Use of flow reactors for an improved synthesis of Tenofovir derivatives
- Authors: Sonti, Thembela
- Date: 2023-04
- Subjects: Antiviral agents -- South Africa , HIV infections –Treatment
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/61190 , vital:69792
- Description: Tenofovir disoproxil fumarate (TDF) is a prescription drug used to treat and prevent human immunodeficiency virus (HIV) infections. It aids in the reduction of HIV in the body, allowing the immune system to function more effectively. This reduces the risk of HIV complications, such as infections, whilst improving the quality of life. TDF belongs to the nucleotide reverse transcriptase inhibitors category of drugs. These drugs limit the ability of the reverse transcriptase, an enzyme essential for each virus to replicate itself. A reduction in the cost of HIV treatment could improve supply security and make it more accessible to patients in need. Thus, this project aims to use flow technology to achieve a guaranteed supply chain and access. In this thesis, a method for the synthesis of TDF was developed using microreactors starting from the readily available adenine. The method was adapted from the traditional batch synthesis as currently there is no literature on the synthesis of TDF in flow chemistry. The batch methods used for the synthesis of the working standards were successfully translated to flow systems. For the best results to be obtained, optimisation of the reaction temperature, reagent molar equivalents and concentration was critical. From the optimisation studies, an improvement in conversion is evident throughout all stages. The flow synthesis of the first intermediate resulted in a conversion of 100 % in N,N-dimethylformamide in 6 min residence time. This study was conducted at 200 °C, which is higher than the boiling point of the solvent with the aid of a back pressure regulator. A key reagent in the synthesis of tenofovir, namely ((tosyloxy)methyl)phosphonic acid, had to be synthesised and it was successfully produced in 96 % yield. The second intermediate was synthesised through a successful coupling reaction between (R)-9-(2-hydroxypropyl)adenine and ((tosyloxy)methyl)- phosphonic acid, which afforded a 100 % conversion of tenofovir in 20 min total residence time. The multistep synthesis of tenofovir was a success as it afforded a 65 % overall conversion. The prodrug TDF was successfully synthesised at 120 °C with a 30 min residence time, yielding a conversion of 100 %. ii | P a g e This thesis consists of four chapters. Chapter one describes the background on HIV and a literature review on HIV drugs. This chapter also demonstrates flow chemistry and microreactors in detail and different routes for the synthesis of TDF in traditional batch methods. Chapter two provides a detailed methodology for batch synthesis and flow synthesis with analytical data. 1H-NMR, 13C-NMR and FTIR spectroscopy was used to evaluate all the compounds synthesised in this chapter. Chapter three thoroughly discusses the results that were obtained graphically, showing that the flow synthesis gives better yields than batch synthesis. In chapter 4, the conclusion of the whole investigation is stated along with the future work for the preparation of TDF. , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Sonti, Thembela
- Date: 2023-04
- Subjects: Antiviral agents -- South Africa , HIV infections –Treatment
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/61190 , vital:69792
- Description: Tenofovir disoproxil fumarate (TDF) is a prescription drug used to treat and prevent human immunodeficiency virus (HIV) infections. It aids in the reduction of HIV in the body, allowing the immune system to function more effectively. This reduces the risk of HIV complications, such as infections, whilst improving the quality of life. TDF belongs to the nucleotide reverse transcriptase inhibitors category of drugs. These drugs limit the ability of the reverse transcriptase, an enzyme essential for each virus to replicate itself. A reduction in the cost of HIV treatment could improve supply security and make it more accessible to patients in need. Thus, this project aims to use flow technology to achieve a guaranteed supply chain and access. In this thesis, a method for the synthesis of TDF was developed using microreactors starting from the readily available adenine. The method was adapted from the traditional batch synthesis as currently there is no literature on the synthesis of TDF in flow chemistry. The batch methods used for the synthesis of the working standards were successfully translated to flow systems. For the best results to be obtained, optimisation of the reaction temperature, reagent molar equivalents and concentration was critical. From the optimisation studies, an improvement in conversion is evident throughout all stages. The flow synthesis of the first intermediate resulted in a conversion of 100 % in N,N-dimethylformamide in 6 min residence time. This study was conducted at 200 °C, which is higher than the boiling point of the solvent with the aid of a back pressure regulator. A key reagent in the synthesis of tenofovir, namely ((tosyloxy)methyl)phosphonic acid, had to be synthesised and it was successfully produced in 96 % yield. The second intermediate was synthesised through a successful coupling reaction between (R)-9-(2-hydroxypropyl)adenine and ((tosyloxy)methyl)- phosphonic acid, which afforded a 100 % conversion of tenofovir in 20 min total residence time. The multistep synthesis of tenofovir was a success as it afforded a 65 % overall conversion. The prodrug TDF was successfully synthesised at 120 °C with a 30 min residence time, yielding a conversion of 100 %. ii | P a g e This thesis consists of four chapters. Chapter one describes the background on HIV and a literature review on HIV drugs. This chapter also demonstrates flow chemistry and microreactors in detail and different routes for the synthesis of TDF in traditional batch methods. Chapter two provides a detailed methodology for batch synthesis and flow synthesis with analytical data. 1H-NMR, 13C-NMR and FTIR spectroscopy was used to evaluate all the compounds synthesised in this chapter. Chapter three thoroughly discusses the results that were obtained graphically, showing that the flow synthesis gives better yields than batch synthesis. In chapter 4, the conclusion of the whole investigation is stated along with the future work for the preparation of TDF. , Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Full Text:
- Date Issued: 2023-04
Validation and adaptation of statistical models based on the SAPS III score to predict in-hospital mortality in a South African ICU
- Authors: Pazi, Sisa
- Date: 2023-04
- Subjects: Police -- South Africa -- Eastern Cape , Statistics – South Africa , Mortality – South Africa
- Language: English
- Type: Doctoral's theses , text
- Identifier: http://hdl.handle.net/10948/61360 , vital:70602
- Description: In-hospital mortality prediction remains an important task in Intensive Care Units (ICUs). In particular, the estimated in-hospital mortality risk is essential to describe case-mix, for research and clinical auditing purposes. Furthermore, in settings with limited hospital resources (e.g beds) such as the South African public health care system, the estimated in-hospital mortality risk is essential for resource allocation and to inform local patient triage guidelines. Commonly used models for prediction of in-hospital mortality in ICU patients includes, but not limited to, the Simplified Acute Physiology Score III (SAPS III). The SAPS III model was developed in 2005. Notably, the SAPS III model was developed without data collected from African based hospitals. Given the general application of the SAPS III model, including benchmarking and quality control, the development of such a model based on local data is of paramount importance. To this end, this study developed a model for prediction of in-hospital mortality based on data collected in a hospital in South Africa. Logistic regression modelling was used to develop the proposed mortality risk assessment model. The results indicated that the proposed model exhibited superior discrimination and classification abilities compared to the SAPS III model. Future research includes the external validation of the proposed model in different hospitals in South Africa. , Thesis (PhD) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Pazi, Sisa
- Date: 2023-04
- Subjects: Police -- South Africa -- Eastern Cape , Statistics – South Africa , Mortality – South Africa
- Language: English
- Type: Doctoral's theses , text
- Identifier: http://hdl.handle.net/10948/61360 , vital:70602
- Description: In-hospital mortality prediction remains an important task in Intensive Care Units (ICUs). In particular, the estimated in-hospital mortality risk is essential to describe case-mix, for research and clinical auditing purposes. Furthermore, in settings with limited hospital resources (e.g beds) such as the South African public health care system, the estimated in-hospital mortality risk is essential for resource allocation and to inform local patient triage guidelines. Commonly used models for prediction of in-hospital mortality in ICU patients includes, but not limited to, the Simplified Acute Physiology Score III (SAPS III). The SAPS III model was developed in 2005. Notably, the SAPS III model was developed without data collected from African based hospitals. Given the general application of the SAPS III model, including benchmarking and quality control, the development of such a model based on local data is of paramount importance. To this end, this study developed a model for prediction of in-hospital mortality based on data collected in a hospital in South Africa. Logistic regression modelling was used to develop the proposed mortality risk assessment model. The results indicated that the proposed model exhibited superior discrimination and classification abilities compared to the SAPS III model. Future research includes the external validation of the proposed model in different hospitals in South Africa. , Thesis (PhD) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2023
- Full Text:
- Date Issued: 2023-04
Visitors' perceptions of the Outeniqua farmers' market in George
- Authors: Oberholzer, Cornelis
- Date: 2023-04
- Subjects: Farmers' Market -- George , Sustainable Development , Garden Route (South Africa)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60729 , vital:66486
- Description: Sustainability has been the focal point of sustainable tourism development in South Africa for a number of years. The ability of attractions to depict the culture of an area and provide visitors with locally produced goods that remain economically viable for vendors, remains crucial for tourism development. Hence, farmers’ markets have recently been identified as potential visitor attractions that can provide sustainable development for communities. However, farmers’ markets and their clientele who attend have not received the necessary scholarly attention particularly within the Western Cape region of South Africa. To further understand what role farmers markets can play in the tourism economy; this study sought to examine the perceptions of visitors at the Outeniqua Farmers’ Market in George. The research objectives were: • To determine the demographic profile of visitors to the Outeniqua Farmers’ Market. • To ascertain the preferences of visitors with regard to the type of products offered at the Outeniqua Farmers’ Market. • To determine whether the Outeniqua Farmers’ Market serves as an attraction to visitors. • To analyse which factors motivate visitors to attend the Outeniqua Farmers’ Market. • To examine the visitors understanding of the impact of COVID-19 pandemic on the Outeniqua Farmers’ Market. To accomplish the objectives of this study, previous research undertaken was consulted in order to better understand how farmers’ markets were performing around the world. In addition, to what methodological approaches would be most appropriate to utilise for such a study. The literature consulted revealed disparate differences in perceptions between farmers’ market visitors in Northern as opposed to Southern hemisphere countries. The effects of COVID 19 and the influence of visitor perceptions on travel behaviour were expounded on. Also, previous research revealed that a quantitative survey would be useful for the study as respondents would be accessible at the farmers’ market to solicit information since it was a confined area. v The findings revealed that visitors were mostly locals to the area, comprising primarily white middle-aged females who often attend with family groups. Furthermore, visitors thoroughly enjoyed the overall experience the market presented. It is further complemented by the availability of ready-to-eat foods as well as the provision of social interactions within a secure environment, while scrutinising the environmental friendliness and uniqueness of the products. , Thesis (MA) -- Faculty of Business and Economic Science, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Oberholzer, Cornelis
- Date: 2023-04
- Subjects: Farmers' Market -- George , Sustainable Development , Garden Route (South Africa)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60729 , vital:66486
- Description: Sustainability has been the focal point of sustainable tourism development in South Africa for a number of years. The ability of attractions to depict the culture of an area and provide visitors with locally produced goods that remain economically viable for vendors, remains crucial for tourism development. Hence, farmers’ markets have recently been identified as potential visitor attractions that can provide sustainable development for communities. However, farmers’ markets and their clientele who attend have not received the necessary scholarly attention particularly within the Western Cape region of South Africa. To further understand what role farmers markets can play in the tourism economy; this study sought to examine the perceptions of visitors at the Outeniqua Farmers’ Market in George. The research objectives were: • To determine the demographic profile of visitors to the Outeniqua Farmers’ Market. • To ascertain the preferences of visitors with regard to the type of products offered at the Outeniqua Farmers’ Market. • To determine whether the Outeniqua Farmers’ Market serves as an attraction to visitors. • To analyse which factors motivate visitors to attend the Outeniqua Farmers’ Market. • To examine the visitors understanding of the impact of COVID-19 pandemic on the Outeniqua Farmers’ Market. To accomplish the objectives of this study, previous research undertaken was consulted in order to better understand how farmers’ markets were performing around the world. In addition, to what methodological approaches would be most appropriate to utilise for such a study. The literature consulted revealed disparate differences in perceptions between farmers’ market visitors in Northern as opposed to Southern hemisphere countries. The effects of COVID 19 and the influence of visitor perceptions on travel behaviour were expounded on. Also, previous research revealed that a quantitative survey would be useful for the study as respondents would be accessible at the farmers’ market to solicit information since it was a confined area. v The findings revealed that visitors were mostly locals to the area, comprising primarily white middle-aged females who often attend with family groups. Furthermore, visitors thoroughly enjoyed the overall experience the market presented. It is further complemented by the availability of ready-to-eat foods as well as the provision of social interactions within a secure environment, while scrutinising the environmental friendliness and uniqueness of the products. , Thesis (MA) -- Faculty of Business and Economic Science, 2023
- Full Text:
- Date Issued: 2023-04
Wage differentials by sector and gender in Botswana
- Authors: Motswapong, Masedi
- Date: 2023-04
- Subjects: Wage differentials -- Botswana , Wage Decomposition
- Language: English
- Type: Doctoral's theses , text
- Identifier: http://hdl.handle.net/10948/62128 , vital:71998
- Description: The study examines wage differentials in the public and private sectors and gender wage gaps within these sectors in Botswana. Raw data from three nationally representative surveys collected is used. These surveys include the 2005/06 Labour force, the 2015/16 Multi-Topic Household and the 2019 Quarterly Multi-Topic. To address the set objectives, the study utilises the quantile regression model and decomposition methods proposed by Firpo, Fortin and Lemieux (2009) and further used the reweighted RIF-OLS OaxacaBlinder decomposition method proposed by Rios-Avila (2020). Results from three surveys demonstrate evidence of wage inequalities in Botswana. Findings revealed that the wage differential in the public and private sectors has weakened over the years, though it is still a significant concern. The public-private sector wage gap decreased from 72% in 2005/06 to 56% in 2019. However, a different trend is observed in the gender wage differentials, where the gap gradually increased over time. Gender wage gaps in the public sector were 4% in 2005/06; in 2015/16, the gap increased to 27% and 49% in 2019. On the other hand, in the private sector, the average wages were 7.34 and 6.98 for males and females in 2005/06, respectively, implying a wage gap of 35%. This trend holds for the other two samples. The gender wage gap in 2015/16 fell to 23% and increased to 28% in 2019. Results from the quantile regression estimates show that returns to education differ in both the sectoral and gender sections. Further, for males and females, returns for education tend to rise as the education level increases. Returns for education for the private sector are higher than for the public sector. For gender wage differences, education returns for females are higher than for males at all levels, supporting findings that females are more educated on average than males. For decomposition results, findings show that observed characteristics, such as education levels, negatively affect wages at the lower levels and positively at other parts of the distribution in the sectoral wage section. For the gender wage gap section, results show that workers’ characteristics had mixed contributions to the wage gap; it narrows the gap at the lower levels and widens it at higher levels of the wage distribution. Further, results suggest the presence of labour market discrimination and evidence of the “sticky-floor” viii effect in both sectors. Additionally, findings from the reweighting RIF-Oaxaca estimates show that the public-private sector wage gap takes an inverted U-shaped distribution in different levels of the wage distribution. Similarly, composition effects positively affect the gap at lower levels, whereas wage structure effects affect the wage gap at the highest distribution level. Overall, the study’s findings have some significant policy recommendations. The study has indicated that the country has no policy to reduce or eliminate wage differentials in the labour market. Hence, Botswana policymakers need to formulate policies to eliminate wage inequalities. Furthermore, it is recommended that the government should continue investing in human capital development. Education is vital in bridging the wage gap within the labour market. Additionally, there is a need to promote tolerance within society and promote ways of appreciating women’s work. It is also recommended that males be encouraged to work in jobs where women are overrepresented. The study's findings contribute to the ongoing wage inequality debate, and it is hoped that the study will benefit policymakers in Botswana. , Thesis (PhD) -- Faculty of Faculty of Business and Economic Sciences, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Motswapong, Masedi
- Date: 2023-04
- Subjects: Wage differentials -- Botswana , Wage Decomposition
- Language: English
- Type: Doctoral's theses , text
- Identifier: http://hdl.handle.net/10948/62128 , vital:71998
- Description: The study examines wage differentials in the public and private sectors and gender wage gaps within these sectors in Botswana. Raw data from three nationally representative surveys collected is used. These surveys include the 2005/06 Labour force, the 2015/16 Multi-Topic Household and the 2019 Quarterly Multi-Topic. To address the set objectives, the study utilises the quantile regression model and decomposition methods proposed by Firpo, Fortin and Lemieux (2009) and further used the reweighted RIF-OLS OaxacaBlinder decomposition method proposed by Rios-Avila (2020). Results from three surveys demonstrate evidence of wage inequalities in Botswana. Findings revealed that the wage differential in the public and private sectors has weakened over the years, though it is still a significant concern. The public-private sector wage gap decreased from 72% in 2005/06 to 56% in 2019. However, a different trend is observed in the gender wage differentials, where the gap gradually increased over time. Gender wage gaps in the public sector were 4% in 2005/06; in 2015/16, the gap increased to 27% and 49% in 2019. On the other hand, in the private sector, the average wages were 7.34 and 6.98 for males and females in 2005/06, respectively, implying a wage gap of 35%. This trend holds for the other two samples. The gender wage gap in 2015/16 fell to 23% and increased to 28% in 2019. Results from the quantile regression estimates show that returns to education differ in both the sectoral and gender sections. Further, for males and females, returns for education tend to rise as the education level increases. Returns for education for the private sector are higher than for the public sector. For gender wage differences, education returns for females are higher than for males at all levels, supporting findings that females are more educated on average than males. For decomposition results, findings show that observed characteristics, such as education levels, negatively affect wages at the lower levels and positively at other parts of the distribution in the sectoral wage section. For the gender wage gap section, results show that workers’ characteristics had mixed contributions to the wage gap; it narrows the gap at the lower levels and widens it at higher levels of the wage distribution. Further, results suggest the presence of labour market discrimination and evidence of the “sticky-floor” viii effect in both sectors. Additionally, findings from the reweighting RIF-Oaxaca estimates show that the public-private sector wage gap takes an inverted U-shaped distribution in different levels of the wage distribution. Similarly, composition effects positively affect the gap at lower levels, whereas wage structure effects affect the wage gap at the highest distribution level. Overall, the study’s findings have some significant policy recommendations. The study has indicated that the country has no policy to reduce or eliminate wage differentials in the labour market. Hence, Botswana policymakers need to formulate policies to eliminate wage inequalities. Furthermore, it is recommended that the government should continue investing in human capital development. Education is vital in bridging the wage gap within the labour market. Additionally, there is a need to promote tolerance within society and promote ways of appreciating women’s work. It is also recommended that males be encouraged to work in jobs where women are overrepresented. The study's findings contribute to the ongoing wage inequality debate, and it is hoped that the study will benefit policymakers in Botswana. , Thesis (PhD) -- Faculty of Faculty of Business and Economic Sciences, 2023
- Full Text:
- Date Issued: 2023-04
Women at work: A Muslim perspective
- Authors: Arghedien, Nuraan
- Date: 2023-04
- Subjects: Personnel management , Muslim women
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60510 , vital:65640
- Description: Globally, women, including Muslim women face challenges advancing within their careers. This is supported by research focusing on the advancement of women. However, a paucity of research exists, focusing on the factors contributing to specifically the success and advancement of Muslim women. This study therefore explored the factors impacting on the experienced career success of women, particularly Muslim women and sought to identify additional barriers faced by Muslim women in the work context. In addition, the study identified interventions that can be used to enhance their success. For the purpose of this study, experienced career success referred to the subjective view of success individuals hold of themselves in relation to their careers. The target population of this study included women and men, irrespective of religious orientation or ethnic profile who reside and work in South Africa (n=243). A self-administered online survey was developed and distributed via an electronic link to individuals within a professional network as well as on various social media platforms. In addition, the study was subjected to various statistical analyses, including an Exploratory Factor Analysis, Reliability, Multiple Correlations, and Group Comparisons using ANOVAs, Tukey HSD, Independent Sample t-tests and Cohen’s d. Moreover, the qualitative analysis included ATLAS.ti, a manual search and the use of word clouds to extract themes that were highlighted or emphasised in the empirical study. The main findings of this study suggest that there are various factors impacting on the experienced career success of Muslim women. Positive significant relationships were found between Internal Factors and Success Indicators, indicating that the higher the level of motivation, the more successful are Muslim women. In addition, Organisational Factors and Success Indicators showed a positive relationship, implying that the importance placed on career-related interventions and commitment from top management influence the success of Muslim women. A significant relationship was found between Organisational Success Strategies and Success Indicators which means that the more aware and exposed Muslim women are to the identified career-related interventions, the greater their success. x No relationships were evident between gender and success, nor were differences found in the responses of men and women, contrary to the perception that the extent to which the factors apply to men and women are different. Furthermore, a model was developed based on the theoretical underpinnings and empirical evidence to assist in understanding the factors impacting on the experienced success of Muslim women. Additionally, strategies in the form of recommendations were advised with the aim of enhancing the experienced success of Muslim women. This study contributes to the body of knowledge relating to the advancement of Muslim women in the South African context. , Thesis (PhD) -- Faculty of Business and Economic Science, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Arghedien, Nuraan
- Date: 2023-04
- Subjects: Personnel management , Muslim women
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60510 , vital:65640
- Description: Globally, women, including Muslim women face challenges advancing within their careers. This is supported by research focusing on the advancement of women. However, a paucity of research exists, focusing on the factors contributing to specifically the success and advancement of Muslim women. This study therefore explored the factors impacting on the experienced career success of women, particularly Muslim women and sought to identify additional barriers faced by Muslim women in the work context. In addition, the study identified interventions that can be used to enhance their success. For the purpose of this study, experienced career success referred to the subjective view of success individuals hold of themselves in relation to their careers. The target population of this study included women and men, irrespective of religious orientation or ethnic profile who reside and work in South Africa (n=243). A self-administered online survey was developed and distributed via an electronic link to individuals within a professional network as well as on various social media platforms. In addition, the study was subjected to various statistical analyses, including an Exploratory Factor Analysis, Reliability, Multiple Correlations, and Group Comparisons using ANOVAs, Tukey HSD, Independent Sample t-tests and Cohen’s d. Moreover, the qualitative analysis included ATLAS.ti, a manual search and the use of word clouds to extract themes that were highlighted or emphasised in the empirical study. The main findings of this study suggest that there are various factors impacting on the experienced career success of Muslim women. Positive significant relationships were found between Internal Factors and Success Indicators, indicating that the higher the level of motivation, the more successful are Muslim women. In addition, Organisational Factors and Success Indicators showed a positive relationship, implying that the importance placed on career-related interventions and commitment from top management influence the success of Muslim women. A significant relationship was found between Organisational Success Strategies and Success Indicators which means that the more aware and exposed Muslim women are to the identified career-related interventions, the greater their success. x No relationships were evident between gender and success, nor were differences found in the responses of men and women, contrary to the perception that the extent to which the factors apply to men and women are different. Furthermore, a model was developed based on the theoretical underpinnings and empirical evidence to assist in understanding the factors impacting on the experienced success of Muslim women. Additionally, strategies in the form of recommendations were advised with the aim of enhancing the experienced success of Muslim women. This study contributes to the body of knowledge relating to the advancement of Muslim women in the South African context. , Thesis (PhD) -- Faculty of Business and Economic Science, 2023
- Full Text:
- Date Issued: 2023-04
Workplace Discrimination Based on Pregnancy
- Authors: Pathiswa, Mbongwana
- Date: 2023-04
- Subjects: Employment discrimination , Pregnancy
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60797 , vital:67819
- Description: In the past, South Africa was marked by widespread discriminatory practices, many of which still exist to date. This study investigates the persistent discrimination against pregnant women. The study revealed that in South Africa, pregnant women continue to face discrimination in employment and are often denied the right to go on maternity leave, nursing or breastfeeding and childcare facilities. Presently, pregnancy is listed as a prohibited ground for discrimination in the South African Constitution as well as many ILO Conventions. Similarly, the South African labour law framework which gives effect to the Constitution provides for the protection of women and pregnant workers. This protection comes in the form of measures that proscribe dismissal and discrimination based on. Despite these legislation, this study finds that the less favorable treatment of women and pregnant workers in South African workplaces has become increasingly common, and this has turned into a contentious subject. This study focused on labour legislation that has been developed to safeguard pregnant women in the workplace in light of applicable constitutional protections. Notwithstanding these legislative protections for pregnant women in the workplace, the analysis shows that many pregnant women continue to be treated unfairly due to their pregnancies or for reasons linked to their pregnancies. Consequently, there has been a regression in the actual execution of laws and regulations protecting pregnant workers. The study highlights the need to establish mechanisms to ensure that legislation protecting pregnant workers in the workplace achieves its intended purpose and is implemented properly. Consequently, this study presents pertinent suggestions about the implementation of labour legislation so that the employment rights of women and pregnant workers are adequately safeguarded. , Thesis (LLB) -- Faculty of Law, School of Mercantile Law, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Pathiswa, Mbongwana
- Date: 2023-04
- Subjects: Employment discrimination , Pregnancy
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60797 , vital:67819
- Description: In the past, South Africa was marked by widespread discriminatory practices, many of which still exist to date. This study investigates the persistent discrimination against pregnant women. The study revealed that in South Africa, pregnant women continue to face discrimination in employment and are often denied the right to go on maternity leave, nursing or breastfeeding and childcare facilities. Presently, pregnancy is listed as a prohibited ground for discrimination in the South African Constitution as well as many ILO Conventions. Similarly, the South African labour law framework which gives effect to the Constitution provides for the protection of women and pregnant workers. This protection comes in the form of measures that proscribe dismissal and discrimination based on. Despite these legislation, this study finds that the less favorable treatment of women and pregnant workers in South African workplaces has become increasingly common, and this has turned into a contentious subject. This study focused on labour legislation that has been developed to safeguard pregnant women in the workplace in light of applicable constitutional protections. Notwithstanding these legislative protections for pregnant women in the workplace, the analysis shows that many pregnant women continue to be treated unfairly due to their pregnancies or for reasons linked to their pregnancies. Consequently, there has been a regression in the actual execution of laws and regulations protecting pregnant workers. The study highlights the need to establish mechanisms to ensure that legislation protecting pregnant workers in the workplace achieves its intended purpose and is implemented properly. Consequently, this study presents pertinent suggestions about the implementation of labour legislation so that the employment rights of women and pregnant workers are adequately safeguarded. , Thesis (LLB) -- Faculty of Law, School of Mercantile Law, 2023
- Full Text:
- Date Issued: 2023-04
A best practice model for international Financial feasibility in property Development
- Authors: Adendorff, Ryan Gregg
- Date: 2022-12
- Subjects: Built environment , Real estate development
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59348 , vital:62073
- Description: Property development is a sector which provides economic benefits to many countries worldwide. Such economic benefits are employment provision and GDP contribution to the economy. Interestingly, financial feasibility is one of the tools that can be used to ensure property development projects’ success. It has been therefore recognised that some of the property development entrepreneurs lack financial feasibility know-how which could position their property development businesses into a competitive edge and sustainability in this continuous fluctuating property market. Hence, the aim of this study was to examine the key factors and variable that drive financial feasibility in property development and generate a financial feasibility model which can be used by property development entrepreneurs to analyse the financial feasibility of property development projects. Based on the aim of this study, an extended review of the literature relating to property business, property development, demand planning and risk management within the built environment discipline was conducted in identifying factors affecting the perceived success of financial feasibility for property development projects internationally. The research reviewed literature in the property development industry by identifying the variables for profitability, outside advice, trend analysis and real estate strategies. The research methodology approach that was used for this study, a qualitative explanatory multi-case study where embedded unit of analysis and valuable insight was provided for the success of financial feasibility in property development internationally. Semistructured interviews were conducted with various industry experts as indicated below: • Project Manager at Property Company; • Project Manager at developer; • Development Manager; • Owner of Property Group; • Part time lecturer at NMU Built Environment; • Development consulting company CEO; vi • Trustgro Developments (Pty) Ltd: Managing Director; • Tswaranang Consulting – Managing Director; • Capelo Development Company (Property Development) Director; and • NMBM - Senior Director: Land Planning and Management. The interview questions and primary and secondary propositions were defined together with the validity and reliability of the research. The purpose of the qualitative research was to unravel key factors that determine the perceived success of international financial feasibility of property development projects. Replication logic was used to generalise the results and the findings of this research effort suggested that the following variables emerging from qualitative themes, positively influences the perceived success of the financial feasibility in property development projects: profitability, risk management, outside advice, trend analysis, property cycles and demand planning. The implication arising from this study is that the perceived success of international financial feasibility in property development projects has the following positive influencing factors: profitability, risk management, outside (specialist) advice, trends analysis, property cycles and demand planning which must be considered by property developers and investors to ensure the success of their property development interventions. The curriculum of property development and real estate management practice should equally take into account the afore-mentioned factors. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Adendorff, Ryan Gregg
- Date: 2022-12
- Subjects: Built environment , Real estate development
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59348 , vital:62073
- Description: Property development is a sector which provides economic benefits to many countries worldwide. Such economic benefits are employment provision and GDP contribution to the economy. Interestingly, financial feasibility is one of the tools that can be used to ensure property development projects’ success. It has been therefore recognised that some of the property development entrepreneurs lack financial feasibility know-how which could position their property development businesses into a competitive edge and sustainability in this continuous fluctuating property market. Hence, the aim of this study was to examine the key factors and variable that drive financial feasibility in property development and generate a financial feasibility model which can be used by property development entrepreneurs to analyse the financial feasibility of property development projects. Based on the aim of this study, an extended review of the literature relating to property business, property development, demand planning and risk management within the built environment discipline was conducted in identifying factors affecting the perceived success of financial feasibility for property development projects internationally. The research reviewed literature in the property development industry by identifying the variables for profitability, outside advice, trend analysis and real estate strategies. The research methodology approach that was used for this study, a qualitative explanatory multi-case study where embedded unit of analysis and valuable insight was provided for the success of financial feasibility in property development internationally. Semistructured interviews were conducted with various industry experts as indicated below: • Project Manager at Property Company; • Project Manager at developer; • Development Manager; • Owner of Property Group; • Part time lecturer at NMU Built Environment; • Development consulting company CEO; vi • Trustgro Developments (Pty) Ltd: Managing Director; • Tswaranang Consulting – Managing Director; • Capelo Development Company (Property Development) Director; and • NMBM - Senior Director: Land Planning and Management. The interview questions and primary and secondary propositions were defined together with the validity and reliability of the research. The purpose of the qualitative research was to unravel key factors that determine the perceived success of international financial feasibility of property development projects. Replication logic was used to generalise the results and the findings of this research effort suggested that the following variables emerging from qualitative themes, positively influences the perceived success of the financial feasibility in property development projects: profitability, risk management, outside advice, trend analysis, property cycles and demand planning. The implication arising from this study is that the perceived success of international financial feasibility in property development projects has the following positive influencing factors: profitability, risk management, outside (specialist) advice, trends analysis, property cycles and demand planning which must be considered by property developers and investors to ensure the success of their property development interventions. The curriculum of property development and real estate management practice should equally take into account the afore-mentioned factors. , Thesis (MA) -- Faculty of Engineering, the Built Environment, and Technology, 2022
- Full Text:
- Date Issued: 2022-12
A co-constructed understanding of teachers’ experiences in a community of practice within a community-university engagement project
- Authors: Newton, Tracey
- Date: 2022-12
- Subjects: To be assigned
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60559 , vital:65839
- Description: Abstract. , Thesis (MSc) -- Faculty of Education, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Newton, Tracey
- Date: 2022-12
- Subjects: To be assigned
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60559 , vital:65839
- Description: Abstract. , Thesis (MSc) -- Faculty of Education, 2022
- Full Text:
- Date Issued: 2022-12
A comparative study of multiculturalism in South Africa and Canada: evaluating successes and failures.
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Anele Mngadi
- Date: 2022-12
- Subjects: Race discrimination -- Economic aspects – South Africa , Social justice -- South Africa , Xenophobia
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59435 , vital:62114
- Description: The purpose of this study was to evaluate the successes and failures of multiculturalism in South Africa and Canada through the lens of critical multiculturalism as its theoretical frame. As Canada is widely-acknowledged as having one of the best multiculturalism policy and implementation programmes in the world, this study aimed to draw lessons from the Canadian model of multiculturalism in order to make recommendations to improve multicultural practices in South Africa. It is worth noting that multiculturalism in Canada is not perfect as government still struggles to implement inclusive and reconciliatory programmes for the previously colonised Indigenous communities. This study used a qualitative thematic analysis to enable a comparison of multiculturalism in these two countries. The findings of this study suggest that having a comprehensive multiculturalism policy is fundamental to ensure that aspirations of a socially cohesive multiculturalism are not merely philosophical, but are formulated into government policies, with guidelines for implementation through the guidance of critical multiculturalism theory. The findings of this study also suggest that the persistent racialised socio-economic inequalities in South Africa continue to undermine multiculturalism and nation-building efforts. , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
A model to predict the development of preeclampsia in South African women
- Authors: Smith, Nathan
- Date: 2022-12
- Subjects: Medical instruments and apparatus -- Design and construction , Hypertension in pregnancy -- measurements-- South Africa , Fetus -- Physiology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59980 , vital:62724
- Description: Preeclampsia is the new onset of hypertension and is one of the leading causes of maternal mortality in South Africa and the world. Preeclampsia is usually diagnosed after 20 weeks’ gestation. Due to South Africa’s poor level of antenatal care, the prediction of pregnant women at risk of developing preeclampsia can be an essential component of improving the level of antenatal. This study used an antenatal care dataset from a South African obstetrician. A review of the literature and existing systems was conducted to identify the eight risk factors. These risk factors are systolic blood pressure, diastolic blood pressure, maternal age, body mass index, diabetes status, hypertension history, nulliparity, and maternal disease. This study used antenatal care datasets from a South African obstetrician. Two models were developed that could accurately predict the development of preeclampsia, one before 16 weeks’ gestation and the other within three check-ups. The model was evaluated using five evaluation metrics: classification accuracy, area under the curve, precision, recall and F-Score. The results of this study show a promising future for the use of machine learning models in health care. To the researcher’s knowledge, this model is the first machine learning model for predicting preeclampsia using a South African dataset. Future work will revolve around validating the model on data collected from field studies in hospitals and clinics around South Africa , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Smith, Nathan
- Date: 2022-12
- Subjects: Medical instruments and apparatus -- Design and construction , Hypertension in pregnancy -- measurements-- South Africa , Fetus -- Physiology
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59980 , vital:62724
- Description: Preeclampsia is the new onset of hypertension and is one of the leading causes of maternal mortality in South Africa and the world. Preeclampsia is usually diagnosed after 20 weeks’ gestation. Due to South Africa’s poor level of antenatal care, the prediction of pregnant women at risk of developing preeclampsia can be an essential component of improving the level of antenatal. This study used an antenatal care dataset from a South African obstetrician. A review of the literature and existing systems was conducted to identify the eight risk factors. These risk factors are systolic blood pressure, diastolic blood pressure, maternal age, body mass index, diabetes status, hypertension history, nulliparity, and maternal disease. This study used antenatal care datasets from a South African obstetrician. Two models were developed that could accurately predict the development of preeclampsia, one before 16 weeks’ gestation and the other within three check-ups. The model was evaluated using five evaluation metrics: classification accuracy, area under the curve, precision, recall and F-Score. The results of this study show a promising future for the use of machine learning models in health care. To the researcher’s knowledge, this model is the first machine learning model for predicting preeclampsia using a South African dataset. Future work will revolve around validating the model on data collected from field studies in hospitals and clinics around South Africa , Thesis (MSc) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
A political economy of transformation in Nelson Mandela University Bay: a critical analysis of the construction sector 2005
- Authors: Mtimka, Ongama
- Date: 2022-12
- Subjects: Transformation -- Port Elizabeth -- Nelson Mandela Bay , Construction industry -- South Africa –Port Elizabeth , Politics -- Nelson Mandela Bay
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/59392 , vital:62077
- Description: In democracies and purportedly free market economies, questions of “who gets what, when, and how” ought to be resolved mainly through free competition, where those with the competitive advantage on merit are guaranteed to succeed. If it is political parties, they only have to compete well and fairly to win elections. If it is businesses, they ought to have the best value and price and they win customers. However, there are institutions which regulate this competition and political economic behaviour. Interest groups such as business chambers, industry and professional associations, as well as various structures of representation engage in the political economic space to sway the distribution outcomes from these “institutions” in the favour of their members. To do so, at times they use methods that affirm the principles and spirit of free competition and at other times, they do not. This thesis reviews the political economy of transformation within the construction sector in Nelson Mandela Bay to further advance knowledge within the subfield of political economy in South Africa. By looking at a specific economic sector, the study adds an important element to the sub-discipline, a nuance to the debates about the role of the state in the economy or macroeconomic policy and the much studied mining-energy complex. The study focuses on the role of small business forums created mostly by newcomers within the construction sector in the city and the methods they used to increase the share of their members in construction sector revenues. Their methods were unconventional and earned them the unfavourable term of ‘the construction mafia’. Through a grounded theoretical research process, this study details the story of the rise and fall of forums and dissects it in line with ongoing debates within political economy and related disciplines, particularly about the nexus between politics and business as well as the role of interest groups in pluralist political systems. Among other things, the study finds that the forums did not see the construction industry as a free market and did not take principles of competition in the sector as a given. As such, they sought to make and remake institutions of the sector in ways that could increase their share of revenues. In similar fashion to the roles of iinjoli nosokhaya in traditional isiXhosa ceremonies, they accorded to themselves the right to distribute benefits to their members contrary to legal and general market prescripts. , Thesis (PhD) -- Faculty of Humanities, School of Government and Social sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mtimka, Ongama
- Date: 2022-12
- Subjects: Transformation -- Port Elizabeth -- Nelson Mandela Bay , Construction industry -- South Africa –Port Elizabeth , Politics -- Nelson Mandela Bay
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/59392 , vital:62077
- Description: In democracies and purportedly free market economies, questions of “who gets what, when, and how” ought to be resolved mainly through free competition, where those with the competitive advantage on merit are guaranteed to succeed. If it is political parties, they only have to compete well and fairly to win elections. If it is businesses, they ought to have the best value and price and they win customers. However, there are institutions which regulate this competition and political economic behaviour. Interest groups such as business chambers, industry and professional associations, as well as various structures of representation engage in the political economic space to sway the distribution outcomes from these “institutions” in the favour of their members. To do so, at times they use methods that affirm the principles and spirit of free competition and at other times, they do not. This thesis reviews the political economy of transformation within the construction sector in Nelson Mandela Bay to further advance knowledge within the subfield of political economy in South Africa. By looking at a specific economic sector, the study adds an important element to the sub-discipline, a nuance to the debates about the role of the state in the economy or macroeconomic policy and the much studied mining-energy complex. The study focuses on the role of small business forums created mostly by newcomers within the construction sector in the city and the methods they used to increase the share of their members in construction sector revenues. Their methods were unconventional and earned them the unfavourable term of ‘the construction mafia’. Through a grounded theoretical research process, this study details the story of the rise and fall of forums and dissects it in line with ongoing debates within political economy and related disciplines, particularly about the nexus between politics and business as well as the role of interest groups in pluralist political systems. Among other things, the study finds that the forums did not see the construction industry as a free market and did not take principles of competition in the sector as a given. As such, they sought to make and remake institutions of the sector in ways that could increase their share of revenues. In similar fashion to the roles of iinjoli nosokhaya in traditional isiXhosa ceremonies, they accorded to themselves the right to distribute benefits to their members contrary to legal and general market prescripts. , Thesis (PhD) -- Faculty of Humanities, School of Government and Social sciences, 2022
- Full Text:
- Date Issued: 2022-12
A social media analytics framework for decision-making in citizen relationship management
- Authors: Yakobi, Khulekani
- Date: 2022-12
- Subjects: Social Media Analytics -- South Africa , Decision making --Mathematical models , Service delivery
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/60048 , vital:62815
- Description: Globally social media has shown unprecedented levels of adoption and Social Media Analytics (SMA) is a rapidly growing topic. For governments, SMA holds the promise of providing tools and frameworks to collect, monitor, analyse and visualise social media data, usually driven by specific requirements from a target application. However, social media data is noisy and unstructured, and organisations struggle to extract knowledge from this data, and convert it into actual intelligence. This study argues that SMA can support intelligent decision-making for Citizen Relationship Management (CzRM). CzRM is a growing effort of governments around the world to strive to respond rapidly to their citizens by fostering a closer relationship thereby creating more effective and efficient service delivery. However, there is a little evidence in literature on empirical studies of any existing decision-making framework for CzRM and SMA adoption. In particular, there is a gap with regards incorporating SMA into decision-making for CzRM of governments, particularly in developing countries like South Africa. The aim of this study was to develop a framework that provides guidelines, including methods and tools, incorporating SMA into decision-making for CzRM in the Gauteng Provincial Government (GPG) and the Free State Provincial Government (FSPG) of South Africa. A Systematic Literature Review (SLR) and conceptual analysis method was conducted to design the Social Media Analytics Framework for Decision-making in the context of CzRM (the SMAF). The findings from the literature review revealed several benefits and challenges with SMA, in particular the shortage of skills, guidelines, methods and tools for SMA. These challenges were used to draft guidelines that were included in the framework, which consists of five components that can be used to derive intelligent information from SMA. The pragmatic philosophy and a case study design was used to generate an in-depth, multifaceted understanding of the underlying problems in the case of the GPG and the FSPG. The German North-West Metropolitan region was used as a third case study to provide a more global perspective and a case of a developed country in terms of Gross Domestic Product. The scope of the study was limited to social media posts by provincial citizens related to CzRM and service delivery. Both formative and summative evaluations of the proposed theoretical framework were conducted. The formative evaluation was conducted v | Page as an Expert Review to receive feedback of the framework from the experts in the field of Computer Science and Information Systems. The findings validated the framework and some minor improvements were made based on the experts’ recommendations. Focus Group Discussions (FGDs) with participants from government managers and decision makers in the three cases were conducted. Case documents for the three cases were collected and reviewed. All collected data was analysed using the Qualitative Content Analysis (QCA) method and common categories and themes were identified. Summative evaluations were conducted in the form of a Field Study, which consisted of an analysis of Twitter data from the three cases, and a closing FGD with Business Intelligence (BI) experts at the primary case of the e-Government department of the GPG. The findings revealed that SMA has been adopted in all three cases; however, while their strategies are comprehensive their implementations are very much in their early stages. The findings also highlighted the status of SMA in government and some potential gaps and areas for implementing the framework. , Thesis (PhD) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Yakobi, Khulekani
- Date: 2022-12
- Subjects: Social Media Analytics -- South Africa , Decision making --Mathematical models , Service delivery
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/60048 , vital:62815
- Description: Globally social media has shown unprecedented levels of adoption and Social Media Analytics (SMA) is a rapidly growing topic. For governments, SMA holds the promise of providing tools and frameworks to collect, monitor, analyse and visualise social media data, usually driven by specific requirements from a target application. However, social media data is noisy and unstructured, and organisations struggle to extract knowledge from this data, and convert it into actual intelligence. This study argues that SMA can support intelligent decision-making for Citizen Relationship Management (CzRM). CzRM is a growing effort of governments around the world to strive to respond rapidly to their citizens by fostering a closer relationship thereby creating more effective and efficient service delivery. However, there is a little evidence in literature on empirical studies of any existing decision-making framework for CzRM and SMA adoption. In particular, there is a gap with regards incorporating SMA into decision-making for CzRM of governments, particularly in developing countries like South Africa. The aim of this study was to develop a framework that provides guidelines, including methods and tools, incorporating SMA into decision-making for CzRM in the Gauteng Provincial Government (GPG) and the Free State Provincial Government (FSPG) of South Africa. A Systematic Literature Review (SLR) and conceptual analysis method was conducted to design the Social Media Analytics Framework for Decision-making in the context of CzRM (the SMAF). The findings from the literature review revealed several benefits and challenges with SMA, in particular the shortage of skills, guidelines, methods and tools for SMA. These challenges were used to draft guidelines that were included in the framework, which consists of five components that can be used to derive intelligent information from SMA. The pragmatic philosophy and a case study design was used to generate an in-depth, multifaceted understanding of the underlying problems in the case of the GPG and the FSPG. The German North-West Metropolitan region was used as a third case study to provide a more global perspective and a case of a developed country in terms of Gross Domestic Product. The scope of the study was limited to social media posts by provincial citizens related to CzRM and service delivery. Both formative and summative evaluations of the proposed theoretical framework were conducted. The formative evaluation was conducted v | Page as an Expert Review to receive feedback of the framework from the experts in the field of Computer Science and Information Systems. The findings validated the framework and some minor improvements were made based on the experts’ recommendations. Focus Group Discussions (FGDs) with participants from government managers and decision makers in the three cases were conducted. Case documents for the three cases were collected and reviewed. All collected data was analysed using the Qualitative Content Analysis (QCA) method and common categories and themes were identified. Summative evaluations were conducted in the form of a Field Study, which consisted of an analysis of Twitter data from the three cases, and a closing FGD with Business Intelligence (BI) experts at the primary case of the e-Government department of the GPG. The findings revealed that SMA has been adopted in all three cases; however, while their strategies are comprehensive their implementations are very much in their early stages. The findings also highlighted the status of SMA in government and some potential gaps and areas for implementing the framework. , Thesis (PhD) -- Faculty of Science, School of Computer Science, Mathematics, Physics and Statistics, 2022
- Full Text:
- Date Issued: 2022-12
A stakeholder framework for sustainable Supply chain management in the Zimbabwean food industry
- Authors: Munuhwa,Shakerod
- Date: 2022-12
- Subjects: Stakeholder , Supply chain management , Food industry -- Zimbabwe
- Language: English
- Type: Doctoral's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60315 , vital:64397
- Description: The food supply chain plays an important role in the Zimbabwean food industry. More so sustainable food supply chain management (SFSCM) is a subject that has not received much attention, and yet it is so pertinent in determining food security in Zimbabwe. Zimbabwe has faced episodes of inadequate grain/cereal food reserves, hence the urgent need to develop a stakeholder framework for sustainable food supply chain management. The main objective of the study was to develop a stakeholder framework for SFSCM in the food industry. To accomplish the main objective, the research intended to achieve the following sub-objectives, namely to: establish the drivers for SFSCM; identify SFSCM practices within the food industry; identify the key stakeholders’ dynamic capabilities (SDCs) in the food industry and identify challenges faced by stakeholders in implementing SFSCM. The study also sought to establish the influence of: SFSCM drivers on implementing SFSCM practices; SFSCM drivers on SDCs; SFSCM practices on SDCs; SFSCM practices on SFSCM performance; SFSCM drivers on SFSCM performance; and SDCs on SFSCM performance. This study further sought to assess the mediation effect of: SFSCM drivers on the relationship between SFSCM practices and SDCs; SDCs on the relationship between SFSCM practices and SFSCM performance; SFSCM drivers on the relationship between SDCs and SFSCM performance and finally to assess the mediation effect of SDCs on the relationship between SFSCM drivers and SFSCM performance. This study employed a pragmatic philosophy that allowed for the collection of primary data using a fixed concurrent mixed methods (qualitative and quantitative) approach. The data analysis for this research included qualitative data from 22 participants and quantitative data from 292 respondents, all of whom were recruited through nine gatekeepers (Grain Marketing Board, Consumer Council of Zimbabwe, Food and Nutrition Association of Zimbabwe, Grain Millers Association of Zimbabwe, Ministry of Lands, Agriculture, Water and Rural Resettlement, Chartered Institute of Purchasing and Supply, Food and Agriculture Organization in Zimbabwe, Confederation of Zimbabwe Retailers and Zimbabwe National Chamber of Commerce). A thematic analysis was used to analyse qualitative data. For the quantitative data, the Statistical Package for the Social Sciences (SPSS) version 27 package was used to perform descriptive analysis, and principal component analysis for factor reduction and dimensional groups. Analysis of a Moment Structures (AMOS 26) program was used viii to perform structural equation modelling (SEM) for model fit evaluations and hypothesis tests. The mixed methods approach (both qualitative and quantitative) results identified regulatory pressure, market pressure, societal pressure, availability of resources, organisational culture and corporate objectives as some of the key SFSCM drivers. Additionally, the results identified the following as the key SFSCM practices: waste management, carbon emission reduction, logistics optimisation, water conservation, energy conservation, cost reduction and price efficiency, employment of competent people, cultivation of profitable grain crops, corporate social responsibility, fair distribution of food, human development on nutritious food consumption, food donations and continuously conducting consumer tastes surveys. Further, the mixed methods approach results cited the following key SDCs: sensing, seizing, reconfiguration, reflexive control, partner development, co-evolving and supply chain integration capabilities. Major challenges faced by stakeholders when implementing SFSCM were also identified and these involved lack of resources, lack of top management commitment, poor information sharing, lack of mutual trust amongst stakeholders, unmotivated employees, lack of government support, ever-changing food regulations, poor customer demand for sustainable and healthy foods, corruption and economic hardship challenges. The study also sought to establish relationships amongst variables. The mixed methods approach results revealed that SFSCM drivers have a positive influence on SFSCM practices, SDCs and SFSCM performance. The results also report a positive and significant influence of SFSCM practices on SDCs. The results further indicate that SDCs have a positive and significant influence on SFSCM performance. Although the qualitative findings reported a positive influence of SFSCM practices on SFSCM performance, the quantitative results from the SEM path analysis reported a very weak positive and insignificant influence of SFSCM practices on SFSCM performance. Mediation analysis was also performed using the quantitative data analysis only, and the results revealed that SFSCM drivers have significant partial mediation effect on the relationship between SFSCM practices and SDCs. The results also report that SDCs have a significant full mediation effect on the relationship between SFSCM practices and SFSCM performance. SFSCM drivers were found to have a significant ix partial mediation influence on the relationship between SDCs and SFSCM performance. Lastly, SDCs have a significant partial mediation effect on the relationship between SFSCM drivers and SFSCM performance. Based on the empirical results, conclusions were drawn, and recommendations were made. The research proposes a new stakeholder framework for SFSCM in the food industry. The study recommends that stakeholders consider providing training and education to all employees about the critical role of SFSCM in ensuring Zimbabwe's food security. Additionally, policymakers are urged to implement supply chain anticorruption and fair-trading policies in order to boost SFSCM performance. Stakeholder institutions are also urged to reward internal stakeholders who perform exceptionally well in terms of SFSCM in order to positively motivate all staff, and ultimately improve SFSCM. , Thesis (PHD) -- Faculty of Business and Economic Sciences, Business School, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Munuhwa,Shakerod
- Date: 2022-12
- Subjects: Stakeholder , Supply chain management , Food industry -- Zimbabwe
- Language: English
- Type: Doctoral's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60315 , vital:64397
- Description: The food supply chain plays an important role in the Zimbabwean food industry. More so sustainable food supply chain management (SFSCM) is a subject that has not received much attention, and yet it is so pertinent in determining food security in Zimbabwe. Zimbabwe has faced episodes of inadequate grain/cereal food reserves, hence the urgent need to develop a stakeholder framework for sustainable food supply chain management. The main objective of the study was to develop a stakeholder framework for SFSCM in the food industry. To accomplish the main objective, the research intended to achieve the following sub-objectives, namely to: establish the drivers for SFSCM; identify SFSCM practices within the food industry; identify the key stakeholders’ dynamic capabilities (SDCs) in the food industry and identify challenges faced by stakeholders in implementing SFSCM. The study also sought to establish the influence of: SFSCM drivers on implementing SFSCM practices; SFSCM drivers on SDCs; SFSCM practices on SDCs; SFSCM practices on SFSCM performance; SFSCM drivers on SFSCM performance; and SDCs on SFSCM performance. This study further sought to assess the mediation effect of: SFSCM drivers on the relationship between SFSCM practices and SDCs; SDCs on the relationship between SFSCM practices and SFSCM performance; SFSCM drivers on the relationship between SDCs and SFSCM performance and finally to assess the mediation effect of SDCs on the relationship between SFSCM drivers and SFSCM performance. This study employed a pragmatic philosophy that allowed for the collection of primary data using a fixed concurrent mixed methods (qualitative and quantitative) approach. The data analysis for this research included qualitative data from 22 participants and quantitative data from 292 respondents, all of whom were recruited through nine gatekeepers (Grain Marketing Board, Consumer Council of Zimbabwe, Food and Nutrition Association of Zimbabwe, Grain Millers Association of Zimbabwe, Ministry of Lands, Agriculture, Water and Rural Resettlement, Chartered Institute of Purchasing and Supply, Food and Agriculture Organization in Zimbabwe, Confederation of Zimbabwe Retailers and Zimbabwe National Chamber of Commerce). A thematic analysis was used to analyse qualitative data. For the quantitative data, the Statistical Package for the Social Sciences (SPSS) version 27 package was used to perform descriptive analysis, and principal component analysis for factor reduction and dimensional groups. Analysis of a Moment Structures (AMOS 26) program was used viii to perform structural equation modelling (SEM) for model fit evaluations and hypothesis tests. The mixed methods approach (both qualitative and quantitative) results identified regulatory pressure, market pressure, societal pressure, availability of resources, organisational culture and corporate objectives as some of the key SFSCM drivers. Additionally, the results identified the following as the key SFSCM practices: waste management, carbon emission reduction, logistics optimisation, water conservation, energy conservation, cost reduction and price efficiency, employment of competent people, cultivation of profitable grain crops, corporate social responsibility, fair distribution of food, human development on nutritious food consumption, food donations and continuously conducting consumer tastes surveys. Further, the mixed methods approach results cited the following key SDCs: sensing, seizing, reconfiguration, reflexive control, partner development, co-evolving and supply chain integration capabilities. Major challenges faced by stakeholders when implementing SFSCM were also identified and these involved lack of resources, lack of top management commitment, poor information sharing, lack of mutual trust amongst stakeholders, unmotivated employees, lack of government support, ever-changing food regulations, poor customer demand for sustainable and healthy foods, corruption and economic hardship challenges. The study also sought to establish relationships amongst variables. The mixed methods approach results revealed that SFSCM drivers have a positive influence on SFSCM practices, SDCs and SFSCM performance. The results also report a positive and significant influence of SFSCM practices on SDCs. The results further indicate that SDCs have a positive and significant influence on SFSCM performance. Although the qualitative findings reported a positive influence of SFSCM practices on SFSCM performance, the quantitative results from the SEM path analysis reported a very weak positive and insignificant influence of SFSCM practices on SFSCM performance. Mediation analysis was also performed using the quantitative data analysis only, and the results revealed that SFSCM drivers have significant partial mediation effect on the relationship between SFSCM practices and SDCs. The results also report that SDCs have a significant full mediation effect on the relationship between SFSCM practices and SFSCM performance. SFSCM drivers were found to have a significant ix partial mediation influence on the relationship between SDCs and SFSCM performance. Lastly, SDCs have a significant partial mediation effect on the relationship between SFSCM drivers and SFSCM performance. Based on the empirical results, conclusions were drawn, and recommendations were made. The research proposes a new stakeholder framework for SFSCM in the food industry. The study recommends that stakeholders consider providing training and education to all employees about the critical role of SFSCM in ensuring Zimbabwe's food security. Additionally, policymakers are urged to implement supply chain anticorruption and fair-trading policies in order to boost SFSCM performance. Stakeholder institutions are also urged to reward internal stakeholders who perform exceptionally well in terms of SFSCM in order to positively motivate all staff, and ultimately improve SFSCM. , Thesis (PHD) -- Faculty of Business and Economic Sciences, Business School, 2022
- Full Text:
- Date Issued: 2022-12
Amendments to the labour relations act to curb violent and intractable strikes
- Authors: Mafa, Bonolo
- Date: 2022-12
- Subjects: labour union , Violence , Labour law
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59841 , vital:62447
- Description: Since the dawn of South Africa’s constitutional democracy, the right to strike has been protected. It is perceived to be fundamental to orderly collective bargaining and the courts have stressed the need to ensure that it is not unjustifiably limited or undermined. In the collective bargaining process, employers and employees have mechanisms at their disposal and a power-play ensues. One such mechanism, for striking employees, is to withhold their labour in an effort to compel employers to succumb to their demands. Newspaper articles and the jurisprudence that has emerged from the courts illustrate that strike-related violence has become a destructive feature of industrial action.[1] Not only are strikes destructive to the economy but they are often associated with violence. The courts have been inundated with claims seeking to interdict violent and protracted strikes. While many commentators are of the view that strike violence is a result of underlying socio-economic issues, which should be addressed by the government, employers and the general public often bear the brunt of the destruction and mayhem left in the wake of violent strikes. In the wake of one of the worst tragedies, the Marikana massacre, which saw 32 striking miners shot and killed when police opened fire at Lonmin's operations in the Northwest province, the South African government, organised labour, and employers were compelled to take swift action to address the deficiencies that existed when it came to the constitutionally entrenched right to strike. The Labour Relations Amendment Act 8 of 2018 seeks to address this. Whilst some of the provisions introduced by the amendments have been the subject matter of litigation resulting in progressive judgments, other provisions are yet to be judicially tested. , Thesis (LLM) -- Faculty of Law, Department of Mercantile law, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mafa, Bonolo
- Date: 2022-12
- Subjects: labour union , Violence , Labour law
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59841 , vital:62447
- Description: Since the dawn of South Africa’s constitutional democracy, the right to strike has been protected. It is perceived to be fundamental to orderly collective bargaining and the courts have stressed the need to ensure that it is not unjustifiably limited or undermined. In the collective bargaining process, employers and employees have mechanisms at their disposal and a power-play ensues. One such mechanism, for striking employees, is to withhold their labour in an effort to compel employers to succumb to their demands. Newspaper articles and the jurisprudence that has emerged from the courts illustrate that strike-related violence has become a destructive feature of industrial action.[1] Not only are strikes destructive to the economy but they are often associated with violence. The courts have been inundated with claims seeking to interdict violent and protracted strikes. While many commentators are of the view that strike violence is a result of underlying socio-economic issues, which should be addressed by the government, employers and the general public often bear the brunt of the destruction and mayhem left in the wake of violent strikes. In the wake of one of the worst tragedies, the Marikana massacre, which saw 32 striking miners shot and killed when police opened fire at Lonmin's operations in the Northwest province, the South African government, organised labour, and employers were compelled to take swift action to address the deficiencies that existed when it came to the constitutionally entrenched right to strike. The Labour Relations Amendment Act 8 of 2018 seeks to address this. Whilst some of the provisions introduced by the amendments have been the subject matter of litigation resulting in progressive judgments, other provisions are yet to be judicially tested. , Thesis (LLM) -- Faculty of Law, Department of Mercantile law, 2022
- Full Text:
- Date Issued: 2022-12
An analysis of corporate power in South Africa’s public policy, 1996-2014
- Authors: Mvenene,Mbasa
- Date: 2022-12
- Subjects: Business enterprises --Law and legislation --South Africa , Political corruption – South Africa , South Africa -- Politics and government
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59489 , vital:62122
- Description: The crux of this study is an analysis of the relations between corporate power and public policy in South Africa, in the period 1996 to 2014. The study’s focus is on corporate power’s influence on South Africa’s public policy and the various means through which power is exerted by the former to shape and control the latter, through the influence of the public policy process and outcome. The study achieves this by arguing that the GEAR and BEE policies failed to achieve their stated objectives, and instead serve as conduits for the exertion of inordinate public policy influence by corporate power. The study analyses how the placing of ANC leaders on major corporate boards has influenced South Africa’s public policy. The study will also examine the ways in which private corporate donations influence public officeholders in the governing ANC. The study also seeks to explore why the ANC with its seemingly progressive stance and history is susceptible to following neoliberal policies pushed for by political forces largely but not exclusively outside the party in the industries described to be targets of redistribution, mining, energy, and finance. The study asserts that private corporate donations made to the governing ANC have a corrupting effect on public policy and corrode democratic decision making and ultimately the public good. This study presents the argument that the ANC-aligned black political elite was co-opted into the structure of economic dominance with the GEAR and BEE policies and hence the prevalence of neoliberal economic policy in post-apartheid South Africa. The study also addresses the intricate relationship between the corporate and political elite, business, and money in South Africa’s elitist public policy landscape , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mvenene,Mbasa
- Date: 2022-12
- Subjects: Business enterprises --Law and legislation --South Africa , Political corruption – South Africa , South Africa -- Politics and government
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59489 , vital:62122
- Description: The crux of this study is an analysis of the relations between corporate power and public policy in South Africa, in the period 1996 to 2014. The study’s focus is on corporate power’s influence on South Africa’s public policy and the various means through which power is exerted by the former to shape and control the latter, through the influence of the public policy process and outcome. The study achieves this by arguing that the GEAR and BEE policies failed to achieve their stated objectives, and instead serve as conduits for the exertion of inordinate public policy influence by corporate power. The study analyses how the placing of ANC leaders on major corporate boards has influenced South Africa’s public policy. The study will also examine the ways in which private corporate donations influence public officeholders in the governing ANC. The study also seeks to explore why the ANC with its seemingly progressive stance and history is susceptible to following neoliberal policies pushed for by political forces largely but not exclusively outside the party in the industries described to be targets of redistribution, mining, energy, and finance. The study asserts that private corporate donations made to the governing ANC have a corrupting effect on public policy and corrode democratic decision making and ultimately the public good. This study presents the argument that the ANC-aligned black political elite was co-opted into the structure of economic dominance with the GEAR and BEE policies and hence the prevalence of neoliberal economic policy in post-apartheid South Africa. The study also addresses the intricate relationship between the corporate and political elite, business, and money in South Africa’s elitist public policy landscape , Thesis (MA) -- Faculty of Humanities, School of Governmental and Social Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An analysis of factors affecting media freedom at the South African Broadcasting Corporation
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
An assessment of broadband infrastructure investment as a primer for inclusive growth in South Africa
- Authors: Dhlamini, Tapiwa James
- Date: 2022-12
- Subjects: Broadband , Economic growth -- South Africa
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/59566 , vital:62172
- Description: This study investigated the impact of investment in the telecommunication and broadband sectors on growth, employment creation, and poverty alleviation. It employs micro-simulation techniques and an economy-wide Leontief-based social accounting matrix multiplier model to assess empirically the influence that fiscal injection into these sectors has in achieving South Africa’s macroeconomic objectives. The study found positive but declining trends in output multipliers in the telecommunication sector over the post-recession period (2009-18), signifying the enervation of the intersectoral multiplier effect over the post-recession period. Fiscal injection into the telecommunication and broadband sectors led to poverty reduction and to job creation in South Africa. However, the overall findings of this study highlight gender biases, spatial imbalances between urban and non-urban, an age gulf between young people and adults and further imbalances between formal and informal employment. The study commends that the government follow a priorities-weighted state spending policy which concurrently targets projects generating high GVA and employment multipliers and with high capacity to address the disparity caused by the legacy of Apartheid. , Thesis (MEcon) -- Faculty of Business and Economic Science, School of Applied Accounting, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Dhlamini, Tapiwa James
- Date: 2022-12
- Subjects: Broadband , Economic growth -- South Africa
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/59566 , vital:62172
- Description: This study investigated the impact of investment in the telecommunication and broadband sectors on growth, employment creation, and poverty alleviation. It employs micro-simulation techniques and an economy-wide Leontief-based social accounting matrix multiplier model to assess empirically the influence that fiscal injection into these sectors has in achieving South Africa’s macroeconomic objectives. The study found positive but declining trends in output multipliers in the telecommunication sector over the post-recession period (2009-18), signifying the enervation of the intersectoral multiplier effect over the post-recession period. Fiscal injection into the telecommunication and broadband sectors led to poverty reduction and to job creation in South Africa. However, the overall findings of this study highlight gender biases, spatial imbalances between urban and non-urban, an age gulf between young people and adults and further imbalances between formal and informal employment. The study commends that the government follow a priorities-weighted state spending policy which concurrently targets projects generating high GVA and employment multipliers and with high capacity to address the disparity caused by the legacy of Apartheid. , Thesis (MEcon) -- Faculty of Business and Economic Science, School of Applied Accounting, 2022
- Full Text:
- Date Issued: 2022-12
An evaluation of hibiscus sabdariffa gold nanoparticles for the treatment of triple negative breast cancer
- Authors: Reddy, Nireshini
- Date: 2022-12
- Subjects: Breast--Cancer--Treatment--Technological innovations , Nanomedicine – South Africa , Roselle
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59945 , vital:62697
- Description: Cancer is responsible for the millions of deaths worldwide every year, being ranked as the second leading cause of mortality in the world. Triple negative breast cancer (TNBC) is the most severe type of breast cancer, as it is the most aggressive and difficult to treat. Current treatment methods involve surgery, hormonal-, radiation- and chemotherapy. These are costly and often have severe adverse effects. There has been increasing research in the development of alternative treatment methods to reduce the side effects of cancer therapeutics, as well as the cost. The rapidly growing field of nanotechnology has allowed for the incorporation of several diagnostic, targeting, and therapeutic agents into nanomaterials for cancer treatment. The application of gold nanoparticles (AuNPs) in the diagnosis and treatment of various types of cancers has been widely investigated. AuNPs vary in size, shape, and structure, allowing for the development of diverse formulations for various treatments. The use of green materials, particularly plant material, to synthesise nanomaterials has allowed for the safe, cost-friendly and eco-friendly production of AuNPs that can be used to treat TNBC. The aim of this study was to evaluate the efficiency of green AuNPs synthesised with Hibiscus sabdariffa to treat TNBC in a pilot murine model. Spherical AuNPs were synthesised using an aqueous extract of the calyces of this plant. The AuNPs were characterised using UV-Vis spectrometry, dynamic light scattering, high resolution – transmission electron microscopy, and in vitro stability testing. A cell viability assay showed that these AuNPs exhibited cytotoxicity towards E0771 cells in a dose-dependent manner, where cells treated with the highest concentration of AuNPs (250 µg/mL) exhibited the lowest cell viability (7%). During the in vivo pilot study, C57BL/6 mice were inoculated with TNBC using the E0771 cells. It was found that TNBC had rapidly spread, resulting in metastasis in the liver, as well as omentum and mesentery. This resulted in a number of mice dying; therefore, shortening treatment time of the AuNPs. It is suggested that AuNP treatment may have exacerbated mouse death by promoting ROS production in metastasised tissue, suggesting that AuNP treatment may not be suitable for stage 4 TNBC. Tumor analysis of caspase-3 content showed that the AuNPs exhibited potential pro-apoptotic activity in the tumours, prompting further research into the tumour uptake and apoptotic mechanism of these AuNPs. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Reddy, Nireshini
- Date: 2022-12
- Subjects: Breast--Cancer--Treatment--Technological innovations , Nanomedicine – South Africa , Roselle
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59945 , vital:62697
- Description: Cancer is responsible for the millions of deaths worldwide every year, being ranked as the second leading cause of mortality in the world. Triple negative breast cancer (TNBC) is the most severe type of breast cancer, as it is the most aggressive and difficult to treat. Current treatment methods involve surgery, hormonal-, radiation- and chemotherapy. These are costly and often have severe adverse effects. There has been increasing research in the development of alternative treatment methods to reduce the side effects of cancer therapeutics, as well as the cost. The rapidly growing field of nanotechnology has allowed for the incorporation of several diagnostic, targeting, and therapeutic agents into nanomaterials for cancer treatment. The application of gold nanoparticles (AuNPs) in the diagnosis and treatment of various types of cancers has been widely investigated. AuNPs vary in size, shape, and structure, allowing for the development of diverse formulations for various treatments. The use of green materials, particularly plant material, to synthesise nanomaterials has allowed for the safe, cost-friendly and eco-friendly production of AuNPs that can be used to treat TNBC. The aim of this study was to evaluate the efficiency of green AuNPs synthesised with Hibiscus sabdariffa to treat TNBC in a pilot murine model. Spherical AuNPs were synthesised using an aqueous extract of the calyces of this plant. The AuNPs were characterised using UV-Vis spectrometry, dynamic light scattering, high resolution – transmission electron microscopy, and in vitro stability testing. A cell viability assay showed that these AuNPs exhibited cytotoxicity towards E0771 cells in a dose-dependent manner, where cells treated with the highest concentration of AuNPs (250 µg/mL) exhibited the lowest cell viability (7%). During the in vivo pilot study, C57BL/6 mice were inoculated with TNBC using the E0771 cells. It was found that TNBC had rapidly spread, resulting in metastasis in the liver, as well as omentum and mesentery. This resulted in a number of mice dying; therefore, shortening treatment time of the AuNPs. It is suggested that AuNP treatment may have exacerbated mouse death by promoting ROS production in metastasised tissue, suggesting that AuNP treatment may not be suitable for stage 4 TNBC. Tumor analysis of caspase-3 content showed that the AuNPs exhibited potential pro-apoptotic activity in the tumours, prompting further research into the tumour uptake and apoptotic mechanism of these AuNPs. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An exploration of teachers’ views and experiences on the effects of community Violence on learners at Lusikisiki
- Authors: Gwarubana, Nolufefe
- Date: 2022-12
- Subjects: Kerr-Soltis model -- Lusikisiki , Posttraumatic Stress Disorder -- Lusikisiki
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60144 , vital:63206
- Description: A significant number of children in the South African context are exposed to community violence and become traumatised. In South Africa, many learners bring trauma histories into the classroom. To attend to this problem, it is important to understand how Exposure to Community Violence (ECV) affects learners, how this exposure is manifested in the classroom, and how teachers and schools can best support and mitigate adverse outcomes for trauma-impacted learners. The study aimed to understand teachers’ views and experiences on the effects of community violence on learners and the nature of the support that they offer to learners with trauma related to community violence. An exploratory design was used within which qualitative data was collected using semi-structured interviews. Data was gathered from Mkhankomo Full Service School, which is located in Lusikisiki. A maximum number of 10 teachers participated in the study and interviews were audio-recorded. Results of this study provide insight into the effects of community violence on the learners who were victims either directly or as witnesses. Based on thematic analysis, the results clearly showed that the effects of community violence were found to be mainly emotional, behavioural and psychological. All these effects were seen to affect the learners’ performance at school in the long run. In addition, the findings point to the teachers showing a willingness to support learners exposed to community violence, however, they felt ill-equipped to do so given that they had never worked with learners exposed to trauma. Also, in their attempts to support learners, teachers implemented support systems such as offering individual lessons to learners and additionally assuming supportive roles such as that of mentor and mother. Moreover, the findings indicated that teachers were not provided with any v training to help them work with learners exposed to trauma and their expectations for the Department of Basic Education to assist were not met. Consequently, the study provides an understanding of the effects of community violence on learners from the perspectives of teachers in the school. It also assists with information regarding teachers’ preparedness and ability to respond to learners’ chronic exposure to community violence. Furthermore, this study gives an understanding of teachers’ approach to supporting learners experiencing traumatic stress in the classroom. , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Gwarubana, Nolufefe
- Date: 2022-12
- Subjects: Kerr-Soltis model -- Lusikisiki , Posttraumatic Stress Disorder -- Lusikisiki
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60144 , vital:63206
- Description: A significant number of children in the South African context are exposed to community violence and become traumatised. In South Africa, many learners bring trauma histories into the classroom. To attend to this problem, it is important to understand how Exposure to Community Violence (ECV) affects learners, how this exposure is manifested in the classroom, and how teachers and schools can best support and mitigate adverse outcomes for trauma-impacted learners. The study aimed to understand teachers’ views and experiences on the effects of community violence on learners and the nature of the support that they offer to learners with trauma related to community violence. An exploratory design was used within which qualitative data was collected using semi-structured interviews. Data was gathered from Mkhankomo Full Service School, which is located in Lusikisiki. A maximum number of 10 teachers participated in the study and interviews were audio-recorded. Results of this study provide insight into the effects of community violence on the learners who were victims either directly or as witnesses. Based on thematic analysis, the results clearly showed that the effects of community violence were found to be mainly emotional, behavioural and psychological. All these effects were seen to affect the learners’ performance at school in the long run. In addition, the findings point to the teachers showing a willingness to support learners exposed to community violence, however, they felt ill-equipped to do so given that they had never worked with learners exposed to trauma. Also, in their attempts to support learners, teachers implemented support systems such as offering individual lessons to learners and additionally assuming supportive roles such as that of mentor and mother. Moreover, the findings indicated that teachers were not provided with any v training to help them work with learners exposed to trauma and their expectations for the Department of Basic Education to assist were not met. Consequently, the study provides an understanding of the effects of community violence on learners from the perspectives of teachers in the school. It also assists with information regarding teachers’ preparedness and ability to respond to learners’ chronic exposure to community violence. Furthermore, this study gives an understanding of teachers’ approach to supporting learners experiencing traumatic stress in the classroom. , Thesis (MA) -- Faculty of Health Sciences, 2022
- Full Text:
- Date Issued: 2022-12
An exploration of the benefits of information and communications technology for SMMEs in the Construction Industry in Gauteng Province, South Africa
- Authors: Klassie, Unathi
- Date: 2022-12
- Subjects: information technology , Small business , Construction industry, Gauteng Province -- South Africa
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/59726 , vital:62386
- Description: This paper explores the beneficial impact of ICT adoption on the performance of Small, Micro to Medium Enterprises (SMMEs) in South Africa, specifically in the construction sector. The population of the study comprises construction SMME owners and managers in Gauteng, South Africa. The objectives of this study are fourfold as follows. Firstly, it aims to determine the benefits of ICT for SMMEs in the construction industry in South Africa. Secondly, it aims to establish the challenges SMMEs face in ICT infrastructure systems. The third aim is to determine the barriers that impede SMMEs from adopting ICT. And fourthly it aims to recommend an ICT framework for the effectiveness and success of ICT infrastructure systems for SMMEs. The research consisted of data collection from 15 SMMEs in the construction industry in Gauteng Province, South Africa through the means of interviews. The study employed an interpretivist paradigm which necessitated a qualitative approach. The data was then analysed thematically. The study was motivated by a Technology-OrganisationEnvironment (TOE) framework. The study findings show that SMMEs profit greatly from the adoption of ICT in their battle for survival and expansion. ICT is one of the main resources that may be employed by organisations in this digital age, according to the Resource-Based Theory. The majority of respondents stated that ICT has improved performance and that tasks are completed more efficiently than before. According to the findings, sustained government help to extend broadband access for underprivileged groups, particularly in places underserved by private sector activities, is suggested. Government funding should be made available to assist SMMEs in developing ICT skills. This financing might be linked to organisations like SEDA to guarantee that new SMMEs are ascertained of the importance of ICT skills that will benefit their enterprises. To improve awareness of the benefits of ICT in the construction industry, training providers, NGOs, and government agencies must collaborate more closely. , Thesis (MBA) -- Faculty of Business and Economic Science, Business School, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Klassie, Unathi
- Date: 2022-12
- Subjects: information technology , Small business , Construction industry, Gauteng Province -- South Africa
- Language: English
- Type: Master's theses , Thesis
- Identifier: http://hdl.handle.net/10948/59726 , vital:62386
- Description: This paper explores the beneficial impact of ICT adoption on the performance of Small, Micro to Medium Enterprises (SMMEs) in South Africa, specifically in the construction sector. The population of the study comprises construction SMME owners and managers in Gauteng, South Africa. The objectives of this study are fourfold as follows. Firstly, it aims to determine the benefits of ICT for SMMEs in the construction industry in South Africa. Secondly, it aims to establish the challenges SMMEs face in ICT infrastructure systems. The third aim is to determine the barriers that impede SMMEs from adopting ICT. And fourthly it aims to recommend an ICT framework for the effectiveness and success of ICT infrastructure systems for SMMEs. The research consisted of data collection from 15 SMMEs in the construction industry in Gauteng Province, South Africa through the means of interviews. The study employed an interpretivist paradigm which necessitated a qualitative approach. The data was then analysed thematically. The study was motivated by a Technology-OrganisationEnvironment (TOE) framework. The study findings show that SMMEs profit greatly from the adoption of ICT in their battle for survival and expansion. ICT is one of the main resources that may be employed by organisations in this digital age, according to the Resource-Based Theory. The majority of respondents stated that ICT has improved performance and that tasks are completed more efficiently than before. According to the findings, sustained government help to extend broadband access for underprivileged groups, particularly in places underserved by private sector activities, is suggested. Government funding should be made available to assist SMMEs in developing ICT skills. This financing might be linked to organisations like SEDA to guarantee that new SMMEs are ascertained of the importance of ICT skills that will benefit their enterprises. To improve awareness of the benefits of ICT in the construction industry, training providers, NGOs, and government agencies must collaborate more closely. , Thesis (MBA) -- Faculty of Business and Economic Science, Business School, 2022
- Full Text:
- Date Issued: 2022-12