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A comparison of representations of the imperative of higher education change as „transformation‟ versus „decolonisation‟ in South African public discourse
- Authors: Makgakge, Rebecca Dineo
- Date: 2020
- Subjects: Education in mass media -- South Africa , Higher education and state -- South Africa , Education, Higher -- Curricula -- South Africa , Discrimination in education -- South Africa , South Africa -- Colonial influence , Educational change -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/142498 , vital:38085
- Description: The context of higher education in South Africa which has been shaped by the legacies of the old apartheid system is faced with a paramount task of the continuous process of restructuring and change. In shaping the restructuring and change of the higher education system the concept of transformation has been a constant theme for the post-apartheid government policies. However more recently we have seen the heightened prominence of the concept of change understood as decolonisation of South African higher education – as opposed to “transformation‘. This thesis was concerned with how these concepts of change, “transformation‘ and “decolonisation‘ have been used in debates surrounding higher education in South Africa. The thesis compares and contrasts the ways and context in which they are used. This study of 177 South African newspaper articles taken form independent media stables from the time 2008 to the present provides an analysis of representations of higher education change as “transformation‘ and as “decolonisation‘ evinced in the corpus. This required using both content and framing analysis as a method to analyse the corpus. Three themes emerged from the analysis that are relevant to the comparison between South African higher education institutional change represented as “transformation‘ and South African higher education institutional change represented at “decolonisation‘: the first theme concerns the differences and similarities in how the two terms are defined; the second theme concerns how the two ideas play themselves out when it comes to curriculum change and the final theme concerns the implications of seeing change as “transformation‘ and seeing change as “decolonisation‘ for changing institutional cultures.
- Full Text:
- Authors: Makgakge, Rebecca Dineo
- Date: 2020
- Subjects: Education in mass media -- South Africa , Higher education and state -- South Africa , Education, Higher -- Curricula -- South Africa , Discrimination in education -- South Africa , South Africa -- Colonial influence , Educational change -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/142498 , vital:38085
- Description: The context of higher education in South Africa which has been shaped by the legacies of the old apartheid system is faced with a paramount task of the continuous process of restructuring and change. In shaping the restructuring and change of the higher education system the concept of transformation has been a constant theme for the post-apartheid government policies. However more recently we have seen the heightened prominence of the concept of change understood as decolonisation of South African higher education – as opposed to “transformation‘. This thesis was concerned with how these concepts of change, “transformation‘ and “decolonisation‘ have been used in debates surrounding higher education in South Africa. The thesis compares and contrasts the ways and context in which they are used. This study of 177 South African newspaper articles taken form independent media stables from the time 2008 to the present provides an analysis of representations of higher education change as “transformation‘ and as “decolonisation‘ evinced in the corpus. This required using both content and framing analysis as a method to analyse the corpus. Three themes emerged from the analysis that are relevant to the comparison between South African higher education institutional change represented as “transformation‘ and South African higher education institutional change represented at “decolonisation‘: the first theme concerns the differences and similarities in how the two terms are defined; the second theme concerns how the two ideas play themselves out when it comes to curriculum change and the final theme concerns the implications of seeing change as “transformation‘ and seeing change as “decolonisation‘ for changing institutional cultures.
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A comparison of three models used to determine water fluxes over the Albany Thicket, Eastern Cape, South Africa:
- Palmer, A R, Ezenne, G I, Choruma, D J, Gwate, O, Mantel, S K, Tanner, J L
- Authors: Palmer, A R , Ezenne, G I , Choruma, D J , Gwate, O , Mantel, S K , Tanner, J L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150047 , vital:38934 , https://doi.org/10.1016/j.agrformet.2020.107984
- Description: The Albany Thicket (AT) biome contains outstanding global biodiversity as well as the potential to achieve carbon credits associated with water-efficient Crasslucean acid metabolism (CAM). Understanding the water fluxes in the AT is crucial to determining carbon (C) sequestration rates and water-use efficiency. Despite large variation in water fluxes across the AT, only a few studies have been conducted in this region with their results validated against short periods of observed data. This study aims to evaluate three models of water fluxes over AT against data from an eddy covariance (EC) system active from October 2015 to May 2018. ET was modelled using the BioGeoChemistry Management (BGC-MAN) model, a biophysical model (Penman-Monteith-Leuning (PML)) and a remotely-sensed product (MOD16), and their results compared with that from the EC system.
- Full Text:
- Authors: Palmer, A R , Ezenne, G I , Choruma, D J , Gwate, O , Mantel, S K , Tanner, J L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150047 , vital:38934 , https://doi.org/10.1016/j.agrformet.2020.107984
- Description: The Albany Thicket (AT) biome contains outstanding global biodiversity as well as the potential to achieve carbon credits associated with water-efficient Crasslucean acid metabolism (CAM). Understanding the water fluxes in the AT is crucial to determining carbon (C) sequestration rates and water-use efficiency. Despite large variation in water fluxes across the AT, only a few studies have been conducted in this region with their results validated against short periods of observed data. This study aims to evaluate three models of water fluxes over AT against data from an eddy covariance (EC) system active from October 2015 to May 2018. ET was modelled using the BioGeoChemistry Management (BGC-MAN) model, a biophysical model (Penman-Monteith-Leuning (PML)) and a remotely-sensed product (MOD16), and their results compared with that from the EC system.
- Full Text:
A computational analysis to decipher the pathways of stability, uncoating and antigenicity of human enterovirus capsids
- Authors: Ross, Caroline Jane
- Date: 2020
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/114788 , vital:34035 , 10.21504/10962/114788
- Description: Expected release date-April 2021
- Full Text: false
- Authors: Ross, Caroline Jane
- Date: 2020
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/114788 , vital:34035 , 10.21504/10962/114788
- Description: Expected release date-April 2021
- Full Text: false
A content analysis of psychology Masters theses from South African universities
- Authors: Robson, Brian
- Date: 2020
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/113924 , vital:33845
- Description: Expected release date-April 2022
- Full Text: false
- Authors: Robson, Brian
- Date: 2020
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/113924 , vital:33845
- Description: Expected release date-April 2022
- Full Text: false
A critical analysis of NGOs in addressing HIV and AIDS in the context of gendered inequality: The case of Makhanda, Eastern Cape, South Africa
- Authors: Mhavika, Moreblessing
- Date: 2020
- Subjects: AIDS (Disease) -- Sex factors , AIDS (Disease) -- Social aspects -- South Africa -- Makhanda , HIV infections -- Sex factors , HIV infections -- Social aspects -- South Africa -- Makhanda , HIV-positive women -- South Africa -- Makhanda , Non-governmental organizations -- South Africa -- Makhanda
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/143225 , vital:38212
- Description: South Africa has the highest number of people living with HIV and AIDS in the world. The HIV pandemic has, and continues to have, negative implications for communities and individuals, especially women, in South Africa and beyond. HIV and AIDS has left women disproportionately more infected and affected than men because of social, cultural and economic factors, leading to the feminisation of HIV. South African NGOs have tried to fill in the gap and to respond to the HIV pandemic, either independently or in partnership with government departments. In this context, the purpose of this thesis is to provide a critical analysis of NGO programmes in Makhanda (in the Eastern Cape Province) to ascertain whether NGOs address the feminisation of HIV and, if so, how. In doing so, the study utilises qualitative analysis with the use of interviews, a focus group discussion and primary documents as research methods. The study concludes that local government in Makhanda has failed to address women’s vulnerabilities to HIV and that it does not provide a sufficiently enabling environment for NGOs in this regard. In addition, inadequate funding from donors, alongside issues of accountability and the failure to engage in HIV programmes from a perspective founded in feminism, were factors found to contribute to NGOs not fully considering women’s vulnerabilities to HIV. Resultantly, NGOs in Makhanda rarely, at least intentionally, address the feminisation of HIV.
- Full Text:
- Authors: Mhavika, Moreblessing
- Date: 2020
- Subjects: AIDS (Disease) -- Sex factors , AIDS (Disease) -- Social aspects -- South Africa -- Makhanda , HIV infections -- Sex factors , HIV infections -- Social aspects -- South Africa -- Makhanda , HIV-positive women -- South Africa -- Makhanda , Non-governmental organizations -- South Africa -- Makhanda
- Language: English
- Type: text , Thesis , Masters , MSocSci
- Identifier: http://hdl.handle.net/10962/143225 , vital:38212
- Description: South Africa has the highest number of people living with HIV and AIDS in the world. The HIV pandemic has, and continues to have, negative implications for communities and individuals, especially women, in South Africa and beyond. HIV and AIDS has left women disproportionately more infected and affected than men because of social, cultural and economic factors, leading to the feminisation of HIV. South African NGOs have tried to fill in the gap and to respond to the HIV pandemic, either independently or in partnership with government departments. In this context, the purpose of this thesis is to provide a critical analysis of NGO programmes in Makhanda (in the Eastern Cape Province) to ascertain whether NGOs address the feminisation of HIV and, if so, how. In doing so, the study utilises qualitative analysis with the use of interviews, a focus group discussion and primary documents as research methods. The study concludes that local government in Makhanda has failed to address women’s vulnerabilities to HIV and that it does not provide a sufficiently enabling environment for NGOs in this regard. In addition, inadequate funding from donors, alongside issues of accountability and the failure to engage in HIV programmes from a perspective founded in feminism, were factors found to contribute to NGOs not fully considering women’s vulnerabilities to HIV. Resultantly, NGOs in Makhanda rarely, at least intentionally, address the feminisation of HIV.
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A critical analysis of the administrative issues related to the Health Promotion Levy in South Africa
- Authors: Herbst, Tamryn
- Date: 2020
- Subjects: Health promotion -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10948/48158 , vital:40515
- Description: The purpose of the treatise was to examine the administrative issues that have arisen related to the implementation of the Health Promotion Levy (HPL) in South Africa, and to identify solutions to these issues. The study commenced with a review of what the HPL is and how it is levied. This was followed by a comparative analysis of issues that have been experienced by four countries, as well as any potential issues that have been identified by the four countries. The HPL is often referred to as sugar tax in many jurisdictions, and was referred to as HPL for the purposes of this treatise. A review was then performed of the solutions that were implemented by these countries in responding to the administrative issues that were identified, as well as guidelines issued by the World Health Organisation for the implementation of this levy. The likelihood of these issues arising in South Africa’s implementation of the Health Promotion Levy was examined based on these comparisons. It was found that the issues experienced by other countries in the implementation of the HPL have been experienced in South Africa, or may be relevant in a South African context. Following this, the solutions implemented by other countries and recommended by the World Health Organisation were analysed to determine if these solutions are practical in a South African context. Many of the solutions implemented by the countries analysed, are relevant in a South African context and have, in fact, already been implemented in South Africa The conclusion reached was that South Africa has been successful in administering the implementation of the HPL and that the administrative costs of the implementation and administration of the HPL are outweighed by the benefits of the health awareness raised by the implementation of the HPL.
- Full Text:
- Authors: Herbst, Tamryn
- Date: 2020
- Subjects: Health promotion -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: http://hdl.handle.net/10948/48158 , vital:40515
- Description: The purpose of the treatise was to examine the administrative issues that have arisen related to the implementation of the Health Promotion Levy (HPL) in South Africa, and to identify solutions to these issues. The study commenced with a review of what the HPL is and how it is levied. This was followed by a comparative analysis of issues that have been experienced by four countries, as well as any potential issues that have been identified by the four countries. The HPL is often referred to as sugar tax in many jurisdictions, and was referred to as HPL for the purposes of this treatise. A review was then performed of the solutions that were implemented by these countries in responding to the administrative issues that were identified, as well as guidelines issued by the World Health Organisation for the implementation of this levy. The likelihood of these issues arising in South Africa’s implementation of the Health Promotion Levy was examined based on these comparisons. It was found that the issues experienced by other countries in the implementation of the HPL have been experienced in South Africa, or may be relevant in a South African context. Following this, the solutions implemented by other countries and recommended by the World Health Organisation were analysed to determine if these solutions are practical in a South African context. Many of the solutions implemented by the countries analysed, are relevant in a South African context and have, in fact, already been implemented in South Africa The conclusion reached was that South Africa has been successful in administering the implementation of the HPL and that the administrative costs of the implementation and administration of the HPL are outweighed by the benefits of the health awareness raised by the implementation of the HPL.
- Full Text:
A critical analysis of the de-peasantisation process in Nepal with specific reference to the role of state land policies since the 1950s
- Authors: Basnet, Jagat
- Date: 2020
- Subjects: Land tenure -- Nepal , Land reform -- Law and legislation -- Nepal , Nepal -- Politics and government , Peasants -- Nepal -- Economic conditions , Panchayat -- Nepal
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/138716 , vital:37667
- Description: The principal objective of this thesis is to offer a critical analysis of the process of de-peasantisation in Nepal since 1950, with a particular focus on the capitalist neo-liberal restructuring of the economy beginning in the early 1990s. The analysis begins by tracing the legacy of feudal land practices and landholdings from the pre-1950 Rana and Shah dynasties. It was under these feudal dynasties that economic and political institutions of extraction first emerged, leading to a landlord-peasant agrarian economy in which peasants (often as tenants/sharecroppers and smallholders) were subordinate to the power nexus between feudal landlords and the ruling dynasties. After 1950, a window of democratic opening was soon interrupted by the formation of the party-less Panchayat system, which lasted from 1960 to 1990. In 1964, a major land reform measure was enacted under the Lands Act, with the goal of enhancing the security and livelihood of the peasantry. However, this process was met with significant resistance by feudal landlords, and actually led to deepening insecurity and the loss of land by peasants, with farmers belonging to lower castes and indigenous groups experiencing this with a greater degree of intensity. The overall result of this period was the beginnings of what is referred to in this study as de-peasantisation. This line of analysis shows that the institutions of extraction remained firmly in place even after the reforms of this period. Finally, the neo-liberal period, which was marked by land titling, the marketisation of land, and the commercialisation of agriculture, represents the late entry of capitalism into Nepal. This period saw the deepening and widening of the process of de-peasantisation, including further loss of peasants’ access to land and a general turn to wage-labour. In this regard, despite propagating the slogan ‘land to the tillers’, the major political parties in Nepal (including the Maoist party) have failed to defend the interests of the peasantry. Some progressive civil society groups have recently sought to do better, but there is also evidence of peasant organisations themselves seeking to resist and oppose the de-peasantisation effects of neo-liberal restructuring. This thesis thus considers the form and extent of de-peasantisation in Nepal, and some responses to it, over an extended period. A broad Marxist-based political economy perspective has been adopted in pursuing the principal thesis objective, but one which argues that there is a symbiotic relationship between economic and political power, such that the latter is not reducible to the former. The thesis draws upon original fieldwork in twenty districts of Nepal, including through the use of a survey, interviews, observations, case studies, and focus group discussions, thus combining both quantitative and qualitative research methods. Based on this fieldwork, it becomes clear that (i) there are major social, economic, and political forces behind the processes of de-peasantisation in the studied districts (and in Nepal more broadly), and that (ii) the Nepali peasantry is becoming increasingly landless, or land-short, and subject to processes of proletarianisation.
- Full Text:
- Authors: Basnet, Jagat
- Date: 2020
- Subjects: Land tenure -- Nepal , Land reform -- Law and legislation -- Nepal , Nepal -- Politics and government , Peasants -- Nepal -- Economic conditions , Panchayat -- Nepal
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/138716 , vital:37667
- Description: The principal objective of this thesis is to offer a critical analysis of the process of de-peasantisation in Nepal since 1950, with a particular focus on the capitalist neo-liberal restructuring of the economy beginning in the early 1990s. The analysis begins by tracing the legacy of feudal land practices and landholdings from the pre-1950 Rana and Shah dynasties. It was under these feudal dynasties that economic and political institutions of extraction first emerged, leading to a landlord-peasant agrarian economy in which peasants (often as tenants/sharecroppers and smallholders) were subordinate to the power nexus between feudal landlords and the ruling dynasties. After 1950, a window of democratic opening was soon interrupted by the formation of the party-less Panchayat system, which lasted from 1960 to 1990. In 1964, a major land reform measure was enacted under the Lands Act, with the goal of enhancing the security and livelihood of the peasantry. However, this process was met with significant resistance by feudal landlords, and actually led to deepening insecurity and the loss of land by peasants, with farmers belonging to lower castes and indigenous groups experiencing this with a greater degree of intensity. The overall result of this period was the beginnings of what is referred to in this study as de-peasantisation. This line of analysis shows that the institutions of extraction remained firmly in place even after the reforms of this period. Finally, the neo-liberal period, which was marked by land titling, the marketisation of land, and the commercialisation of agriculture, represents the late entry of capitalism into Nepal. This period saw the deepening and widening of the process of de-peasantisation, including further loss of peasants’ access to land and a general turn to wage-labour. In this regard, despite propagating the slogan ‘land to the tillers’, the major political parties in Nepal (including the Maoist party) have failed to defend the interests of the peasantry. Some progressive civil society groups have recently sought to do better, but there is also evidence of peasant organisations themselves seeking to resist and oppose the de-peasantisation effects of neo-liberal restructuring. This thesis thus considers the form and extent of de-peasantisation in Nepal, and some responses to it, over an extended period. A broad Marxist-based political economy perspective has been adopted in pursuing the principal thesis objective, but one which argues that there is a symbiotic relationship between economic and political power, such that the latter is not reducible to the former. The thesis draws upon original fieldwork in twenty districts of Nepal, including through the use of a survey, interviews, observations, case studies, and focus group discussions, thus combining both quantitative and qualitative research methods. Based on this fieldwork, it becomes clear that (i) there are major social, economic, and political forces behind the processes of de-peasantisation in the studied districts (and in Nepal more broadly), and that (ii) the Nepali peasantry is becoming increasingly landless, or land-short, and subject to processes of proletarianisation.
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A critical appraisal of Saule’s portrayal of women as Amadelakufa (resilient)
- Authors: Molubo, Rendani
- Date: 2020
- Subjects: Women in literature , Feminism -- Africa , Saule, N -- Vuleka Mhlaba , Saule, N -- Inkululeko Isentabeni , Saule, N -- Libambe Lingatshoni , Xhosa fiction -- History and criticism
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/143982 , vital:38300
- Description: This study seeks to explore how Professor Ncedile Saule’s works Vuleka Mhlaba (2006), Inkululeko Isentabeni (2010) and Libambe Lingatshoni (2017), depict female characters to reveal the inner resilience women embody. It is important to portray females as bold, intelligent and courageous beings as African women are subjected to major patriarchal myths. South Africa prides itself with a progressive Constitution and Bill of Rights that speaks of gender equality and the liberation of all persons. However, in practice women still live under patriarchal bondages and their efforts are side-lined, thus, the essentiality of writings that contributes towards the empowerment of women through displaying their resilience. Women in literature are mostly depicted as subordinate, submissive and emotional. At times they are portrayed as victims. They are very seldom portrayed as heroes or independent beings. They are constantly placed behind a man instead of in front of a man. This research aims to display women as heroes in their own capacity, without having to be dimmed by a man. The researcher decided to utilise writings of a male author so as to provide a different perspective from the norm that most male authors are known to write about in issues pertaining female characters. This is also deliberately done to encourage more male writers to change the mythical narration about women and start admiring their contributions without having them shadow any man. The projection of female resilience through the gaze of a male author gives hope that there are men who see and admire women’s efforts. It also indicates that men realise now that African feminisms are not against men and instead advocate for equality between men and women and recognise the greatness that could come out of a partnership between the two genders. Women’s behaviour and characteristics are mostly socially constructed, hence the need to exhibit the boldness that black women possess, instead of them only being utilised as nurturing sources and household caretakers. One of the purposes of this research study is to illustrate the resilience that women possess and analyse the forms of torment that women in Saule’s chosen novels have experienced and how their experience engenders resilience and a determination to succeed. The women in Saule’s three novels selected for this study break the traditional status quo. The approach that this paper will utilize is that of African Feminisms, focusing on Walker’s Womanism, Ogunyemi’s Africana Womanism, and Stiwanism as the theoretical approaches. This is because African Feminisms concentrates on the issues related to gender, race and class that African women across spectrums face.
- Full Text:
- Authors: Molubo, Rendani
- Date: 2020
- Subjects: Women in literature , Feminism -- Africa , Saule, N -- Vuleka Mhlaba , Saule, N -- Inkululeko Isentabeni , Saule, N -- Libambe Lingatshoni , Xhosa fiction -- History and criticism
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/143982 , vital:38300
- Description: This study seeks to explore how Professor Ncedile Saule’s works Vuleka Mhlaba (2006), Inkululeko Isentabeni (2010) and Libambe Lingatshoni (2017), depict female characters to reveal the inner resilience women embody. It is important to portray females as bold, intelligent and courageous beings as African women are subjected to major patriarchal myths. South Africa prides itself with a progressive Constitution and Bill of Rights that speaks of gender equality and the liberation of all persons. However, in practice women still live under patriarchal bondages and their efforts are side-lined, thus, the essentiality of writings that contributes towards the empowerment of women through displaying their resilience. Women in literature are mostly depicted as subordinate, submissive and emotional. At times they are portrayed as victims. They are very seldom portrayed as heroes or independent beings. They are constantly placed behind a man instead of in front of a man. This research aims to display women as heroes in their own capacity, without having to be dimmed by a man. The researcher decided to utilise writings of a male author so as to provide a different perspective from the norm that most male authors are known to write about in issues pertaining female characters. This is also deliberately done to encourage more male writers to change the mythical narration about women and start admiring their contributions without having them shadow any man. The projection of female resilience through the gaze of a male author gives hope that there are men who see and admire women’s efforts. It also indicates that men realise now that African feminisms are not against men and instead advocate for equality between men and women and recognise the greatness that could come out of a partnership between the two genders. Women’s behaviour and characteristics are mostly socially constructed, hence the need to exhibit the boldness that black women possess, instead of them only being utilised as nurturing sources and household caretakers. One of the purposes of this research study is to illustrate the resilience that women possess and analyse the forms of torment that women in Saule’s chosen novels have experienced and how their experience engenders resilience and a determination to succeed. The women in Saule’s three novels selected for this study break the traditional status quo. The approach that this paper will utilize is that of African Feminisms, focusing on Walker’s Womanism, Ogunyemi’s Africana Womanism, and Stiwanism as the theoretical approaches. This is because African Feminisms concentrates on the issues related to gender, race and class that African women across spectrums face.
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A critical investigation of leadership in a Technical, Vocational Education and Training college in the Eastern Cape
- Authors: Chagi, Nonkonzo
- Date: 2020
- Subjects: Technical education -- South Africa , Vocational education -- South Africa , Educational leadership -- South Africa , Postsecondary education -- South Africa -- Administration
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/140045 , vital:37827
- Description: Far-reaching reforms of the TVET college system – including a merger and frequent revisioning of the colleges’ role in the educational landscape of South Africa – have focused renewed attention on this sector. The fact that the sector has been plagued by poor performance – even to the extent that several colleges have been placed under administration – suggests problems at the level of leadership. This study sought to explore key role-players’ understanding of the leadership and management challenges faced by a TVET college and, by examining responses to these challenges, develop a sense of what leadership means in the sector. The study drew on three leadership theories – distributed leadership, transactional leadership as depicted in political models of management, and critical leadership – to help make sense of the findings. A qualitative case study design was used to explore key respondents’ views and lived experiences. The respondents were the principal, two deputy principals, a council member, three campus managers and a programme head. Interviews, questionnaires and document analysis were the chief data collection tools. The study found that critical leadership was the dominant approach at the college. This was revealed in the college leadership’s awareness of broader societal needs and its own role in operating in a socially just manner. College leadership also revealed signs of rejecting the status quo and opposing state control and bureaucracy, in favour of reactionary initiatives. There was limited evidence of distributed and transactional leadership. In fact, ‘leadership’ as such, seemed not to be part of the college discourse, suggesting that the concept and habit of leadership was not broadly discussed, shared and promoted. This sense was strengthened by the fact that at the time of the study, the college was headed by a charismatic and visionary leader. Indeed, the problem at the college seemed to be the Department of Higher Education and Training, which has failed the college in a number of ways.
- Full Text:
- Authors: Chagi, Nonkonzo
- Date: 2020
- Subjects: Technical education -- South Africa , Vocational education -- South Africa , Educational leadership -- South Africa , Postsecondary education -- South Africa -- Administration
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/140045 , vital:37827
- Description: Far-reaching reforms of the TVET college system – including a merger and frequent revisioning of the colleges’ role in the educational landscape of South Africa – have focused renewed attention on this sector. The fact that the sector has been plagued by poor performance – even to the extent that several colleges have been placed under administration – suggests problems at the level of leadership. This study sought to explore key role-players’ understanding of the leadership and management challenges faced by a TVET college and, by examining responses to these challenges, develop a sense of what leadership means in the sector. The study drew on three leadership theories – distributed leadership, transactional leadership as depicted in political models of management, and critical leadership – to help make sense of the findings. A qualitative case study design was used to explore key respondents’ views and lived experiences. The respondents were the principal, two deputy principals, a council member, three campus managers and a programme head. Interviews, questionnaires and document analysis were the chief data collection tools. The study found that critical leadership was the dominant approach at the college. This was revealed in the college leadership’s awareness of broader societal needs and its own role in operating in a socially just manner. College leadership also revealed signs of rejecting the status quo and opposing state control and bureaucracy, in favour of reactionary initiatives. There was limited evidence of distributed and transactional leadership. In fact, ‘leadership’ as such, seemed not to be part of the college discourse, suggesting that the concept and habit of leadership was not broadly discussed, shared and promoted. This sense was strengthened by the fact that at the time of the study, the college was headed by a charismatic and visionary leader. Indeed, the problem at the college seemed to be the Department of Higher Education and Training, which has failed the college in a number of ways.
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A critique of the language of record in South African courts in relation to selected university language policies
- Authors: Docrat, Zakeera
- Date: 2020
- Subjects: Language policy -- South Africa , Forensic linguistics -- South Africa , Communication in law -- South Africa , Language planning -- South Africa , Linguistic rights -- South Africa , Court interpreting and translating -- South Africa , Multilingual education -- South Africa , Language and education -- South Africa , Education, Higher -- Social aspects -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PHD
- Identifier: http://hdl.handle.net/10962/141394 , vital:37968
- Description: This interdisciplinary research located in the research area of forensic linguistics seeks to provide a critique of the monolingual language of record directive for courts in South Africa, while investigating how university language policies contribute the formulation of a monolingual language of record policy for courts, by graduating monolingual LLB students. The research commences with identifying the research problem, goals and objectives and how the language of record policy for courts is linked to university language planning. The research proceeds to an overview of scholarly literature concerning the historical developments of language planning in both the legal system and higher education in South Africa. The theoretical principles concerning the enacting of language legislation and policies is advanced in relation to the constitutional framework. This research furthermore provides a thorough critique of the constitutional framework where the language rights the other related language provisions are discussed in relation to the theory and the application thereof in case law. The research explicates that the language rights of African language speaking litigants is unfairly limited and that access to justice for these litigants is either unattainable or achieved to a lesser extent. The disparities between language, law and power are brought to the fore, where the relevant legislation and language policies fail to determine the language of record in courts as well as legislate the African language requirements for legal practitioners in giving meaning to the constitutional language rights. The language policies of six selected universities is discussed in relation to the legal system’s legislative and policy frameworks, outlining the need to transform the language of learning and teaching and develop the curriculum to support the legal system. In doing so, the shortcomings of the interpretation profession in South Africa are highlighted and the effects thereof on the language rights of litigants. This thesis advances seven African and international case studies, comprising Kenya, Morocco, Nigeria, Australia, Belgium, Canada and India. Each of the case studies provides an in-depth analysis of the language of record/proceedings in courts and the language competencies of legal practitioners and judicial officers in relation to their university education. The African case studies are illustrative that English on the African continent in courts and higher education is dominate and the resultant loss of indigenous languages marginalises people from mainstream society. The international case studies provide two models, Belgium and Canada, which South Africa can emulate, in enacting new legislation and policies and the amendment of current legislation, to ensure bilingual/ multilingual language policies are drafted for courts per province, where the language demographics present majority spoken languages alongside English. Furthermore, where courts interpret language rights and legislative and policy provisions in a purposive manner, where African language speakers are able to, fully realise their rights. Australia and India as multilingual models serve as important case studies where South Africa can learn from what to avoid, how to subvert challenges or adequately address these. These case studies highlight the dangers of a political elite who pursue an English only agenda at the expense of the indigenous languages and the speakers thereof. This thesis in conclusion provides interdisciplinary recommendations that need to be implemented in order to address the language question in South African courts and higher education.
- Full Text:
- Authors: Docrat, Zakeera
- Date: 2020
- Subjects: Language policy -- South Africa , Forensic linguistics -- South Africa , Communication in law -- South Africa , Language planning -- South Africa , Linguistic rights -- South Africa , Court interpreting and translating -- South Africa , Multilingual education -- South Africa , Language and education -- South Africa , Education, Higher -- Social aspects -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PHD
- Identifier: http://hdl.handle.net/10962/141394 , vital:37968
- Description: This interdisciplinary research located in the research area of forensic linguistics seeks to provide a critique of the monolingual language of record directive for courts in South Africa, while investigating how university language policies contribute the formulation of a monolingual language of record policy for courts, by graduating monolingual LLB students. The research commences with identifying the research problem, goals and objectives and how the language of record policy for courts is linked to university language planning. The research proceeds to an overview of scholarly literature concerning the historical developments of language planning in both the legal system and higher education in South Africa. The theoretical principles concerning the enacting of language legislation and policies is advanced in relation to the constitutional framework. This research furthermore provides a thorough critique of the constitutional framework where the language rights the other related language provisions are discussed in relation to the theory and the application thereof in case law. The research explicates that the language rights of African language speaking litigants is unfairly limited and that access to justice for these litigants is either unattainable or achieved to a lesser extent. The disparities between language, law and power are brought to the fore, where the relevant legislation and language policies fail to determine the language of record in courts as well as legislate the African language requirements for legal practitioners in giving meaning to the constitutional language rights. The language policies of six selected universities is discussed in relation to the legal system’s legislative and policy frameworks, outlining the need to transform the language of learning and teaching and develop the curriculum to support the legal system. In doing so, the shortcomings of the interpretation profession in South Africa are highlighted and the effects thereof on the language rights of litigants. This thesis advances seven African and international case studies, comprising Kenya, Morocco, Nigeria, Australia, Belgium, Canada and India. Each of the case studies provides an in-depth analysis of the language of record/proceedings in courts and the language competencies of legal practitioners and judicial officers in relation to their university education. The African case studies are illustrative that English on the African continent in courts and higher education is dominate and the resultant loss of indigenous languages marginalises people from mainstream society. The international case studies provide two models, Belgium and Canada, which South Africa can emulate, in enacting new legislation and policies and the amendment of current legislation, to ensure bilingual/ multilingual language policies are drafted for courts per province, where the language demographics present majority spoken languages alongside English. Furthermore, where courts interpret language rights and legislative and policy provisions in a purposive manner, where African language speakers are able to, fully realise their rights. Australia and India as multilingual models serve as important case studies where South Africa can learn from what to avoid, how to subvert challenges or adequately address these. These case studies highlight the dangers of a political elite who pursue an English only agenda at the expense of the indigenous languages and the speakers thereof. This thesis in conclusion provides interdisciplinary recommendations that need to be implemented in order to address the language question in South African courts and higher education.
- Full Text:
A critique of translated (isiXhosa to English) sworn statements by the South African Police Service
- Authors: Mvabaza, Aviwe
- Date: 2020
- Subjects: Forensic linguistics , Translators -- South Africa , Xhosa language -- Translating , Police administration -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/122869 , vital:35361
- Description: The thesis provides a critique of sworn statement translations in the South African Police Service. The study is a mixed method study, which is rooted in Translation and Forensic Linguistics. It focuses on translations of two languages, IsiXhosa and English, an activity that was observed by the researcher at the Ndevana Police Station under the Buffalo City Municipality near King William’s Town in the Eastern Cape Province. In addition to the data collection strategies, among others, the study also collected data through the use of questionnaires responded to by the Ndevana Location’s community members. Furthermore, it used a method of consented interviews with the police officers. The main aim of these interviews was to unearth the police officers’ views on whether they require Translators and Forensic Linguists to assist them. Moreover, the other data collection strategy used was the consented recordings of verbal statements made by complainants, facilitated by the capturing of translated written dockets after the reporting of an incident. The police officers involved and who were available in the precinct were Constables, Sergeants, Detectives, Warrant officers and the Captain. The study period was 90 days, and the data presented in the form of graphs is contained in the relevant upcoming chapters. The findings of the study were that there was indeed a need for Translators and/or Forensic Linguists in the precinct, as the statistics revealed, by both the police officers and the community members. An analysis of the transcribed material, the interviews with the police and the verbal statements made by the complainants written by the police were evidence of the need for Translators and Forensic Linguists by the South African Police Services.
- Full Text:
- Authors: Mvabaza, Aviwe
- Date: 2020
- Subjects: Forensic linguistics , Translators -- South Africa , Xhosa language -- Translating , Police administration -- South Africa
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/122869 , vital:35361
- Description: The thesis provides a critique of sworn statement translations in the South African Police Service. The study is a mixed method study, which is rooted in Translation and Forensic Linguistics. It focuses on translations of two languages, IsiXhosa and English, an activity that was observed by the researcher at the Ndevana Police Station under the Buffalo City Municipality near King William’s Town in the Eastern Cape Province. In addition to the data collection strategies, among others, the study also collected data through the use of questionnaires responded to by the Ndevana Location’s community members. Furthermore, it used a method of consented interviews with the police officers. The main aim of these interviews was to unearth the police officers’ views on whether they require Translators and Forensic Linguists to assist them. Moreover, the other data collection strategy used was the consented recordings of verbal statements made by complainants, facilitated by the capturing of translated written dockets after the reporting of an incident. The police officers involved and who were available in the precinct were Constables, Sergeants, Detectives, Warrant officers and the Captain. The study period was 90 days, and the data presented in the form of graphs is contained in the relevant upcoming chapters. The findings of the study were that there was indeed a need for Translators and/or Forensic Linguists in the precinct, as the statistics revealed, by both the police officers and the community members. An analysis of the transcribed material, the interviews with the police and the verbal statements made by the complainants written by the police were evidence of the need for Translators and Forensic Linguists by the South African Police Services.
- Full Text:
A drug utilisation review of lithium at a public sector psychiatric hospital
- Authors: Mapfumo, Charlotte
- Date: 2020
- Subjects: Lithium -- Therapeutic use , Psychiatric hospitals -- South Africa -- Grahamstown , Drug utilization , Psychiatric hospital care , Manic-depressive illness , Lithium -- Toxicology , Drug monitoring
- Language: English
- Type: text , Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/150541 , vital:38983
- Description: Key words: Bipolar disorder, drug utilisation review, lithium, narrow therapeutic index, toxicity, therapeutic drug monitoring. Introduction: Bipolar disorder (BD) is a common mental condition that affects about 60 million people globally. Lithium is among the drugs of choice used to treat BD and other affective disorders such as schizoaffective disorder (SD). Lithium is a mood stabiliser with antimanic, antidepressant and anti-suicidal properties. Lithium has complex mechanisms of action and a narrow therapeutic index (NTI). Therapeutic drug monitoring (TDM) is a vital component of lithium therapy due to its NTI. Lithium toxicity can occur at therapeutic levels and is characterised by symptoms such as blurred vision and convulsions. Lithium interacts with a number of drugs resulting in lithium toxicity or diminished effects of lithium. Symptoms of lithium toxicity range from abdominal pain, convulsions and death. Lithium use is associated with serious adverse effects on renal and thyroid function. Other adverse effects include tremor and weight gain. Monitoring of lithium serum levels, renal and thyroid function are therefore recommended for patients on lithium therapy. Monitoring of these parameters assists in the early detection of any problems associated with lithium use. The metabolic monitoring of lithium is vital due to the adverse effect profile of lithium and the current South African Standard Treatment Guidelines Hospital level: Adults, do not have any recommendations for the monitoring of metabolic parameters. The National Institute for Health and Care Excellence (NICE) may be used and adapted for the South African setting. Aim and Objectives: The general aim of the study was to conduct a drug utilisation review (DUR) on lithium through investigating its prescribing and monitoring patterns in both inpatients and outpatients at Fort England Hospital. Methodology: The study was in the form of a retrospective DUR. Data was collected from 40 files (n=40) of patients who were on treatment with lithium between 1 January 2017-31 December 2017 at Fort England Hospital. The data was collected retrospectively for both in- and outpatients. Compliance of the monitoring requirements with both South African and international guidelines was analysed. Results and Discussion: In 87.50% (n=37) of the cases, patients had been on lithium therapy before 2017 with most patients (n=13; 37.50%) being maintained on 500 mg of lithium. Non-compliance with the South African and NICE guidelines for renal baseline monitoring was 65.00% (n=26) in both guidelines. Non-compliance for baseline thyroid monitoring was 70.00% (n=28) for both guidelines. There was non-compliance in 45.00% (n=18) of the cases for lithium serum level monitoring for both guidelines. Non-compliance with follow-up renal monitoring was 47.50% (n=19) for both guidelines. Compliance with the NICE guidelines for follow-up metabolic monitoring was 67.50% (n=27). Conclusion: There was non-compliance in most cases leaving room for clinical improvement in the monitoring of lithium. Healthcare professionals should be educated on the recommended monitoring guidelines to promote the rational use of lithium in South Africa. Pharmacists should be more involved in the TDM of lithium to promote its safe and effective use.
- Full Text:
- Authors: Mapfumo, Charlotte
- Date: 2020
- Subjects: Lithium -- Therapeutic use , Psychiatric hospitals -- South Africa -- Grahamstown , Drug utilization , Psychiatric hospital care , Manic-depressive illness , Lithium -- Toxicology , Drug monitoring
- Language: English
- Type: text , Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/150541 , vital:38983
- Description: Key words: Bipolar disorder, drug utilisation review, lithium, narrow therapeutic index, toxicity, therapeutic drug monitoring. Introduction: Bipolar disorder (BD) is a common mental condition that affects about 60 million people globally. Lithium is among the drugs of choice used to treat BD and other affective disorders such as schizoaffective disorder (SD). Lithium is a mood stabiliser with antimanic, antidepressant and anti-suicidal properties. Lithium has complex mechanisms of action and a narrow therapeutic index (NTI). Therapeutic drug monitoring (TDM) is a vital component of lithium therapy due to its NTI. Lithium toxicity can occur at therapeutic levels and is characterised by symptoms such as blurred vision and convulsions. Lithium interacts with a number of drugs resulting in lithium toxicity or diminished effects of lithium. Symptoms of lithium toxicity range from abdominal pain, convulsions and death. Lithium use is associated with serious adverse effects on renal and thyroid function. Other adverse effects include tremor and weight gain. Monitoring of lithium serum levels, renal and thyroid function are therefore recommended for patients on lithium therapy. Monitoring of these parameters assists in the early detection of any problems associated with lithium use. The metabolic monitoring of lithium is vital due to the adverse effect profile of lithium and the current South African Standard Treatment Guidelines Hospital level: Adults, do not have any recommendations for the monitoring of metabolic parameters. The National Institute for Health and Care Excellence (NICE) may be used and adapted for the South African setting. Aim and Objectives: The general aim of the study was to conduct a drug utilisation review (DUR) on lithium through investigating its prescribing and monitoring patterns in both inpatients and outpatients at Fort England Hospital. Methodology: The study was in the form of a retrospective DUR. Data was collected from 40 files (n=40) of patients who were on treatment with lithium between 1 January 2017-31 December 2017 at Fort England Hospital. The data was collected retrospectively for both in- and outpatients. Compliance of the monitoring requirements with both South African and international guidelines was analysed. Results and Discussion: In 87.50% (n=37) of the cases, patients had been on lithium therapy before 2017 with most patients (n=13; 37.50%) being maintained on 500 mg of lithium. Non-compliance with the South African and NICE guidelines for renal baseline monitoring was 65.00% (n=26) in both guidelines. Non-compliance for baseline thyroid monitoring was 70.00% (n=28) for both guidelines. There was non-compliance in 45.00% (n=18) of the cases for lithium serum level monitoring for both guidelines. Non-compliance with follow-up renal monitoring was 47.50% (n=19) for both guidelines. Compliance with the NICE guidelines for follow-up metabolic monitoring was 67.50% (n=27). Conclusion: There was non-compliance in most cases leaving room for clinical improvement in the monitoring of lithium. Healthcare professionals should be educated on the recommended monitoring guidelines to promote the rational use of lithium in South Africa. Pharmacists should be more involved in the TDM of lithium to promote its safe and effective use.
- Full Text:
A dynamics based analysis of allosteric modulation in heat shock proteins
- Authors: Penkler, David Lawrence
- Date: 2020
- Subjects: Heat shock proteins , Molecular chaperones , Allosteric regulation , Homeostasis , Protein kinases , Transcription factors , Adenosine triphosphatase , Cancer -- Chemotherapy , Molecular dynamics , High throughput screening (Drug development)
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/115948 , vital:34273
- Description: The 70 kDa and 90 kDa heat shock proteins (Hsp70 and Hsp90) are molecular chaperones that play central roles in maintaining cellular homeostasis in all organisms of life with the exception of archaea. In addition to their general chaperone function in protein quality control, Hsp70 and Hsp90 cooperate in the regulation and activity of some 200 known natively folded protein clients which include protein kinases, transcription factors and receptors, many of which are implicated as key regulators of essential signal transduction pathways. Both chaperones are considered to be large multi-domain proteins that rely on ATPase activity and co-chaperone interactions to regulate their conformational cycles for peptide binding and release. The unique positioning of Hsp90 at the crossroads of several fundamental cellular pathways coupled with its known association with diverse oncogenic peptide clients has brought the molecular chaperone under increasing interest as a potential anti-cancer target that is crucially implicated with all eight hallmarks of the disease. Current orthosteric drug discovery efforts aimed at the inhibition of the ATPase domain of Hsp90 have been limited due to high levels of associated toxicity. In an effort to circumnavigate this, the combined focus of research efforts is shifting toward alternative approaches such as interference with co-chaperone binding and the allosteric inhibition/activation of the molecular chaperone. The overriding aim of this thesis was to demonstrate how the computational technique of Perturbation response scanning (PRS) coupled with all-atom molecular dynamics simulations (MD) and dynamic residue interaction network (DRN) analysis can be used as a viable strategy to efficiently scan and accurately identify allosteric control element capable of modulating the functional dynamics of a protein. In pursuit of this goal, this thesis also contributes to the current understanding of the nucleotide dependent allosteric mechanisms at play in cellular functionality of both Hsp70 and Hsp90. All-atom MD simulations of E. coli DnaK provided evidence of nucleotide driven modulation of conformational dynamics in both the catalytically active and inactive states. PRS analysis employed on these trajectories demonstrated sensitivity toward bound nucleotide and peptide substrate, and provided evidence of a putative allosterically active intermediate state between the ATPase active and inactive conformational states. Simultaneous binding of ATP and peptide substrate was found to allosterically prime the chaperone for interstate conversion regardless of the transition direction. Detailed analysis of these allosterically primed states revealed select residue sites capable of selecting a coordinate shift towards the opposite conformational state. In an effort to validate these results, the predicted allosteric hot spot sites were cross-validated with known experimental works and found to overlap with functional sites implicated in allosteric signal propagation and ATPase activation in Hsp70. This study presented for the first time, the application of PRS as a suitable diagnostic tool for the elucidation and quantification of the allosteric potential of select residues to effect functionally relevant global conformational rearrangements. The PRS methodology described in this study was packaged within the Python programming environment in the MD-TASK software suite for command-line ease of use and made freely available. Homology modelling techniques were used to address the lack of experimental structural data for the human cytosolic isoform of Hsp90 and for the first time provided accurate full-length structural models of human Hsp90α in fully-closed and partially-open conformations. Long-range all-atom MD simulations of these structures revealed nucleotide driven modulation of conformational dynamics in Hsp90. Subsequent DRN and PRS analysis of these MD trajectories allowed for the quantification and elucidation of nucleotide driven allosteric modulation in the molecular chaperone. A detailed PRS analysis revealed allosteric inter-domain coupling between the extreme terminals of the chaperone in response to external force perturbations at either domain. Furthermore PRS also identified several individual residue sites that are capable of selecting conformational rearrangements towards functionally relevant states which may be considered to be putative allosteric target sites for future drug discovery efforts Molecular docking techniques were employed to investigate the modulation of conformational dynamics of human Hsp90α in response to ligand binding interactions at two identified allosteric sites at the C-terminal. High throughput screening of a small library of natural compounds indigenous to South Africa revealed three hit compounds at these sites: Cephalostatin 17, 20(29)-Lupene-3β isoferulate and 3'-Bromorubrolide F. All-atom MD simulations on these protein-ligand complexes coupled with DRN analysis and several advanced trajectory based analysis techniques provided evidence of selective allosteric modulation of Hsp90α conformational dynamics in response to the identity and location of the bound ligands. Ligands bound at the four-helix bundle presented as putative allosteric inhibitors of Hsp90α, driving conformational dynamics in favour of dimer opening and possibly dimer separation. Meanwhile, ligand interactions at an adjacent sub-pocket located near the interface between the middle and C-terminal domains demonstrated allosteric activation of the chaperone, modulating conformational dynamics in favour of the fully-closed catalytically active conformational state. Taken together, the data presented in this thesis contributes to the understanding of allosteric modulation of conformational dynamics in Hsp70 and Hsp90, and provides a suitable platform for future biochemical and drug discovery studies. Furthermore, the molecular docking and computational identification of allosteric compounds with suitable binding affinity for allosteric sites at the CTD of human Hsp90α provide for the first time “proof-of-principle” for the use of PRS in conjunction with MD simulations and DRN analysis as a suitable method for the rapid identification of allosteric sites in proteins that can be probed by small molecule interaction. The data presented in this section could pave the way for future allosteric drug discovery studies for the treatment of Hsp90 associated pathologies.
- Full Text:
- Authors: Penkler, David Lawrence
- Date: 2020
- Subjects: Heat shock proteins , Molecular chaperones , Allosteric regulation , Homeostasis , Protein kinases , Transcription factors , Adenosine triphosphatase , Cancer -- Chemotherapy , Molecular dynamics , High throughput screening (Drug development)
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/115948 , vital:34273
- Description: The 70 kDa and 90 kDa heat shock proteins (Hsp70 and Hsp90) are molecular chaperones that play central roles in maintaining cellular homeostasis in all organisms of life with the exception of archaea. In addition to their general chaperone function in protein quality control, Hsp70 and Hsp90 cooperate in the regulation and activity of some 200 known natively folded protein clients which include protein kinases, transcription factors and receptors, many of which are implicated as key regulators of essential signal transduction pathways. Both chaperones are considered to be large multi-domain proteins that rely on ATPase activity and co-chaperone interactions to regulate their conformational cycles for peptide binding and release. The unique positioning of Hsp90 at the crossroads of several fundamental cellular pathways coupled with its known association with diverse oncogenic peptide clients has brought the molecular chaperone under increasing interest as a potential anti-cancer target that is crucially implicated with all eight hallmarks of the disease. Current orthosteric drug discovery efforts aimed at the inhibition of the ATPase domain of Hsp90 have been limited due to high levels of associated toxicity. In an effort to circumnavigate this, the combined focus of research efforts is shifting toward alternative approaches such as interference with co-chaperone binding and the allosteric inhibition/activation of the molecular chaperone. The overriding aim of this thesis was to demonstrate how the computational technique of Perturbation response scanning (PRS) coupled with all-atom molecular dynamics simulations (MD) and dynamic residue interaction network (DRN) analysis can be used as a viable strategy to efficiently scan and accurately identify allosteric control element capable of modulating the functional dynamics of a protein. In pursuit of this goal, this thesis also contributes to the current understanding of the nucleotide dependent allosteric mechanisms at play in cellular functionality of both Hsp70 and Hsp90. All-atom MD simulations of E. coli DnaK provided evidence of nucleotide driven modulation of conformational dynamics in both the catalytically active and inactive states. PRS analysis employed on these trajectories demonstrated sensitivity toward bound nucleotide and peptide substrate, and provided evidence of a putative allosterically active intermediate state between the ATPase active and inactive conformational states. Simultaneous binding of ATP and peptide substrate was found to allosterically prime the chaperone for interstate conversion regardless of the transition direction. Detailed analysis of these allosterically primed states revealed select residue sites capable of selecting a coordinate shift towards the opposite conformational state. In an effort to validate these results, the predicted allosteric hot spot sites were cross-validated with known experimental works and found to overlap with functional sites implicated in allosteric signal propagation and ATPase activation in Hsp70. This study presented for the first time, the application of PRS as a suitable diagnostic tool for the elucidation and quantification of the allosteric potential of select residues to effect functionally relevant global conformational rearrangements. The PRS methodology described in this study was packaged within the Python programming environment in the MD-TASK software suite for command-line ease of use and made freely available. Homology modelling techniques were used to address the lack of experimental structural data for the human cytosolic isoform of Hsp90 and for the first time provided accurate full-length structural models of human Hsp90α in fully-closed and partially-open conformations. Long-range all-atom MD simulations of these structures revealed nucleotide driven modulation of conformational dynamics in Hsp90. Subsequent DRN and PRS analysis of these MD trajectories allowed for the quantification and elucidation of nucleotide driven allosteric modulation in the molecular chaperone. A detailed PRS analysis revealed allosteric inter-domain coupling between the extreme terminals of the chaperone in response to external force perturbations at either domain. Furthermore PRS also identified several individual residue sites that are capable of selecting conformational rearrangements towards functionally relevant states which may be considered to be putative allosteric target sites for future drug discovery efforts Molecular docking techniques were employed to investigate the modulation of conformational dynamics of human Hsp90α in response to ligand binding interactions at two identified allosteric sites at the C-terminal. High throughput screening of a small library of natural compounds indigenous to South Africa revealed three hit compounds at these sites: Cephalostatin 17, 20(29)-Lupene-3β isoferulate and 3'-Bromorubrolide F. All-atom MD simulations on these protein-ligand complexes coupled with DRN analysis and several advanced trajectory based analysis techniques provided evidence of selective allosteric modulation of Hsp90α conformational dynamics in response to the identity and location of the bound ligands. Ligands bound at the four-helix bundle presented as putative allosteric inhibitors of Hsp90α, driving conformational dynamics in favour of dimer opening and possibly dimer separation. Meanwhile, ligand interactions at an adjacent sub-pocket located near the interface between the middle and C-terminal domains demonstrated allosteric activation of the chaperone, modulating conformational dynamics in favour of the fully-closed catalytically active conformational state. Taken together, the data presented in this thesis contributes to the understanding of allosteric modulation of conformational dynamics in Hsp70 and Hsp90, and provides a suitable platform for future biochemical and drug discovery studies. Furthermore, the molecular docking and computational identification of allosteric compounds with suitable binding affinity for allosteric sites at the CTD of human Hsp90α provide for the first time “proof-of-principle” for the use of PRS in conjunction with MD simulations and DRN analysis as a suitable method for the rapid identification of allosteric sites in proteins that can be probed by small molecule interaction. The data presented in this section could pave the way for future allosteric drug discovery studies for the treatment of Hsp90 associated pathologies.
- Full Text:
A five year comparative analysis of annual baseline neurocognitive test scores for South African high school athletes
- Reichling, Marcelle Antoinette
- Authors: Reichling, Marcelle Antoinette
- Date: 2020
- Subjects: High school athletes -- Intelligence testing , Sports -- Psychological aspects , Neuropsychological tests , Brain -- Wounds and injuries -- Psychology , Sports injuries -- Psychological aspects , Brain -- Concussion , Head -- Wounds and injuries
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/145863 , vital:38473
- Description: The primary objective of this study was to assess the pattern of change in neurocognitive performance for adolescent athletes on baseline measures of the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT) test, over five consecutive years, with a view to providing an indication of the optimal interval for repeat baseline testing of high school athletes. Participants were non-clinical, predominantly South African high school athletes in the overall age range 13 to 18 years (N = 108), divided into five groups (Grades 8,9, 10, 11 and 12), and tested at five test intervals. Repeated-measures ANOVA analyses examined differences in score performance across the test intervals for each of the five composite scores of the ImPACT test (Verbal Memory, Visual Memory, Visual Motor Speed, Reaction Time, Impulse Control). For the Verbal Memory, Visual Memory, Visual Motor Speed and Reaction Time composites there were significant neurocognitive score changes between several test intervals. Taking these results into account, in conjunction with substantial variability in performance, it is concluded that there is a need for annual baseline testing throughout the high school years. The secondary objective was to generate normative tables (Means and Standard Deviations) on the ImPACT test for the five participant groups at each of the five test intervals, including data for: the five composite scores (Verbal Memory, Visual Memory, Visual Motor Speed, Reaction Time, Impulse Control); for the twelve subtest scores test that go to make up the composite scores; and for four additional memory subcomponent scores (Word Memory immediate recall, Word Memory delayed recall, Design Memory immediate recall, Design Memory delayed recall). The results provide a clinical and heuristic normative platform for future use with brain injured individuals, which can be used to facilitate clinical interpretations of postconcussion assessments.
- Full Text:
- Authors: Reichling, Marcelle Antoinette
- Date: 2020
- Subjects: High school athletes -- Intelligence testing , Sports -- Psychological aspects , Neuropsychological tests , Brain -- Wounds and injuries -- Psychology , Sports injuries -- Psychological aspects , Brain -- Concussion , Head -- Wounds and injuries
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/145863 , vital:38473
- Description: The primary objective of this study was to assess the pattern of change in neurocognitive performance for adolescent athletes on baseline measures of the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT) test, over five consecutive years, with a view to providing an indication of the optimal interval for repeat baseline testing of high school athletes. Participants were non-clinical, predominantly South African high school athletes in the overall age range 13 to 18 years (N = 108), divided into five groups (Grades 8,9, 10, 11 and 12), and tested at five test intervals. Repeated-measures ANOVA analyses examined differences in score performance across the test intervals for each of the five composite scores of the ImPACT test (Verbal Memory, Visual Memory, Visual Motor Speed, Reaction Time, Impulse Control). For the Verbal Memory, Visual Memory, Visual Motor Speed and Reaction Time composites there were significant neurocognitive score changes between several test intervals. Taking these results into account, in conjunction with substantial variability in performance, it is concluded that there is a need for annual baseline testing throughout the high school years. The secondary objective was to generate normative tables (Means and Standard Deviations) on the ImPACT test for the five participant groups at each of the five test intervals, including data for: the five composite scores (Verbal Memory, Visual Memory, Visual Motor Speed, Reaction Time, Impulse Control); for the twelve subtest scores test that go to make up the composite scores; and for four additional memory subcomponent scores (Word Memory immediate recall, Word Memory delayed recall, Design Memory immediate recall, Design Memory delayed recall). The results provide a clinical and heuristic normative platform for future use with brain injured individuals, which can be used to facilitate clinical interpretations of postconcussion assessments.
- Full Text:
A formative intervention study of how learner voice and leadership can be developed within a Learner Representative Council (LRC) in an urban combined school, Namibia
- Authors: Shipopyeni, Salomo S M
- Date: 2020
- Subjects: Education, Secondary -- Namibia , Student government -- Namibia -- Case studies , Student participation in administration -- Namibia -- Case studies
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/144934 , vital:38393
- Description: The Namibian Education system, after the country gained independence, introduced various reforms to ensure the attainment of the educational goals of access, quality, equity and democracy in schools. One of the policies introduced to promote democracy in our schools was The Educational Act 16 of 2001, which gave birth to the establishment of Learners Representatives Councils (LRC) in schools. The LRC body is the legal learner leadership body established to ensure learners are represented in school leadership. However, various studies have revealed that this legal body of learners in many schools has been merely ‘rubber-stamping’ decisions made by teachers; learners have had very little input in decisions that affect them as learners. Thus, I was prompted to conduct this formative intervention study on learner leadership at an urban combined school in Namibia. Informed by distributed and transformative leadership theories, the study aimed to develop leadership within the LRC members and the needed expansive transformation regarding leadership practices in school. The intention was for learners to be enabled to practice their democratic right in decision-making processes in matters that concerned their schooling and learning. This study was theoretically and analytically framed by second generation CulturalHistorical Activity Theory. The participants included 12 LRC members, the LRC liaison teacher, the class register teacher, three school management team members and the principal. The research method was a case study, underpinned by the critical paradigm to bring about the fundamental expansive transformation in learner leadership practices at the case study school. This qualitative study was divided into two phases, a contextual profiling phase and an intervention phase. Data were generated through document analysis, observation, questionnaires, focus group interviews and Change Laboratory Workshops. The data were generated to answer the over-arching question: How learner voice and leadership can be developed within a Learner Representative Council (LRC) in an urban combined school, Namibia. The data were analysed inductively and abductively. The key findings were: first, there were a variety of understandings of the concept learner leadership; second, the involvement of LRC members in decision-making processes was limited to involvement in organising extracurricular activities and controlling of other learners at school; third, leadership development opportunities for learners at the case study school were only provided through training at the beginning of the year and the LRC carrying out various activities and roles at the case study school. Several challenges that constrained the LRC voice and leadership development were surfaced and, through Change Laboratory Workshops, the participants of the activity system together with me (the researcher-interventionist), identified the expansive learning opportunities to develop leadership amongst Learner Representative Council (LRC) members. In the final analysis, this study will contribute to the production of knowledge on the concept of learner leadership in the context of Namibia. Fellow scholars, professionals, colleagues and policy makers in education are requested to engage with this thesis to contribute to our understanding of this important aspect of our field and speak back to policy.
- Full Text:
- Authors: Shipopyeni, Salomo S M
- Date: 2020
- Subjects: Education, Secondary -- Namibia , Student government -- Namibia -- Case studies , Student participation in administration -- Namibia -- Case studies
- Language: English
- Type: text , Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/144934 , vital:38393
- Description: The Namibian Education system, after the country gained independence, introduced various reforms to ensure the attainment of the educational goals of access, quality, equity and democracy in schools. One of the policies introduced to promote democracy in our schools was The Educational Act 16 of 2001, which gave birth to the establishment of Learners Representatives Councils (LRC) in schools. The LRC body is the legal learner leadership body established to ensure learners are represented in school leadership. However, various studies have revealed that this legal body of learners in many schools has been merely ‘rubber-stamping’ decisions made by teachers; learners have had very little input in decisions that affect them as learners. Thus, I was prompted to conduct this formative intervention study on learner leadership at an urban combined school in Namibia. Informed by distributed and transformative leadership theories, the study aimed to develop leadership within the LRC members and the needed expansive transformation regarding leadership practices in school. The intention was for learners to be enabled to practice their democratic right in decision-making processes in matters that concerned their schooling and learning. This study was theoretically and analytically framed by second generation CulturalHistorical Activity Theory. The participants included 12 LRC members, the LRC liaison teacher, the class register teacher, three school management team members and the principal. The research method was a case study, underpinned by the critical paradigm to bring about the fundamental expansive transformation in learner leadership practices at the case study school. This qualitative study was divided into two phases, a contextual profiling phase and an intervention phase. Data were generated through document analysis, observation, questionnaires, focus group interviews and Change Laboratory Workshops. The data were generated to answer the over-arching question: How learner voice and leadership can be developed within a Learner Representative Council (LRC) in an urban combined school, Namibia. The data were analysed inductively and abductively. The key findings were: first, there were a variety of understandings of the concept learner leadership; second, the involvement of LRC members in decision-making processes was limited to involvement in organising extracurricular activities and controlling of other learners at school; third, leadership development opportunities for learners at the case study school were only provided through training at the beginning of the year and the LRC carrying out various activities and roles at the case study school. Several challenges that constrained the LRC voice and leadership development were surfaced and, through Change Laboratory Workshops, the participants of the activity system together with me (the researcher-interventionist), identified the expansive learning opportunities to develop leadership amongst Learner Representative Council (LRC) members. In the final analysis, this study will contribute to the production of knowledge on the concept of learner leadership in the context of Namibia. Fellow scholars, professionals, colleagues and policy makers in education are requested to engage with this thesis to contribute to our understanding of this important aspect of our field and speak back to policy.
- Full Text:
A framework for digital signature implementations for e-government services
- Authors: Kumalo, Mmaphefo Octavia
- Date: 2020
- Subjects: Electronic government information , Internet in public administration , Municipal government -- Data processing
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: http://hdl.handle.net/10948/46086 , vital:39490
- Description: The advent of the Internet has brought with it new innovations, new ways of doing business, new ways of working, new ways of engaging, and new forms of business models. It has ultimately disrupted the traditional ways in which we communicate, socialise, and live life in general. This era has heralded the requirement for digitization and has brought about the digital economy and the Fourth Industrial Revolution. The fundamental ways in which companies and governments do business are changing due to the increased innovation, and the cost efficiencies that this era has brought with it. Like most governments worldwide, the South African government has responded to the Internet revolution and is taking advantage of it through e-government initiatives. The direct effects of e-government include cost savings, efficiencies, improved and continuous interactions and communications with citizens, better public procurement, and improved tax collection. The area of digitization has the potential to improve how the South African government delivers services to citizens and those that reside within the borders of the country. Amongst the five elements of successful e-government transformation, process reform is at the top of the list. e-Government is not just about the automation of existing processes and inefficiencies. It is also about the creation of new processes and new relationships between all the stakeholders involved. In the South African context, the lack of optimised, automated, and digitalised processes within various government departments has impeded crossfunctional processes’ effectiveness and efficiencies. Manual interventions in processing and transactions occur to comply with the legal requirement to manually sign documents. This poses difficulties in integrating processes within government departments to achieve a seamless experience for the citizen. As a result, this treatise sets out to answer the question of what needs to be in place to allow for the utilisation of digital signatures in automating the processing of e-government services for a seamless experience for citizens and businesses. The resulting Digital Signature Framework can be used by government departments to implement digital signatures and provides providing guidance, facilitating understanding, and providing ease of use, scalability, and agility.
- Full Text:
- Authors: Kumalo, Mmaphefo Octavia
- Date: 2020
- Subjects: Electronic government information , Internet in public administration , Municipal government -- Data processing
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: http://hdl.handle.net/10948/46086 , vital:39490
- Description: The advent of the Internet has brought with it new innovations, new ways of doing business, new ways of working, new ways of engaging, and new forms of business models. It has ultimately disrupted the traditional ways in which we communicate, socialise, and live life in general. This era has heralded the requirement for digitization and has brought about the digital economy and the Fourth Industrial Revolution. The fundamental ways in which companies and governments do business are changing due to the increased innovation, and the cost efficiencies that this era has brought with it. Like most governments worldwide, the South African government has responded to the Internet revolution and is taking advantage of it through e-government initiatives. The direct effects of e-government include cost savings, efficiencies, improved and continuous interactions and communications with citizens, better public procurement, and improved tax collection. The area of digitization has the potential to improve how the South African government delivers services to citizens and those that reside within the borders of the country. Amongst the five elements of successful e-government transformation, process reform is at the top of the list. e-Government is not just about the automation of existing processes and inefficiencies. It is also about the creation of new processes and new relationships between all the stakeholders involved. In the South African context, the lack of optimised, automated, and digitalised processes within various government departments has impeded crossfunctional processes’ effectiveness and efficiencies. Manual interventions in processing and transactions occur to comply with the legal requirement to manually sign documents. This poses difficulties in integrating processes within government departments to achieve a seamless experience for the citizen. As a result, this treatise sets out to answer the question of what needs to be in place to allow for the utilisation of digital signatures in automating the processing of e-government services for a seamless experience for citizens and businesses. The resulting Digital Signature Framework can be used by government departments to implement digital signatures and provides providing guidance, facilitating understanding, and providing ease of use, scalability, and agility.
- Full Text:
A framework for enhancing compliance with Employee Performance Management and Development Systems(EPMDS) among public sector doctors in BCMM health facilities
- Bayeni, Luvuyo Lonwabo Precious
- Authors: Bayeni, Luvuyo Lonwabo Precious
- Date: 2020
- Subjects: Performance -- Management
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/47520 , vital:40116
- Description: This research explored an employee performance management and development system in the context of the public health centres in the Eastern Cape Province of South Africa. The study reviewed the literature on EPMDS in the public health sector of South Africa, noting the shortfalls, challenges, and ways in which it could be improved. The major findings from the study include the need to review the entire policy, revise the pay-scales, and co-create a new EPMDS policy creating space for the representation of the views of the employees. Without completing the development and performance evaluation, grade progression cannot be implemented despite years of service; hence the problem doctors face with their salary levels. The current EPMDS was found to be ineffective due to the wide discrepancy that exists between doctors and other health professionals in public health institutions. Among the commitment motivators highlighted by the respondents, was the need to develop an organisational culture that permits employees to recognise that they are appreciated. Future research must consider using mixed research methods, in the context of other South African Provinces and include a larger sample of research participants.
- Full Text:
- Authors: Bayeni, Luvuyo Lonwabo Precious
- Date: 2020
- Subjects: Performance -- Management
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/47520 , vital:40116
- Description: This research explored an employee performance management and development system in the context of the public health centres in the Eastern Cape Province of South Africa. The study reviewed the literature on EPMDS in the public health sector of South Africa, noting the shortfalls, challenges, and ways in which it could be improved. The major findings from the study include the need to review the entire policy, revise the pay-scales, and co-create a new EPMDS policy creating space for the representation of the views of the employees. Without completing the development and performance evaluation, grade progression cannot be implemented despite years of service; hence the problem doctors face with their salary levels. The current EPMDS was found to be ineffective due to the wide discrepancy that exists between doctors and other health professionals in public health institutions. Among the commitment motivators highlighted by the respondents, was the need to develop an organisational culture that permits employees to recognise that they are appreciated. Future research must consider using mixed research methods, in the context of other South African Provinces and include a larger sample of research participants.
- Full Text:
A framework for price tariffs in the costing structures of South African private hospitals
- Authors: Botha, Gideon
- Date: 2020
- Subjects: Hospitals, Proprietary
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47489 , vital:40126
- Description: The increase of South African health care costs can be extrapolated into the global healthcare cost challenge, with various factors contributing to this problem. One of the factors viewed as being central to the rising cost of health care is the inability of health care provider organisations to accurately measure unit costs of resources used to treat a patient for their medical condition and patient outcomes. The measurement of an accurate unit cost and patient outcomes is imperative to improving value, which is seen as an improvement in outcomes for every rand spent. The determination of price tariffs and the price tariff payment model used to onward bill the price tariff for medical services have also been identified as having a central role in improving value in health care. In order for price tariffs to improve value, they should be reflective and be based on an accurate unit cost that reflects the cost of resources used to provide efficient and effective care for a patient’s medical condition. For the price tariff payment model to improve value, it needs to reward providers for delivering superior patient outcomes at a lower cost by making price tariffs contingent on achieving specified outcomes as well as incorporating performance payments or holdbacks based on outcomes achieved. This study provides a framework for price tariffs in the costing structures of South African private hospitals. Secondary research was conducted in the form of a comprehensive literature search in order to do an interpretative analysis of the strengths and weaknesses of the various combinations of unit costing models and price tariff payment models used to determine prices in private hospitals. The literature review was followed by primary research that involved three phases, all of which used a qualitative research approach. In Phase 1, primary data were collected using unobtrusive measures that consisted of a data request first, followed by unstructured interviews with representatives of Hospital A and Hospital B to obtain an analysis of the combinations of unit costing model and price tariff payment model used for a laparoscopic appendectomy. In Phase 2, data were collected by means of an unstructured interview with a surgeon describing a laparoscopic appendectomy procedure in detail and based on this process description, the approximate costs for the various resources that were sourced from different suppliers could be calculated. The data analysis and interpretation were done in three phases, with each phase having different research objectives. The data were first coded and then interpreted. In the first primary research phase, the combinations of unit costing models and price tariff payment models used by private Hospital A and Hospital B were evaluated. In the second phase, the recommended combination of unit costing model and price tariff payment model was applied to a hypothetical example and evaluated. In the final phase, based on the outcome of the first and second research phases, a combination of unit costing model and price tariff payment model for private hospitals was recommended. The results showed that the recommended combination of unit costing and price tariff payment model namely time-driven activity-based costing with the global fee price tariff payment model was the most appropriate to determine price tariffs in private hospitals when compared to the unit costing models and price tariff payment models used by Hospital A and Hospital B for a laparoscopic appendectomy. Furthermore, the recommended combination of unit costing model and price tariff payment model was found to be usable for the determination of price tariffs in the costing structures of private hospitals. The time-driven activity-based costing model and global fee price tariff payment model should be adopted or used as guidelines for determining price tariffs in private hospitals in South Africa. Price tariffs would be more transparent as they would reflect the actual resource cost of treating the patient and the resources used and treatment provided could then be assessed against the delivery value chain that charts the principal activities involved in a patient’s care for a medical condition to ensure that patient best-practice protocols are followed. The proposed framework enables the determination of price tariffs based on an accurate unit cost reflecting the actual resources used to provide efficient and effective care and also improve value for the patient.
- Full Text:
- Authors: Botha, Gideon
- Date: 2020
- Subjects: Hospitals, Proprietary
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/47489 , vital:40126
- Description: The increase of South African health care costs can be extrapolated into the global healthcare cost challenge, with various factors contributing to this problem. One of the factors viewed as being central to the rising cost of health care is the inability of health care provider organisations to accurately measure unit costs of resources used to treat a patient for their medical condition and patient outcomes. The measurement of an accurate unit cost and patient outcomes is imperative to improving value, which is seen as an improvement in outcomes for every rand spent. The determination of price tariffs and the price tariff payment model used to onward bill the price tariff for medical services have also been identified as having a central role in improving value in health care. In order for price tariffs to improve value, they should be reflective and be based on an accurate unit cost that reflects the cost of resources used to provide efficient and effective care for a patient’s medical condition. For the price tariff payment model to improve value, it needs to reward providers for delivering superior patient outcomes at a lower cost by making price tariffs contingent on achieving specified outcomes as well as incorporating performance payments or holdbacks based on outcomes achieved. This study provides a framework for price tariffs in the costing structures of South African private hospitals. Secondary research was conducted in the form of a comprehensive literature search in order to do an interpretative analysis of the strengths and weaknesses of the various combinations of unit costing models and price tariff payment models used to determine prices in private hospitals. The literature review was followed by primary research that involved three phases, all of which used a qualitative research approach. In Phase 1, primary data were collected using unobtrusive measures that consisted of a data request first, followed by unstructured interviews with representatives of Hospital A and Hospital B to obtain an analysis of the combinations of unit costing model and price tariff payment model used for a laparoscopic appendectomy. In Phase 2, data were collected by means of an unstructured interview with a surgeon describing a laparoscopic appendectomy procedure in detail and based on this process description, the approximate costs for the various resources that were sourced from different suppliers could be calculated. The data analysis and interpretation were done in three phases, with each phase having different research objectives. The data were first coded and then interpreted. In the first primary research phase, the combinations of unit costing models and price tariff payment models used by private Hospital A and Hospital B were evaluated. In the second phase, the recommended combination of unit costing model and price tariff payment model was applied to a hypothetical example and evaluated. In the final phase, based on the outcome of the first and second research phases, a combination of unit costing model and price tariff payment model for private hospitals was recommended. The results showed that the recommended combination of unit costing and price tariff payment model namely time-driven activity-based costing with the global fee price tariff payment model was the most appropriate to determine price tariffs in private hospitals when compared to the unit costing models and price tariff payment models used by Hospital A and Hospital B for a laparoscopic appendectomy. Furthermore, the recommended combination of unit costing model and price tariff payment model was found to be usable for the determination of price tariffs in the costing structures of private hospitals. The time-driven activity-based costing model and global fee price tariff payment model should be adopted or used as guidelines for determining price tariffs in private hospitals in South Africa. Price tariffs would be more transparent as they would reflect the actual resource cost of treating the patient and the resources used and treatment provided could then be assessed against the delivery value chain that charts the principal activities involved in a patient’s care for a medical condition to ensure that patient best-practice protocols are followed. The proposed framework enables the determination of price tariffs based on an accurate unit cost reflecting the actual resources used to provide efficient and effective care and also improve value for the patient.
- Full Text:
A framework to integrate secure programming principles into undergraduate computing curricula
- Authors: Bangani, Sifiso Matthews
- Date: 2020
- Subjects: Information technology -- Study and teaching (Higher) , Electronic data processing personnel -- Training of , Computer software -- Development
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/46019 , vital:39409
- Description: Many graduate software developers are not competent in secure programming, resulting in risks that are caused by vulnerabilities in the application code of software applications. These graduate software developers are equipped with programming knowledge and skills from universities, however, these software developers are rarely equipped with secure programming knowledge and skills from the undergraduate level. Although there are various techniques for writing secure code in the current body of knowledge, these techniques are rarely fundamental components of a computing curriculum, resulting in incompetent graduate software developers. The security aspect of software applications, is considered as an important aspect that can reflect the ability of a system to prevent data exposures and loss of information. For businesses that rely on software applications to keep operations running, a failure of a software application can stop production, interrupt processes, and may lead to data breaches and financial losses. This research argued that secure programming education needs to be included across computing curricula, and thus, the primary objective of this dissertation was: To develop a framework for integrating secure programming principles into undergraduate computing curricula. It proposes a framework for the incorporation of secure programming principles into undergraduate computing curricula, through a step-by-step approach. This framework includes the identification of application risks and secure programming practices as they relate to each other, and to the basic programming concepts taught to undergraduate students. It specifically aims to improve the security of software applications developed in the .Net framework environment. The main research methods used in this study included a literature view, thematic content analysis, argumentation, and modelling.
- Full Text:
- Authors: Bangani, Sifiso Matthews
- Date: 2020
- Subjects: Information technology -- Study and teaching (Higher) , Electronic data processing personnel -- Training of , Computer software -- Development
- Language: English
- Type: Thesis , Masters , MIT
- Identifier: http://hdl.handle.net/10948/46019 , vital:39409
- Description: Many graduate software developers are not competent in secure programming, resulting in risks that are caused by vulnerabilities in the application code of software applications. These graduate software developers are equipped with programming knowledge and skills from universities, however, these software developers are rarely equipped with secure programming knowledge and skills from the undergraduate level. Although there are various techniques for writing secure code in the current body of knowledge, these techniques are rarely fundamental components of a computing curriculum, resulting in incompetent graduate software developers. The security aspect of software applications, is considered as an important aspect that can reflect the ability of a system to prevent data exposures and loss of information. For businesses that rely on software applications to keep operations running, a failure of a software application can stop production, interrupt processes, and may lead to data breaches and financial losses. This research argued that secure programming education needs to be included across computing curricula, and thus, the primary objective of this dissertation was: To develop a framework for integrating secure programming principles into undergraduate computing curricula. It proposes a framework for the incorporation of secure programming principles into undergraduate computing curricula, through a step-by-step approach. This framework includes the identification of application risks and secure programming practices as they relate to each other, and to the basic programming concepts taught to undergraduate students. It specifically aims to improve the security of software applications developed in the .Net framework environment. The main research methods used in this study included a literature view, thematic content analysis, argumentation, and modelling.
- Full Text:
A framework to measure the degree of alignment between corporate and IT/IS objectives at Randwater
- Authors: Sigasa, Moshane Lydia
- Date: 2020
- Subjects: Business enterprises -- Computer networks -- Security measures , Data protection , Information technology -- Security measures
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: http://hdl.handle.net/10948/47156 , vital:39818
- Description: The South African Government has institutionalised a Corporate Governance of ICT Policy Framework which was developed by Department of Public Service and Administration (DPSA). The framework has adopted some elements of KING III, ISO 38500 and COBIT. Consequently, it is now a requirement by the South African Government that all its entities must adopt this framework. Nevertheless, it is not clear how government has emphasised this alignment in such entities. The problem statement in this study was that Randwater is unable to realise full value of the investment in IT/IS because there is misalignment between IT objectives or deliverables and the corporate objectives. This study sought to identify a suitable framework which meets the ICT policy criteria as set out by the DPSA, which will facilitate the alignment between corporate objectives and IT/IS objectives at Randwater. This was achieved through the development and refinement of the artefact through the various iteration phases. Additionally, an online survey was used to collect data from a focus group comprising IT experts and senior management at Randwater. The Information Technology Governance Institute Framework was employed to assist in the development of the questions. The survey results were utilised during the validation of the artefact produced by this research study in a workshop. The findings were then linked with the related literature which either supported or rejected the findings through discussions on the literature and thereafter conclusions were made based on these findings. Furthermore, a literature review was conducted to gain a better understanding of what has been done in the field of research in order to assist in defining the problem that this research seeks to solve so as to inform the development of design characteristics. The research process employed the Nelson Mandela University – Design Science Strategy Methodology referred to as (NMU – DSSM) with the goal of developing an artefact in the form of a framework. The research process entailed studying the existing literature and analysing the aspects relating to corporate governance, IT governance, frameworks, and strategies to be able to measure the degree of alignment. The phases of designing the artefact were analysis, design, evaluate, validate and diffuse phases. The final artefact developed was a framework that incorporated the principles of King IV and ISO 38500 in corporate governance and ICT goals alignment. The final artefact also embedded transparency, accountability and security as important elements in the implementation of the artefact. The survey findings were instrumental in the development of the artefact that brings alignment between business strategy and IT objectives at Randwater. From the findings, in terms of IT flexibility, it was revealed that the interrelated parts of the system at Randwater were modular. It was also concluded that there is lack of communication about the manner in which the components of the information systems are organised and integrated in order to allow for rapid changes and that the organisational IT infrastructure and applications were loosely coupled. The findings further revealed that the business had established corporate rules and standards for hardware and operating systems to ensure platform compatibility. It was also revealed that organisational IT applications were developed based on compliance guidelines. In terms of IT-enabled dynamic capabilities, it was revealed that IT systems at Randwater are not capable of scanning the environment and identifying new business opportunities and are not capable of anticipating discontinuities arising in the business domain by developing greater reactive and proactive strength. It was also revealed that it was concluded that IT systems were capable of achieving strategic alignment between IT flexibility and dynamic capabilities. Therefore, design science was the ideal research paradigm towards addressing the research problem and the artefact designed was a viable research contribution. The significance of the study was that it contributed to the development of technology-based solutions to an important and relevant business problem of alignment of business strategy to IT goals. The design evaluation, the utility, quality, and efficacy of the final design artefact was rigorously demonstrated via well-executed evaluation methods. The study also contributed to the literature
- Full Text:
- Authors: Sigasa, Moshane Lydia
- Date: 2020
- Subjects: Business enterprises -- Computer networks -- Security measures , Data protection , Information technology -- Security measures
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: http://hdl.handle.net/10948/47156 , vital:39818
- Description: The South African Government has institutionalised a Corporate Governance of ICT Policy Framework which was developed by Department of Public Service and Administration (DPSA). The framework has adopted some elements of KING III, ISO 38500 and COBIT. Consequently, it is now a requirement by the South African Government that all its entities must adopt this framework. Nevertheless, it is not clear how government has emphasised this alignment in such entities. The problem statement in this study was that Randwater is unable to realise full value of the investment in IT/IS because there is misalignment between IT objectives or deliverables and the corporate objectives. This study sought to identify a suitable framework which meets the ICT policy criteria as set out by the DPSA, which will facilitate the alignment between corporate objectives and IT/IS objectives at Randwater. This was achieved through the development and refinement of the artefact through the various iteration phases. Additionally, an online survey was used to collect data from a focus group comprising IT experts and senior management at Randwater. The Information Technology Governance Institute Framework was employed to assist in the development of the questions. The survey results were utilised during the validation of the artefact produced by this research study in a workshop. The findings were then linked with the related literature which either supported or rejected the findings through discussions on the literature and thereafter conclusions were made based on these findings. Furthermore, a literature review was conducted to gain a better understanding of what has been done in the field of research in order to assist in defining the problem that this research seeks to solve so as to inform the development of design characteristics. The research process employed the Nelson Mandela University – Design Science Strategy Methodology referred to as (NMU – DSSM) with the goal of developing an artefact in the form of a framework. The research process entailed studying the existing literature and analysing the aspects relating to corporate governance, IT governance, frameworks, and strategies to be able to measure the degree of alignment. The phases of designing the artefact were analysis, design, evaluate, validate and diffuse phases. The final artefact developed was a framework that incorporated the principles of King IV and ISO 38500 in corporate governance and ICT goals alignment. The final artefact also embedded transparency, accountability and security as important elements in the implementation of the artefact. The survey findings were instrumental in the development of the artefact that brings alignment between business strategy and IT objectives at Randwater. From the findings, in terms of IT flexibility, it was revealed that the interrelated parts of the system at Randwater were modular. It was also concluded that there is lack of communication about the manner in which the components of the information systems are organised and integrated in order to allow for rapid changes and that the organisational IT infrastructure and applications were loosely coupled. The findings further revealed that the business had established corporate rules and standards for hardware and operating systems to ensure platform compatibility. It was also revealed that organisational IT applications were developed based on compliance guidelines. In terms of IT-enabled dynamic capabilities, it was revealed that IT systems at Randwater are not capable of scanning the environment and identifying new business opportunities and are not capable of anticipating discontinuities arising in the business domain by developing greater reactive and proactive strength. It was also revealed that it was concluded that IT systems were capable of achieving strategic alignment between IT flexibility and dynamic capabilities. Therefore, design science was the ideal research paradigm towards addressing the research problem and the artefact designed was a viable research contribution. The significance of the study was that it contributed to the development of technology-based solutions to an important and relevant business problem of alignment of business strategy to IT goals. The design evaluation, the utility, quality, and efficacy of the final design artefact was rigorously demonstrated via well-executed evaluation methods. The study also contributed to the literature
- Full Text: