are guidelines and routes that are more beneficial to the investor depending on the current market, environment and economic standing. A survey was undertaken by members of the public that are involved in residential real estate investment, relative to the maximisation of the return on investment in residential real estate. The salient findings include: Investors in residential real estate spend more than average to extensive time prior, to investment researching the chosen residential real estate property; Investors in residential real estate perform a feasibility study before committing to the development whereas; Investors in residential real estate make use of financial advisors/valuers/estate agents or other investors' knowledge bases in deciding whether to invest in a residential property development; Investors in residential real estate believe that their degree of knowledge about the residential property market and residential property investments are average to very high. Investors in residential real estate somewhat agree that residential real estate investors do not effectively manage their investments. It was recommended that investors make use of help and guidance when investing in residential real estate, perform a feasibility study and ensure that they know their market before investing in a project. It was also noted that location plays a large role when deciding on an investment opportunity worth investing into. By creating awareness and ensuring that all methods and guidelines have been used to maximise the returns that their proposed residential real estate investment, investors can ensure a stronger, healthier cash flow and reap the highest possible benefits from their residential real estate portfolio.
- Full Text:
- Date Issued: 2015
Defect-related photoluminescence of zinc oxide nanorods
- Authors: Mbulanga, Crispin Munyelele
- Date: 2015
- Subjects: Photoluminescence Zinc oxide
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/10318 , vital:26652
- Description: In this dissertation, Zinc oxide (ZnO) nanorods grown by a two-step chemical bath deposition method on Si substrate is characterized. Research was conducted on ZnO nanorods for the understanding of their optical properties at room temperature (RT), with the emphasis on the visible luminescence. To this end, controlled thermal treatments of as-grown ZnO nanorods were conducted under different conditions, such as annealing time and environment, at atmospheric pressure. Results related to the following studies are reported: an investigation of the structure of ZnO nanorods, an analysis of the chemical composition of the surface, an investigation of the surface stoichiometry of the rods, and a study of defect-related photoluminescence of ZnO nanorods upon thermal treatment in different ambients.To achieve this, the samples were investigated by Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), X-ray Photoelectron Spectroscopy (XPS), Auger Electron Spectroscopy (AES) and room temperature (RT) photoluminescence Spectroscopy (PL). As-grown ZnO nanorods exhibit a hexagonal shape and have the wurtzite structure; they have, respectively, an average length and diameter of ~900 nm and ~50 nm, and most of the rods are perpendicular to the substrate. The main extrinsic species found in as-grown nanostructures are C, H, F, S, and Cl. ToF-SIMS and XPS confirmed the presence of H related-defects, and the oxygen 1 S XPS peak at 531.5 eV is therefore assigned to oxygen bound to H-related defects. Based on stoichiometry studies, it is found that the near surface regions of as-grown ZnO nanorods (2 to 10 monolayers) are rich in Zn. The RT luminescence of as-grown ZnO nanorods exhibits a near band edge emission centered at ~379.5 nm and deep level emission extending from ~450 nm to ~850 nm. When these nanorods are thermally treated at high temperatures (>850 oC), it is found that even though their crystalline quality is preserved, their morphology is significantly affected, regardless of annealing ambient. Furthermore, in the near surface regions of annealed ZnO nanorods it is found that the Zn/O stoichiometric ratios deviate from unity. Specifically, oxygen vacancies form within the first 100 nm from the sample surface. Further from the surface, the material is deficient in Zn. It is deduced from XPS and AES that the ambient affects the activation rate of intrinsic defects. Furthermore, the only extrinsic defects that are affected by thermal treatment are found to be H-related defects. At high annealing temperatures (300 oC to ~700 oC), H-related defects are removed, and this removal process is found to affect significantly the RT luminescence properties of ZnO nanorods. Specifically, hydrogen passivates vacancy-related defects, depending on the thermal treatment. PL spectroscopy is used to follow this passivation effect as a function of annealing temperature, which causes an initial quenching followed by an enhancement of the green and the red luminescence, regardless of the ambient. Finally, the green luminescence that arises following annealing above ~800 oC is assigned to Zn vacancy-related defects, while the red luminescence that dominates the visible band of ZnO nanorods upon annealing between 400 oC and 600 oC is suggested to be due to oxygen vacancy-related defects.
- Full Text:
- Date Issued: 2015
- Authors: Mbulanga, Crispin Munyelele
- Date: 2015
- Subjects: Photoluminescence Zinc oxide
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/10318 , vital:26652
- Description: In this dissertation, Zinc oxide (ZnO) nanorods grown by a two-step chemical bath deposition method on Si substrate is characterized. Research was conducted on ZnO nanorods for the understanding of their optical properties at room temperature (RT), with the emphasis on the visible luminescence. To this end, controlled thermal treatments of as-grown ZnO nanorods were conducted under different conditions, such as annealing time and environment, at atmospheric pressure. Results related to the following studies are reported: an investigation of the structure of ZnO nanorods, an analysis of the chemical composition of the surface, an investigation of the surface stoichiometry of the rods, and a study of defect-related photoluminescence of ZnO nanorods upon thermal treatment in different ambients.To achieve this, the samples were investigated by Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD), Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), X-ray Photoelectron Spectroscopy (XPS), Auger Electron Spectroscopy (AES) and room temperature (RT) photoluminescence Spectroscopy (PL). As-grown ZnO nanorods exhibit a hexagonal shape and have the wurtzite structure; they have, respectively, an average length and diameter of ~900 nm and ~50 nm, and most of the rods are perpendicular to the substrate. The main extrinsic species found in as-grown nanostructures are C, H, F, S, and Cl. ToF-SIMS and XPS confirmed the presence of H related-defects, and the oxygen 1 S XPS peak at 531.5 eV is therefore assigned to oxygen bound to H-related defects. Based on stoichiometry studies, it is found that the near surface regions of as-grown ZnO nanorods (2 to 10 monolayers) are rich in Zn. The RT luminescence of as-grown ZnO nanorods exhibits a near band edge emission centered at ~379.5 nm and deep level emission extending from ~450 nm to ~850 nm. When these nanorods are thermally treated at high temperatures (>850 oC), it is found that even though their crystalline quality is preserved, their morphology is significantly affected, regardless of annealing ambient. Furthermore, in the near surface regions of annealed ZnO nanorods it is found that the Zn/O stoichiometric ratios deviate from unity. Specifically, oxygen vacancies form within the first 100 nm from the sample surface. Further from the surface, the material is deficient in Zn. It is deduced from XPS and AES that the ambient affects the activation rate of intrinsic defects. Furthermore, the only extrinsic defects that are affected by thermal treatment are found to be H-related defects. At high annealing temperatures (300 oC to ~700 oC), H-related defects are removed, and this removal process is found to affect significantly the RT luminescence properties of ZnO nanorods. Specifically, hydrogen passivates vacancy-related defects, depending on the thermal treatment. PL spectroscopy is used to follow this passivation effect as a function of annealing temperature, which causes an initial quenching followed by an enhancement of the green and the red luminescence, regardless of the ambient. Finally, the green luminescence that arises following annealing above ~800 oC is assigned to Zn vacancy-related defects, while the red luminescence that dominates the visible band of ZnO nanorods upon annealing between 400 oC and 600 oC is suggested to be due to oxygen vacancy-related defects.
- Full Text:
- Date Issued: 2015
Determination of the effects of sunlight and UV irradiation on the structure, viability and reapplication frequency of the biopesticide cryptophlebia leucotreta granulovirus in the protection against false codling moth infestation of citrus crops
- Authors: Mwanza, Patrick
- Date: 2015
- Subjects: Cryptophlebia leucotreta -- Effect of ultraviolet radiation on , Natural pesticides
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/6346 , vital:21075
- Description: Cryptophlebia leucotreta granulovirus (CrleGV-SA) is a baculovirus specifically pathogenic to the citrus pest false codling moth, Thaumatotibia leucotreta. CrleGV- SA is formulated as a commercial biopesticide, Cryptogran® (River Bioscience, South Africa). The virus has a stable, proteinaceous crystalline occlusion body (OB) that protects the nucleocapsid. The major limitation to the use of baculoviruses is their susceptibility to the ultraviolet (UV) component of sunlight, which rapidly and greatly reduces their efficacy as biopesticides. The UVA and UVB components are the most destructive to biological organisms. To date no publication has reported the effect of UV on the structure and virulence of CrleGV, or the effectiveness of the OB as a UV protectant. In this study the effect of UV irradiation on the structure and infectivity of pure CrleGV-SA and Cryptogran® was investigated using scanning electron microscopy (SEM), Raman spectroscopy, qPCR, and bioassays. The project included laboratory and field studies. In the laboratory, CrleGV-SA and Cryptogran® were exposed to either UVA or UVB for periods of 24 hours to 7 days before analysis. In the field, Cryptogran® was applied to trees in a citrus orchard with young fruit. The fruit were collected from 24 hours to 28 days after application and bioassays conducted to assess the effect of sunlight over time on virus structure and efficacy when applied to the northern or southern sides of the trees. No surface morphological changes to the virus were detected using SEM. However, small compositional changes were detected by Raman spectroscopy. qPCR and bioassays demonstrated that UV irradiation damaged the viral DNA, greatly reducing the infectivity of pure CrleGV-SA and Cryptogran®. Exposure to UVB reduced the virulence of the virus more than UVA. The field studies revealed that the activity of CrleGV-SA decreased more on the northern side of the trees than on the southern side.
- Full Text:
- Date Issued: 2015
- Authors: Mwanza, Patrick
- Date: 2015
- Subjects: Cryptophlebia leucotreta -- Effect of ultraviolet radiation on , Natural pesticides
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/6346 , vital:21075
- Description: Cryptophlebia leucotreta granulovirus (CrleGV-SA) is a baculovirus specifically pathogenic to the citrus pest false codling moth, Thaumatotibia leucotreta. CrleGV- SA is formulated as a commercial biopesticide, Cryptogran® (River Bioscience, South Africa). The virus has a stable, proteinaceous crystalline occlusion body (OB) that protects the nucleocapsid. The major limitation to the use of baculoviruses is their susceptibility to the ultraviolet (UV) component of sunlight, which rapidly and greatly reduces their efficacy as biopesticides. The UVA and UVB components are the most destructive to biological organisms. To date no publication has reported the effect of UV on the structure and virulence of CrleGV, or the effectiveness of the OB as a UV protectant. In this study the effect of UV irradiation on the structure and infectivity of pure CrleGV-SA and Cryptogran® was investigated using scanning electron microscopy (SEM), Raman spectroscopy, qPCR, and bioassays. The project included laboratory and field studies. In the laboratory, CrleGV-SA and Cryptogran® were exposed to either UVA or UVB for periods of 24 hours to 7 days before analysis. In the field, Cryptogran® was applied to trees in a citrus orchard with young fruit. The fruit were collected from 24 hours to 28 days after application and bioassays conducted to assess the effect of sunlight over time on virus structure and efficacy when applied to the northern or southern sides of the trees. No surface morphological changes to the virus were detected using SEM. However, small compositional changes were detected by Raman spectroscopy. qPCR and bioassays demonstrated that UV irradiation damaged the viral DNA, greatly reducing the infectivity of pure CrleGV-SA and Cryptogran®. Exposure to UVB reduced the virulence of the virus more than UVA. The field studies revealed that the activity of CrleGV-SA decreased more on the northern side of the trees than on the southern side.
- Full Text:
- Date Issued: 2015
Ecological risk assessment of fisheries on sea turtles in the South Western Indian Ocean
- Authors: Mellet, Bernice
- Date: 2015
- Subjects: Sea turtles -- Indian Ocean Fisheries -- Indian Ocean
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/9957 , vital:26636
- Description: The SWIO is an area of great biodiversity and included in the diverse species that occupy the region are five species of sea turtles that include green turtles, hawksbills, leatherbacks, loggerheads and olive ridleys. Despite considerable conservation efforts at sea turtle rookeries in the South Western Indian Ocean, only green and loggerhead turtle populations have shown an increase in population size in recent years (<10 years), whereas leatherbacks remained stable and hawksbills and olive ridleys declined. This begs the question if fisheries (or other offshore pressures) are responsible for slowing the recovery of these populations in the region, and if so, which specific fisheries are responsible for this trend? Several offshore (mostly industrial) and coastal (mostly artisanal) fisheries overlap with sea turtle distribution at sea. Industrial fisheries that are globally known to have a demonstrable impact on sea turtle populations are longline and to a lesser extent purse seine fisheries, whilst prawn trawl, gillnet and beach seine fisheries are coastal fisheries with a known negative impact on sea turtle populations. Holistic conservation strategies should be developed that include both land and sea protection for sea turtle species. It is thus necessary to identify and manage offshore threats including fisheries activities, particularly those fisheries that are showing the highest risk to sea turtle populations. This prompted an investigation into the bycatch rates and mortality of all sea turtle species that occur in the SWIO region in several offshore and coastal fisheries including both industrial (longline, purse seine and prawn trawl) and artisanal (including gillnet and beach seine) fisheries. The specific aims were (i) to identify and quantify the interactions (and if possible mortality) of sea turtle species in fisheries and (ii) to identify vulnerable species/populations to fishing operations using a semi-quantitative Ecological Risk Assessment (ERA) in the form of a Productivity-Susceptibility Analysis (PSA). Published information, online databases and technical reports were used as data sources to establish a database containing essential information regarding fishing effort and sea turtle bycatch in the region. The existing information was used to map fisheries extent and effort within the region, and to perform bycatch calculations. Interactions and mortality rates for sea turtles in five fisheries were quantified using bycatch rates from regional studies. Between 2000 – 2011, industrial longline and purse seine fisheries captured sea turtles at a rate of 4 388 indiv.y-1, with the mortality rate being 189 indiv.y-1. The bulk of these interactions were in the longline industry that captured 4 129 ± 1 376 indiv.y-1, with a corresponding mortality rate of 167 ± 53 indiv.y-1. The most commonly caught species (in longlines) were loggerheads and leatherback turtles, but the greatest impact is expected to be on the leatherback population due to the high interaction rate relative to population size. The bycatch (259 ± 34 indiv.y-1) and mortality (20 ± 2 indiv.y-1) rates of sea turtles in the purse seine fishery was considerably lower than the longline fishery. The purse seine fishery thus does not seem to have a significant impact on sea turtle populations in the SWIO. The impact of all forms of fish aggregation devices were excluded from the analysis as the impacts of these are poorly documented. Coastal prawn trawl, gillnet and beach seine fisheries captured an estimate of between 50 164 - 52 370 indiv.y-1 from 2000-2011. The highest bycatch rate was estimated for gillnet fisheries (40 264 indiv.y-1) followed by beach seine fisheries (9 171 indiv.y-1) and prawn trawl fisheries (at 1089 – 2795 indiv.y-1). The gillnet fishery could be responsible for slowing the recovery rate of green turtle and leatherback populations in the SWIO due to the high capture rates in this fishery compared to the population sizes of the species. Beach seine and prawn trawl fisheries are not expected to be hamper the recovery rate of any of the populations in the SWIO due to the low levels of interactions and low mortality rates compared to the population sizes. There are however very few data available regarding the bycatch of sea turtle species within these fisheries, highlighting the need for further research regarding this. A productivity-Susceptibility Analysis (PSA) was used to evaluate the relative vulnerability of species to fisheries, and is frequently applied in data poor situations. Limited data on sea turtle life history characteristics and population dynamics of species in the SWIO prompted the use of a PSA to determine the species most vulnerable to fisheries in the region. Results of the PSA indicated that gillnet fisheries poses the largest fishery-related threat to sea turtle populations, specifically the green and leatherback populations. The longline fishery that poses a particular threat to the leatherback population in the SWIO is also a particular concern. A cumulative impact assessment (combining fisheries and other threats) indicated that the SWIO leatherback population is extremely vulnerable to the combination of threats that influence this population in the SWIO. Even though individual fisheries may pose a small threat, the cumulative impacts of the fisheries can lead to severe impacts on populations such as slowing the recovery rate of populations. There are however significant data gaps that require attention in order to fully assess the impact of these fisheries on sea turtle populations. Despite the fact that fisheries are not implicated as a mayor reason for the decline in the hawksbill and olive ridley populations in the region, these two species are in decline indicating that there are other factors responsible for the decline not yet identified. It however remains imperative to reduce the mortality from all sources to ensure the continued viability of sea turtle populations in the region.
- Full Text:
- Date Issued: 2015
- Authors: Mellet, Bernice
- Date: 2015
- Subjects: Sea turtles -- Indian Ocean Fisheries -- Indian Ocean
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/9957 , vital:26636
- Description: The SWIO is an area of great biodiversity and included in the diverse species that occupy the region are five species of sea turtles that include green turtles, hawksbills, leatherbacks, loggerheads and olive ridleys. Despite considerable conservation efforts at sea turtle rookeries in the South Western Indian Ocean, only green and loggerhead turtle populations have shown an increase in population size in recent years (<10 years), whereas leatherbacks remained stable and hawksbills and olive ridleys declined. This begs the question if fisheries (or other offshore pressures) are responsible for slowing the recovery of these populations in the region, and if so, which specific fisheries are responsible for this trend? Several offshore (mostly industrial) and coastal (mostly artisanal) fisheries overlap with sea turtle distribution at sea. Industrial fisheries that are globally known to have a demonstrable impact on sea turtle populations are longline and to a lesser extent purse seine fisheries, whilst prawn trawl, gillnet and beach seine fisheries are coastal fisheries with a known negative impact on sea turtle populations. Holistic conservation strategies should be developed that include both land and sea protection for sea turtle species. It is thus necessary to identify and manage offshore threats including fisheries activities, particularly those fisheries that are showing the highest risk to sea turtle populations. This prompted an investigation into the bycatch rates and mortality of all sea turtle species that occur in the SWIO region in several offshore and coastal fisheries including both industrial (longline, purse seine and prawn trawl) and artisanal (including gillnet and beach seine) fisheries. The specific aims were (i) to identify and quantify the interactions (and if possible mortality) of sea turtle species in fisheries and (ii) to identify vulnerable species/populations to fishing operations using a semi-quantitative Ecological Risk Assessment (ERA) in the form of a Productivity-Susceptibility Analysis (PSA). Published information, online databases and technical reports were used as data sources to establish a database containing essential information regarding fishing effort and sea turtle bycatch in the region. The existing information was used to map fisheries extent and effort within the region, and to perform bycatch calculations. Interactions and mortality rates for sea turtles in five fisheries were quantified using bycatch rates from regional studies. Between 2000 – 2011, industrial longline and purse seine fisheries captured sea turtles at a rate of 4 388 indiv.y-1, with the mortality rate being 189 indiv.y-1. The bulk of these interactions were in the longline industry that captured 4 129 ± 1 376 indiv.y-1, with a corresponding mortality rate of 167 ± 53 indiv.y-1. The most commonly caught species (in longlines) were loggerheads and leatherback turtles, but the greatest impact is expected to be on the leatherback population due to the high interaction rate relative to population size. The bycatch (259 ± 34 indiv.y-1) and mortality (20 ± 2 indiv.y-1) rates of sea turtles in the purse seine fishery was considerably lower than the longline fishery. The purse seine fishery thus does not seem to have a significant impact on sea turtle populations in the SWIO. The impact of all forms of fish aggregation devices were excluded from the analysis as the impacts of these are poorly documented. Coastal prawn trawl, gillnet and beach seine fisheries captured an estimate of between 50 164 - 52 370 indiv.y-1 from 2000-2011. The highest bycatch rate was estimated for gillnet fisheries (40 264 indiv.y-1) followed by beach seine fisheries (9 171 indiv.y-1) and prawn trawl fisheries (at 1089 – 2795 indiv.y-1). The gillnet fishery could be responsible for slowing the recovery rate of green turtle and leatherback populations in the SWIO due to the high capture rates in this fishery compared to the population sizes of the species. Beach seine and prawn trawl fisheries are not expected to be hamper the recovery rate of any of the populations in the SWIO due to the low levels of interactions and low mortality rates compared to the population sizes. There are however very few data available regarding the bycatch of sea turtle species within these fisheries, highlighting the need for further research regarding this. A productivity-Susceptibility Analysis (PSA) was used to evaluate the relative vulnerability of species to fisheries, and is frequently applied in data poor situations. Limited data on sea turtle life history characteristics and population dynamics of species in the SWIO prompted the use of a PSA to determine the species most vulnerable to fisheries in the region. Results of the PSA indicated that gillnet fisheries poses the largest fishery-related threat to sea turtle populations, specifically the green and leatherback populations. The longline fishery that poses a particular threat to the leatherback population in the SWIO is also a particular concern. A cumulative impact assessment (combining fisheries and other threats) indicated that the SWIO leatherback population is extremely vulnerable to the combination of threats that influence this population in the SWIO. Even though individual fisheries may pose a small threat, the cumulative impacts of the fisheries can lead to severe impacts on populations such as slowing the recovery rate of populations. There are however significant data gaps that require attention in order to fully assess the impact of these fisheries on sea turtle populations. Despite the fact that fisheries are not implicated as a mayor reason for the decline in the hawksbill and olive ridley populations in the region, these two species are in decline indicating that there are other factors responsible for the decline not yet identified. It however remains imperative to reduce the mortality from all sources to ensure the continued viability of sea turtle populations in the region.
- Full Text:
- Date Issued: 2015
Efficiency evaluation of South Africa tertiary education institutions using data envelopment analysis
- Authors: Chitekedza, Ignatious
- Date: 2015
- Subjects: Data envelopment analysis -- South Africa , Principal components analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4764 , vital:20674
- Description: With an increasing number of students enrolling at higher education institutions in South Africa, it has become important to investigate whether these institutions are using their resources adequately. This study uses data envelopment analysis (DEA) to estimate the efficiency of 23 South African tertiary education institutions based on both teaching and research outputs. Using DEA we are able to rank South African universities according to their use of resources in these two areas. These rankings can identify institutions which are performing well and also those which require improvement. The effect that merging institutions has on this efficiency is also determined. Owing to the limited sample size, variable reduction techniques, including the efficiency contribution measure (ECM) and principal components analysis (PCA-DEA), were used to improve the discrimination of the analysis.
- Full Text:
- Date Issued: 2015
- Authors: Chitekedza, Ignatious
- Date: 2015
- Subjects: Data envelopment analysis -- South Africa , Principal components analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/4764 , vital:20674
- Description: With an increasing number of students enrolling at higher education institutions in South Africa, it has become important to investigate whether these institutions are using their resources adequately. This study uses data envelopment analysis (DEA) to estimate the efficiency of 23 South African tertiary education institutions based on both teaching and research outputs. Using DEA we are able to rank South African universities according to their use of resources in these two areas. These rankings can identify institutions which are performing well and also those which require improvement. The effect that merging institutions has on this efficiency is also determined. Owing to the limited sample size, variable reduction techniques, including the efficiency contribution measure (ECM) and principal components analysis (PCA-DEA), were used to improve the discrimination of the analysis.
- Full Text:
- Date Issued: 2015
Enantioselective transformations using tetrol as a chiral mediator
- Authors: Dorfling, Sasha-Lee
- Date: 2015
- Subjects: Enantioselective catalysis , Trichothecenes , Catalysts , Titanium
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10445 , http://hdl.handle.net/10948/d1021195
- Description: (+)-(2R,3R)-1,1,4,4-Tetraphenylbutane-1,2,3,4-tetraol (TETROL) and its derivatives were reacted with varying molar ratios of titanium isopropoxide (2:1, 1:1 and 1:2 tetraol:titanium isopropoxide) in an attempt to prepare potential titanium-based tetraol catalysts for enantioselective transformations. In each case, infrared and HNMR spectra suggested that the product was formed. We tentatively proposed that the structure of the catalyst was a spiro-type, but we could not determine conclusively what its exact structure was, despite using numerous techniques at our disposal (molecular modelling calculations, H NMR and IR spectroscopy, thermal analyses, powder diffraction, and single crystal X-ray diffraction). The catalyst and derivatives thereof were able to act catalytically for the enantioselective additions of diethylzinc compounds to aldehydes. The effects of temperature and solvent were investigated, and toluene and -78 °C were selected as optimal from the results obtained. (The reaction could, however, not be maintained at this low temperature for extended periods due to the fact that we did not have, at our disposal, the correct equipment. Each 16 h reaction was thus allowed to reach room temperature in each case.) The selectivity for the product 1-phenylpropan-1-ol (when benzaldehyde was the starting aldehyde) varied depending on the nature of the aryl substituents of the titanium-based catalyst. Using 0.2 molar equivalents of the chiral titanates, the highest selectivity was 42 percent (e.e.), but only when excess Ti(O-i-Pr)4 had been added to the reaction mixture. This was achieved with the tetra(ortho-methoxyphenyl)-TETROLate derivative. TETROL and its derivatives were also successful in metal-free catalysis where higher conversions and selectivities were observed, compared to when these were complexed to titanium. The highest selectivity was 70 percent (e.e.), achieved with the tetra(ortho-methylphenyl)TETROL derivative.
- Full Text:
- Date Issued: 2015
- Authors: Dorfling, Sasha-Lee
- Date: 2015
- Subjects: Enantioselective catalysis , Trichothecenes , Catalysts , Titanium
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10445 , http://hdl.handle.net/10948/d1021195
- Description: (+)-(2R,3R)-1,1,4,4-Tetraphenylbutane-1,2,3,4-tetraol (TETROL) and its derivatives were reacted with varying molar ratios of titanium isopropoxide (2:1, 1:1 and 1:2 tetraol:titanium isopropoxide) in an attempt to prepare potential titanium-based tetraol catalysts for enantioselective transformations. In each case, infrared and HNMR spectra suggested that the product was formed. We tentatively proposed that the structure of the catalyst was a spiro-type, but we could not determine conclusively what its exact structure was, despite using numerous techniques at our disposal (molecular modelling calculations, H NMR and IR spectroscopy, thermal analyses, powder diffraction, and single crystal X-ray diffraction). The catalyst and derivatives thereof were able to act catalytically for the enantioselective additions of diethylzinc compounds to aldehydes. The effects of temperature and solvent were investigated, and toluene and -78 °C were selected as optimal from the results obtained. (The reaction could, however, not be maintained at this low temperature for extended periods due to the fact that we did not have, at our disposal, the correct equipment. Each 16 h reaction was thus allowed to reach room temperature in each case.) The selectivity for the product 1-phenylpropan-1-ol (when benzaldehyde was the starting aldehyde) varied depending on the nature of the aryl substituents of the titanium-based catalyst. Using 0.2 molar equivalents of the chiral titanates, the highest selectivity was 42 percent (e.e.), but only when excess Ti(O-i-Pr)4 had been added to the reaction mixture. This was achieved with the tetra(ortho-methoxyphenyl)-TETROLate derivative. TETROL and its derivatives were also successful in metal-free catalysis where higher conversions and selectivities were observed, compared to when these were complexed to titanium. The highest selectivity was 70 percent (e.e.), achieved with the tetra(ortho-methylphenyl)TETROL derivative.
- Full Text:
- Date Issued: 2015
Environmental flows, health and importance of macrophytes in the estuaries of water management area 11
- Authors: Cowie, Meredith
- Date: 2015
- Subjects: Estuarine ecology -- South Africa , Estuaries -- South Africa -- Management , Aquatic plants -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/7930 , vital:24324
- Description: Estuaries require sufficient quantity, quality and appropriate timing of freshwater inflow, referred to as environmental flow requirements, to ensure adequate health and functioning. In South Africa the environmental flow requirements of estuaries is determined using Resource Directed Measures (RDM). The present health and importance of an estuary must be considered when determining the ecological flow required to maintain an estuary in its desired state. An Estuarine Health Index that quantifies changes in abiotic and biotic components from natural conditions to present day is used. Health of biotic components is assessed according to changes in species richness, abundance and community composition. There has, however, been debate regarding the calculation of these attributes. In particular, for macrophytes, the inclusion of all habitat within the Estuarine Functional Zone (i.e. 5 m topographical contour) would affect the health and changes over time determined in past assessments. This is due to different areas being included as different areas would be included The aim of this study was to test the validity and suggest improvements to South Africa’s RDM macrophyte health score determination. The health of macrophytes were assessed at varying levels of intensity from desktop studies to thorough field studies. Rapid field studies provided a visual estimate of macrophyte health; while the intermediate and comprehensive assessments quantified change by mapping the distribution of macrophyte habitats from aerial photographs. These approaches were applied to the 64 estuaries within the Mvoti-Mzimkulu Water Management Area (WMA 11), situated in KwaZulu-Natal (KZN) on the subtropical east coast. Historically, these estuaries have supported restricted macrophyte habitats. Consequently, estuaries that presently or historically supported range limited habitats such as mangroves and swamp forest are considered important. Submerged macrophytes are scarce in KZN estuaries due to siltation and low turbidity and thus estuaries supporting this macrophyte habitat are also important. Based on available literature important estuaries were highlighted and selected for field studies. Transects spanning from the estuary water channel to the boundary of the EFZ provided a generalised distribution of KZN vegetation along an elevation gradient. The transition from estuarine to terrestrial vegetation can be used to improve the current EFZ boundaries, as estuarine area has been found to occur outside of the 5 m contour in some estuaries. Results from the desktop assessment indicated that most of the estuaries are moderately modified. There was a 50 % similarity in the macrophyte health scores determined by the desktop assessment to the 2011 National Biodiversity Assessment (NBA). Field studies mostly confirmed the desktop assessment aside from seven estuaries that had different scores. There has been a significant loss of macrophyte habitat with 100% loss of certain habitats from 9 of the 22 estuaries for which there were field assessments. Submerged macrophytes were not found at any of the estuaries that were assessed in the field. Black mangroves, Bruguiera gymnorrhiza (L.) Lam., were rediscovered at Ngane Estuary, however the few individuals could not be considered a ‘mappable’ community (i.e. <0.5 ha). Mtamvuna and Mkomazi estuaries both supported small stands of mangroves that, compared to data from 2006, appeared healthy. Macrophyte habitats and surrounding coastal forest matched the species composition described in the Vegetation Map of South Africa. The freshwater mangrove or Powder puff tree, Barringtonia racemosa (L.) Roxb, was not abundant in the estuaries. It was only found at four (Damba, Fafa, Little Amanzimtoti and Mvoti) of the estuaries that were assessed in the field. Important estuaries, from a botanical perspective, included some of the larger estuaries such as Mgeni, Durban Bay and Sipingo. Smaller, healthier estuaries that presently support mangrove and swamp forest habitat were also identified as important from a botanical perspective. Macrophyte habitats have mainly been lost due to non-flow related pressures. Sugarcane cultivation occurred within the floodplain of 25% of the estuaries. Nutrient enrichment was evident for 12.5% of the estuaries and reed encroachment was evident for 27% of estuaries for which there were field assessments. Development, aside from the N2 road bridges, was evident for 40% of the estuaries assessed in the field. Invasive plant species, including aquatic invasive plants, were present in all estuaries assessed in the field. The extent of invasive plant species was related to the degree of disturbance and surrounding land use pressures. The Mkomazi and Mvoti estuaries that were assessed at a comprehensive level, as they have earmarked for further water abstraction, had the poorest macrophyte health scores. The macrophyte health of these estuaries was much lower than previously determined by the NBA. The decline in health was attributed to the removal of macrophyte habitat for sugarcane cultivation and development as well as displacement by invasive plant species. The areas covered by the macrophyte habitats also differed from the NBA highlighting the importance of updated mapping and ground truthing. Largely differing macrophyte health scores were produced when attributes were calculated using different combinations of macrophyte habitats. Results indicate that only macrophyte habitats and no other floodplain vegetation should be included when calculating abundance. All macrophyte habitats, physical habitats and floodplain should be incorporated when calculating community composition. The minimum of these attributes is used as the overall macrophyte health score as a precautionary approach is followed. Scoring of health is subjective and the only benchmark for determining the most appropriate method is comparion with previous RDM studies. This study illustrates the need for a standardised RDM scoring method that is presented in a manner that ensures the same results irregardless of the speciliast conducting the study. The updated estuary health and importance scores for WMA 11 are necessary to inform management, particularly as few of the estuaries receive formal protection. In conclusion, this study contributed to the limited knowledge of the estuaries of WMA 11 and assisted in determining appropriate methods for assessing the health and importance of estuary macrophytes.
- Full Text:
- Date Issued: 2015
- Authors: Cowie, Meredith
- Date: 2015
- Subjects: Estuarine ecology -- South Africa , Estuaries -- South Africa -- Management , Aquatic plants -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/7930 , vital:24324
- Description: Estuaries require sufficient quantity, quality and appropriate timing of freshwater inflow, referred to as environmental flow requirements, to ensure adequate health and functioning. In South Africa the environmental flow requirements of estuaries is determined using Resource Directed Measures (RDM). The present health and importance of an estuary must be considered when determining the ecological flow required to maintain an estuary in its desired state. An Estuarine Health Index that quantifies changes in abiotic and biotic components from natural conditions to present day is used. Health of biotic components is assessed according to changes in species richness, abundance and community composition. There has, however, been debate regarding the calculation of these attributes. In particular, for macrophytes, the inclusion of all habitat within the Estuarine Functional Zone (i.e. 5 m topographical contour) would affect the health and changes over time determined in past assessments. This is due to different areas being included as different areas would be included The aim of this study was to test the validity and suggest improvements to South Africa’s RDM macrophyte health score determination. The health of macrophytes were assessed at varying levels of intensity from desktop studies to thorough field studies. Rapid field studies provided a visual estimate of macrophyte health; while the intermediate and comprehensive assessments quantified change by mapping the distribution of macrophyte habitats from aerial photographs. These approaches were applied to the 64 estuaries within the Mvoti-Mzimkulu Water Management Area (WMA 11), situated in KwaZulu-Natal (KZN) on the subtropical east coast. Historically, these estuaries have supported restricted macrophyte habitats. Consequently, estuaries that presently or historically supported range limited habitats such as mangroves and swamp forest are considered important. Submerged macrophytes are scarce in KZN estuaries due to siltation and low turbidity and thus estuaries supporting this macrophyte habitat are also important. Based on available literature important estuaries were highlighted and selected for field studies. Transects spanning from the estuary water channel to the boundary of the EFZ provided a generalised distribution of KZN vegetation along an elevation gradient. The transition from estuarine to terrestrial vegetation can be used to improve the current EFZ boundaries, as estuarine area has been found to occur outside of the 5 m contour in some estuaries. Results from the desktop assessment indicated that most of the estuaries are moderately modified. There was a 50 % similarity in the macrophyte health scores determined by the desktop assessment to the 2011 National Biodiversity Assessment (NBA). Field studies mostly confirmed the desktop assessment aside from seven estuaries that had different scores. There has been a significant loss of macrophyte habitat with 100% loss of certain habitats from 9 of the 22 estuaries for which there were field assessments. Submerged macrophytes were not found at any of the estuaries that were assessed in the field. Black mangroves, Bruguiera gymnorrhiza (L.) Lam., were rediscovered at Ngane Estuary, however the few individuals could not be considered a ‘mappable’ community (i.e. <0.5 ha). Mtamvuna and Mkomazi estuaries both supported small stands of mangroves that, compared to data from 2006, appeared healthy. Macrophyte habitats and surrounding coastal forest matched the species composition described in the Vegetation Map of South Africa. The freshwater mangrove or Powder puff tree, Barringtonia racemosa (L.) Roxb, was not abundant in the estuaries. It was only found at four (Damba, Fafa, Little Amanzimtoti and Mvoti) of the estuaries that were assessed in the field. Important estuaries, from a botanical perspective, included some of the larger estuaries such as Mgeni, Durban Bay and Sipingo. Smaller, healthier estuaries that presently support mangrove and swamp forest habitat were also identified as important from a botanical perspective. Macrophyte habitats have mainly been lost due to non-flow related pressures. Sugarcane cultivation occurred within the floodplain of 25% of the estuaries. Nutrient enrichment was evident for 12.5% of the estuaries and reed encroachment was evident for 27% of estuaries for which there were field assessments. Development, aside from the N2 road bridges, was evident for 40% of the estuaries assessed in the field. Invasive plant species, including aquatic invasive plants, were present in all estuaries assessed in the field. The extent of invasive plant species was related to the degree of disturbance and surrounding land use pressures. The Mkomazi and Mvoti estuaries that were assessed at a comprehensive level, as they have earmarked for further water abstraction, had the poorest macrophyte health scores. The macrophyte health of these estuaries was much lower than previously determined by the NBA. The decline in health was attributed to the removal of macrophyte habitat for sugarcane cultivation and development as well as displacement by invasive plant species. The areas covered by the macrophyte habitats also differed from the NBA highlighting the importance of updated mapping and ground truthing. Largely differing macrophyte health scores were produced when attributes were calculated using different combinations of macrophyte habitats. Results indicate that only macrophyte habitats and no other floodplain vegetation should be included when calculating abundance. All macrophyte habitats, physical habitats and floodplain should be incorporated when calculating community composition. The minimum of these attributes is used as the overall macrophyte health score as a precautionary approach is followed. Scoring of health is subjective and the only benchmark for determining the most appropriate method is comparion with previous RDM studies. This study illustrates the need for a standardised RDM scoring method that is presented in a manner that ensures the same results irregardless of the speciliast conducting the study. The updated estuary health and importance scores for WMA 11 are necessary to inform management, particularly as few of the estuaries receive formal protection. In conclusion, this study contributed to the limited knowledge of the estuaries of WMA 11 and assisted in determining appropriate methods for assessing the health and importance of estuary macrophytes.
- Full Text:
- Date Issued: 2015
Factors affecting the success of reseeding rehabilitation in the semi-arid Karoo, South Africa
- Authors: Matthee, Willem
- Date: 2015
- Subjects: Ecological disturbances -- South Africa -- Karoo , Arid regions -- South Africa -- Karoo , Environmental degradation -- South Africa -- Karoo
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/2889 , vital:20360
- Description: Due to overgrazing, mining and other anthropogenic disturbances, large sections of the Karoo region have been degraded, resulting in areas with low vegetation cover, where erosion rates are high and vegetation is dominated by unpalatable species. These areas have low and unpredictable rainfall, with slow to non-existent autogenic recovery, and this often forces landowners to implement reseeding rehabilitation in an attempt to increase both overall vegetation cover and the relative abundance of palatable plants. Landowners use soil preparation treatments, which include creating micro-catchments, ripping, mulching and brush packing, to supplement land rehabilitation. This study investigated the significance of initial rainfall, mean monthly rainfall, soil preparation techniques, slope, existing vegetation cover, litter, mulch and stone cover in determining the success of reseeding rehabilitation. Rainfall had the most significant influence, where long-lived shrubs established best under low initial rainfall and high mean monthly rainfall, and grasses established best after receiving high initial rainfall. Micro-catchments proved the most successful soil preparation technique for the establishment of long-lived shrubs, while ripping and mulching impacted negatively on grass establishment. A combination of mulch and micro-catchments aided Osteospermum sinuatum establishment in soils where soil shrinkage cracks occurred. Temperature influenced seed germination and drought tolerance of Lessertia annularis, Fingerhuthia africana and O. sinuatum, with higher germination success of O. sinuatum under temperatures simulating summer, and of F. africana under temperatures simulating winter. L. annularis germination had a faster growth rate and higher survival when germinated under autumn/spring temperatures. Landowners are advised to sow seeds of more than one species during rehabilitation, to include micro-catchments as soil preparation treatment, and to sow seeds during a time when rainfall is predicted to be high.
- Full Text:
- Date Issued: 2015
- Authors: Matthee, Willem
- Date: 2015
- Subjects: Ecological disturbances -- South Africa -- Karoo , Arid regions -- South Africa -- Karoo , Environmental degradation -- South Africa -- Karoo
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/2889 , vital:20360
- Description: Due to overgrazing, mining and other anthropogenic disturbances, large sections of the Karoo region have been degraded, resulting in areas with low vegetation cover, where erosion rates are high and vegetation is dominated by unpalatable species. These areas have low and unpredictable rainfall, with slow to non-existent autogenic recovery, and this often forces landowners to implement reseeding rehabilitation in an attempt to increase both overall vegetation cover and the relative abundance of palatable plants. Landowners use soil preparation treatments, which include creating micro-catchments, ripping, mulching and brush packing, to supplement land rehabilitation. This study investigated the significance of initial rainfall, mean monthly rainfall, soil preparation techniques, slope, existing vegetation cover, litter, mulch and stone cover in determining the success of reseeding rehabilitation. Rainfall had the most significant influence, where long-lived shrubs established best under low initial rainfall and high mean monthly rainfall, and grasses established best after receiving high initial rainfall. Micro-catchments proved the most successful soil preparation technique for the establishment of long-lived shrubs, while ripping and mulching impacted negatively on grass establishment. A combination of mulch and micro-catchments aided Osteospermum sinuatum establishment in soils where soil shrinkage cracks occurred. Temperature influenced seed germination and drought tolerance of Lessertia annularis, Fingerhuthia africana and O. sinuatum, with higher germination success of O. sinuatum under temperatures simulating summer, and of F. africana under temperatures simulating winter. L. annularis germination had a faster growth rate and higher survival when germinated under autumn/spring temperatures. Landowners are advised to sow seeds of more than one species during rehabilitation, to include micro-catchments as soil preparation treatment, and to sow seeds during a time when rainfall is predicted to be high.
- Full Text:
- Date Issued: 2015
Formulation and process optimisation of ethionamide 250 MGtablets using quality by design principles
- Authors: Isaacs, Nasreen
- Date: 2015
- Subjects: Pharmaceutical chemistry , Drugs -- Design , Pharmaceutical technology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3979 , vital:20497
- Description: The traditional approach of Quality by Testing (QbT) limits the assurance of product quality to in-process and post-production testing. To overcome these limitations, a more proactive and systematic means to product development and optimisation is required. Quality by Design (QbD) is an example of such an approach which focuses on understanding the product and its manufacturing process and emphasises that quality should be built into the product and not merely tested. The study aims to optimise ethionamide tablets, an immediate release oral solid dosage form using QbD.
- Full Text:
- Date Issued: 2015
Formulation and process optimisation of ethionamide 250 MGtablets using quality by design principles
- Authors: Isaacs, Nasreen
- Date: 2015
- Subjects: Pharmaceutical chemistry , Drugs -- Design , Pharmaceutical technology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3979 , vital:20497
- Description: The traditional approach of Quality by Testing (QbT) limits the assurance of product quality to in-process and post-production testing. To overcome these limitations, a more proactive and systematic means to product development and optimisation is required. Quality by Design (QbD) is an example of such an approach which focuses on understanding the product and its manufacturing process and emphasises that quality should be built into the product and not merely tested. The study aims to optimise ethionamide tablets, an immediate release oral solid dosage form using QbD.
- Full Text:
- Date Issued: 2015