Healthcare issues in disaster management : preparedness in the pharmacy profession
- Authors: Vhiriri, Eunice Paidamoyo
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178591 , vital:42953
- Description: Access restricted until April 2023. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2021
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- Date Issued: 2021-04
How selected Grade 7 participants develop conceptual understanding in solving algebraic problems as a result of participating in a screencast intervention
- Authors: Wienekus, George Renier
- Date: 2021-04
- Subjects: Algebra -- Study and teaching -- South Africa , Mathematics -- Study and teaching (Elementary) -- South Africa , Problem solving in children , Algebra -- Ability testing , Algebra -- Computer-assisted instruction
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/176833 , vital:42763
- Description: This research project is an interventionist case study, oriented in the interpretive paradigm, which aims to investigate how selected Grade 7 participants develop conceptual understanding in solving algebraic problems as a result of participating in screencast interventions. The aim of my screencast intervention programme, which lies at the heart of this study, is to develop practices, inter alia, of how such devices and software may be “used to develop conceptual rather than procedural or decorative knowledge” (Larkin & Calder, 2015:1) in solving linear equations. The planned intervention was delivered in the form of a series of screencasts: these take the form of audio-video lessons with an emphasis on the visual impact, and were recorded using an application called Explain Everything. The screencast interventions were delivered via Google Classroom and included animations supported by such conceptual explanations of early algebra as are relevant to Grade 7 students, and in line with the South African Curriculum and Assessment Policy Statements - Department of Education, 2011. The fundamental components of an early algebraic equation that would be relevant to a Grade 7 student were considered and used to develop an analytic framework. This was based on a taxonomy designed according to four identified “clusters” in order to analyse the workings of the purposefully selected Grade 7 participants who were video recorded and questioned in a talk-aloud interview while they completed a post-intervention pencil-and-paper test. What emerges from this research project is that there is a significant need for specific and concentrated technology-based techniques, such as the interventions undertaken here, and that exploration and development in the field could benefit the delivery of a pedagogy for algebra. The pedagogical methods implemented and studied in the form of screencasts proved to be successful and were well received by the learners particularly in relation to the conceptualisation of “symbol sense” and transformation in early algebra. The structure and design of the screencast interventions were important in supporting the acquisition of these concepts and were demonstrated to be worthwhile tools for an epistemological application in a classroom or teaching context. , Thesis (MEd) -- Rhodes University, Faculty of Education, Education, 2021
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- Date Issued: 2021-04
Impact of sovereign credit ratings on emerging bond and stock market returns
- Authors: Mkhonto, Zoyisile
- Date: 2021-04
- Subjects: Rating agencies (Finance) , Credit ratings , Bond market
- Language: English
- Type: thesis , text , Masters , MCom
- Identifier: http://hdl.handle.net/10962/177170 , vital:42796
- Description: The primary role of credit rating agencies is to reduce asymmetric information between the parties in a lending relationship. The three major rating agencies have received extensive criticism over the years. These rating agencies have been accused of providing inaccurate ratings which ultimately led to various financial calamities. Late rating action has also been blamed for exacerbating financial and economic cycles. Moreover, there is an argument that emerging markets are unfairly rated in comparison to developed economies. Hence, the reliability and informational value of the assessments provided by credit rating agencies is met with scepticism. Despite these criticisms, rating agencies are characterised as gatekeepers to capital and credit ratings remain essential financial market indicators. Albeit, the literature regarding the impact of sovereign credit ratings on bond and stock markets is inconclusive. This study aims to add to the body of literature and provide insights into the informational value of sovereign credit ratings in emerging markets. More specifically to estimate the relationship between various sovereign credit rating announcements, and bond and stock market returns. Also, to examine whether sovereign credit ratings have a differential impact between bond and stock markets. As well as address the question does it matter who provides the rating? Using an event study, abnormal returns surrounding rating announcements from 2009 to 2019 for 24 emerging markets were analyzed. Firstly, this study concluded that sovereign credit ratings are informative. Secondly, the degree of informativeness differs between the bond and stock markets. Thirdly, an asymmetrical impact was observed between the types of rating announcements. Lastly, that it does matter which rating agency provides the rating because each agency has a unique reputation. The findings of this research have implications on how investors and portfolio managers decide on asset allocation. Furthermore, policymakers may find our investment grade analysis of value when evaluating regulatory reform. It’s recommended that future research refines the event methodology and examines country specific characteristics within each of the emerging markets. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2021
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- Date Issued: 2021-04
In My Flesh : Fabricating the Bulimic Body
- Authors: Hodgson, Ashley
- Date: 2021-04
- Subjects: Bulimia , Human body -- Social aspects , Human figure in art , Diseases in art , Art therapy
- Language: English
- Type: thesis , text , Masters , MFA
- Identifier: http://hdl.handle.net/10962/177317 , vital:42809
- Description: My MFA exhibition In My Flesh, explores my own personal experience of an eating disorder: bulimia nervosa, through the medium of sculpture and installation. Situated in the Fine Art Sculpture and Painting building on Rhodes University campus, this practical submission takes the form of a multi-sensory installation depicting the fleshy interior of a bulimic body. The sculptural works that make up the installation resemble enlarged bodily forms and cavities, namely the mouth; the oesophagus, the stomach; the intestines; and the flesh. These anatomical forms are made from fabric which has been melted, manipulated, and stained using food and other synthetic dyes. The arrangement of the sculptural components (parts of the body affected by bulimia) does not mirror the human body exactly, and their intentionally disordered placement creates a feeling of dis-ease and disturbance for the participant experiencing the installation. This mini-thesis, In My Flesh: Fabricating the Bulimic Body, unpacks the visual, tactile and audio elements of this practice as research submission as they relate to my interest in bodily boundaries, corporeal traces and material extensions. I look at these themes as they translate into installation, and discuss the way in which bulimia is experienced, theorised and represented. I position my work in relation to the concept of the abject as proposed by Julia Kristeva, and visually analyse artworks by Mona Hatoum, Heidi Bucher and Ernesto Neto who make use of immersive installation strategies that resonate with my own practice. This supporting document considers the three conceptual elements informing my installation: embodiment, space, and materiality. In the first chapter of this document: Embodying the Bulimic Body, I address bulimia as less open to visual interpretations than other eating disorders because of its secretive and hidden nature. I go on to frame the illness in relation to theories around bodily boundaries and abjection and argue that bulimia epitomises abjection. In Chapter Two: Architecture of the Bulimic Body I engage with the idea of architectural structures as having anatomic features. I interrogate how the body moves through space, leaving traces of itself behind. Chapter Three: Fabricating the Bulimic Body concentrates on the main medium used in In My Flesh: fabric. In my discussion of this material, I unpack its metaphoric and symbolic qualities, as well as its personal resonance with my own lived experience. , Thesis (MFA) -- Faculty of Humanities, Fine Art, 2021
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- Date Issued: 2021-04
In silico identification of selective novel hits against the active site of wild type mycobacterium tuberculosis pyrazinamidase and its mutants
- Authors: Gowo, Prudence
- Date: 2021-04
- Subjects: Mycobacterium tuberculosis , Pyrazinamide , Multidrug resistance , Antitubercular agents , Molecular dynamics , Hydrogen bonding , Ligand binding (Biochemistry) , Dynamic Residue Network
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178007 , vital:42898
- Description: The World Health Organization declared Tuberculosis a global health emergency and has set a goal to eradicate it by 2035. However, effective treatment and control of the disease is being hindered by the emerging Multi-Drug Resistant and Extensively Drug Resistant strains on the most effective first line prodrug, Pyrazinamide (PZA). Studies have shown that the main cause of PZA resistance is due to mutations in the pncA gene that codes for the target protein Pyrazinamidase (PZase). Therefore, this study aimed to identify novel drug compounds that bind to the active site of wild type PZase and study the dynamics of these potential anti-TB drugs in the mutant systems of PZase. This approach will aid in identifying drugs that may be repurposed for TB therapy and/or designed to counteract PZA resistance. This was achieved by screening 2089 DrugBank compounds against the whole wild type (WT) PZase protein in molecular docking using AutoDOCK4.2. Compound screening based on docking binding energy, hydrogen bonds, molecular weight and active site proximity identified 47 compounds meeting all the set selection criteria. The stability of these compounds were analysed in Molecular Dynamic (MD) simulations and were further studied in PZase mutant systems of A3P, A134V, A146V, D8G, D49A, D49G, D63G, H51P, H137R, L85R, L116R, Q10P, R140S, T61P, V139M and Y103S. Generally, mutant-ligand systems displayed little deviation from the WT systems. The compound systems remained compact, with less fluctuations and more hydrogen bond interactions throughout the simulation (DB00255, DB00655, DB00672, DB00782, DB00977, DB01196, DB04573, DB06414, DB08981, DB11181, DB11760, DB13867, DB13952). From this research study, potential drugs that may be repurposed for TB therapy were identified. Majority of these drugs are currently used in the treatment of hypertension, menopause disorders and inflammation. To further understand the mutant-ligand dynamic systems, calculations such as Dynamic Residue Network (DRN) may be done. Also, the bioactivity of these drugs on Mycobacterium tuberculosis may be studied in wet laboratory, to understand their clinical impart in vivo experiments. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
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- Date Issued: 2021-04
Indigenous knowledge of ecosystem services in rural communities of the Eastern Cape, South Africa
- Authors: Murata, Chenai
- Date: 2021-04
- Subjects: Ethnoscience -- South Africa -- Eastern Cape , Ecosystem management -- South Africa -- Eastern Cape , Nature -- Effect of human beings on -- South Africa -- Eastern Cape , Human ecology -- South Africa -- Eastern Cape , Human beings -- Effect of environment on -- South Africa -- Eastern Cape , South Africa -- Eastern Cape -- Rural conditions
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/177929 , vital:42891 , 10.21504/10962/177929
- Description: This thesis is on indigenous knowledge of ecosystem services. The ecosystem service framework and its associated concepts are fairly young, having been introduced in the ecological discipline in the 1980s. The ecosystem service framework posits that the wellbeing of humans and their communities is dependent on services supplied by ecosystems. It emphasises that for the ecosystems to be able to supply the services, they need to be in a well-functioning state. This idea of well-functioning is predicated on the argument that the ecosystem service framework enjoins resource users to exercise responsible stewardship to prevent degradation and overharvesting. Moreover, the concept of dependence suggests that ecosystem services are of value to humans. The dominant means of measuring the value of ecosystem services has been the economic valuation method in which the contribution that each service makes to human wellbeing is quantified into monetary units. The framework disaggregates the services into four groups, namely provisioning, cultural, supporting and regulatory and seeks to all the pillars of human wellbeing including health, subsistence and spirituality into each of these groups. In doing all this, the framework significantly reconfigures the way we look at and present human-nature relations. This change has the potential to influence significant shifts in how ecological research and intervention programmes are conducted in the foreseeable future. However, the reality that the ecosystem service framework was formulated within, and is informed by the scientific epistemology begs the question: what do traditional rural communities who depend mainly on indigenous knowledge systems (IKS) for shaping and interoperating their relations with nature know of the ecosystem service concept? Rural communities are the ones who interact directly with nature on a day-to-day basis. This makes them a very critical component in the ecosystem service framework. Although South Africa has had studies in the ecosystem service theme, little has been done to attempt to investigate and document indigenous knowledge of ecosystem services that rural communities possess. By focusing only on scientific knowledge of ecosystem services, the South African literature does not do justice to the plural epistemologies of the ecosystem service users in the country. More importantly, the continued dearth of public information on indigenous knowledge of ecosystem services can potentially obstruct implementation of locally sensitive intervention programmes because nothing is known about how the local communities conceptualise the ecosystem service framework. All this presents a crucial gap in the South African research; one that unless effort is made to contribute towards filling it, our knowledge of how communities experience the ecosystem service framework in South Africa will remain skewed. This study set out to investigate and document indigenous knowledge of ecosystem services in order to contribute towards filling this gap. Indigenous knowledge system is an umbrella epistemic system that includes lay ecological knowledge (LEK), traditional ecological knowledge (TEK) and many other related organized systems of knowing. Although the thesis has a chapter on LEK, its primary focus was TEK because the thesis was interested in unravelling how aspects of tradition including taboos, customs, traditional rules and belief in ancestral forces influence local communities’ knowledge of some key aspects of the ecosystem service framework including knowledge of various ecosystem services, valuation of ecosystem services, management of ecosystem services and perceptions of the management practices. The decision to focus on TEK was based on the reasoning that rural communities of the Eastern Cape boast a strong reputation of being traditional, recognizing ancestral spirits, legends and taboos as critical tools of knowledge generation and transmission. Using both mixed methods in some chapters and the qualitative approach alone in others, the study collected data in five villages of Mgwalana, Mahlungulu, Colana, Gogela and Nozitshena located in the north eastern part of Eastern Cape Province of South Africa, a region formerly called Transkei. The data were collected not on ecosystem services; but on the local people’s knowledge of ecosystem services. Although literature was consulted, the study regarded respondents as the primary source of data, hence the findings and conclusions presented in this thesis are about what local people know about ecosystem services. The study uses critical realist theoretical lenses to interpret respondents’ reports. The lenses included the principle of the separation between ontology and epistemology, the iceberg metaphor of ontology, epistemological pluralism and the hermeneutic dimension. These lenses were used to make sense of both the knowledge system of local people and the things about which their knowledge was. As part of discussing the local people’s knowledge, the study sometimes refers to science. This is not because I expected them to demonstrate knowledge similar to science. Instead, it was a critical realist dialectical way of explaining what something is by demonstrating what it is not. The study made a couple of key findings that can potentially enhance the growth of the South African ecosystem service discipline. First, respondents demonstrated knowledge of ecosystem services by mentioning a range of them such as drinking water, medicinal plants, cultural plants and fuelwood and how they affect the wellbeing of humans. However, what they did not have good knowledge of is that nature services can be classified into the four groups of supporting, regulatory, cultural and provisioning. Among the four ecosystem services groups, respondents could identify two only; provisional and cultural. Second, local communities depend heavily on ecosystem services for their well-being. The services include fuelwood, construction timber, medicinal plants, wild fruits, wild fish, cultural services and thatch grass. Although they appreciate that ecosystem services have value to their wellbeing, local people found it difficult to represent the value in monetary units. The conditions that make it difficult for local people to perceive ecosystem services as commodities include the absence of well-defined property system, lack of a quantitative consumer tradition and absence of an economic conception of nature. Third, local people understand the need to keep ecosystems in a well-functioning state hence they implement several traditional practices to manage ecosystem services. These practices include taboos, designating certain resources as sacred, legends, customary law, as well as some secular practices including gelesha and stone terracing. However, it is not easy to understand how traditional management practices work because they are not empirically observable. Fourth, local people possess knowledge of the reality that if not well managed, ecosystems can undergo degradation and hence fail to supply the services needed for human wellbeing. However, they explain the causes of degradation in terms of changes observable at the empirical level and the invisible causal power of supernatural forces. The inclusion of natural forces in degradation explanations marks a departure from the scientific explanations that revolve around biophysical processes. Fifth, the use of traditional management practices such as taboos to management ecosystems is under threat at the local communities. The threat can be attributed to three groups of causes, namely changes in worldviews due to adoption of formal education and Christianity, institutional disharmony playing out between the state and local traditional leadership, and lifestyle changes. These challenges constrain the opportunity for local people to apply traditional management practices to prevent the degradation of ecosystems. The net implication of this is that it renders it difficult for researchers and policy makers to assess the effectiveness of traditional management practices because they are not being implemented in full. In light of all these findings, the thesis concludes that TEK is underlabouring for the ecosystem service framework in the sense that it is used by local communities to generate knowledge of ecological concepts and phenomena. This means that TEK does not exist for the sake of its own self. Drawing from this finding, the study proposes a framework of analysing TEK as an underlabourer for social-ecological triggers or issues. Nonetheless, there are few factors that can be sources of limitation to the study. These include the reality that it was difficult to access pure traditional knowledge because over the years the local communities have received many state-sponsored ecological intervention programmes and a possible personal bias given the reality that I grew up in a traditional household and my father was a key holder or TEK. , Thesis (PhD) -- Faculty of Science, Environmental Science, 2021 , Thesis chapter to be published in 'Green and Low-Carbon Economy'. Journal available: https://ojs.bonviewpress.com/index.php/GLCE/index
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- Date Issued: 2021-04
Inhibitor search and variant analysis of Acetylcholinesterase
- Authors: Ras, Harnaud
- Date: 2021-04
- Subjects: Acetylcholinesterase , Alzheimer's disease , Acetylcholinesterase -- Inhibitors , Alzheimer's disease -- Chemotherapy , Cerebrovascular disease -- Treatment , Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA)
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178191 , vital:42919
- Description: Acetylcholinesterase (AChE) inhibition is used to treat Alzheimer's disease by increasing the availability of acetylcholine to carry nerve signals in the brain. The response to this treatment varies widely, which may be due to altered affnity to the current drugs caused by genetic variation. Various negative side-effects limit their use. As this is one of the only available therapeutic drug targets to treat Alzheimer's disease, decreasing the negative effects is of great importance. AChE is involved in biological processes that occur after acute ischemic stroke. Stroke is the third leading cause of death worldwide, and 87% of all stroke cases belong to ischemic stroke. AchEI (cholinesterase inhibitors) have been suggested to have properties that lower the risk of stroke. AChE is one of 15 verified drug targets under study for treatment of stroke. In addition to Alzheimer's disease and stroke, Lewy body disease (LBD) may be treated using cholinesterase inhibitors. The goals of this study are to find inhibitors that can potentially be used to treat Alzheimer's disease and/or stroke and to investigate variants which may affect protein dynamics and function. Two variants were analyzed, P247L and T229S. Molecular simulation of the P247L variant resulted in a disruption in protein dynamics in comparison to the wildtype. A total of 5728 molecules were screened and 10 nanosecond simulations were used to narrow down the set of compounds. The four best performing molecules were simulated for 10 nanoseconds. MM-PBSA was performed to identify molecules with high binding free energies. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
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- Date Issued: 2021-04
Investigating the factors that influence use of ICTs for citizen engagement in Malawi
- Authors: Sibande, Rachel Chavula
- Date: 2021-04
- Subjects: Information technology -- Malawi , Political participation -- Malawi , Mobile apps -- Malawi , UTAUT , Mzinda
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/177019 , vital:42782 , 10.21504/10962/177019
- Description: Literature has suggested that Malawians are keen to participate. Malawian’s willingness to participate is evident as the country has recorded high voter turnouts during the elections in recent decades. However, literature also suggests that there is minimal citizen engagement in between elections. Elsewhere, Information and Communication Technologies (ICTs) have been used to enhance citizen engagement, but ICT led citizen engagement is still an emerging field and yet to be explored as an area of research particularly in Malawi. We thus sought to explore if the use of ICTs could improve citizen engagement with councils, councilors, and utility companies that provide water and electricity in Malawi. We developed and deployed an ICT platform called Mzinda which means My location in Malawi’s populous Chichewa language. The platform provided various channels for citizens and duty bearers to engage via SMS, USSD, web and a mobile application. We sought to understand the factors that influence citizen’s behavior intention to use an ICT platform to engage. We applied the modified UTAUT model by including Attitude and Self Efficacy social constructs that have among others been cited as limitations of the UTAUT model. We conducted factor loadings of six social constructs of the modified UTAUT model to validate content and reexamine the model in the context of citizen engagement using ICTs in Malawi. We found that, Attitude and Self Efficacy were not significant determinants of the Behaviour Intention for citizens to use the ICT platform. However, 75% of the Behaviour Intention was influenced by Perfomance Expectancy and Effort Expectancy as moderated by age and gender. Empirical evidence showed that responsiveness and actionability of councils and councillors had improved. We also learned that citizens believed that service delivery had improved and that they had more influence over councils, councillors, and the utility companies because of using the ICT platform. We conclude by noting that improvements in service delivery; enhanced responsiveness and actionability of councils, councillors and the utility companies were not necessarily as a result of the ICT platform alone; but a combination of ICTs and non-technology mechanisms of engaging the stakeholders through community campaigns, radio programs, print media engagement, community meetings and debates among others. It is evident that ICTs are not the panacea of all citizen engagement problems. This research can be useful to researchers and practitioners in the technology and citizen engagement domains. , Thesis (MSc) -- Faculty of Science, Department of Computer Science, 2021
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- Date Issued: 2021-04
Larval fish dynamics within the coastal nearshore of the Eastern Cape, South Africa
- Authors: Sotshongaye, Oko
- Date: 2021-04
- Subjects: Fishes -- Larvae -- South Africa -- Eastern Cape , Fishes -- Larvae -- Development -- South Africa -- Eastern Cape , Fishes -- Larvae -- Ecology -- South Africa -- Eastern Cape , Coastal ecology -- South Africa -- Eastern Cape , Fishes -- Larvae -- Dispersal -- South Africa -- Eastern Cape
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/176977 , vital:42776
- Description: The coastal nearshore is important for the early development of fishes as it is used for spawning and/or as a nursery. One of the central concerns in coastal ecology is understanding the role of the nearshore for larvae, ultimately providing key knowledge on population dynamics and hence helping in making decisions pertaining to conservation and resource management. The aim of this study was to investigate the alongshore and cross-shore distribution of larval fishes and the links to the physio-chemical conditions (including prevailing winds) and hydrodynamics in the region of Algoa Bay, situated on the south east coast in the warm temperate region of South Africa. Fish larvae were sampled at nine sites for the first component of the study (January 2016 –March 2017) and at four sites for the second component (November 2019), near the surface and bottom (15-50 m) of the water column as well as at two different distances from shore (~400 m/~3 km) using a set of bongo plankton nets towed behind a boat. Environmental data were simultaneously collected using and acoustic Doppler current profiler (ADCP) and conductivity, temperature, depth (CTD) profiler. Larval fish abundance generally decreased with increasing distance from the shore, however, this varied in space and time, with some larval species recorded in high abundances offshore. Close inshore the larvae of coastal fish species producing benthic eggs (CBE) including the Blenniidae and Gobiesocidae mostly dominated, while offshore the larvae of coastal fish species producing pelagic eggs (CPE) i.e. Sparidae and Cynoglossidae, as well as pelagic fish species producing pelagic eggs (PPE) i.e. Clupeidae and Engraulidae mostly dominated. Vertical distribution of larvae differed according to taxon, with the Callionymidae (CPE), Cynoglossidae and Gobiesocidae occurring at high densities at the bottom of the water column, while the Blenniidae dominated near the surface. Fluorescence, temperature and salinity varied with depth (surface/bottom), being particularly high at the surface; currents moved faster at the surface than the bottom of the water column. Increased abundances of larval fishes were evident after upwelling events (associated with easterly winds) in the Bay, while during downwelling (associated with westerly winds), low densities were generally recorded, except for the sites situated near headlands/capes where there were higher densities of fish larvae during downwelling events. Overall, the results of this study suggest that spawning mode of the adults, oceanography and environmental conditions coupled with what is known of the behaviour of fish larvae, were important in shaping the larval fish community of the Algoa Bay region. These results highlight the importance of incorporating multiple biological (developmental stage, reproductive mode, species) and physical (currents, fluorescence, wind-driven up/down-welling) factors when addressing the mechanims of transport of larval fish in the coastal nearshore. , Thesis (MSc) -- Faculty of Science, Department of Zoology and Entomology, 2021
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- Date Issued: 2021-04
Making Sense of Barkhuizen 2 : An Investigation into the Public Policy Defence of ‘Unfair Enforcement’ in South African Law, with Reference to the Law on Covenants in Restraint of Trade
- Authors: Moroeng, Tsukudu Kenyatta
- Date: 2021-04
- Subjects: Restraint of trade -- South Africa , Public policy (Law) -- South Africa , Contracts (Roman-Dutch law) , Customary law -- South Africa , Barkhuizen v Napier
- Language: English
- Type: thesis , text , Masters , LLM
- Identifier: http://hdl.handle.net/10962/177147 , vital:42794
- Description: This thesis investigates the application of the public policy test for determining the enforceability of a valid contractual clause established in Barkhuizen v Napier. After analysing the historical development of the application of the doctrine of public policy, the study examines the conceptualisation and application of the public policy test in the leading cases in South Africa. The study then provides an analysis of the recent judgment of Beadica 231 CC and Others v Trustees for the time being of the Oregon Trust and Others, which outlined the current legal position on the proper constitutional approach to the judicial enforcement of valid contractual clauses. The study argues that, although the Constitutional Court in Beadica provided some clarity on what public policy is in modern South African law, it did not, from a practical point of view, set out the method that should be used to adjudicate such cases. The study thereafter suggests that, to address this issue, our courts should consider developing a methodological approach to measuring public policy in unfair enforcement cases. To support this proposition, the study examines the law on determining the enforcement of restraint of trade agreements. It is argued that, within that context, the courts have formulated a methodological approach in the form of a list of standard questions that a judge should ask when determining the enforceability of a restraint clause. The thesis then closes with a case study, using guidelines established from the approach in restraint cases, to illustrate how the proposed guideline may be formulated, and how it could be applied in general unfair enforcement cases. The thesis argues that a practical guide of this nature would serve as a useful tool for judges to use when faced with a claim relating to the unfair enforcement of a valid clause other than a restraint clause, and would thus ensure consistency in contractual enforcement analysis in South Africa. , Thesis (LLM) -- Faculty of Law, Law, 2021
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- Date Issued: 2021-04
Mapping the pyrroloiminoquinone diversity produced by latrunculid sponges using tandem mass spectrometry-driven molecular networking
- Authors: Kalinski, Jarmo-Charles J
- Date: 2021-04
- Subjects: To be added
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178468 , vital:42942
- Description: Access restricted until April 2023. , Thesis (PhD) -- Faculty of Science, Chemistry, 2021
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- Date Issued: 2021-04
Motivation to learn science and make sense of the concept of malleability through the traditional blast furnace in a grade 9 Physical Science class
- Authors: Kudumo, Wilfred Peter
- Date: 2021-04
- Subjects: Science -- Study and teaching (Secondary) -- Namibia -- Kavango West , Metals -- Effect of high temperatures on , Blast furnaces , Ethnoscience -- Namibia -- Kavango West , Ubuntu (Philosophy) , Culturally relevant pedagogy , Motivation in education -- Namibia -- Kavango West , Continuity Argumentative Theory (CAT)
- Language: English
- Type: thesis , text , Masters , MEd
- Identifier: http://hdl.handle.net/10962/177262 , vital:42804
- Description: The current situation of teaching and learning science in Namibia is of great concern since it does not seem to take into consideration learners’ socio-cultural backgrounds. As a result, learners are finding that science is not relevant to their everyday life experiences and hence are not motivated to learn it. This is compounded in part by the fact that the Namibian curriculum seems to be silent on how science teachers should include learners’ socio-cultural backgrounds, for example, local or indigenous knowledge in their teaching repertoires. It is against this background that in this study I explored how mobilising the cultural practice of a traditional blast furnace (mudukuto) as an approach enables and/or constrains learners’ motivation to learn science and make sense of the concept of malleability. This is a qualitative case study underpinned by a combination of interpretive and Ubuntu paradigms. It was carried out in a rural school in Namibia, Kavango West Region, where I am currently teaching. The participants in the study were grade 9 learners and one expert community member. Focus group interviews, participatory observation, learners’ reflections, and stimulated recall interviews were used to gather qualitative data. Vygotsky’s socio-cultural theory was used as a theoretical framework and Ogunniyi`s Continuity Argumentative Theory (CAT) was used as analytical framework or lens to analyse the data. A thematic approach to analyse data was employed. That is, qualitative data were analysed inductively to come up with sub-themes and themes. The findings of the study revealed that the traditional furnace motivated the learners involved in this study to learn science and learners were able to extract science concepts on malleability from the traditional practice. The implication for this study is that when science is related to learners’ daily life or real-world experiences, they are enabled to bridge the gap from what they learn at home or in the community with school science. The study thus recommends that teachers should make an effort to integrate local or indigenous knowledge and practices to make science accessible and relevant in their classrooms. , Thesis (MEd) -- Faculty of Education, Education, 2021
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- Date Issued: 2021-04
Nature conservation, protected areas and local communities : the Tsitsikamma National Park
- Authors: Le Fleur, Yvette Adele
- Date: 2021-04
- Subjects: National parks and reserves -- South Africa -- Eastern Cape , Protected areas -- Management , Programme of Work on Protected Areas , Human ecology -- South Africa -- Tsitsikamma , Nature conservation -- Citizen participation
- Language: English
- Type: thesis , text , Masters , MSocSc
- Identifier: http://hdl.handle.net/10962/177247 , vital:42803
- Description: Since the twentieth century, protected areas, usually in the form of nature reserves or national parks, have become increasingly more dominant as an international conservation strategy. An important factor in protected area management is the relationship between protected areas and its surrounding communities. Historically, the fortress conservation model based on the exclusion of human use and occupation prevailed in relation to protected areas. It is known that this approach brought with it many social and environmental injustices to local communities living in or adjacent to parks. However, a shift in conservation thinking occurred towards the end of the twentieth century, where it has increasingly been advocated for a more participatory approach in protected area management. South Africa has signed the international Convention on Biological Diversity that promotes a participatory approach to nature conservation, which is also reflected in the country’s national laws and policies. In relation to the literature and the lens of political ecology, this thesis sets out to assess in what ways and to what extent the participatory approach has been embraced by South Africa’s conservation authorities. As a case study, it looks at the Tsitsikamma National P ark ( incorporated into the larger Garden Route National Park). In order to get insight on h ow the participatory approach plays itself out at the T NP and what the nature of local communities’ relationship with the park is, this study looks at the aspects of (1) local communities’ socio-economic conditions, (2) their relationship with their natural environment, (3) their perception of nature conservation and (4) their perception of tourism. Then, taking all these aspects into account, (5) how local communities, in general, perceive their relationship with the p ark and its authorities. This study looked at the communities of Kurland, Nature’s Valley, Covie and Storms River. It shows in concurrence with other studies, that despite progressive laws and policies that express the intention of the South African state and SANParks to embrace the participatory approach, its implementation o n t he g round is riddled with challenges. , Thesis (MSocSc) -- Faculty of Humanities, Athropology, 2021
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- Date Issued: 2021-04
Night-time gravity waves detected with multi-frequency airglow imager
- Authors: Machubeng, Karabo Pebane
- Date: 2021-04
- Subjects: Gravity waves , Airglow , Gravity waves -- Seasonal variations , All Sky Imager
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178341 , vital:42931
- Description: This thesis shows the statistics of atmospheric gravity waves (AGWs) observed in the OI emission 557.7 nm at _97 km altitude using an all-sky imager based in Sutherland, South Africa (32.37_ S, 20.81_ E) in the year 2017. The wavelengths were determined using the propagation vector method, velocity was determined using the cross correlation of 1D FFT and the period was determined using the equation that relates wavelength and velocity. It was found that the horizontal wavelength in summer was almost evenly distributed between 10 and 40 km and for autumn, winter and spring were mostly between 10 and 30 km. The favoured speeds were between 40 and 50 m/s in autumn, as well as 30 and 50 m/s in summer, but the AGWs in winter had a bimodal speed distribution of 20 - 40 and 50 - 70 m/s. The majority of periods observed in all seasons were less than 20 minutes with a dominant peak of 5 - 10 minutes in autumn and spring. There was no favoured propagation direction for spring, but AGWs favoured a southeastward propagation in summer, and a southward propagation in autumn and winter. , Thesis (MSc) -- Faculty of Science, Physics and Electronics, 2021
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- Date Issued: 2021-04
Observations of cosmic re-ionisation with the Hydrogen Epoch of Reionization Array: simulations of closure phase spectra
- Authors: Charles, Ntsikelelo
- Date: 2021-04
- Subjects: Epoch of reionization , Space interferometry , Astronomy -- Observations , Closure phase spectra
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/174470 , vital:42480
- Description: The 21 cm transition from neutral Hydrogen promises to be the best observational probe of the Epoch of Reionisation. It has driven the construction of the new generation of low frequency radio interferometric arrays, including the Hydrogen Epoch of Reionization Array (HERA). The main difficulty in measuring the 21 cm signal is the presence of bright foregrounds that require very accurate interferometric calibration. Thyagarajan et al. (2018) proposed the use of closure phase quantities as a means to detect the 21 cm signal, which has the advantage of being independent (to first order) from calibration errors and therefore, bypasses the need for accurate calibration. Closure phases are, however, affected by so-called direction dependent effects, e.g. the fact that the dishes - or antennas - of an interferometric array are not identical to each other and , therefore, yield different antenna primary beam responses. In this thesis, we investigate the impact of direction dependent effects on closure quantities and simulate the impact that primary antenna beams affected by mutual coupling have on the foreground closure phase and its power spectrum i.e. the power spectrum of the bispectrum phase (Thyagarajan et al., 2020). Our simulations show that primary beams affected by mutual coupling lead to an overall leakage of foreground power in the so-called EoR window, i.e. power from smooth-spectrum foregrounds is confined to low k modes. We quantified this effect and found that the leakage is up to ~ 8 orders magnitude higher than the case of an ideal beam at kǁ > 0:5 h Mpc-1. We also found that the foreground leakage is worse when edge antennas are included, as they have a more different primary beam compared to antennas at the centre of the array. The leakage magnitude is worse when bright foregrounds appear in the antenna sidelobes, as expected. Our simulations provide a useful framework to interpret observations and assess which power spectrum region is expected to be most contaminated by foreground power leakage.
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- Date Issued: 2021-04
Perceptions of the role of Lantana camara on human well-being and rural livelihoods in Vhembe Biosphere Reserve, South Africa
- Authors: Mhlongo, Edward Swazi
- Date: 2021-04
- Subjects: Lantana camara -- South Africa -- Vhembe District Municipality , Introduced organisms -- South Africa -- Vhembe District Municipality , Biological invasions -- South Africa -- Vhembe District Municipality , Plant invasions -- South Africa -- Vhembe District Municipality , Lantana camara -- Control -- South Africa -- Vhembe District Municipality , South Africa -- Rural conditions , Ethnoscience -- South Africa -- Vhembe District Municipality
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177952 , vital:42893
- Description: In the past, social aspects on biological invasions were less documented, this hindered the development of sound and effective management of Invasive Alien Species (IAS). However, there has been a shift in trends with more studies on biological invasions integrating local knowledge together with ecological studies to develop effective management interventions. Invasive Alien Species are widespread throughout Southern Africa and are usually prevalent in the rural areas. Limpopo province consists of large rural areas where people depend on natural resources, wild and exotic species for their livelihoods. Lantana camara is one of the major invaders that is problematic worldwide having detrimental impacts on biodiversity, ecosystem functions, and economies. This study assessed the perceptions of the role of L. camara on the well-being and rural livelihoods of local communities in the Vhembe Biosphere Reserve using household surveys. A total of 300 surveys were administered in six villages. The study further used a two-pronged approach to examine invasion extent and management options. The two-pronged approach included (i) detailed vegetation surveys in 50 household yards within each village, and (ii) focus group to solicit local knowledge of invasion extent and managing L. camara by the rural communities. The results of the study showed that almost all the respondents knew L. camara and could describe it. Most of the respondents were of the view that L. camara had no negative impacts on their livelihoods. Other respondents stated costs associated with L. camara were more than benefits and wanted a reduction in L. camara densities in the area. Most respondents wanted more government intervention to help in managing L. camara, this is because of the perceived future impacts of L. camara. Vegetation survey results showed no significant difference in L. camara abundances and plant heights among the six study villages. The average number of L. camara counted per household yard in all villages was (2.41 ± 0.20) plants, with average plant basal diameter of (0.94 ± 0.02 cm). There were significant differences in canopy width of L. camara among the six study villages. Plant basal diameter was high in Tshakhuma (1.05 ± 0.04 m) and Duthuni (1.00 ± 0.04 m) villages, and low in Ha Mutsha village (0.82 ± 0.03 m). Lantana camara canopy width at household level across all villages averaged 1.34 ± 0.03 m. Canopy cover was high in Tshakhuma village (1.70 ± 0.09 m) and low at Ha Mutsha village (1.03 ± 0.03 m). In all six village focus group discussions, it was noted that mechanical clearing of L. camara was the most used method, but they reported minimum help from the government particularly Working for Water (WfW). The study concludes that L. camara has no substantial adverse impacts to most of the respondents. The study further noted that L. camara is dominant in most household yards ii and that management is taking place however current control options are not enough on their own. Suggestions for further research are to explore more alternative indigenous species present or easily accessible to the community members which may offer the same benefits as IAS. Furthermore, additional research at local level is required for implementing management techniques best suited for the area. , Thesis (MSc) -- Faculty of Science, Environmental Science, 2021
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- Date Issued: 2021-04
Photodynamic antimicrobial chemotherapy against Staphylococcus aureus and Escherichia coli sensitized using indium (III) cationic porphyrins linked to core-shell magnetic nanoparticles
- Authors: Makola, Lekgowa Collen
- Date: 2021-04
- Subjects: Photochemotherapy , Photosensitizing compounds , Staphylococcus aureus , Escherichia coli , Indium , Porphyrins , Magnetic nanoparticles , Quaternize
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177225 , vital:42801
- Description: Photodynamic antimicrobial chemotherapy (PACT) is a well-known antimicrobial therapy technique used against multi-drug resistant pathogens. In this study, the syntheses, characterization, photophysicochemical properties, and the applications of symmetrically and asymmetrically substituted cationic indium (III) porphyrins linked to silver/copper ferrite core-shell (Ag/CuFe2O4) magnetic nanoparticles (MNPs) as potential photosensitizers for PACT are reported. The synthesized complexes include axially modified porphyrins quaternized through an axial ligand. All the asymmetrically substituted porphyrins were linked to the NPs via an ester bond and the symmetrically substituted porphyrins were linked (peripherally and /or axially) via self-assembly (Ag-S and/or Ag-N). The impact of axial modification, peripheral substituents, conjugation to the NPs, the number of positive charges, and the chain length of the alkyl halides quaternizing agents on PACT efficacy and photophysicochemical properties of porphyrins were studied. High singlet oxygen quantum yields and antimicrobial log reductions were observed. Lipophilicity and hydrophilicity of the porphyrins were also studies, where the complexes quaternized with methyl iodide showed relatively high hydrophilicity character. Upon in vitro PACT studies, the quaternized complexes were observed to have 0% viable colony, signifying their effectiveness. Moreover, the highest log reductions of 9.27 were observed against S. aureus and 9.58 were observed against E. coli. The findings from this work delineate that singlet oxygen generation alone is not a distinct factor on the PACT efficacy of the porphyrin complexes, since some of the complexes have practically the same singlet oxygen quantum but different PACT activity. However, other contributing factors including water solubility play a significant role. , Thesis (MSc) -- Faculty of Science, Department of Chemistry, 2021
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- Date Issued: 2021-04
Physical activity, physical fitness, sedentary behaviour and screen time profiles of primary school children in a school within the Makana Municipality, Eastern Cape, South Africa
- Authors: Kade, Andréa Gaby
- Date: 2021-04
- Subjects: Sedentary behavior in children -- South Africa -- Makana Municipality , Physical fitness for children -- South Africa -- Makana Municipality , Exercise -- Physiological aspects , Exercise -- Health aspects , Diabetes -- Risk factors , Heart -- Diseases -- Risk factors
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/177282 , vital:42806
- Description: There is a lack of data on the physical activity, physical fitness and sedentary behaviour of children in South Africa. Furthermore chronic diseases such as type II diabetes and coronary heart disease have been linked to childhood inactivity, and improving cardiorespiratory fitness and increasing levels of physical activity has been shown to be beneficial in reducing the risk of such diseases. In South Africa more broadly there is a lack of information on levels of physical activity and sedentary behaviour as well as physical fitness measures particularly in children. Objective: The purpose of this study was to enhance the existing body of knowledge on this, by measuring the prevalence of physical inactivity, sedentary behaviour and screen time of primary school children in a private school from the Makana Municipal region in the Eastern Cape Province of South Africa, where the evidence is most sparse. A secondary aim was to assess levels of physical fitness in this cohort, as well as to compare across grades and sexes. Method: After ethical approval was granted, stature and body mass measurements were taken and body mass index was computed for primary school children (Grade one to seven) from a private school in the Makana Municipality. Sitting stature was measured in order to determine each child’s peak height velocity and maturity offset. Five different physical fitness tests were conducted on the children and blood pressure and heart rate values were measured at rest. Physical activity and screen time questionnaires were completed by the children’s parents for a seven day period. Results: Females were found to mature faster than males. In addition females were more physically active (Females= 916 min/week; Males= 669 min/week) while also accumulating more sedentary time (Females= 1241 min/week; Males= 970 min/week) as compared to males, although no significant differences were found between males and females for these variables. The sample participated in more than 60 minutes of moderate-to-vigorous physical activity and less than two hours of screen time daily, which is in accordance with guidelines. No differences were found between grades and sexes for accumulated screen time. Strength increased significantly with grade and age, and there were also statistical differences between the sexes for all three strength measures with males being stronger than females. Females were more flexible than males and no statistical differences were found between sexes for the shuttle run test. Blood pressure correlated positively with mass, as did all the strength measures as well as maturity offset. No correlations were found between screen time and all other variables. A negative relationship was recorded between screen time and physical activity, although not significant. For females a strong positive correlation was found between sedentary behaviour and physical activity. Conclusion: The study was successful in adding to the body of knowledge regarding the prevalence of physical inactivity, sedentary behaviour and screen time within school children from the Makana Municipality in the Eastern Cape Province of South Africa. The sample was considered physically active as they accumulated on average more than 60 minutes of moderate-to-vigorous physical activity daily (Males= 96 min/day; Females 130 min/day), which is in accordance with guidelines recommended by the World Health Organization (World Health Organization, 2018). The sample accumulated more sedentary behaviour than physical activity, although not significant. Screen time was below regulations of two hours daily, indicating this population participated in more non screen related sedentary behaviour. More research is needed into the risks presented with different forms of sedentary behaviour. Physical fitness increased with increasing grade and age and males were considerably more fit. The current study did not present any concern with regards to the effects of increased physical activity and fitness levels within school aged children. More research into the current levels of physical activity, physical fitness and sedentary behaviour of school aged children in South Africa in general, and in the Eastern Cape Province, is needed. , Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 2021
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- Date Issued: 2021-04
Salt in my footsteps
- Authors: Radebe, Mxolisi Vusumuzi
- Date: 2021-04
- Subjects: Creative writing (Higher education) -- South Africa , South African poetry (English) -- 21st century , South African fiction (English) -- 21st century
- Language: English
- Type: thesis , text , Masters , MA
- Identifier: http://hdl.handle.net/10962/178201 , vital:42920
- Description: My thesis is a collection of poems which focus on human experiences related to my background. I grew up in a countryside village, freely experiencing nature in unrestricted walks to the rivers and mountains; communal living instilled in me the humanitarian values which I uphold to the present. I use short and long lyrical prose poems to bring life and humanise the untold or unexpressed stories of my community. My use of simple everyday language and clear, concrete but surprising images that resonate with deeper meanings and emotions is influenced by Seitlhamo Motsapi’s poems, especially his collection of poems titled earthstepper/the ocean is very shallow and Mxolisi Nyezwa’s poetry book, Song Trials. Spanish poems in English translations by the 20th century Spanish poets: Blas de Otero, Juan Roman Jimenez and Federico Garcia Lorca, published in the book titled Roots and Wings have had a huge impact on my construction of images. I also draw from the free-form and narrative prose poetry experiments of poets: Mangaliso Buzani, vangile gantsho and Ivy Alvarez. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
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- Date Issued: 2021-04
Selection for improved virulence of Cryptophlebia peltastica nucleopolyhedrovirus (CrpeNPV) to False Codling Moth, Thaumatotibia leucotreta, by serial passage through a heterologous host
- Authors: Iita, Petrus Paulus
- Date: 2021-04
- Subjects: Cryptophlebia leucotreta -- Biological control , Biological pest control agents , Citrus -- Diseases and pests , Baculoviruses , Cryptophlebia peltastica nucleopolyhedrovirus (CrpeNPV)
- Language: English
- Type: thesis , text , Masters , MSc
- Identifier: http://hdl.handle.net/10962/178180 , vital:42918
- Description: The false codling moth (FCM), Thaumatotibia leucotreta (Meyrick) (Lepidoptera: Tortricidae) is endemic to southern Africa, and strongly associated with citrus. As South African citrus production is mainly for export to foreign markets, the market access risk due to the phytosanitary status of this pest is considerable and its control is therefore imperative. Various control measures as part of a rigorous integrated pest management (IPM) programme targeted against T. leucotreta have been effective at suppressing the pest in citrus, but there is still a growing need for continued improvement of the programme and augmentation of the available control options. Of these control options, biological control, particularly the use of Cryptophlebia leucotreta granulovirus (CrleGV-SA), is a key component of IPM in citrus orchards and it has been very successful at reducing T. leucotreta populations in the field for almost two decades. There is however, a growing need for more baculovirus variants with an improved virulence against T. leucotreta for a more efficient pest management system. The newly identified insect virus, Cryptophlebia peltastica nucleopolyhedrovirus (CrpeNPV) offers a unique opportunity for an additional biopesticide in IPM for control of T. leucotreta in the field. This study aimed to conduct serial passaging of CrpeNPV through a heterologous host, T. leucotreta, in order to determine the potential for improved virulence or speed of kill against it. In order to select for a variant of CrpeNPV with improved virulence against T. leucotreta, a high dose (LC90) of the virus OBs was used to perform 12 serial passages through T. leucotreta larvae in surface-dose bioassays. Whole genome sequencing and analysis of the passaged virus, along with restriction endonuclease profiling in silico was performed to determine if the genetic identity of the virus had changed during serial passage, in relation to the original virus. These analyses indicated that the dominant genotype of CrpeNPV was maintained following 12 serial passages through the heterologous host. The biological activity of the passaged virus, along with the original virus was evaluated against neonate T. leucotreta in surface-dose bioassays and compared. Results from dose-response bioassays showed that the virulence of CrpeNPV did not improve after 12 serial passages. The LC50 values of the passaged virus and the original virus were estimated at 1.96 × 104 and 1.58 × 104 OBs/ml, respectively, whereas the LC90 values were estimated at 3.46 × 104 OBs/ml for the passaged virus and 3.68 × 104 for the original virus. Similarly, the results from time-response bioassays showed that the speed of kill of CrpeNPV did not improve after 12 serial passages. The LT50 values of the passaged virus and the original virus were 88.44 hours (3 days and 16 hours) and 83.74 hours (3 days and 12 hours), respectively, whereas the LT90 values were 115 hours (4 days 19 hours) for the passaged virus and 102 hours (4 days 6 hours) for the original virus. The virulence and speed of kill of the passaged virus decreased significantly, in relation to the original virus. When the full genome of the passaged virus was sequenced and analysed, only a few SNPs were detected in the viral genome, in comparison to the original virus. No detectable difference in REN digestion patterns were observed following REN analysis of gDNA of the passaged virus with several restriction enzymes in silico. The results for this study suggest that CrpeNPV may already be optimally suited to the heterologous host as it persists under these conditions without significant changes to the genome. These results have positive implications for the genetic integrity of CrpeNPV as a potential biocontrol agent in the field. This study is the first to report the virulence selection of CrpeNPV by serial passage through a heterologous host, and also the first to record bioassay data in terms of dose response (or lethal concentration) against T. leucotreta second instars. The data obtained have added to the knowledge about interactions between CrpeNPV and its heterologous host, and may be fundamental to continued investigation into the effect of serial passage on pathogenicity and genetic diversity of CrpeNPV. , Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
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- Date Issued: 2021-04