The evaluation of autoxidation procedures for the selective oxidation of aliphatic alcohols
- Authors: Bacela, Siyabulela Mawande
- Date: 2001
- Subjects: Oxidation , Aliphatic compounds
- Language: English
- Type: Thesis , Masters , MTech (Chemistry)
- Identifier: vital:10950 , http://hdl.handle.net/10948/59 , Oxidation , Aliphatic compounds
- Description: The homogeneously catalyzed oxidation of 1-propanol by dioxygen in glacial acetic acid using cobalt(II)acetate and sodium bromide as the catalyst system has been investigated with the view of determining the significance of various experimental variables during the oxidation. The results of this investigation show unequivocally that a number of reaction variables have a direct influence upon catalytic activity and hence the reaction products. It is quite evident that the major product of this autoxidation reaction is propionic acid with the respective esters as side-products. This is an indication that the autoxidation mechanism occurs via a two-stage pathway, namely, the oxidation of 1-propanol to propionaldehyde as the primary product and, subsequently, the further oxidation of the propionaldehyde to propionic acid as the major product. Thus the esterification process of the propionic acid with the substrate 1-propanol could be termed as a side-reaction because its not facilitated by the catalyst system and it consumes the formed product. The catalyst activity has been demonstrated to depend on a number of factors, including the bromide concentration, the cobalt(II)acetate concentration, the water concentration, reaction temperature, and the presence of metal acetates as co-catalysts. There is an observed decrease in catalytic activity at high bromide concentration, which may be explained in terms of cobalt bromide complexes that form at these high concentrations. Subsequently, the same trend of catalyst activity reduction at high cobalt(II)acetate concentration may be ascribed to the “inactive” metal complexes that are susceptible to form at high metal ion concentrations. The catalytic activity increases with increase in total concentration and rapidly decreases at very high concentrations. This can be explained in terms of the observations made during the investigation of the effect of cobalt(II)acetate and bromide concentrations. The high increase in catalytic activity with increasing temperature is ascribed to the Arrhenius law, which relates the rate constant for a particular reaction to temperature. However, there is an observed loss of catalyst selectivity at high temperatures which maybe due to two possible factors. The first is simply related to an increased loss of volatile material from the reactor in the oxygen gas stream as the temperature is increased. The second relates to the increasing activity of the catalyst system for the selective decarboxylation of the carboxylic acid product. The addition of water to the reaction system rapidly reduces the catalyst activity. This detrimental effect is an indication that there is an effective competition by water with bromide for coordination sites on cobalt(II), thereby preventing the formation of the active catalyst species. The introduction of metal acetates as co-catalyst reduces the catalyst activity quite dramatically. This inhibition effect is suggested to relate to the redox potential of the respective metal ions. The results of statistical analysis of the experimentally derived response surface during the oxidation of 1-propanol, show no significant lack of fit, and the residuals obtained by applying the response surface to the design settings show that the data is normally distributed. The response surface is therefore reliable, but keeping in mind that the central composite design used is not rotatable so that its predictive power, especially outside the experimental domain investigated, is quite limited. However, several interesting observations were still possible The oxidative dehydrogenation of ethanol over supported noble-metal catalysts has been investigated with the view of identifying the most active supported noble-metal and also to compare this oxidation procedure with the autoxidation procedure. Secondly, the effect of an acidic resin as a co-catalyst was also investigated during the said oxidation. On the basis of results presented in this study during oxidative dehydrogenation of ethanol, catalysts no.2 (10% Pd/C), 8 (2% Pd/Al – Pb-promoted) and 9 (2% Pt/8% Pd/C) appear to be the most active in terms of relative rates, while catalysts 6 (10% Pd/C- Pbpromoted), 7 (5% Pd/C-shell reduced-Pb -promoted) and 10 (5% Pt 5% Pd on C) are more active based on the comparison of average rates. Two other observations are of interest. Firstly, the promotion of the Pd catalysts with lead appears to improve catalyst activity to some extent as shown by the comparisons between catalysts 1 and 5, 4 and 8, 2 and 6 and 3 and 7. Secondly, the introduction of Pt up to equal amounts with palladium seems to produce the most active catalysts. On its own, platinum appears to be a better catalyst than Pd when supported on activated carbon (catalysts 1 and 12). In comparison with the homogeneous, cobalt-bromide catalyzed oxidation of 1- propanol in the liquid-phase, oxidations over noble-metal catalysts in the liquid-phase appear to be significantly less active. The presence of the resin promoted the formation of ethyl acetate to some extent, the improvements are not as dramatic as expected.
- Full Text:
- Date Issued: 2001
- Authors: Bacela, Siyabulela Mawande
- Date: 2001
- Subjects: Oxidation , Aliphatic compounds
- Language: English
- Type: Thesis , Masters , MTech (Chemistry)
- Identifier: vital:10950 , http://hdl.handle.net/10948/59 , Oxidation , Aliphatic compounds
- Description: The homogeneously catalyzed oxidation of 1-propanol by dioxygen in glacial acetic acid using cobalt(II)acetate and sodium bromide as the catalyst system has been investigated with the view of determining the significance of various experimental variables during the oxidation. The results of this investigation show unequivocally that a number of reaction variables have a direct influence upon catalytic activity and hence the reaction products. It is quite evident that the major product of this autoxidation reaction is propionic acid with the respective esters as side-products. This is an indication that the autoxidation mechanism occurs via a two-stage pathway, namely, the oxidation of 1-propanol to propionaldehyde as the primary product and, subsequently, the further oxidation of the propionaldehyde to propionic acid as the major product. Thus the esterification process of the propionic acid with the substrate 1-propanol could be termed as a side-reaction because its not facilitated by the catalyst system and it consumes the formed product. The catalyst activity has been demonstrated to depend on a number of factors, including the bromide concentration, the cobalt(II)acetate concentration, the water concentration, reaction temperature, and the presence of metal acetates as co-catalysts. There is an observed decrease in catalytic activity at high bromide concentration, which may be explained in terms of cobalt bromide complexes that form at these high concentrations. Subsequently, the same trend of catalyst activity reduction at high cobalt(II)acetate concentration may be ascribed to the “inactive” metal complexes that are susceptible to form at high metal ion concentrations. The catalytic activity increases with increase in total concentration and rapidly decreases at very high concentrations. This can be explained in terms of the observations made during the investigation of the effect of cobalt(II)acetate and bromide concentrations. The high increase in catalytic activity with increasing temperature is ascribed to the Arrhenius law, which relates the rate constant for a particular reaction to temperature. However, there is an observed loss of catalyst selectivity at high temperatures which maybe due to two possible factors. The first is simply related to an increased loss of volatile material from the reactor in the oxygen gas stream as the temperature is increased. The second relates to the increasing activity of the catalyst system for the selective decarboxylation of the carboxylic acid product. The addition of water to the reaction system rapidly reduces the catalyst activity. This detrimental effect is an indication that there is an effective competition by water with bromide for coordination sites on cobalt(II), thereby preventing the formation of the active catalyst species. The introduction of metal acetates as co-catalyst reduces the catalyst activity quite dramatically. This inhibition effect is suggested to relate to the redox potential of the respective metal ions. The results of statistical analysis of the experimentally derived response surface during the oxidation of 1-propanol, show no significant lack of fit, and the residuals obtained by applying the response surface to the design settings show that the data is normally distributed. The response surface is therefore reliable, but keeping in mind that the central composite design used is not rotatable so that its predictive power, especially outside the experimental domain investigated, is quite limited. However, several interesting observations were still possible The oxidative dehydrogenation of ethanol over supported noble-metal catalysts has been investigated with the view of identifying the most active supported noble-metal and also to compare this oxidation procedure with the autoxidation procedure. Secondly, the effect of an acidic resin as a co-catalyst was also investigated during the said oxidation. On the basis of results presented in this study during oxidative dehydrogenation of ethanol, catalysts no.2 (10% Pd/C), 8 (2% Pd/Al – Pb-promoted) and 9 (2% Pt/8% Pd/C) appear to be the most active in terms of relative rates, while catalysts 6 (10% Pd/C- Pbpromoted), 7 (5% Pd/C-shell reduced-Pb -promoted) and 10 (5% Pt 5% Pd on C) are more active based on the comparison of average rates. Two other observations are of interest. Firstly, the promotion of the Pd catalysts with lead appears to improve catalyst activity to some extent as shown by the comparisons between catalysts 1 and 5, 4 and 8, 2 and 6 and 3 and 7. Secondly, the introduction of Pt up to equal amounts with palladium seems to produce the most active catalysts. On its own, platinum appears to be a better catalyst than Pd when supported on activated carbon (catalysts 1 and 12). In comparison with the homogeneous, cobalt-bromide catalyzed oxidation of 1- propanol in the liquid-phase, oxidations over noble-metal catalysts in the liquid-phase appear to be significantly less active. The presence of the resin promoted the formation of ethyl acetate to some extent, the improvements are not as dramatic as expected.
- Full Text:
- Date Issued: 2001
The experiences of couples in relationships characterized by alcohol dependency
- Authors: Mgilane, Nomgcobo Eunice
- Date: 2001
- Subjects: Alcoholism -- South Africa Alcoholics -- Family relationships Alcoholics' spouses -- South Africa Alcoholics -- South Africa -- Conduct of life
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:702 , http://hdl.handle.net/10962/d1006461
- Description: The study focused on the expenences of Xhosa-speaking couples in relationships characterized by alcohol dependency. The goal was to generate greater understanding of the descriptions of relationship issues faced by alcohol dependent respondents and their partners. Specifically, the study focused on exploring how the alcohol dependent respondents relate to their partners, their behaviour at home when drinking prior to their admission for rehabilitation, the experiences of their partners in living with alcohol dependent partners and how they coped with the situation. In order to meet this goal, literature and empirical studies were conducted. The literature study focuses on the alcohol dependent individual's behaviour, his emotions, relapse, the family's coping strategies, alcohol and marital problems and the role of the social worker as part of the rehabilitation team. During the empirical research phase, a non-probability purposive sampling procedure was adopted. Fifteen alcohol dependent clients who were admitted for treatment and rehabilitation at Thembelitsha Rehabilitation Centre (TRC) were selected. These clients were admitted to TRC during the period starting from January 1997 to June 1999 and were discharged to their homes during the research study. To collect data, interviews were conducted separately to a total of thirty respondents. Two interview schedules were used, one for the alcohol dependent respondents (Appendix A) and the other for their partners (Appendix B). This study revealed a remarkable consistency in the descriptions of relationship issues faced by alcohol dependent respondents and their partners. These are abusive behaviours by alcohol dependent respondents. The partners were reluctant and feared challenging the behaviour. The way in which partners responded to drinking and the reactions of alcohol dependent respondents are indicative of the difficult issues faced by the couples. The study also revealed that couples experience communication, financial and sexual relationship problems. The study concludes with recommendations based on the research findings
- Full Text:
- Date Issued: 2001
- Authors: Mgilane, Nomgcobo Eunice
- Date: 2001
- Subjects: Alcoholism -- South Africa Alcoholics -- Family relationships Alcoholics' spouses -- South Africa Alcoholics -- South Africa -- Conduct of life
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:702 , http://hdl.handle.net/10962/d1006461
- Description: The study focused on the expenences of Xhosa-speaking couples in relationships characterized by alcohol dependency. The goal was to generate greater understanding of the descriptions of relationship issues faced by alcohol dependent respondents and their partners. Specifically, the study focused on exploring how the alcohol dependent respondents relate to their partners, their behaviour at home when drinking prior to their admission for rehabilitation, the experiences of their partners in living with alcohol dependent partners and how they coped with the situation. In order to meet this goal, literature and empirical studies were conducted. The literature study focuses on the alcohol dependent individual's behaviour, his emotions, relapse, the family's coping strategies, alcohol and marital problems and the role of the social worker as part of the rehabilitation team. During the empirical research phase, a non-probability purposive sampling procedure was adopted. Fifteen alcohol dependent clients who were admitted for treatment and rehabilitation at Thembelitsha Rehabilitation Centre (TRC) were selected. These clients were admitted to TRC during the period starting from January 1997 to June 1999 and were discharged to their homes during the research study. To collect data, interviews were conducted separately to a total of thirty respondents. Two interview schedules were used, one for the alcohol dependent respondents (Appendix A) and the other for their partners (Appendix B). This study revealed a remarkable consistency in the descriptions of relationship issues faced by alcohol dependent respondents and their partners. These are abusive behaviours by alcohol dependent respondents. The partners were reluctant and feared challenging the behaviour. The way in which partners responded to drinking and the reactions of alcohol dependent respondents are indicative of the difficult issues faced by the couples. The study also revealed that couples experience communication, financial and sexual relationship problems. The study concludes with recommendations based on the research findings
- Full Text:
- Date Issued: 2001
The garden as a metaphor for paradise
- Authors: Adlard, Michelle Catherine
- Date: 2001
- Subjects: Paradise in art , Garden of paradise , Gardens -- Design -- Early works to 1800
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2391 , http://hdl.handle.net/10962/d1002187 , Paradise in art , Garden of paradise , Gardens -- Design -- Early works to 1800
- Description: In this half thesis the use of the garden as a metaphor for paradise has been explored. The English word “ paradise“ was derived from the Greek word “ paradeisos” which in turn was derived from the Old Avestana “ pairi-daeza,” meaning an enclosure. In Ancient Persia the concept applied to an enclosed garden in the modern sense of the word. For this reason the thesis begins with an examination of the development of the garden in this desert region. A more-or-less continuous chain of development in both the physical and allegorical nature of the garden is traced through history from these Ancient Persian beginnings to the height of Mughal architecture (epitomised by the Taj Mahal), by way of the Muslim expansion through Central Asia and Europe. While the core elements of garden design were set in Ancient Persian times, and recur throughout the period studied, the impact of Islam on the local Persian culture brought about a new development of allegorical meaning associated with the garden. This allegorical development reached its apex, too, in the Taj Mahal in which, it is argued, the metaphorical representation of paradise in the garden tomb was made astonishingly explicit. The research for this mini thesis was gathered from secondary sources, including many published books and academic papers, photographic and diagrammatic evidence of extant ancient gardens, and reproductions of carpet designs.
- Full Text:
- Date Issued: 2001
- Authors: Adlard, Michelle Catherine
- Date: 2001
- Subjects: Paradise in art , Garden of paradise , Gardens -- Design -- Early works to 1800
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2391 , http://hdl.handle.net/10962/d1002187 , Paradise in art , Garden of paradise , Gardens -- Design -- Early works to 1800
- Description: In this half thesis the use of the garden as a metaphor for paradise has been explored. The English word “ paradise“ was derived from the Greek word “ paradeisos” which in turn was derived from the Old Avestana “ pairi-daeza,” meaning an enclosure. In Ancient Persia the concept applied to an enclosed garden in the modern sense of the word. For this reason the thesis begins with an examination of the development of the garden in this desert region. A more-or-less continuous chain of development in both the physical and allegorical nature of the garden is traced through history from these Ancient Persian beginnings to the height of Mughal architecture (epitomised by the Taj Mahal), by way of the Muslim expansion through Central Asia and Europe. While the core elements of garden design were set in Ancient Persian times, and recur throughout the period studied, the impact of Islam on the local Persian culture brought about a new development of allegorical meaning associated with the garden. This allegorical development reached its apex, too, in the Taj Mahal in which, it is argued, the metaphorical representation of paradise in the garden tomb was made astonishingly explicit. The research for this mini thesis was gathered from secondary sources, including many published books and academic papers, photographic and diagrammatic evidence of extant ancient gardens, and reproductions of carpet designs.
- Full Text:
- Date Issued: 2001
The goddess, the witch and the bitch : three studies in the perception of women
- Authors: Hare, Nicola Tracy
- Date: 2001
- Subjects: Feminism in literature , Women's rights in literature , Feminism and literature , Patriarchy in literature
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10986 , http://hdl.handle.net/10948/278 , Feminism in literature , Women's rights in literature , Feminism and literature , Patriarchy in literature
- Description: In the minds of many people all over the world, women are ‘second class citizens’, standing accused of the downfall of mankind ever since Eve allegedly ate the apple. Even amongst those who do not openly denigrate women, there are many who do so in other, more subtle ways even if they are unaware of it. This study proposes to challenge such a view of women by exposing the ways in which perceptions of women are constructed by society, which frequently wants to maintain the status quo of male dominance. This study employs a feminist approach in examining this gynocentric theme, along with cultural studies which, with its focus on power relations and ways of decentring power structures, is also clearly of use. In addition, this multidisciplinary approach of cultural studies offers the possibility of studying literary texts as well as popular culture. Three specific time periods are examined, with a view to uncovering negative perceptions of women and ways that women can resist such attempts to control them. In chapter one, the focus turns to contemporary perceptions of prehistoric women and the ways that so-called ‘objective’ science has failed to represent women accurately. Similarly, ‘objective’ accounts of Goddess-worship – which frequently fail to examine this phenomenon adequately – are revisited. Alice Walker’s The Temple of My Familiar (1989) is discussed as a text which acts as a site of resistance to societally-informed perceptions. Chapter two continues this investigation by turning to the concept of the witch and its maligned association with women. Woman and witchcraft, having been associated for centuries, are investigated as a pairing which frequently results because iii of attempts to control women by androcentric society. In such situations, the practising of witchcraft can actually become a form of resistance to patriarchy. The pernicious effect of society’s need to purge itself – by witch hunts – of witches is also investigated. The Devil’s Chimney (1997) by Anne Landsman and “The prophetess” (1994) by Njabulo S. Ndebele are discussed as texts which examine fictionalised South African versions of this phenomenon. Sinead O’Connor, the Irish singer, is the ‘bitch’ discussed in chapter three. She is examined as a woman who offers strong and on-going resistance to patriarchal ways of thinking which would ‘box’ women in. This singer refuses to accept societal roles which are offered to women and so offers means of resistance to patriarchy, many of which are discussed in this chapter. This study concludes that it is the responsibility of women to resist patriarchy and to define roles for themselves. The three chapters examine various means of resistance and offer women insight into the forms of opposition they themselves can take.
- Full Text:
- Date Issued: 2001
- Authors: Hare, Nicola Tracy
- Date: 2001
- Subjects: Feminism in literature , Women's rights in literature , Feminism and literature , Patriarchy in literature
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10986 , http://hdl.handle.net/10948/278 , Feminism in literature , Women's rights in literature , Feminism and literature , Patriarchy in literature
- Description: In the minds of many people all over the world, women are ‘second class citizens’, standing accused of the downfall of mankind ever since Eve allegedly ate the apple. Even amongst those who do not openly denigrate women, there are many who do so in other, more subtle ways even if they are unaware of it. This study proposes to challenge such a view of women by exposing the ways in which perceptions of women are constructed by society, which frequently wants to maintain the status quo of male dominance. This study employs a feminist approach in examining this gynocentric theme, along with cultural studies which, with its focus on power relations and ways of decentring power structures, is also clearly of use. In addition, this multidisciplinary approach of cultural studies offers the possibility of studying literary texts as well as popular culture. Three specific time periods are examined, with a view to uncovering negative perceptions of women and ways that women can resist such attempts to control them. In chapter one, the focus turns to contemporary perceptions of prehistoric women and the ways that so-called ‘objective’ science has failed to represent women accurately. Similarly, ‘objective’ accounts of Goddess-worship – which frequently fail to examine this phenomenon adequately – are revisited. Alice Walker’s The Temple of My Familiar (1989) is discussed as a text which acts as a site of resistance to societally-informed perceptions. Chapter two continues this investigation by turning to the concept of the witch and its maligned association with women. Woman and witchcraft, having been associated for centuries, are investigated as a pairing which frequently results because iii of attempts to control women by androcentric society. In such situations, the practising of witchcraft can actually become a form of resistance to patriarchy. The pernicious effect of society’s need to purge itself – by witch hunts – of witches is also investigated. The Devil’s Chimney (1997) by Anne Landsman and “The prophetess” (1994) by Njabulo S. Ndebele are discussed as texts which examine fictionalised South African versions of this phenomenon. Sinead O’Connor, the Irish singer, is the ‘bitch’ discussed in chapter three. She is examined as a woman who offers strong and on-going resistance to patriarchal ways of thinking which would ‘box’ women in. This singer refuses to accept societal roles which are offered to women and so offers means of resistance to patriarchy, many of which are discussed in this chapter. This study concludes that it is the responsibility of women to resist patriarchy and to define roles for themselves. The three chapters examine various means of resistance and offer women insight into the forms of opposition they themselves can take.
- Full Text:
- Date Issued: 2001
The identification of operations strategies based on business principles that will enhance the public sector's ability to retain its client departments
- Authors: Davids, Shahied
- Date: 2001
- Subjects: Eastern Cape (South Africa) -- Public Works Department , Customer services
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10941 , http://hdl.handle.net/10948/d1006192 , Eastern Cape (South Africa) -- Public Works Department , Customer services
- Description: The research problem addressed in this study was to identify operational strategies that will enhance the ability of National Public Works Department (NPWD) of the Eastern Cape to retain its Client Departments. Privatisation has lead to performance management becoming essential to satisfy the client departments needs and requirements. In order to identify operational strategies which will enhance NPWD’s operation’s performance, questionnaires with relevant operation questions were used as well as a brain-writing session. The findings of the literature survey clearly highlight the specific areas where attention is required for improvements.
- Full Text:
- Date Issued: 2001
- Authors: Davids, Shahied
- Date: 2001
- Subjects: Eastern Cape (South Africa) -- Public Works Department , Customer services
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10941 , http://hdl.handle.net/10948/d1006192 , Eastern Cape (South Africa) -- Public Works Department , Customer services
- Description: The research problem addressed in this study was to identify operational strategies that will enhance the ability of National Public Works Department (NPWD) of the Eastern Cape to retain its Client Departments. Privatisation has lead to performance management becoming essential to satisfy the client departments needs and requirements. In order to identify operational strategies which will enhance NPWD’s operation’s performance, questionnaires with relevant operation questions were used as well as a brain-writing session. The findings of the literature survey clearly highlight the specific areas where attention is required for improvements.
- Full Text:
- Date Issued: 2001
The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution
- Authors: Lebete, Mosimotsana Leah
- Date: 2001 , 2013-04-26
- Subjects: Midazolam -- Solubility
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3823 , http://hdl.handle.net/10962/d1005923 , Midazolam -- Solubility
- Description: Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a solubilizer. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
- Authors: Lebete, Mosimotsana Leah
- Date: 2001 , 2013-04-26
- Subjects: Midazolam -- Solubility
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3823 , http://hdl.handle.net/10962/d1005923 , Midazolam -- Solubility
- Description: Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a solubilizer. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
The influence of a performance management programme on the achievement of organisational and individual goals : a case study
- Authors: Van Huyssteen, Hannes
- Date: 2001
- Subjects: Performance -- Management , Goal setting in personnel management
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:10915 , http://hdl.handle.net/10948/63 , Performance -- Management , Goal setting in personnel management
- Description: Many organisations are continuously searching for methods which can be used to improve performance. One such method is by means of implementing a performance management programme. This research study addresses the influence that a performance management programme has on the achievement of organisational and individual performance. To achieve this objective a comprehensive literature study was performed to determine the views on performance, and on performance management programmes. The study also included an investigation into the extent to which a performance management programme should be aligned with organisational and individual goals. Questionnaires, developed from the literature study, were distributed amongst randomly selected respondents, in order to determine the extent to which a specific organisation manages performance, in line with the guidelines provided by the literature study. The information obtained from the questionnaires were compared with the guidelines provided by the literature study in order to identify shortcomings in the influence that the performance management programme has on the achievement of organisational and individual goals at the selected organisation. The final step of this study entailed the formulation of recommendations. Three of these recommendations are regarded as critical to ensure the successful improvement of performance by means of a performance management programme: Firstly, it is of utmost importance that training and development, and the necessary resources to achieve objectives is provided. Secondly, feedback forms an integral part of a performance management programme. Those who provide feedback, need to acquire the necessary skills, so as to ensure that both positive and negative feedback is given to employees, which could ultimately enhance performance. Thirdly, the success of a performance management programme resides with both management and employees. Management need to be committed to the programme, and the well-being of their employees. Management also needs to be able to eliminate problems that negatively influence performance. On the other hand, employees need to realise that a performance management programme is not only linked to pay, but also the development of each individual, and the improvement of performance.
- Full Text:
- Date Issued: 2001
- Authors: Van Huyssteen, Hannes
- Date: 2001
- Subjects: Performance -- Management , Goal setting in personnel management
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:10915 , http://hdl.handle.net/10948/63 , Performance -- Management , Goal setting in personnel management
- Description: Many organisations are continuously searching for methods which can be used to improve performance. One such method is by means of implementing a performance management programme. This research study addresses the influence that a performance management programme has on the achievement of organisational and individual performance. To achieve this objective a comprehensive literature study was performed to determine the views on performance, and on performance management programmes. The study also included an investigation into the extent to which a performance management programme should be aligned with organisational and individual goals. Questionnaires, developed from the literature study, were distributed amongst randomly selected respondents, in order to determine the extent to which a specific organisation manages performance, in line with the guidelines provided by the literature study. The information obtained from the questionnaires were compared with the guidelines provided by the literature study in order to identify shortcomings in the influence that the performance management programme has on the achievement of organisational and individual goals at the selected organisation. The final step of this study entailed the formulation of recommendations. Three of these recommendations are regarded as critical to ensure the successful improvement of performance by means of a performance management programme: Firstly, it is of utmost importance that training and development, and the necessary resources to achieve objectives is provided. Secondly, feedback forms an integral part of a performance management programme. Those who provide feedback, need to acquire the necessary skills, so as to ensure that both positive and negative feedback is given to employees, which could ultimately enhance performance. Thirdly, the success of a performance management programme resides with both management and employees. Management need to be committed to the programme, and the well-being of their employees. Management also needs to be able to eliminate problems that negatively influence performance. On the other hand, employees need to realise that a performance management programme is not only linked to pay, but also the development of each individual, and the improvement of performance.
- Full Text:
- Date Issued: 2001
The legal protection afforded to the consumer under current South African law with emphasis on the legal position in specific credit agreements contained in standard-form contracts
- Authors: Ndou, Fulufhelo Clyde
- Date: 2001
- Subjects: Consumer protection , Consumer protection -- Law and legislation -- South Africa
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:3688 , http://hdl.handle.net/10962/d1003203 , Consumer protection , Consumer protection -- Law and legislation -- South Africa
- Description: The thesis covers the field of the contract law known as the consumer credit law. It deals with the legal protection afforded to the consumer under current South African law with emphasis on the legal position in specific credit agreements contained in standard-form contracts. The thesis focuses on those credit contracts in which the legal relationship between the consumer and the dominant party is contained in the standard-form contracts, specifically credit agreements relating to money lending transactions in which the credit grantor’s rights are secured either by means of mortgage agreement, a suretyship contract, or a deed of cession. In South Africa the right to equality and human dignity, as opposed to the classical theories of contract: pacta sunt servanda and the principle of freedom of contract, are supported by the Constitution of the Republic of South Africa Act 108 of 1996 which entrenched democratic values permeating all areas of the law including contract law. In this thesis the harmonisation of these classical theories of contract law and the constitutional values of human dignity and equality have been considered. As has been shown in a number of cases, notably those relating to the contracts of suretyship, cession in securitatem debiti, and mortgage, the current law regulating the relationship between the credit grantors and the credit receivers is in need of law reform to fall in line with the constitutional values of equality and human dignity. The greatest difficulty inherent in this area of the law is the reluctance of the courts to intervene at the instance of consumers. The courts would only intervene in the clearest of the cases, and would only do so in the public interest. In this thesis the current South African Law is considered in the light of the developments elsewhere. The tendency of credit providers to alter the terms of the contracts unilaterally and the growing number of conflicting decisions of the Provincial Divisions of High Court has also been considered. The writer also considers the role of the newly created Consumer Affairs Court.
- Full Text:
- Date Issued: 2001
- Authors: Ndou, Fulufhelo Clyde
- Date: 2001
- Subjects: Consumer protection , Consumer protection -- Law and legislation -- South Africa
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:3688 , http://hdl.handle.net/10962/d1003203 , Consumer protection , Consumer protection -- Law and legislation -- South Africa
- Description: The thesis covers the field of the contract law known as the consumer credit law. It deals with the legal protection afforded to the consumer under current South African law with emphasis on the legal position in specific credit agreements contained in standard-form contracts. The thesis focuses on those credit contracts in which the legal relationship between the consumer and the dominant party is contained in the standard-form contracts, specifically credit agreements relating to money lending transactions in which the credit grantor’s rights are secured either by means of mortgage agreement, a suretyship contract, or a deed of cession. In South Africa the right to equality and human dignity, as opposed to the classical theories of contract: pacta sunt servanda and the principle of freedom of contract, are supported by the Constitution of the Republic of South Africa Act 108 of 1996 which entrenched democratic values permeating all areas of the law including contract law. In this thesis the harmonisation of these classical theories of contract law and the constitutional values of human dignity and equality have been considered. As has been shown in a number of cases, notably those relating to the contracts of suretyship, cession in securitatem debiti, and mortgage, the current law regulating the relationship between the credit grantors and the credit receivers is in need of law reform to fall in line with the constitutional values of equality and human dignity. The greatest difficulty inherent in this area of the law is the reluctance of the courts to intervene at the instance of consumers. The courts would only intervene in the clearest of the cases, and would only do so in the public interest. In this thesis the current South African Law is considered in the light of the developments elsewhere. The tendency of credit providers to alter the terms of the contracts unilaterally and the growing number of conflicting decisions of the Provincial Divisions of High Court has also been considered. The writer also considers the role of the newly created Consumer Affairs Court.
- Full Text:
- Date Issued: 2001
The mandibular gland secretions and ovarial development of worker honeybees (Apis Mellifera) in the Eastern Cape Province of South Africa
- Authors: Reece, Sacha Louise
- Date: 2001
- Subjects: Honeybee -- South Africa -- Eastern Cape , Honeybee -- Behavior , Honeybee -- Physiology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5729 , http://hdl.handle.net/10962/d1005415 , Honeybee -- South Africa -- Eastern Cape , Honeybee -- Behavior , Honeybee -- Physiology
- Description: The Eastern Cape is an area in which Apis mellifera capensis, A. m. scutellata and their hybrid are known to naturally occur. I investigated the mandibular gland profiles and ovarial development of queenright workers from 4 localities. Their queens were then removed to determine how these aspects changed upon queen loss. In addition, drifted bees were analysed in the same way to determine how these factors changed once they had gained entry to a foreign hive. The queenright bees, form all 4 localities were found to have 9HDA as the most abundant of the 5 fatty acids measured and all localities had small percentages of 9ODA in their mandibular gland secretions. This resulted in relatively high queenright 9ODA:10HDA and 9HDA:10HDAA ratios. Despite this the percentage of bees with undeveloped ovaries was consistent with their queenright status. The mean values of these 2 ratios were significantly higher in the bees from East London and Cradock than those from Port Elizabeth. Steynsburg's bees were intermediate in this regard. Upon queen loss, the bees from all 4 localities had an increase in the percentage of 9ODA but the other compound changes in varying ways. East London's bees were the only ones not to become significantly more queen-like after queen loss. After 14 days without a queen, the mean values of these 2 ratios were much higher in the bees from Port Elizabeth than those from the other localities. Certain individuals from Port Elizabeth had values of these ratios that exceeded those found in A. m. capensis queens. Port Elizabeth was the only locality to display any surrogate queens and exhibited the highest increase in the number of bees with partially or fully developed ovaries. While certain individuals from the other localities had values of these ratios that exceeded these values reported in A. m. scutellata queens, Steynsburg's bees were the only ones that did increase in in terms of the number of bees with developed ovaries subsequent. The bees from Steynsburg were shown to suppress the mandibular gland and ovarial development of drifters from Port Elizabeth while bees from East London did not.
- Full Text:
- Date Issued: 2001
- Authors: Reece, Sacha Louise
- Date: 2001
- Subjects: Honeybee -- South Africa -- Eastern Cape , Honeybee -- Behavior , Honeybee -- Physiology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5729 , http://hdl.handle.net/10962/d1005415 , Honeybee -- South Africa -- Eastern Cape , Honeybee -- Behavior , Honeybee -- Physiology
- Description: The Eastern Cape is an area in which Apis mellifera capensis, A. m. scutellata and their hybrid are known to naturally occur. I investigated the mandibular gland profiles and ovarial development of queenright workers from 4 localities. Their queens were then removed to determine how these aspects changed upon queen loss. In addition, drifted bees were analysed in the same way to determine how these factors changed once they had gained entry to a foreign hive. The queenright bees, form all 4 localities were found to have 9HDA as the most abundant of the 5 fatty acids measured and all localities had small percentages of 9ODA in their mandibular gland secretions. This resulted in relatively high queenright 9ODA:10HDA and 9HDA:10HDAA ratios. Despite this the percentage of bees with undeveloped ovaries was consistent with their queenright status. The mean values of these 2 ratios were significantly higher in the bees from East London and Cradock than those from Port Elizabeth. Steynsburg's bees were intermediate in this regard. Upon queen loss, the bees from all 4 localities had an increase in the percentage of 9ODA but the other compound changes in varying ways. East London's bees were the only ones not to become significantly more queen-like after queen loss. After 14 days without a queen, the mean values of these 2 ratios were much higher in the bees from Port Elizabeth than those from the other localities. Certain individuals from Port Elizabeth had values of these ratios that exceeded those found in A. m. capensis queens. Port Elizabeth was the only locality to display any surrogate queens and exhibited the highest increase in the number of bees with partially or fully developed ovaries. While certain individuals from the other localities had values of these ratios that exceeded these values reported in A. m. scutellata queens, Steynsburg's bees were the only ones that did increase in in terms of the number of bees with developed ovaries subsequent. The bees from Steynsburg were shown to suppress the mandibular gland and ovarial development of drifters from Port Elizabeth while bees from East London did not.
- Full Text:
- Date Issued: 2001
The nature of economic integration and co-operation within the South African region and a survey of economic benefits to member states
- Authors: Mutambara, Tsitsi Effie
- Date: 2001
- Subjects: Africa, Southern -- Economic integration , Southern African Development Community
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:938 , http://hdl.handle.net/10962/d1002671 , Africa, Southern -- Economic integration , Southern African Development Community
- Description: The transformation of SADCC into the Southern African Development Community (SADC) has paved the way towards closer regional economic integration in southern Africa. The regional grouping no longer only focuses on sectoral cooperation, but is steadily moving towards increased cooperation in trade development and promotion, industrial development and the diversification of national economies, with the aim of increasing regional economic integration. A free trade area ranks second lowest in the steps towards the highest levels of economic integration. Thus, the signing of the SADC Trade Protocol, which serves to pave way for a SADC Free Trade Area, has initiated steps to facilitate and promote the formal economic integration of all countries in the southern African region. It has been noted that at various periods, the region has adopted a variety of approaches to integration. As such, the present study reviews the different approaches to integration, namely the market integration model, the neo-functional integration model, the development integration model and the theory of common markets. Since the essential question with which this thesis is concerned is whether, and to what extent, the benefits expected from SADC and SACU in terms of their aims and objectives have accrued to member states, an insight into the expected benefits arising from the application of each theoretical framework can help to facilitate an evaluation of the benefits which the countries have enjoyed from these two regional groupings. The thesis highlights that throughout the ten years during which the original SADCC was in place, it based its approach to regional integration on the neo-functional and development integration models, although the former tended to be more dominant. With the regional grouping transforming into SADC, the market integration model was adopted, even though the grouping still had features of the aforementioned approaches. The relevance of the three approaches can be seen in: (i) the continued importance of SADC's sectoral projects, particularly in the field of transport and communication: (ii) continued attempts to put in place a suitable regional) industrial development strategy and implement policies to attract foreign investment; and (iii) the signing of the SADCC Trade Protocol to facilitate the implementation of a free trade area. The thesis argues that member states have enjoyed considerable economic benefits from the SADC sectoral projects. However, in some cases, members have lost out on potential benefits as a result of projects failing to be implemented or completed, mainly due to inadequate funding. Further, delays and inefficiencies at some border posts constitute significant non-tariff barriers which could be a hindrance to intra-regional trade. Progress towards diversification of exports has been limited as the region still relies mostly on the export of the traditional agricultural and mineral raw materials. While all countries have made efforts to diversify their industrial bases, attempts at implementing a meaningful regional industrial development strategy have met with limited success. Intra-regional trade has been increasing over the years. Since the SADC Trade Protocol only came into effect in September 2000, the increased levels of trade integration in the region appear to have been a result of the bilateral trade agreements between countries, and the customs union between South Africa and Botswana, Lesotho, Namibia and Swaziland (BLNS), as well as the structural adjustment programmes and the significant growth experienced in some countries. Outstanding intra-regional trade volumes have been experienced within SACU. In trade terms, benefits have varied between member states, with the more powerful countries like South Africa, Zimbabwe and Mauritius experiencing substantial trade surpluses vis-a.-vis their trade, partners. Countries with bilateral preferential trade agreements have also benefited more due to increased access into each other's markets compared to those without or with bilateral trade agreements of an MFN nature. However, it is important to note that, despite the increase in trade integration in the region, southern Africa is still heavily dependent on the rest of the world for its export markets and as its source of imports. The study finds that intra-industry trade (IIT) exists within the region and, in a number of sectors, high IIT indices are recorded;--although some such sectors do not display significant trade - voIumes. The opening of the region through the implementation of the SADC FTA could promote the expansion of IIT .as-the free trade area )'Till create an enlarged regional market. As such, SADC could benefit from dynamic effects such as scale economies in production and marketing, with member states working on having complementary production structures so as to facilitate specialisation. The thesis argues that the potential for intra-regional trade expansion in the SADC FT A also exists bearing in mind trade complementarity between countries as well as revealed comparative advantages in different sectors. One of the benefits which have accrued to the region as a result of facilitating and promoting greater cooperation and deepening the integration process has been an expansion in cross border investment. The study finds that the 1990s witnessed a gradual increase in cross border investment to take advantage of investment opportunities in member states. South Africa has become the primary source of foreign direct investment flows to a number of SADC countries, with mergers and acquisitions being the dominant mode of its foreign direct investment. Cross border investment helps in supplementing low domestic savings, thus providing substantial parts of the shortfall in capital needed to finance economic growth and development. It can thus promote development in the industrial sector, transfer of capital, skills and technology, and development of infrastructure. Many SADC countries are unable to compete effectively due to lack of export supply capacity. The thesis suggests that capitalising on investment by South African firms could enhance local supply capabilities and raise export competitiveness. The study concludes that for market integration to succeed in the SADC region, the neofunctional and development integration approaches need to be actively pursued simultaneously, particularly with respect to infrastructural and industrial development.
- Full Text:
- Date Issued: 2001
- Authors: Mutambara, Tsitsi Effie
- Date: 2001
- Subjects: Africa, Southern -- Economic integration , Southern African Development Community
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:938 , http://hdl.handle.net/10962/d1002671 , Africa, Southern -- Economic integration , Southern African Development Community
- Description: The transformation of SADCC into the Southern African Development Community (SADC) has paved the way towards closer regional economic integration in southern Africa. The regional grouping no longer only focuses on sectoral cooperation, but is steadily moving towards increased cooperation in trade development and promotion, industrial development and the diversification of national economies, with the aim of increasing regional economic integration. A free trade area ranks second lowest in the steps towards the highest levels of economic integration. Thus, the signing of the SADC Trade Protocol, which serves to pave way for a SADC Free Trade Area, has initiated steps to facilitate and promote the formal economic integration of all countries in the southern African region. It has been noted that at various periods, the region has adopted a variety of approaches to integration. As such, the present study reviews the different approaches to integration, namely the market integration model, the neo-functional integration model, the development integration model and the theory of common markets. Since the essential question with which this thesis is concerned is whether, and to what extent, the benefits expected from SADC and SACU in terms of their aims and objectives have accrued to member states, an insight into the expected benefits arising from the application of each theoretical framework can help to facilitate an evaluation of the benefits which the countries have enjoyed from these two regional groupings. The thesis highlights that throughout the ten years during which the original SADCC was in place, it based its approach to regional integration on the neo-functional and development integration models, although the former tended to be more dominant. With the regional grouping transforming into SADC, the market integration model was adopted, even though the grouping still had features of the aforementioned approaches. The relevance of the three approaches can be seen in: (i) the continued importance of SADC's sectoral projects, particularly in the field of transport and communication: (ii) continued attempts to put in place a suitable regional) industrial development strategy and implement policies to attract foreign investment; and (iii) the signing of the SADCC Trade Protocol to facilitate the implementation of a free trade area. The thesis argues that member states have enjoyed considerable economic benefits from the SADC sectoral projects. However, in some cases, members have lost out on potential benefits as a result of projects failing to be implemented or completed, mainly due to inadequate funding. Further, delays and inefficiencies at some border posts constitute significant non-tariff barriers which could be a hindrance to intra-regional trade. Progress towards diversification of exports has been limited as the region still relies mostly on the export of the traditional agricultural and mineral raw materials. While all countries have made efforts to diversify their industrial bases, attempts at implementing a meaningful regional industrial development strategy have met with limited success. Intra-regional trade has been increasing over the years. Since the SADC Trade Protocol only came into effect in September 2000, the increased levels of trade integration in the region appear to have been a result of the bilateral trade agreements between countries, and the customs union between South Africa and Botswana, Lesotho, Namibia and Swaziland (BLNS), as well as the structural adjustment programmes and the significant growth experienced in some countries. Outstanding intra-regional trade volumes have been experienced within SACU. In trade terms, benefits have varied between member states, with the more powerful countries like South Africa, Zimbabwe and Mauritius experiencing substantial trade surpluses vis-a.-vis their trade, partners. Countries with bilateral preferential trade agreements have also benefited more due to increased access into each other's markets compared to those without or with bilateral trade agreements of an MFN nature. However, it is important to note that, despite the increase in trade integration in the region, southern Africa is still heavily dependent on the rest of the world for its export markets and as its source of imports. The study finds that intra-industry trade (IIT) exists within the region and, in a number of sectors, high IIT indices are recorded;--although some such sectors do not display significant trade - voIumes. The opening of the region through the implementation of the SADC FTA could promote the expansion of IIT .as-the free trade area )'Till create an enlarged regional market. As such, SADC could benefit from dynamic effects such as scale economies in production and marketing, with member states working on having complementary production structures so as to facilitate specialisation. The thesis argues that the potential for intra-regional trade expansion in the SADC FT A also exists bearing in mind trade complementarity between countries as well as revealed comparative advantages in different sectors. One of the benefits which have accrued to the region as a result of facilitating and promoting greater cooperation and deepening the integration process has been an expansion in cross border investment. The study finds that the 1990s witnessed a gradual increase in cross border investment to take advantage of investment opportunities in member states. South Africa has become the primary source of foreign direct investment flows to a number of SADC countries, with mergers and acquisitions being the dominant mode of its foreign direct investment. Cross border investment helps in supplementing low domestic savings, thus providing substantial parts of the shortfall in capital needed to finance economic growth and development. It can thus promote development in the industrial sector, transfer of capital, skills and technology, and development of infrastructure. Many SADC countries are unable to compete effectively due to lack of export supply capacity. The thesis suggests that capitalising on investment by South African firms could enhance local supply capabilities and raise export competitiveness. The study concludes that for market integration to succeed in the SADC region, the neofunctional and development integration approaches need to be actively pursued simultaneously, particularly with respect to infrastructural and industrial development.
- Full Text:
- Date Issued: 2001
The need for formal training in social work supervision
- Authors: Moss, Antoinette Rosemary
- Date: 2001
- Subjects: Social workers -- Supervision of , Social workers -- Training of
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:703 , http://hdl.handle.net/10962/d1006466 , Social workers -- Supervision of , Social workers -- Training of
- Description: The research is based on the need for formal training in social work supervision with the emphasis on the experiences and feelings associated with the role change from supervisee to supervisor. Practice has shown that the transition from supervisee to supervisor takes place with very little, if any, formal training. It is assumed that any experienced social worker could give supervision as if this is merely an extension of your field work activities – which include casework, group work and community work. Whilst doing supervision cognisance was taken of the fact that the task of the supervisor was to help the supervisee gain access to a more advantageous position from which to consider or view their work. A supervisor had a crucial role in professional development. The opinion is upheld that there has to be a working alliance to attain this development. This working alliance can be taken further when viewed by the fact that the supervisor also has to establish communication networks that enable the supervisor to work both at a managerial level while maintaining positive relationships with his or her supervisees – a process which is fraught with complications. Semi-structured interviews were conducted with fourteen social work supervisors and a focus group was conducted with five social work supervisors from the Department of Welfare and Private Welfare Organizations. These interviews were conducted to obtain their perspectives on the need for training in social work supervision and how training could help them in their supervision role which ultimately could result in a more efficient service that is rendered to the client. The data analysis was conducted at the same time as the data collection. The researcher had a clear plan for the data management. The researcher utilized reasoning strategies, identified themes, categories and subcategories. It was borne in mind that there was no one way of performing data analysis. The researcher was open and flexible. Final conclusions of the data analysis was grounded in the data obtained. The key issue in ensuring the trustworthiness was the verification of the results of the data analysis. The research study suggests that there is a genuine need for formal training in social work supervision. With training the supervisors can develop competencies, knowledge and professional attitudes, they can be helpful to neophytes and to each other. With training they can avoid some of the pitfalls in supervision and become more efficient and competent
- Full Text:
- Date Issued: 2001
- Authors: Moss, Antoinette Rosemary
- Date: 2001
- Subjects: Social workers -- Supervision of , Social workers -- Training of
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:703 , http://hdl.handle.net/10962/d1006466 , Social workers -- Supervision of , Social workers -- Training of
- Description: The research is based on the need for formal training in social work supervision with the emphasis on the experiences and feelings associated with the role change from supervisee to supervisor. Practice has shown that the transition from supervisee to supervisor takes place with very little, if any, formal training. It is assumed that any experienced social worker could give supervision as if this is merely an extension of your field work activities – which include casework, group work and community work. Whilst doing supervision cognisance was taken of the fact that the task of the supervisor was to help the supervisee gain access to a more advantageous position from which to consider or view their work. A supervisor had a crucial role in professional development. The opinion is upheld that there has to be a working alliance to attain this development. This working alliance can be taken further when viewed by the fact that the supervisor also has to establish communication networks that enable the supervisor to work both at a managerial level while maintaining positive relationships with his or her supervisees – a process which is fraught with complications. Semi-structured interviews were conducted with fourteen social work supervisors and a focus group was conducted with five social work supervisors from the Department of Welfare and Private Welfare Organizations. These interviews were conducted to obtain their perspectives on the need for training in social work supervision and how training could help them in their supervision role which ultimately could result in a more efficient service that is rendered to the client. The data analysis was conducted at the same time as the data collection. The researcher had a clear plan for the data management. The researcher utilized reasoning strategies, identified themes, categories and subcategories. It was borne in mind that there was no one way of performing data analysis. The researcher was open and flexible. Final conclusions of the data analysis was grounded in the data obtained. The key issue in ensuring the trustworthiness was the verification of the results of the data analysis. The research study suggests that there is a genuine need for formal training in social work supervision. With training the supervisors can develop competencies, knowledge and professional attitudes, they can be helpful to neophytes and to each other. With training they can avoid some of the pitfalls in supervision and become more efficient and competent
- Full Text:
- Date Issued: 2001
The operation of letters of credit with particular reference to the doctrine of strict compliance, the principle of independence, the fraud exception and conflict of laws
- Makobe, Melanchton Phillip Malepe
- Authors: Makobe, Melanchton Phillip Malepe
- Date: 2001
- Subjects: Letters of credit Conflict of laws Fraud
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:3710 , http://hdl.handle.net/10962/d1007281
- Description: The thesis covers aspects of the law relating to letters of credit. It deals with the operation of letters of credit with particular reference to the doctrine of strict compliance, the principle of independence, the fraud exception and conflict of laws. According to the principle of independence, banks must make payment in terms of the letter of credit irrespective of any dispute that may exist between the buyer and the seller in an underlying contract or other contracts. Although the principle of independence is clearly established, it is not absolute. An exception occurs in the case of fraud. Thus, if the seller has committed fraud, such as tendering forged documents, the buyer can instruct the bank not to make payment in terms of the credit. If the bank refuses to dishonour the letter of credit, the buyer can apply to a court to interdict the bank from making payment. In South African law the buyer must establish that the seller was party to fraud in relation to the documents presented to the bank for payment before the court can grant an interdict. This thesis also examines the standard of proof of fraud required in letters of credit transactions and proposes a standard of proof which will not unduly favour the seller whose good faith is in dispute. The fast growing technology of computers and telecommunications is rapidly changing the methods of transacting business by paper documentation and letter of credit transactions are no exception. At present the buyer can apply to the bank to issue a letter of credit through the computer and banks also communicate letter of credit transactions through computer networks. However, the beneficiary still has to present documents to the bank for payment in paper form. It is proposed that the Uniform Custom and Practice For Documentary Credits (UCP) be amended to provide for fully computerised letters of credit transactions. Another objective of the thesis is to examine the doctrine of strict compliance. In terms of the doctrine of strict compliance documents presented under the credit must comply strictly with the requirements set out in the credit. If banks are satisfied that the documents presented by the seller strictly conform with the requirements of the credit they are obliged to make payment as required by the credit. It is proposed that the doctrine of strict compliance should not be applied strictly. In other words, the banks should make payment in terms of the credit if the discrepancy in the documents is trivial. The thesis also covers conflict of laws issues. As the UCP does not have rules dealing with conflict of laws, most jurisdictions have developed their own rules to be applied by the courts in cases of conflict of laws. The thesis examines the different rules of conflict of laws as developed and practiced by different jurisdictions.
- Full Text:
- Date Issued: 2001
- Authors: Makobe, Melanchton Phillip Malepe
- Date: 2001
- Subjects: Letters of credit Conflict of laws Fraud
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:3710 , http://hdl.handle.net/10962/d1007281
- Description: The thesis covers aspects of the law relating to letters of credit. It deals with the operation of letters of credit with particular reference to the doctrine of strict compliance, the principle of independence, the fraud exception and conflict of laws. According to the principle of independence, banks must make payment in terms of the letter of credit irrespective of any dispute that may exist between the buyer and the seller in an underlying contract or other contracts. Although the principle of independence is clearly established, it is not absolute. An exception occurs in the case of fraud. Thus, if the seller has committed fraud, such as tendering forged documents, the buyer can instruct the bank not to make payment in terms of the credit. If the bank refuses to dishonour the letter of credit, the buyer can apply to a court to interdict the bank from making payment. In South African law the buyer must establish that the seller was party to fraud in relation to the documents presented to the bank for payment before the court can grant an interdict. This thesis also examines the standard of proof of fraud required in letters of credit transactions and proposes a standard of proof which will not unduly favour the seller whose good faith is in dispute. The fast growing technology of computers and telecommunications is rapidly changing the methods of transacting business by paper documentation and letter of credit transactions are no exception. At present the buyer can apply to the bank to issue a letter of credit through the computer and banks also communicate letter of credit transactions through computer networks. However, the beneficiary still has to present documents to the bank for payment in paper form. It is proposed that the Uniform Custom and Practice For Documentary Credits (UCP) be amended to provide for fully computerised letters of credit transactions. Another objective of the thesis is to examine the doctrine of strict compliance. In terms of the doctrine of strict compliance documents presented under the credit must comply strictly with the requirements set out in the credit. If banks are satisfied that the documents presented by the seller strictly conform with the requirements of the credit they are obliged to make payment as required by the credit. It is proposed that the doctrine of strict compliance should not be applied strictly. In other words, the banks should make payment in terms of the credit if the discrepancy in the documents is trivial. The thesis also covers conflict of laws issues. As the UCP does not have rules dealing with conflict of laws, most jurisdictions have developed their own rules to be applied by the courts in cases of conflict of laws. The thesis examines the different rules of conflict of laws as developed and practiced by different jurisdictions.
- Full Text:
- Date Issued: 2001
The phloem unloading and sucrose-sequestration pathway in the internodal stem tissue of the Saccharum hybrid var. NCo376
- Authors: Gerber, Jacqués
- Date: 2001
- Subjects: Saccharum , Sugarcane , Sugar -- Synthesis , Sugar growing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4194 , http://hdl.handle.net/10962/d1003763
- Description: Internodes 5-8, 10, 13 and 15 of Saccharum sp. var. NCo376 were examined for evidence of symplasmic phloem unloading of sucrose from the phloem, via the bundle sheath to the storage parenchyma. The vascular bundle possesses wellisolated phloem comprised of large diameter sieve elements and small diameter companion cells. A layer of phloem parenchyma surrounds the phloem, except where the phloem abuts the crushed protophloem. Outside this is a sclerenchymatous sheath, directly endarch to a parenchymatous bundle sheath, which is surrounded by storage parenchyma. The bundle sheath is interrupted at the centrifugal pole of the vascular bundle by a phloem fibre cap. Scanning Electron Microscopy revealed plasmodesmal fields throughout the bundle sheath and pith tissue. Transmission Electron Microscopy studies provided evidence of plasmodesmal occlusion, but not in all tissues. Aniline blue reactions under UV light indicate the presence of occluded plasmodesmal fields at the phloem parenchyma / sclerenchymatous sheath interface, and in localised regions of cells which are smaller than the surrounding storage parenchyma cells. This suggests a symplasmic transport pathway at these locations, and, based on these positive aniline blue reactions, with regulation via callose-mediated transplasmodesmal transport. Osmotic stress experiments, which included the addition of Ca2+, did not reveal further callose occlusion in the parenchyma, suggesting that the plasmodesmata in these regions may be closed via a noncallosic mechanism. Dye-coupling studies, using Lucifer Yellow (LYCH), which was iontophoretically injected following turgor-pressure equalisation, showed only rare, limited symplastic transport, usually only between the injected cell and one adjacent cell. Most injections did not result in transport of LYCH, suggesting either a lack of plasmodesmal connectivity, occlusion, or gating of any plasmodesmata present. This limited symplasmic transport, combined with the presence of occluded plasmodesmata at the phloem parenchyma / sclerenchymatous sheath interface suggests the presence of a two-domain phloem-unloading pathway. While symplastic transport may occur from the phloem to the sclerenchymatous sheath, further sucrose transport to the storage parenchyma appears to proceed apoplasmically from the sclerenchymatous sheath / bundle sheath interface, and into storage parenchyma cells across the cell wall and cell membrane via specialised sucrose transporters.
- Full Text:
- Date Issued: 2001
- Authors: Gerber, Jacqués
- Date: 2001
- Subjects: Saccharum , Sugarcane , Sugar -- Synthesis , Sugar growing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4194 , http://hdl.handle.net/10962/d1003763
- Description: Internodes 5-8, 10, 13 and 15 of Saccharum sp. var. NCo376 were examined for evidence of symplasmic phloem unloading of sucrose from the phloem, via the bundle sheath to the storage parenchyma. The vascular bundle possesses wellisolated phloem comprised of large diameter sieve elements and small diameter companion cells. A layer of phloem parenchyma surrounds the phloem, except where the phloem abuts the crushed protophloem. Outside this is a sclerenchymatous sheath, directly endarch to a parenchymatous bundle sheath, which is surrounded by storage parenchyma. The bundle sheath is interrupted at the centrifugal pole of the vascular bundle by a phloem fibre cap. Scanning Electron Microscopy revealed plasmodesmal fields throughout the bundle sheath and pith tissue. Transmission Electron Microscopy studies provided evidence of plasmodesmal occlusion, but not in all tissues. Aniline blue reactions under UV light indicate the presence of occluded plasmodesmal fields at the phloem parenchyma / sclerenchymatous sheath interface, and in localised regions of cells which are smaller than the surrounding storage parenchyma cells. This suggests a symplasmic transport pathway at these locations, and, based on these positive aniline blue reactions, with regulation via callose-mediated transplasmodesmal transport. Osmotic stress experiments, which included the addition of Ca2+, did not reveal further callose occlusion in the parenchyma, suggesting that the plasmodesmata in these regions may be closed via a noncallosic mechanism. Dye-coupling studies, using Lucifer Yellow (LYCH), which was iontophoretically injected following turgor-pressure equalisation, showed only rare, limited symplastic transport, usually only between the injected cell and one adjacent cell. Most injections did not result in transport of LYCH, suggesting either a lack of plasmodesmal connectivity, occlusion, or gating of any plasmodesmata present. This limited symplasmic transport, combined with the presence of occluded plasmodesmata at the phloem parenchyma / sclerenchymatous sheath interface suggests the presence of a two-domain phloem-unloading pathway. While symplastic transport may occur from the phloem to the sclerenchymatous sheath, further sucrose transport to the storage parenchyma appears to proceed apoplasmically from the sclerenchymatous sheath / bundle sheath interface, and into storage parenchyma cells across the cell wall and cell membrane via specialised sucrose transporters.
- Full Text:
- Date Issued: 2001
The refining of calcium using a sulfate reducing bacterial system
- Authors: Horne, Kerry Allison
- Date: 2001
- Subjects: Calcium carbonate -- Synthesis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3915 , http://hdl.handle.net/10962/d1003974 , Calcium carbonate -- Synthesis
- Description: White lime is used in many industries in South Africa but is not produced locally and must be imported. Many technologies have been suggested for the large-scale manufacture of calcium carbonate but these are not necessarily suitable for application in South Africa. This study investigated a chemical preparation of calcium carbonate combined with biological purification Calcium containing materials from the Pretoria Portland Cement, Lime Division factory at Lime Acres in the Northern Cape were studied as the starting materials for the manufacture. Investigation showed that they contained various impurities, including iron and manganese compounds which were largely responsible for the brown-grey colour of the lime products. Complete dissolution of calcium hydroxide, the purest of the potential starting materials, and subsequent hydroxide precipitation was not successful in removing all iron and manganese. Precipitation with sulfide ions was successfill, decreasing levels of metals to below the detection limit of atomic absorption spectrophotometry. Studies of all potential starting materials revealed that the levels of impurities in the starting material did not have a large effect on levels of impurities in the calcium carbonate produced. It was therefore possible to convert the residual calcium oxide or hydroxide in waste lime dusts to white calcium carbonate, a marketable prciduct Recycling of the water and starting material used in the process served to increase, rather than decrease, the purity of the calcium carbonate product. This allows for water conservation as water is not consumed in the process but merely utilised. When waste lime dust was used as the starting material, sulfate was found in the product. While still a white lime, the calcium carbonate was not chemically pure. Sulfate removal was therefore investigated and the use of sulfate-reducing bacteria was studied as a novel application. A mixed sulfate-reducing bacterial population was isolated and found to be hIghly active at sulfate concentrations between 0.2 and 2 ~~~. They were capable of autotrophic growth and could reduce sulfate in solutions with elevated pH and in calcium carbonate suspensions, although they did not grow readily in these media. A process was designed for the production of bulk quantities of calcium carbonate making use of the facilities and materials available at Lime Acres. This was tested using a small scale bench-top reactor series, with favourable results. The process would allow automatic, continuous production of large quantities of white lime using waste lime dust. Provision was also made for manufacture of smaller quantities of pure calcium carbonate using sulfate-reducing bacteria to remove the sulfate impurity.
- Full Text:
- Date Issued: 2001
- Authors: Horne, Kerry Allison
- Date: 2001
- Subjects: Calcium carbonate -- Synthesis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3915 , http://hdl.handle.net/10962/d1003974 , Calcium carbonate -- Synthesis
- Description: White lime is used in many industries in South Africa but is not produced locally and must be imported. Many technologies have been suggested for the large-scale manufacture of calcium carbonate but these are not necessarily suitable for application in South Africa. This study investigated a chemical preparation of calcium carbonate combined with biological purification Calcium containing materials from the Pretoria Portland Cement, Lime Division factory at Lime Acres in the Northern Cape were studied as the starting materials for the manufacture. Investigation showed that they contained various impurities, including iron and manganese compounds which were largely responsible for the brown-grey colour of the lime products. Complete dissolution of calcium hydroxide, the purest of the potential starting materials, and subsequent hydroxide precipitation was not successful in removing all iron and manganese. Precipitation with sulfide ions was successfill, decreasing levels of metals to below the detection limit of atomic absorption spectrophotometry. Studies of all potential starting materials revealed that the levels of impurities in the starting material did not have a large effect on levels of impurities in the calcium carbonate produced. It was therefore possible to convert the residual calcium oxide or hydroxide in waste lime dusts to white calcium carbonate, a marketable prciduct Recycling of the water and starting material used in the process served to increase, rather than decrease, the purity of the calcium carbonate product. This allows for water conservation as water is not consumed in the process but merely utilised. When waste lime dust was used as the starting material, sulfate was found in the product. While still a white lime, the calcium carbonate was not chemically pure. Sulfate removal was therefore investigated and the use of sulfate-reducing bacteria was studied as a novel application. A mixed sulfate-reducing bacterial population was isolated and found to be hIghly active at sulfate concentrations between 0.2 and 2 ~~~. They were capable of autotrophic growth and could reduce sulfate in solutions with elevated pH and in calcium carbonate suspensions, although they did not grow readily in these media. A process was designed for the production of bulk quantities of calcium carbonate making use of the facilities and materials available at Lime Acres. This was tested using a small scale bench-top reactor series, with favourable results. The process would allow automatic, continuous production of large quantities of white lime using waste lime dust. Provision was also made for manufacture of smaller quantities of pure calcium carbonate using sulfate-reducing bacteria to remove the sulfate impurity.
- Full Text:
- Date Issued: 2001
The Rhodes BioSure process in the treatment of acid mine drainage wastewaters
- Authors: Corbett, Christopher John
- Date: 2001 , 2013-05-03
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4077 , http://hdl.handle.net/10962/d1007405
- Description: While sulphate-enriched wastewaters are generated in a number of industrial processes, such as tanning, paper manufacture and metals processing, the principal contributors to large-scale pollution from this source in South Africa are the gold and coal mining industries. Both biological and physico-chemical processes, set in train by mining operations, give rise to the oxidation of sulphur species, and the resultant generation of AMD. The Vaal River system is most affected and receives large tonnages of mining related salinity as both direct discharges, and in diffuse runoff flows. The long-term burden of this problem, and sustaining ongoing treatment over the time-frames involved will almost certainly resort to the community inhabiting the area, notwithstanding progressive mine closure legislation and comprehensive regulation governing the polluterpays principle. The volume and time-frame of the AMD problem, and the need for a long-term and sustainable response has focused interest in biological treatment approaches. These have concentrated on active and passive treatment systems, both of which rely on microbial activity related to the biological sulphur cycle. Notwithstanding the reactor type, and the particular treatment approach used, widespread application of active AMD treatment has not yet been seen on any large scale. Singular factors constraining process development are bioreactor design, cost of bioreactor construction, and the cost of the carbon source and electron donor for the biological sulphate reduction process. The SRB are able to utilise only a limited range of small organic molecules. The studies reported here were motivated by the need to evaluate low-cost options and the treatment of high volume AMD flows. This has focussed research activity on bioprocess developments using complex organic compounds derived from waste streams as electron donor sources, and the integration of AMD treatment with other waste treatment objectives. The co-disposal of organic wastes with AMD treatment would enable the development of an 'integrated resource management' approach to the problem, including sustainability of treatment operations over the long time-frames involved. Apart from the cost advantages accrued to waste treatment, the recovery of the treated water as a resource to the wider community provides a potentially important value-added function to the combined operation. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
- Authors: Corbett, Christopher John
- Date: 2001 , 2013-05-03
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:4077 , http://hdl.handle.net/10962/d1007405
- Description: While sulphate-enriched wastewaters are generated in a number of industrial processes, such as tanning, paper manufacture and metals processing, the principal contributors to large-scale pollution from this source in South Africa are the gold and coal mining industries. Both biological and physico-chemical processes, set in train by mining operations, give rise to the oxidation of sulphur species, and the resultant generation of AMD. The Vaal River system is most affected and receives large tonnages of mining related salinity as both direct discharges, and in diffuse runoff flows. The long-term burden of this problem, and sustaining ongoing treatment over the time-frames involved will almost certainly resort to the community inhabiting the area, notwithstanding progressive mine closure legislation and comprehensive regulation governing the polluterpays principle. The volume and time-frame of the AMD problem, and the need for a long-term and sustainable response has focused interest in biological treatment approaches. These have concentrated on active and passive treatment systems, both of which rely on microbial activity related to the biological sulphur cycle. Notwithstanding the reactor type, and the particular treatment approach used, widespread application of active AMD treatment has not yet been seen on any large scale. Singular factors constraining process development are bioreactor design, cost of bioreactor construction, and the cost of the carbon source and electron donor for the biological sulphate reduction process. The SRB are able to utilise only a limited range of small organic molecules. The studies reported here were motivated by the need to evaluate low-cost options and the treatment of high volume AMD flows. This has focussed research activity on bioprocess developments using complex organic compounds derived from waste streams as electron donor sources, and the integration of AMD treatment with other waste treatment objectives. The co-disposal of organic wastes with AMD treatment would enable the development of an 'integrated resource management' approach to the problem, including sustainability of treatment operations over the long time-frames involved. Apart from the cost advantages accrued to waste treatment, the recovery of the treated water as a resource to the wider community provides a potentially important value-added function to the combined operation. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
The right of the HIV/AIDS patient to treatment
- Authors: Hoffmann, Toinette
- Date: 2001
- Subjects: AIDS (Disease) -- Patients -- Legal status, Laws, etc. -- South Africa , Hiv-positive Persons -- Legal status, Laws, etc. -- South Africa , AIDS (Disease) -- Government policy -- South Africa , AIDS (Disease) -- Treatment , AIDS (Disease) -- Social aspects
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:11042 , http://hdl.handle.net/10948/277 , AIDS (Disease) -- Patients -- Legal status, Laws, etc. -- South Africa , Hiv-positive Persons -- Legal status, Laws, etc. -- South Africa , AIDS (Disease) -- Government policy -- South Africa , AIDS (Disease) -- Treatment , AIDS (Disease) -- Social aspects
- Description: The objective of this treatise is to establish whether a right to social security exists in South Africa, which would entitle HIV positive persons in South Africa citizens to medical care. A study was made of various articles in journals and on the Internet to determine the South African government's policy on a right to social security and to providing medical treatment. It was found that South Africa lacks an integrated, holistic approach to social security and does not guarantee the right to social security, merely the right to have access to social security. The same was found with the right to medical care. Although there seems to be a general right to medical care which extends to and includes HIV-positive patients, the state merely guarantees the right to apply for medical treatment but does not guarantee the granting thereof. It is submitted that the Department of Health's refusal to implement a vertical transmission prevention programme and the failure to offer treatment as an alternative, for whatever reason, is "penny wise and pound foolish". In the long run more money is spent dealing with pediatric AIDS. It was further found that although the government attempted to lay a groundwork with the formulation and acceptance of the national AIDS plan, the successful implementation thereof is seriously hindered due to the lack of inter- and intra-departmental collaboration, essential health services and funding.
- Full Text:
- Date Issued: 2001
- Authors: Hoffmann, Toinette
- Date: 2001
- Subjects: AIDS (Disease) -- Patients -- Legal status, Laws, etc. -- South Africa , Hiv-positive Persons -- Legal status, Laws, etc. -- South Africa , AIDS (Disease) -- Government policy -- South Africa , AIDS (Disease) -- Treatment , AIDS (Disease) -- Social aspects
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:11042 , http://hdl.handle.net/10948/277 , AIDS (Disease) -- Patients -- Legal status, Laws, etc. -- South Africa , Hiv-positive Persons -- Legal status, Laws, etc. -- South Africa , AIDS (Disease) -- Government policy -- South Africa , AIDS (Disease) -- Treatment , AIDS (Disease) -- Social aspects
- Description: The objective of this treatise is to establish whether a right to social security exists in South Africa, which would entitle HIV positive persons in South Africa citizens to medical care. A study was made of various articles in journals and on the Internet to determine the South African government's policy on a right to social security and to providing medical treatment. It was found that South Africa lacks an integrated, holistic approach to social security and does not guarantee the right to social security, merely the right to have access to social security. The same was found with the right to medical care. Although there seems to be a general right to medical care which extends to and includes HIV-positive patients, the state merely guarantees the right to apply for medical treatment but does not guarantee the granting thereof. It is submitted that the Department of Health's refusal to implement a vertical transmission prevention programme and the failure to offer treatment as an alternative, for whatever reason, is "penny wise and pound foolish". In the long run more money is spent dealing with pediatric AIDS. It was further found that although the government attempted to lay a groundwork with the formulation and acceptance of the national AIDS plan, the successful implementation thereof is seriously hindered due to the lack of inter- and intra-departmental collaboration, essential health services and funding.
- Full Text:
- Date Issued: 2001
The role of a symbiotic bryozoan in the chemical ecology of a marine benthic predator-prey interaction
- Authors: Gray, Christopher Anthony
- Date: 2001
- Subjects: Marine animals , Marine ecology , Benthic animals
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5756 , http://hdl.handle.net/10962/d1005444 , Marine animals , Marine ecology , Benthic animals
- Description: The subtidal whelk Burnupena papyracea (Brugière) co-occurs with a voracious predator, the rock lobster Jasus lalandii (Milne Edwards), in situations where other potential prey are largely eliminated. This has been ascribed to a symbiotic bryozoan, Alcyonidium nodosum (O’Donoghue and de Watteville), which characteristically encrusts the shells of B. papyracea and deters feeding by Jasus. In this study it is shown that this is not due to physical effects of either induced physical defences in the bryozoan or increased shell strength due to the presence of the bryozoan. Neither spectroscopic screening of chemical extracts of the bryozoan nor analysis for volatile constituents revealed any apparent chemical components that are likely to deter feeding. Chemical extracts also failed to show larvicidal effects in a standard toxicity assay using the brine shrimp Artemia salina (Leach). Despite this, bioassays using individual Jasus indicated a chemical basis for feeding deterrence. The assays were run separately on three sets of Jasus and some repeats of assays gave contradictory results. However, assays showing no significant effect of treatment occurred with moulting Jasus, involved very low overall feeding rates and so gave a less convincing result. In other assays Jasus always avoided Burnupena papyracea with live Alcyonidium encrusting the shell, and food pellets containing Alcyonidium or an Alcyonidium extract. Significant preferences were shown for an unencrusted whelk, B. cincta (Röding), over B. papyracea; for B. papyracea with the bryozoan scraped off over natural B. papyracea; for B. papyracea on which the bryozoans had been killed with liquid nitrogen over untreated B. papyracea; and for food pellets prepared from ground, dried mussel over pellets prepared with dried mussel mixed with A. nodosum or its crude organic extract. It is concluded that the protection which Alcyonidium confers on Burnupena papyracea does have a chemical basis, but that the chemical responsible is either present in only trace quantities, or that it is a structurally unremarkable compound which is distasteful to Jasus. This work highlights both the advantages of using ecologically relevant bioassays (positive results when standard techniques give a negative result) and also the disadvantages (logistic constraints on sample sizes when using large test animals and individual variability in a relatively sophisticated test animal).
- Full Text:
- Date Issued: 2001
- Authors: Gray, Christopher Anthony
- Date: 2001
- Subjects: Marine animals , Marine ecology , Benthic animals
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5756 , http://hdl.handle.net/10962/d1005444 , Marine animals , Marine ecology , Benthic animals
- Description: The subtidal whelk Burnupena papyracea (Brugière) co-occurs with a voracious predator, the rock lobster Jasus lalandii (Milne Edwards), in situations where other potential prey are largely eliminated. This has been ascribed to a symbiotic bryozoan, Alcyonidium nodosum (O’Donoghue and de Watteville), which characteristically encrusts the shells of B. papyracea and deters feeding by Jasus. In this study it is shown that this is not due to physical effects of either induced physical defences in the bryozoan or increased shell strength due to the presence of the bryozoan. Neither spectroscopic screening of chemical extracts of the bryozoan nor analysis for volatile constituents revealed any apparent chemical components that are likely to deter feeding. Chemical extracts also failed to show larvicidal effects in a standard toxicity assay using the brine shrimp Artemia salina (Leach). Despite this, bioassays using individual Jasus indicated a chemical basis for feeding deterrence. The assays were run separately on three sets of Jasus and some repeats of assays gave contradictory results. However, assays showing no significant effect of treatment occurred with moulting Jasus, involved very low overall feeding rates and so gave a less convincing result. In other assays Jasus always avoided Burnupena papyracea with live Alcyonidium encrusting the shell, and food pellets containing Alcyonidium or an Alcyonidium extract. Significant preferences were shown for an unencrusted whelk, B. cincta (Röding), over B. papyracea; for B. papyracea with the bryozoan scraped off over natural B. papyracea; for B. papyracea on which the bryozoans had been killed with liquid nitrogen over untreated B. papyracea; and for food pellets prepared from ground, dried mussel over pellets prepared with dried mussel mixed with A. nodosum or its crude organic extract. It is concluded that the protection which Alcyonidium confers on Burnupena papyracea does have a chemical basis, but that the chemical responsible is either present in only trace quantities, or that it is a structurally unremarkable compound which is distasteful to Jasus. This work highlights both the advantages of using ecologically relevant bioassays (positive results when standard techniques give a negative result) and also the disadvantages (logistic constraints on sample sizes when using large test animals and individual variability in a relatively sophisticated test animal).
- Full Text:
- Date Issued: 2001
The role of strategic control in implementing an empowerment strategy in a selected higher education institution
- Kolver, Willem Andreas Pieter
- Authors: Kolver, Willem Andreas Pieter
- Date: 2001
- Subjects: Education, Higher -- South Africa -- Management , Employee empowerment , Strategic planning
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:10890 , http://hdl.handle.net/10948/71 , Education, Higher -- South Africa -- Management , Employee empowerment , Strategic planning
- Description: Higher education institutions in South Africa are under pressure on account of changes in their environment so those institutions which can adapt to the changes and continue to carry out their purposes will be the most successful. According to Wellins, Byham and Wilson (1991:21) the employee empowerment and energy that comes with a feeling of ownership, are necessary prerequisites for continuous improvement. When organisational values, leadership actions and human resources systems, for example, rewards, training, and organisational structures are focused on empowerment, continuous improvement actions result. These, in turn, could lead to competitive quality, increased productivity and improved customer service. This dissertation aims to assess what would be an appropriate strategic control model when implementing an empowerment strategy. To this end an empowerment process management model is presented, as well as an investigation into the most effective environment where empowerment can be implemented and the management style needed. Secondly, the characteristics of strategic control are considered and lastly, the particular circumstances of a tertiary education institution are discussed. The findings of this study are that the concept of strategic control and empowerment and the reality which exists at the selected higher education institution concur in certain instances, from the managers’ perspective. Further research to investigate the role of strategic control in implementing an empowerment strategy at the selected higher education institution when all role players are included, is recommended.
- Full Text:
- Date Issued: 2001
- Authors: Kolver, Willem Andreas Pieter
- Date: 2001
- Subjects: Education, Higher -- South Africa -- Management , Employee empowerment , Strategic planning
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:10890 , http://hdl.handle.net/10948/71 , Education, Higher -- South Africa -- Management , Employee empowerment , Strategic planning
- Description: Higher education institutions in South Africa are under pressure on account of changes in their environment so those institutions which can adapt to the changes and continue to carry out their purposes will be the most successful. According to Wellins, Byham and Wilson (1991:21) the employee empowerment and energy that comes with a feeling of ownership, are necessary prerequisites for continuous improvement. When organisational values, leadership actions and human resources systems, for example, rewards, training, and organisational structures are focused on empowerment, continuous improvement actions result. These, in turn, could lead to competitive quality, increased productivity and improved customer service. This dissertation aims to assess what would be an appropriate strategic control model when implementing an empowerment strategy. To this end an empowerment process management model is presented, as well as an investigation into the most effective environment where empowerment can be implemented and the management style needed. Secondly, the characteristics of strategic control are considered and lastly, the particular circumstances of a tertiary education institution are discussed. The findings of this study are that the concept of strategic control and empowerment and the reality which exists at the selected higher education institution concur in certain instances, from the managers’ perspective. Further research to investigate the role of strategic control in implementing an empowerment strategy at the selected higher education institution when all role players are included, is recommended.
- Full Text:
- Date Issued: 2001
The role of Venda culture in nature conservation : a case study of the inhabitants of the Tshivhase area
- Khorommbi, Konanani Christopher
- Authors: Khorommbi, Konanani Christopher
- Date: 2001
- Subjects: Nature conservation -- South Africa -- Venda , Venda (South Africa)
- Language: English
- Type: Thesis , Masters , MTech (Nature Conservation)
- Identifier: vital:10975 , http://hdl.handle.net/10948/d1002119 , Nature conservation -- South Africa -- Venda , Venda (South Africa)
- Description: This thesis investigates the role of Venda culture in nature conservation and natural resource management. The project is based on the premise that the survival of human beings is entirely dependent on the extent to which different cultures conserve the natural environment. The researcher assumes that the scientific approach is not the only one that is capable of addressing environmental issues but that indigenous technology has a positive role to play. The study specifically looks at the relationship between the Venda culture and conservation of land, water, plants and animals. In order to achieve this goal, the study was divided into five chapters. The introductory chapter includes the statement of problem, delimitations of the study, the definitions of concepts, the assumptions, and the significance of the study. The literature review provides an overview of the indigenous strategies of nature conservation and natural resource management from a broader international approach to a specifically Venda approach. The researcher looked at the cultural perspective of the four areas under investigation. This chapter is followed by themethodological justification that discusses the social survey as a researchmethod for carrying out this study. The results presented in the fourth chapter comprise raw data from the three sectors of respondents, namely traditional leaders, traditional healers and villagers. Under each item, common responses have been grouped together for presentation and specific responses for the three sectors were presented independently from one another. This has provided the researcher with the opportunity to identify areas of similarities and differences among the three sectors. Both complementary and conflicting ideas are summarised and used as a basis for analysis. The results reflect a high degree of agreement among respondents. The discussion in chapter five was based on the results and relevant literature. The researcher’s approach was to depict the most common views among the three sectors and their conservation implications. In the discussion, the strengths and weaknesses of the Venda cultural approach were exposed in relation to the five sub-problems under investigation. The recognition of the Venda indigenous technology of natural resource management has been proposed because of its importance in nature conservation. In the recommendations the formulation of policy that overlooks local values was criticised. The use of the Venda approach as a basis for the development of conservation projects was strongly recommended. Lastly, itwas proposed that further investigations of specific aspects of the Venda cultural be considered for possible incorporation in future management of the natural environment.
- Full Text:
- Date Issued: 2001
- Authors: Khorommbi, Konanani Christopher
- Date: 2001
- Subjects: Nature conservation -- South Africa -- Venda , Venda (South Africa)
- Language: English
- Type: Thesis , Masters , MTech (Nature Conservation)
- Identifier: vital:10975 , http://hdl.handle.net/10948/d1002119 , Nature conservation -- South Africa -- Venda , Venda (South Africa)
- Description: This thesis investigates the role of Venda culture in nature conservation and natural resource management. The project is based on the premise that the survival of human beings is entirely dependent on the extent to which different cultures conserve the natural environment. The researcher assumes that the scientific approach is not the only one that is capable of addressing environmental issues but that indigenous technology has a positive role to play. The study specifically looks at the relationship between the Venda culture and conservation of land, water, plants and animals. In order to achieve this goal, the study was divided into five chapters. The introductory chapter includes the statement of problem, delimitations of the study, the definitions of concepts, the assumptions, and the significance of the study. The literature review provides an overview of the indigenous strategies of nature conservation and natural resource management from a broader international approach to a specifically Venda approach. The researcher looked at the cultural perspective of the four areas under investigation. This chapter is followed by themethodological justification that discusses the social survey as a researchmethod for carrying out this study. The results presented in the fourth chapter comprise raw data from the three sectors of respondents, namely traditional leaders, traditional healers and villagers. Under each item, common responses have been grouped together for presentation and specific responses for the three sectors were presented independently from one another. This has provided the researcher with the opportunity to identify areas of similarities and differences among the three sectors. Both complementary and conflicting ideas are summarised and used as a basis for analysis. The results reflect a high degree of agreement among respondents. The discussion in chapter five was based on the results and relevant literature. The researcher’s approach was to depict the most common views among the three sectors and their conservation implications. In the discussion, the strengths and weaknesses of the Venda cultural approach were exposed in relation to the five sub-problems under investigation. The recognition of the Venda indigenous technology of natural resource management has been proposed because of its importance in nature conservation. In the recommendations the formulation of policy that overlooks local values was criticised. The use of the Venda approach as a basis for the development of conservation projects was strongly recommended. Lastly, itwas proposed that further investigations of specific aspects of the Venda cultural be considered for possible incorporation in future management of the natural environment.
- Full Text:
- Date Issued: 2001
The strategic impact of HIV/AIDS on first level component suppliers to the motor industry, located in the Nelson Mandela Metropole
- Authors: Hughes, Edward Peter Clive
- Date: 2001
- Subjects: Automobile industry and trade -- Management , Labor productivity , Production management , AIDS (Disease) -- Economic aspects -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10943 , http://hdl.handle.net/10948/d1006722 , Automobile industry and trade -- Management , Labor productivity , Production management , AIDS (Disease) -- Economic aspects -- South Africa
- Description: HIV/AIDS is undoubtedly the single most important and daunting health problem facing Africa. Globally too, this is one of the most serious health, medical and social preoccupations of our time (Chinery-Hesse, 2000: 1). The aim of this research study is to evaluate the strategic impact of HIV/AIDS on first level component suppliers to the motor industry located in the Nelson Mandela Metropole. To achieve this aim a literature study was undertaken to determine the patterns of development, the infection statistics and to explore strategic options and actions for dealing with the effects of the disease. An empirical study has been conducted to assess the opinions of senior management within first level component suppliers. The results from the study indicate that most companies in the selected group believe that HIV/AIDS will have a serious impact on their organisations. In conclusion, various recommendations have been made with regards to the findings ascertained in the literature review and empirical study.
- Full Text:
- Date Issued: 2001
- Authors: Hughes, Edward Peter Clive
- Date: 2001
- Subjects: Automobile industry and trade -- Management , Labor productivity , Production management , AIDS (Disease) -- Economic aspects -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10943 , http://hdl.handle.net/10948/d1006722 , Automobile industry and trade -- Management , Labor productivity , Production management , AIDS (Disease) -- Economic aspects -- South Africa
- Description: HIV/AIDS is undoubtedly the single most important and daunting health problem facing Africa. Globally too, this is one of the most serious health, medical and social preoccupations of our time (Chinery-Hesse, 2000: 1). The aim of this research study is to evaluate the strategic impact of HIV/AIDS on first level component suppliers to the motor industry located in the Nelson Mandela Metropole. To achieve this aim a literature study was undertaken to determine the patterns of development, the infection statistics and to explore strategic options and actions for dealing with the effects of the disease. An empirical study has been conducted to assess the opinions of senior management within first level component suppliers. The results from the study indicate that most companies in the selected group believe that HIV/AIDS will have a serious impact on their organisations. In conclusion, various recommendations have been made with regards to the findings ascertained in the literature review and empirical study.
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- Date Issued: 2001