Rhodes University Graduation Ceremony 2013
- Authors: Rhodes University
- Date: 2013
- Language: English
- Type: text
- Identifier: vital:8134 , http://hdl.handle.net/10962/d1007241
- Description: Rhodes University 2013 Installation of Lex Mpati as 7th Chancellor of Rhodes University and Graduation Ceremony [at] 1820 Settlers National Monument Thursday, 4 April 2013 at 18.00 , Rhodes University Graduation Ceremony [at] 1820 Settlers National Monument Friday, 5 April at 10.00; 14:30 & 18:00 [and] Saturday, 6 April at 10:00 , Rhodes University Awards, Scholarships, Bursaries and Prizes 2013
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- Date Issued: 2013
SANLiC 2013 Workshop : Ever Evolving Ebooks
- Authors: Clack, Chantel
- Date: 2013
- Subjects: Electronic books , Collection development , Ebooks , Marketing , ROI , Return on investment , Trends
- Language: English
- Type: text
- Identifier: vital:7953 , http://hdl.handle.net/10962/d1001516 , Electronic books
- Description: Feedback report presented to RUL Staff after attending the SANLIC 2013 Workshop, 13-16 May 2013, Misty Hills.
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- Date Issued: 2013
SANLiC 2013 Workshop : Ever Evolving Ebooks
- Authors: Stoltz, Brenda
- Date: 2013
- Subjects: Electronic books , Collection development , Patron driven acquisitions , PDA , ERM , Licensing , Ebooks
- Language: English
- Type: text
- Identifier: vital:7951 , http://hdl.handle.net/10962/d1001390 , Electronic books
- Description: Feedback report presented to RUL Staff after attending the SANLIC 2013 Workshop, 13-16 May 2013, Misty Hills.
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- Date Issued: 2013
SANLiC 2013 Workshop : Ever Evolving Ebooks
- Authors: Martindale, Debbie
- Date: 2013
- Subjects: Electronic books , Open access publishing , Ebooks , Open access policy , Collection development , Electronic textbooks
- Language: English
- Type: text
- Identifier: vital:7952 , http://hdl.handle.net/10962/d1001391 , http://orcid.org/0000-0002-4497-8129 , Electronic books , Open access publishing
- Description: Feedback report presented to RUL Staff after attending the SANLIC 2013 Workshop, 13-16 May 2013, Misty Hills.
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- Date Issued: 2013
The development and assessment of sustained release nevirapine tablets
- Authors: Mwila, Chiluba
- Date: 2013
- Language: English
- Type: text , Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/54667 , vital:26598
- Description: The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is a Biopharmaceutics Classification System (BCS) Class II compound. Although NVP exhibits good oral absorption, it induces self-metabolism leading to low and sometimes unpredictable bioavailability. NVP is commercially available as an immediate release and extended release dosage form, viz., Viramune® XR. Formulation of a generic sustained release (SR) dosage form for once daily dosing would result in delivery of constant amount of the drug to the circulation, reduce dose related adverse effects, improve patient compliance to medication and reduce the costs of therapy. A simple RP-HPLC method was developed and optimised using a central composite design approach. The method was validated using ICH guidelines and was found to be linear, precise, specific and accurate for the analysis of NVP both in bulk and dosage forms. Direct compression was used as the method of tablet manufacture. Different polymers were assessed for suitability as rate retarding polymers and included Methocel® K4M, Carbopol® 71G NF and Eudragit® RSPO. Powder blends were assessed for flow properties using the angle of repose, bulk and tapped density, Carr’s Compressibility index and Hausner’s ratio. The traditional approach of changing the amount of polymers and diluents systematically to achieve a desired NVP release profile was used for the development of a preliminary formulation. Response surface methodology was used for the optimisation of the formulation using a Box-Behnken quadratic design. Physical characteristics of the tablets such as thickness, weight, hardness, tensile strength and friability were assessed and the tablets passed Pharmacopoeial testing. NVP assay and content uniformity were assessed using a validated RP-HPLC method. Initially, USP Apparatus 2 was used to study NVP release over a 24 hour period and subsequently dissolution studies were performed using USP Apparatus 3 as it can be used to simulate GIT conditions. The dissolution profiles generated were used to determine the agitation rate for USP Apparatus 3 that would be equivalent to an agitation rate of 50 rpm when using USP Apparatus 2. The effect of the mesh screen pore size, buffer molarity strength and concentration of surfactant on NVP release were also investigated in order to select discriminatory dissolution test conditions for the test formulation. Dissolution profiles were compared to those of the commercially available Viramune® XR using the FDA recommended difference (f1) and similarity (f2) factors. The calculated values for f1 and f2 revealed that the dissolution profile for the optimised formulation that was identified was statistically similar to Viramune® XR. In vitro release data were fitted to different kinetic models to study the release kinetics of NVP. The overall mechanism of NVP release was best described using the Korsmeyer-Peppas diffusion exponent value, n. NVP release was found to be anomalous, implying that the release was influenced by a combination of diffusion, swelling and polymer chain relaxation. The Hixson-Crowell model revealed that there was constant change in surface area of the dosage form suggesting that erosion and swelling were significant factors affecting NVP release from the hydrophilic matrix technology. The release kinetics data were also used to design the optimised formulation. Tablets manufactured using the optimised formulation were subjected to water uptake and erosion studies and the results revealed that swelling and erosion occur simultaneously. The effects of pH and molarity on the swelling and erosion of the tablets were also investigated. The data suggest that increase in pH resulted in a slight increase in swelling while an increase in molarity did not have a significant effect on swelling. The change in pH did not have a significant effect on erosion while an increase in molarity strength resulted in a decrease in matrix erosion. The effect of HPMC grade on swelling, erosion and NVP release revealed that the grade of HPMC used had a significant effect on NVP release, with the release rate decreasing, swelling increasing and erosion decreasing as the viscosity of the HPMC grade increased. The effect of the particle size of MCC on NVP release was also studied by manufacturing tablets containing different grades of MCC and these studies revealed that particle size did not appear to have a significant effect on NVP release. Similarly the use of different types of lactose did not appear to have a significant impact on NVP release. In conclusion a sustained release NVP tablet formulation that has the potential for further development and optimisation has been developed, assessed and manufactured successfully and has been shown to exhibit similar dissolution behaviour to Viramune® XR, a commercially available NVP extended release product.
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- Date Issued: 2013
The development of an arousal and anxiety control mental skills training programme for the Rhodes University archery club
- Authors: Chiweshe, Malvern Tatenda
- Date: 2013
- Subjects: Anxiety , Arousal , Mental skills , Training , Sports -- Psychological aspects -- Research -- South Africa , Archers -- Training of -- Research -- South Africa , Archers -- Psychological aspects -- Research -- South Africa , Psychology, Applied
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2917 , http://hdl.handle.net/10962/d1002082
- Description: Research on the development of Mental Skills Training (MST) programmes in sport psychology has largely increased as sport has become more competitive. MST programmes have been seen to improve the performance of athletes. This particular research study focuses on the development of an anxiety and arousal control MST programme designed specifically for, and tailored exclusively to, the needs of four archers from the Rhodes Archery Club in Grahamstown, Eastern Cape, South Africa. The development of the programme was guided by the Organisational Development Process model as the research methodology design. Data from two quantitative measures (CSAI-2 and Sport Grid-R), a focus group, and an individual interview were integrated with currently existing mental skills literature and theory to devise this particular MST programme. The results of the assessment phase showed that individual archers have different experiences in how anxiety and arousal affect their performances. The results also showed that archers have different zones in which they feel their performance is good. These zones depend on their subjective interpretations of anxiety and arousal. The results also showed that other factors that include personality differences, level of experience and level of expertise also influence how anxiety and arousal affect performance. The archers had previous exposure to MST programmes although they had not received systematic training in mental skills training. The programme was developed in the form of MST workshops that would run over a three week period. As part of the programme the archers would be given a mental skills manual to aid in the mental skills training. It is recommended in future that more research in MST programmes be done as a way of improving the performance of athletes in South Africa
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- Date Issued: 2013
The family in Shakespeare's plays: a study of South African revisions
- Authors: Hjul, Lauren Martha
- Date: 2013
- Subjects: Parents , Parental bonds , Family , Shakespeare, William, 1564-1616 -- In literature -- Research , Coetzee, J M, 1940-. Disgrace , Gordimer, Nadine. My son's story , Peteni, R L, 1915-. Hill of fools , English drama -- 17th century -- History and criticism , Families in literature , English literature -- History and criticism
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2181 , http://hdl.handle.net/10962/d1001832
- Description: This thesis provides a detailed consideration of the family in Shakespeare’s canon and the engagement therewith in three South African novels: Hill of Fools (1976) by R. L. Peteni, My Son’s Story (1990) by Nadine Gordimer, and Disgrace (1999) by J. M. Coetzee. The study is divided into an introduction, three chapters each addressing one of the South African novels and its relationship with a Shakespeare text or texts, and a conclusion. The introductory chapter provides an analysis of the two strands of criticism in which the thesis is situated – studies of the family in Shakespeare and studies of appropriations of Shakespeare – and discusses the ways in which these two strands may be combined through a detailed discussion of the presence of power dynamics in the relationship between parent and child in all of the texts considered. The three chapters each contextualise the South African text and provide detailed discussions of the family dynamics within the relevant texts, with particular reference to questions of authority and autonomy. The focus in each chapter is determined by the nature of the intertextual relationship between the South African novel and the Shakespearean text being discussed. Thus, the first chapter, “The Dissolution of Familial Structures in Hill of Fools” considers power dynamics in the family as an inherent part of the Romeo and Juliet genre, of which William Shakespeare’s Romeo and Juliet is but a part. Similarly, the impact of a socio-political identity, and the secrecy it necessitates, is the focus of the second chapter, “Fathers, Sons and Legacy in My Son’s Story” as is the role of Shakespeare and literature within South Africa. These concerns are connected to the novel’s use of Shakespeare’s Sonnets, King Lear, and Hamlet. In the third chapter, “Reclaiming Agency through the Daughter in Disgrace and The Tempest”, I expand on Laurence Wright’s argument that Disgrace is an engagement with The Tempest and consider ways in which the altered power dynamic between father and daughter results in the reconciliation of the father figure with society. The thesis thus addresses the tension between parental bonds and parental bondage
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- Date Issued: 2013
The new Africans: a textual analysis of the construction of 'African-ness' in Chaz Maviyane-Davies' 1996 poster depictions of the Universal Declaration of Human Rights
- Authors: Garman, Brian Donald
- Date: 2013
- Subjects: Human rights , Posters , African perspective , Stereotypes , Black men , Maviyane-Davies, Chaz -- Criticism and interpretation , Universal Declaration of Human Rights -- Posters -- Research , Ethnicity -- Research -- Africa , Human rights -- Africa , Pan-Africanism
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:3413 , http://hdl.handle.net/10962/d1001844
- Description: In 1996, Zimbabwean graphic designer Chaz Maviyane-Davies created a set of human rights posters which represent several articles of the Universal Declaration of Human Rights, from what he calls an “African perspective”. In this study I investigate how Maviyane-Davies has constructed ‘African-ness’ and probe what he refers to as the “alternative aesthetic” that he is trying to create. I use a visual social semiotic approach to examine the discourses he draws on to re-image and re-imagine Africa and Africans in a manner that contests the stereotypical representations found in political, news and economic discourses about Africa, paying particular attention to the ways he uses images of the body. My analysis of the posters shows how complex and difficult it can be to contest regimes of representation that work to fix racialised and derogatory meanings. In response to the pejorative stereotypes of the black body, Maviyane-Davies uses images of strong, healthy, and magnificent people (mostly men) to construct a more affirmative representation of Africa and Africans. Significantly, he draws on sports, touristic, traditional and hegemonic discourses of masculinity in an attempt to expand the complexity and range of possible representations of African-ness. In so doing he runs the risk of reproducing many of the stereotypes that sustain not only the racialised and gendered (masculinist) representations of Africa, but also a sentimentalisation and romanticisation of a place, a people and their traditions. Apart from women in prominent positions, other conspicuous absences from these images include white people and hegemonic references to Western modernity. I do not believe he is discarding whites and modernity as un-African, but is rejecting the naturalisation of whiteness as standing in for humanity, and particular icons of Western modernity as significations of ‘modernity’ itself
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- Date Issued: 2013
The talisman
- Authors: Reed, Graham Conan
- Date: 2013
- Subjects: Fiction , Short stories , English , South Africa , Creative writing (Higher education) , Short stories, South African (English) -- 21st century , South African fiction (English) -- 21st century , English language -- Writing
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:5967 , http://hdl.handle.net/10962/d1001817
- Description: The Talisman is an adventure story set in a future where much of today's cultural memory and technology has been lost. Following a hunting accident, a young man named Forest survives a life-threatening wound and embarks on a quest for knowledge. Rising sea levels, bands of marauders, wild animals and the perils of survival in the broken world are not the only problems facing the survivors. The nature of the collapse of the society, what triggered it and its subsequent unfolding, bequeaths an existential quandary upon them that only Forest, and a rare text as old as the earth itself, can unravel
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- Date Issued: 2013
Vital threats to human security in Southern Africa : the regional ramifications of the public health crisis in Zimbabwe
- Authors: Mtero, Shingirai
- Date: 2013
- Subjects: Human security -- Africa, Southern , Communicable diseases -- Africa, Southern , Public health -- Zimbabwe , Poverty -- Africa, Southern
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2891 , http://hdl.handle.net/10962/d1018251
- Description: The southern African region is beset with numerous security concerns: pervasive poverty, deepening inequality, starvation, contamination of essential natural resources, violent crime and state oppression. However, the most vital of the region’s security concerns in the 21st century is the spread of infectious disease. The region shoulders a disproportionate amount of the continent’s infectious disease burden, with diseases such as HIV/AIDS, tuberculosis and malaria claiming more lives every year than any other factor. The nature of these diseases and their propensity to spread, coupled with inadequate regional public health structures pose a significant threat to regional security and stability. The study asserts that southern Africa’s security concerns are most appropriately characterised under the paradigm of Human Security. It further asserts that if such vital threats to human security are not adequately managed they have the ability to permeate across state borders, spelling numerous negative ramifications for the region. To this end, the study details the public health crisis in Zimbabwe and its effects on regional security and stability in southern Africa. An enduring political and economic collapse in Zimbabwe led to the dramatic deterioration of its public health sector, the concomitant mass migration of Zimbabwean nationals across the region presented a unique and complex challenge to the Southern African Development Community (SADC) and its member states. As the premier regional governance institution, SADC has failed to adequately mobilise its structures and member states to respond to the challenges resulting from the public health crisis in Zimbabwe. The study explores the factors accounting for this regional inertia, and asserts that while infectious diseases are at present the most vital of the human security threats, similar threats to human security have the potential to affect the region if SADC fails to recognise and prioritise threats to human security as legitimate regional security concerns.
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- Date Issued: 2013
Who knew
- Authors: Gaunt, Hailey Kathryn
- Date: 2013
- Subjects: Poetry , Memory , Nature , Marriage , Faith , Death , Meaning , English language -- Writing , South African poetry (English) -- 21st century , Creative writing (Higher education)
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:5962 , http://hdl.handle.net/10962/d1001812
- Description: This book of poems ranges in style from narrative to condensed lyric moment, and shifts in perspective from observation to introspection. Thematically, these poems explore everyday life through its many manifestations – memory, nature, marriage, faith and death – with an emphasis on finding meaning in absolutely ordinary things. Though their tone is often vulnerable and tender, even when it is more distant the poems are always searching.
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- Date Issued: 2013