A STAT3 of addiction: adipose tissue, adipocytokine signalling and STAT3 as mediators of metabolic remodelling in the tumour microenvironment
- Kadye, Rose, Stoffels, Mihlali, Fanucci, Sidne, Mbanxa, Siso, Prinsloo, Earl
- Authors: Kadye, Rose , Stoffels, Mihlali , Fanucci, Sidne , Mbanxa, Siso , Prinsloo, Earl
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149395 , vital:38846 , https://doi.org/10.3390/cells9041043
- Description: Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
- Full Text:
- Date Issued: 2020
- Authors: Kadye, Rose , Stoffels, Mihlali , Fanucci, Sidne , Mbanxa, Siso , Prinsloo, Earl
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149395 , vital:38846 , https://doi.org/10.3390/cells9041043
- Description: Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
- Full Text:
- Date Issued: 2020
Habitat requirements affect genetic variation in three species of mayfly (Ephemeroptera, Baetidae) from South Africa:
- Taylor, Chantal L, Barker, Nigel P, Barber-James, Helen M, Villet, Martin H, Pereira-da-Conceicoa, Lyndall L
- Authors: Taylor, Chantal L , Barker, Nigel P , Barber-James, Helen M , Villet, Martin H , Pereira-da-Conceicoa, Lyndall L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149314 , vital:38824 , https://doi.org/10.3897/zookeys.936.38587
- Description: This study investigates genetic diversity in three species of Ephemeroptera, one eurytopic and therefore widespread (Afroptilum sudafricanum) and two stenotopic and thus endemic (Demoreptus natalensis and Demoreptus capensis) species, all of which co-occur in the southern Great Escarpment, South Africa. Mitochondrial DNA was analysed to compare the genetic diversity between the habitat generalist and the two habitat specialists. Afroptilum sudafricanum showed no indication of population genetic structure due to geographic location, while both Demoreptus species revealed clear genetic differentiation between geographic localities and catchments, evident from phylogenetic analyses and high FST values from AMOVA.
- Full Text:
- Date Issued: 2020
- Authors: Taylor, Chantal L , Barker, Nigel P , Barber-James, Helen M , Villet, Martin H , Pereira-da-Conceicoa, Lyndall L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149314 , vital:38824 , https://doi.org/10.3897/zookeys.936.38587
- Description: This study investigates genetic diversity in three species of Ephemeroptera, one eurytopic and therefore widespread (Afroptilum sudafricanum) and two stenotopic and thus endemic (Demoreptus natalensis and Demoreptus capensis) species, all of which co-occur in the southern Great Escarpment, South Africa. Mitochondrial DNA was analysed to compare the genetic diversity between the habitat generalist and the two habitat specialists. Afroptilum sudafricanum showed no indication of population genetic structure due to geographic location, while both Demoreptus species revealed clear genetic differentiation between geographic localities and catchments, evident from phylogenetic analyses and high FST values from AMOVA.
- Full Text:
- Date Issued: 2020
Impact of early pandemic stage mutations on molecular dynamics of SARS-CoV-2 Mpro:
- Amamuddy, Olivier S, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
- Authors: Amamuddy, Olivier S , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162330 , vital:40835 , https://0-doi.org.wam.seals.ac.za/10.1021/acs.jcim.0c00634
- Description: A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality. All-atom molecular dynamics (MD) simulations (100 ns) of 50 mutant Mpro dimers obtained from filtered sequences from the GISAID database were analyzed using root-mean-square deviation, root-mean-square fluctuation, Rg, averaged betweenness centrality, and geometry calculations.
- Full Text:
- Date Issued: 2020
Ruthenium complexes with mono-or bis-heterocyclic chelates: DNA/BSA binding, Antioxidant and Anticancer studies
- Maikoo, Sanam, Chakraborty, Abir, Vukea, Nyeleti, Dingle, Laura M K, Samson, William J, de la Mare, Jo-Anne, Edkins, Adrienne L, Booysen, Irvin N
- Authors: Maikoo, Sanam , Chakraborty, Abir , Vukea, Nyeleti , Dingle, Laura M K , Samson, William J , de la Mare, Jo-Anne , Edkins, Adrienne L , Booysen, Irvin N
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165463 , vital:41246 , DOI: 10.1080/07391102.2020.1775126
- Description: Deoxyribonucleic acid (DNA) and bovine serum albumin (BSA) binding interactions for a series of ruthenium heterocyclic complexes were monitored using ultraviolet-visible (UV-Vis) spectrophotometry, fluorescence emission spectroscopy and agarose gel electrophoresis. Investigations of the DNA interactions for the metal complexes revealed that they are groove-binders with intrinsic binding constants in the order of 104 – 107 M−1.
- Full Text:
- Date Issued: 2020
- Authors: Maikoo, Sanam , Chakraborty, Abir , Vukea, Nyeleti , Dingle, Laura M K , Samson, William J , de la Mare, Jo-Anne , Edkins, Adrienne L , Booysen, Irvin N
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165463 , vital:41246 , DOI: 10.1080/07391102.2020.1775126
- Description: Deoxyribonucleic acid (DNA) and bovine serum albumin (BSA) binding interactions for a series of ruthenium heterocyclic complexes were monitored using ultraviolet-visible (UV-Vis) spectrophotometry, fluorescence emission spectroscopy and agarose gel electrophoresis. Investigations of the DNA interactions for the metal complexes revealed that they are groove-binders with intrinsic binding constants in the order of 104 – 107 M−1.
- Full Text:
- Date Issued: 2020
Urban nature and biocultural realities:
- Shackleton, Charlie M, Cocks, Michelle L
- Authors: Shackleton, Charlie M , Cocks, Michelle L
- Date: 2020
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175709 , vital:42617 , ISBN 9781000215182
- Description: There is no longer any doubt that an important component of and contributor to human wellbeing is the natural environment in which people live, work and relax (Summers et al. 2012). Whilst initial ideas of human wellbeing, early in the second half of the 20th century, focussed on objective measures that could be quantified and contribute to humans’ basic needs, they have evolved a great deal since, despite the lack of consensus on a precise definition of human wellbeing (Summers et al. 2012). Over the last five decades the conceptions of human wellbeing have become more complex and inclusive of the more subjective and less tangible components of human existence, including the natural environment (King et al. 2014).
- Full Text:
- Date Issued: 2020
- Authors: Shackleton, Charlie M , Cocks, Michelle L
- Date: 2020
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/175709 , vital:42617 , ISBN 9781000215182
- Description: There is no longer any doubt that an important component of and contributor to human wellbeing is the natural environment in which people live, work and relax (Summers et al. 2012). Whilst initial ideas of human wellbeing, early in the second half of the 20th century, focussed on objective measures that could be quantified and contribute to humans’ basic needs, they have evolved a great deal since, despite the lack of consensus on a precise definition of human wellbeing (Summers et al. 2012). Over the last five decades the conceptions of human wellbeing have become more complex and inclusive of the more subjective and less tangible components of human existence, including the natural environment (King et al. 2014).
- Full Text:
- Date Issued: 2020
Cosmolocal orientations: trickster spatialization and the politics of cultural bargaining in Zambia
- Authors: Simbao, Ruth K
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146044 , vital:38490 , DOI 10.1080/19301944.2018.1532379
- Description: The spatialization of Africa is fraught, and places within Africa tend to be stereotyped by geographies of morality and simplistic rural/urban divides. Focusing on the spatial, cultural, and political bargaining of contemporary chiefs and cultural festivals in 21st-century Zambia, this article delinks cosmopolitanism and Afropolitanism from the city and associated attitudes of urbanity. Positioning place as a trickster character, it argues for a nuanced understanding of time-space imaginaries that refuses to bind people and identities to closed-down notions of place. In this article I propose the term cosmolocal, suggesting that the cosmolocal is an outward-engaging orientation that understands place as a profoundly discursive and situational process and that has the potential to exist anywhere. Many contemporary chiefs in Zambia embrace cosmolocalism, enabling them to escape the limitations of being viewed merely as custodians of culture who are limited to the space of the village framed historically as the warehouse of culture.
- Full Text:
- Date Issued: 2019
- Authors: Simbao, Ruth K
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146044 , vital:38490 , DOI 10.1080/19301944.2018.1532379
- Description: The spatialization of Africa is fraught, and places within Africa tend to be stereotyped by geographies of morality and simplistic rural/urban divides. Focusing on the spatial, cultural, and political bargaining of contemporary chiefs and cultural festivals in 21st-century Zambia, this article delinks cosmopolitanism and Afropolitanism from the city and associated attitudes of urbanity. Positioning place as a trickster character, it argues for a nuanced understanding of time-space imaginaries that refuses to bind people and identities to closed-down notions of place. In this article I propose the term cosmolocal, suggesting that the cosmolocal is an outward-engaging orientation that understands place as a profoundly discursive and situational process and that has the potential to exist anywhere. Many contemporary chiefs in Zambia embrace cosmolocalism, enabling them to escape the limitations of being viewed merely as custodians of culture who are limited to the space of the village framed historically as the warehouse of culture.
- Full Text:
- Date Issued: 2019
Language policy and linguistic landscapes at schools in South Africa:
- Kaschula, Russell H, Kretzer, Michael M
- Authors: Kaschula, Russell H , Kretzer, Michael M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174635 , vital:42496 , https://doi.org/10.1080/14790718.2019.1666849
- Description: Language policy and Linguistic Landscapes (LL) are a highly contested area in South Africa. Due to Apartheid, the education system constitutes the core of such contestation. In Post-Apartheid South Africa the new Constitution of 1996, the South African Schools Act (SASA) and recent political initiatives such as the Use of Official Languages Act of 2012 form the foundation of language policy at schools. The Constitution declares 11 official languages on a macro-level. Nevertheless, English dominates the LL in South Africa. African Languages are significantly underrepresented in the public sphere. The vast majority of research emphasises the urban or semi-urban areas. This research tries to close the existing research gap with a broad comparative study in three research provinces.
- Full Text:
- Date Issued: 2019
- Authors: Kaschula, Russell H , Kretzer, Michael M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/174635 , vital:42496 , https://doi.org/10.1080/14790718.2019.1666849
- Description: Language policy and Linguistic Landscapes (LL) are a highly contested area in South Africa. Due to Apartheid, the education system constitutes the core of such contestation. In Post-Apartheid South Africa the new Constitution of 1996, the South African Schools Act (SASA) and recent political initiatives such as the Use of Official Languages Act of 2012 form the foundation of language policy at schools. The Constitution declares 11 official languages on a macro-level. Nevertheless, English dominates the LL in South Africa. African Languages are significantly underrepresented in the public sphere. The vast majority of research emphasises the urban or semi-urban areas. This research tries to close the existing research gap with a broad comparative study in three research provinces.
- Full Text:
- Date Issued: 2019
Wild edible fruits: A systematic review of an under-researched multifunctional NTFP (non-timber forest product)
- Sardeshpande, Mallika, Shackleton, Charlie M
- Authors: Sardeshpande, Mallika , Shackleton, Charlie M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177752 , vital:42856 , https://doi.org/10.3390/f10060467
- Description: Wild edible fruits (WEFs) are among the most widely used non-timber forest products (NTFPs), and important sources of nutrition, medicine, and income for their users. In addition to their use as food, WEF species may also yield fiber, fuel, and a range of processed products. Besides forests, WEF species also thrive in diverse environments, such as agroforestry and urban landscapes, deserts, fallows, natural lands, and plantations. Given the multifunctional, ubiquitous nature of WEFs, we conducted a systematic review on the literature specific to WEFs and highlighted links between different domains of the wider knowledge on NTFPs.
- Full Text:
- Date Issued: 2019
- Authors: Sardeshpande, Mallika , Shackleton, Charlie M
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/177752 , vital:42856 , https://doi.org/10.3390/f10060467
- Description: Wild edible fruits (WEFs) are among the most widely used non-timber forest products (NTFPs), and important sources of nutrition, medicine, and income for their users. In addition to their use as food, WEF species may also yield fiber, fuel, and a range of processed products. Besides forests, WEF species also thrive in diverse environments, such as agroforestry and urban landscapes, deserts, fallows, natural lands, and plantations. Given the multifunctional, ubiquitous nature of WEFs, we conducted a systematic review on the literature specific to WEFs and highlighted links between different domains of the wider knowledge on NTFPs.
- Full Text:
- Date Issued: 2019
Art topples monuments: artistic practice and colonial/postcolonial relations in the public space of Luanda
- Authors: Siegert, Nadine
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147014 , vital:38585
- Description: Even though there have been very few modern and contemporary artworks in the urban space of Luanda in the years after independence in 1975—and especially after the end of the civil war in 2002—there are two works by Angolan artists that are of particular interest: the sculpture Mitologias II (1984) by António Ole (b. 1951) and the photographic series Redefining the Power (2011) by Kiluanji Kia Henda (b. 1978). Both works address the possibility of using contemporary art as a symbolic form of the replacement of power, since both are built on pedestals that had previously supported monuments of Portuguese colonial power. They might, therefore, be read as a form of substitution for monuments that would commemorate and celebrate independence or the end of colonialism. This article also discusses whether these two artworks can also be regarded as counter-monuments and this contributes to the discourse on the visual and material culture of Lusophone Africa.
- Full Text:
- Date Issued: 2018
- Authors: Siegert, Nadine
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147014 , vital:38585
- Description: Even though there have been very few modern and contemporary artworks in the urban space of Luanda in the years after independence in 1975—and especially after the end of the civil war in 2002—there are two works by Angolan artists that are of particular interest: the sculpture Mitologias II (1984) by António Ole (b. 1951) and the photographic series Redefining the Power (2011) by Kiluanji Kia Henda (b. 1978). Both works address the possibility of using contemporary art as a symbolic form of the replacement of power, since both are built on pedestals that had previously supported monuments of Portuguese colonial power. They might, therefore, be read as a form of substitution for monuments that would commemorate and celebrate independence or the end of colonialism. This article also discusses whether these two artworks can also be regarded as counter-monuments and this contributes to the discourse on the visual and material culture of Lusophone Africa.
- Full Text:
- Date Issued: 2018
How Far, Where To?: regionalism, the Southern African Development Community and decision-making into the Millennium
- Authors: Bischoff, Paul, 1954-
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/161638 , vital:40649 , ISBN 9781138726093
- Description: This title was first published in 2002: The resurgence of the democratization movement in Africa in the post-Cold War era is gradually replacing authoritarianism with forms of democratic systems. These changes have put into question the traditional big man image of African states’ foreign policy and foreign policy-making. The first book of its kind to focus on the foreign policy-making process of Southern African countries in the era of globalization, these instructive and rewarding case studies contextualize the increasing involvement of other internal actors in African states foreign policy-making process. Foreign policy actors such as the Presidency, Ministries of Defence, Foreign Affairs, Trade, Finance and the Intelligence Community, among others, are examined in a comparative perspective.
- Full Text:
- Date Issued: 2018
- Authors: Bischoff, Paul, 1954-
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/161638 , vital:40649 , ISBN 9781138726093
- Description: This title was first published in 2002: The resurgence of the democratization movement in Africa in the post-Cold War era is gradually replacing authoritarianism with forms of democratic systems. These changes have put into question the traditional big man image of African states’ foreign policy and foreign policy-making. The first book of its kind to focus on the foreign policy-making process of Southern African countries in the era of globalization, these instructive and rewarding case studies contextualize the increasing involvement of other internal actors in African states foreign policy-making process. Foreign policy actors such as the Presidency, Ministries of Defence, Foreign Affairs, Trade, Finance and the Intelligence Community, among others, are examined in a comparative perspective.
- Full Text:
- Date Issued: 2018
Navigating Multiple Tensions for Engaged Praxis in a Complex Social-Ecological System
- Cockburn, Jessica J, Palmer, Carolyn G, Biggs, Harry, Rosenberg, Eureta
- Authors: Cockburn, Jessica J , Palmer, Carolyn G , Biggs, Harry , Rosenberg, Eureta
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/127886 , vital:36052 , https://doi.org/10.3390/land7040129
- Description: Recently, the 33-year journey of the Southern African Journal of Environmental Education (SAJEE) was the subject of reflection during an Open Access Publishing week convened by Rhodes University Library Services. Two former and current editors-in-chief shared the SAJEE’s story of publishing ‘from the margins into the centre’. In the early 1990s, the Journal was mailed to the Environmental Education Association of Southern Africa (EEASA) membership from the foyer of the Rhodes Education Department (which had the floor space for stuffing and stacking A4 envelopes). In the first decade of this century, the Journal arrived at a symbolic ‘centre’ with digital distribution, first on the EEASA website and then from the Open Access platform provided by African Journals Online (AJOL). The digital move was vital for sustained and increased distribution in a time of shrinking budgets and growing costs. The results, shared with the EEASA Council earlier this year, were nothing short of spectacular: In March 2017, the SAJEE received more than 1 250 article downloads (www.ajol.info/index.php/sajee), and the number of downloads have stayed above 500 each month subsequently (Figure 1). Views and downloads are recorded around the world including,
- Full Text:
- Date Issued: 2018
- Authors: Cockburn, Jessica J , Palmer, Carolyn G , Biggs, Harry , Rosenberg, Eureta
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/127886 , vital:36052 , https://doi.org/10.3390/land7040129
- Description: Recently, the 33-year journey of the Southern African Journal of Environmental Education (SAJEE) was the subject of reflection during an Open Access Publishing week convened by Rhodes University Library Services. Two former and current editors-in-chief shared the SAJEE’s story of publishing ‘from the margins into the centre’. In the early 1990s, the Journal was mailed to the Environmental Education Association of Southern Africa (EEASA) membership from the foyer of the Rhodes Education Department (which had the floor space for stuffing and stacking A4 envelopes). In the first decade of this century, the Journal arrived at a symbolic ‘centre’ with digital distribution, first on the EEASA website and then from the Open Access platform provided by African Journals Online (AJOL). The digital move was vital for sustained and increased distribution in a time of shrinking budgets and growing costs. The results, shared with the EEASA Council earlier this year, were nothing short of spectacular: In March 2017, the SAJEE received more than 1 250 article downloads (www.ajol.info/index.php/sajee), and the number of downloads have stayed above 500 each month subsequently (Figure 1). Views and downloads are recorded around the world including,
- Full Text:
- Date Issued: 2018
Perspectives about the execution of police powers and functions in the republic of Zimbabwe
- Mugari, Ishmael, Obioha, Emeka, E
- Authors: Mugari, Ishmael , Obioha, Emeka, E
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4928 , vital:44304 , http://cjssp.uni-corvinus.hu/index.php/cjssp/article/view/220
- Description: This study was conducted to explore views about the execution of powers and functions of the police in the light of related challenges. This study made use of data from a total of 83 adult participants (a survey involving 73 individuals, and 10 in-depth interviews), including males and females of diverse occupational backgrounds from Bindura and Mount Darwin policing districts in Zimbabwe. A closed-ended, mostly Likert-scale-based questionnaire was used to collect data about the prevalent forms of police abuse of powers and functions, while an in-depth interview guide was provided to harvest information qualitatively. Findings reveal that police officers abuse their powers through unlawful arrests, arbitrary search and seizure, excessive use of force, unlawful methods of investigation, and ill treatment of detainees. Though not as prevalent as other forms of abuse, malicious criminal prosecution and partisan policing were also cited.K EYWOR DS: powers, abuse, function, police, Zimbabwe
- Full Text:
- Date Issued: 2018
- Authors: Mugari, Ishmael , Obioha, Emeka, E
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4928 , vital:44304 , http://cjssp.uni-corvinus.hu/index.php/cjssp/article/view/220
- Description: This study was conducted to explore views about the execution of powers and functions of the police in the light of related challenges. This study made use of data from a total of 83 adult participants (a survey involving 73 individuals, and 10 in-depth interviews), including males and females of diverse occupational backgrounds from Bindura and Mount Darwin policing districts in Zimbabwe. A closed-ended, mostly Likert-scale-based questionnaire was used to collect data about the prevalent forms of police abuse of powers and functions, while an in-depth interview guide was provided to harvest information qualitatively. Findings reveal that police officers abuse their powers through unlawful arrests, arbitrary search and seizure, excessive use of force, unlawful methods of investigation, and ill treatment of detainees. Though not as prevalent as other forms of abuse, malicious criminal prosecution and partisan policing were also cited.K EYWOR DS: powers, abuse, function, police, Zimbabwe
- Full Text:
- Date Issued: 2018
Protection of rights of urban refugees in Kenya: revisiting Kituo Cha Sheria v The Attorney General
- Authors: Juma, Laurence
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125174 , vital:35740 , DOI: 10.25159/2522-6800/3291
- Description: This article discusses the judgment in the landmark case of Kituo Cha Sheria and Others v Attorney General in the light of the emerging rights jurisprudence in the area of refugee rights. It also explores the impact the judgment could have on the articulation of the rights of urban refugees in Kenya. Based on the assumption that Kenya’s 2010 Constitution provides an opportunity for the robust enforcement of rights, the article analyses the key rights and protection imperatives that were at the centre of the dispute. These include the right to dignity, freedom of movement and to work, and also the principle of refoulement. These rights are at the core of the protection agenda for urban refugees.
- Full Text: false
- Date Issued: 2018
- Authors: Juma, Laurence
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/125174 , vital:35740 , DOI: 10.25159/2522-6800/3291
- Description: This article discusses the judgment in the landmark case of Kituo Cha Sheria and Others v Attorney General in the light of the emerging rights jurisprudence in the area of refugee rights. It also explores the impact the judgment could have on the articulation of the rights of urban refugees in Kenya. Based on the assumption that Kenya’s 2010 Constitution provides an opportunity for the robust enforcement of rights, the article analyses the key rights and protection imperatives that were at the centre of the dispute. These include the right to dignity, freedom of movement and to work, and also the principle of refoulement. These rights are at the core of the protection agenda for urban refugees.
- Full Text: false
- Date Issued: 2018
Sub-volcanic intrusions and the link to global climatic and environmental changes:
- Svensen, Henrik H, Planke, Sverre, Neumann, Else-Ragnhild, Aarnes, Ingrid, Marsh, Julian S, Polteau, Stéphane, Harstad, Camilla H, Chevallier, Luc
- Authors: Svensen, Henrik H , Planke, Sverre , Neumann, Else-Ragnhild , Aarnes, Ingrid , Marsh, Julian S , Polteau, Stéphane , Harstad, Camilla H , Chevallier, Luc
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/145166 , vital:38414 , ISBN 9783319140841 , https://link.springer.com/chapter/10.1007/11157_2015_10
- Description: Most of the Large Igneous Provinces (LIPs) formed during the last 260 million years are associated with climatic changes, oceanic anoxia, or extinctions in marine and terrestrial environments. Current hypotheses involve (1) degassing of carbon from either oceans or shallow sea-bed reservoirs, (2) degassing from flood basalts, or from (3) sedimentary basins heavily intruded by LIP-related sills. These hypotheses are based on detailed geological and geochemical studies from LIPSs or relevant proxy data sequences. Here we present new data on gas generation and degassing from a LIP, based on the LA1/68 borehole north of the Ladybrand area in the Karoo Basin, South Africa.
- Full Text:
- Date Issued: 2018
- Authors: Svensen, Henrik H , Planke, Sverre , Neumann, Else-Ragnhild , Aarnes, Ingrid , Marsh, Julian S , Polteau, Stéphane , Harstad, Camilla H , Chevallier, Luc
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/145166 , vital:38414 , ISBN 9783319140841 , https://link.springer.com/chapter/10.1007/11157_2015_10
- Description: Most of the Large Igneous Provinces (LIPs) formed during the last 260 million years are associated with climatic changes, oceanic anoxia, or extinctions in marine and terrestrial environments. Current hypotheses involve (1) degassing of carbon from either oceans or shallow sea-bed reservoirs, (2) degassing from flood basalts, or from (3) sedimentary basins heavily intruded by LIP-related sills. These hypotheses are based on detailed geological and geochemical studies from LIPSs or relevant proxy data sequences. Here we present new data on gas generation and degassing from a LIP, based on the LA1/68 borehole north of the Ladybrand area in the Karoo Basin, South Africa.
- Full Text:
- Date Issued: 2018
“Telling freedom” or “telling the spades back home how to behave”? re-examining Peter Abrahams’s writing in London
- Authors: Thorpe, Andrea
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68412 , vital:29253 , https://dx.doi.org/10.4314/eia.v45i1.3
- Description: Publisher version , This article considers the notable dearth of recent scholarship on Peter Abrahams’s writing in the context of his exile and his complex, shifting ideological self-positioning throughout his career. To attempt to address this lacuna in South African literary criticism, and to partially explain why Abrahams has been under-researched, I look at key moments during his early career, including the publication of Dark Testament (1942), Song of the City (1945) and Return to Goli (1953). By focusing on texts by Abrahams that were published during his time in London, I also wish to address the significance of the city in the history of South African literature, and in African anti-colonial and anti-racist thinking more broadly.
- Full Text: false
- Date Issued: 2018
- Authors: Thorpe, Andrea
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68412 , vital:29253 , https://dx.doi.org/10.4314/eia.v45i1.3
- Description: Publisher version , This article considers the notable dearth of recent scholarship on Peter Abrahams’s writing in the context of his exile and his complex, shifting ideological self-positioning throughout his career. To attempt to address this lacuna in South African literary criticism, and to partially explain why Abrahams has been under-researched, I look at key moments during his early career, including the publication of Dark Testament (1942), Song of the City (1945) and Return to Goli (1953). By focusing on texts by Abrahams that were published during his time in London, I also wish to address the significance of the city in the history of South African literature, and in African anti-colonial and anti-racist thinking more broadly.
- Full Text: false
- Date Issued: 2018
Germinating in the cracks: the identity of contemporary Zambian art
- Authors: Mulenga, Andrew
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/146222 , vital:38506 , ISBN 9783863883065
- Description: Culture is the heritage of us all. Some may be more interested than others in the treasures of the past, but no one can fail to take pride in his country's participation in the story of mankind as represented in carvings, sculpture, music, painting, and the other arts (Simon Mwansa Kapwepwe 1964). After gaining independence in 1964, the next move for Zambia, like most newly-born African states at the time, was nation-building.
- Full Text:
- Date Issued: 2017
- Authors: Mulenga, Andrew
- Date: 2017
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/146222 , vital:38506 , ISBN 9783863883065
- Description: Culture is the heritage of us all. Some may be more interested than others in the treasures of the past, but no one can fail to take pride in his country's participation in the story of mankind as represented in carvings, sculpture, music, painting, and the other arts (Simon Mwansa Kapwepwe 1964). After gaining independence in 1964, the next move for Zambia, like most newly-born African states at the time, was nation-building.
- Full Text:
- Date Issued: 2017
No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:
- Kimuda, Magambo Phillip, Noyes, Harry, Mulindwa, Julius, Enyaru, John, Alibu, Vincent Pius, Sidibe, Issa, Mumba, Dieuodonne, Hertz-Fowler, Christiane, MacLeod, Annette, Tastan Bishop, Özlem, Matovu, Enock
- Authors: Kimuda, Magambo Phillip , Noyes, Harry , Mulindwa, Julius , Enyaru, John , Alibu, Vincent Pius , Sidibe, Issa , Mumba, Dieuodonne , Hertz-Fowler, Christiane , MacLeod, Annette , Tastan Bishop, Özlem , Matovu, Enock
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148272 , vital:38725 , doi: 10.1371/journal.pntd.0006300
- Description: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
- Full Text:
- Date Issued: 2017
- Authors: Kimuda, Magambo Phillip , Noyes, Harry , Mulindwa, Julius , Enyaru, John , Alibu, Vincent Pius , Sidibe, Issa , Mumba, Dieuodonne , Hertz-Fowler, Christiane , MacLeod, Annette , Tastan Bishop, Özlem , Matovu, Enock
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/148272 , vital:38725 , doi: 10.1371/journal.pntd.0006300
- Description: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT.
- Full Text:
- Date Issued: 2017
Die Universiteit van die Werkersklas 1960-2010: die klem op studente
- Authors: Thomas, Cornelius
- Date: 2016
- Language: Afrikaans
- Type: book chapter , text
- Identifier: http://hdl.handle.net/10962/59778 , vital:27648 , http://naledi.online/product/ons-kom-van-ver/
- Description: Die Universiteit van die Werkersklas 1960-2010: die klem op studente
- Full Text: false
- Date Issued: 2016
- Authors: Thomas, Cornelius
- Date: 2016
- Language: Afrikaans
- Type: book chapter , text
- Identifier: http://hdl.handle.net/10962/59778 , vital:27648 , http://naledi.online/product/ons-kom-van-ver/
- Description: Die Universiteit van die Werkersklas 1960-2010: die klem op studente
- Full Text: false
- Date Issued: 2016
Emergence of Environment and Sustainability Education (ESE) in teacher education contexts in Southern Africa : a common good concern
- Mandikonza, Caleb, Lotz-Sisitka, Heila
- Authors: Mandikonza, Caleb , Lotz-Sisitka, Heila
- Date: 2016
- Subjects: Sustainable development -- Study and teaching -- South Africa , Environmental education -- South Africa , SADC Regional Environmental Education Programme
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/10962/59624 , vital:27632 , http://dx.doi.org/10.17159/2221-4070/2016/v5i1a7
- Description: Environmental and sustainability issues prevail in modern society. Southern Africa, where this study is based, is one of the regions most at risk from intersecting issues of climate health risk, and poverty-related ills. Education has the potential to facilitate catalytic transformation of society through development of understandings of these intersecting environment and sustainability concerns, and to support engagements in more sustainable social practices oriented towards the common good. This requires a rethinking of education within a wider common good frame. It also has implications for how quality education is considered. However, little is said of how this could be done, especially in teacher education. The paper shares two cases of teacher educators’ change project experiences, as they emerged via professional development support and the mediatory processes applied in courses conducted by the Southern African Development Community Regional Environmental Education Programme (SADC REEP) aimed at enhancing professional capacity of teacher educators and other environmental educators for mainstreaming environment and sustainability education (ESE)1. These courses are framed using a change project approach, and involve teacher educators as main participants. In-depth data were generated from interviews with two teacher educators, their assignment write-ups, and observations of their teacher education practice. Realist social theory, particularly the principle of emergence, was used to trace the emergence of change in teacher education practice. Sociocultural learning theory was used to explain mediation of learning-oriented changes in teacher education practice. We illustrate how the change project model and approach contributed to mediating change in practice, showing emergent attributes of capacity for mainstreaming ESE and elements of a concept of quality education among course participants oriented towards the common good. In conclusion, we argue that ESE seems to be a sensitising construct for initiating and sustaining change for ESE in teacher education. In addition, the change project has proved to be a potential vehicle for mainstreaming the notion and practice of ESE into social systems and teacher education practices. We argue that reflexive ESE praxis provides a sensitising focus, initiating quality education with humanising properties necessary for the common good.
- Full Text:
- Date Issued: 2016
- Authors: Mandikonza, Caleb , Lotz-Sisitka, Heila
- Date: 2016
- Subjects: Sustainable development -- Study and teaching -- South Africa , Environmental education -- South Africa , SADC Regional Environmental Education Programme
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/10962/59624 , vital:27632 , http://dx.doi.org/10.17159/2221-4070/2016/v5i1a7
- Description: Environmental and sustainability issues prevail in modern society. Southern Africa, where this study is based, is one of the regions most at risk from intersecting issues of climate health risk, and poverty-related ills. Education has the potential to facilitate catalytic transformation of society through development of understandings of these intersecting environment and sustainability concerns, and to support engagements in more sustainable social practices oriented towards the common good. This requires a rethinking of education within a wider common good frame. It also has implications for how quality education is considered. However, little is said of how this could be done, especially in teacher education. The paper shares two cases of teacher educators’ change project experiences, as they emerged via professional development support and the mediatory processes applied in courses conducted by the Southern African Development Community Regional Environmental Education Programme (SADC REEP) aimed at enhancing professional capacity of teacher educators and other environmental educators for mainstreaming environment and sustainability education (ESE)1. These courses are framed using a change project approach, and involve teacher educators as main participants. In-depth data were generated from interviews with two teacher educators, their assignment write-ups, and observations of their teacher education practice. Realist social theory, particularly the principle of emergence, was used to trace the emergence of change in teacher education practice. Sociocultural learning theory was used to explain mediation of learning-oriented changes in teacher education practice. We illustrate how the change project model and approach contributed to mediating change in practice, showing emergent attributes of capacity for mainstreaming ESE and elements of a concept of quality education among course participants oriented towards the common good. In conclusion, we argue that ESE seems to be a sensitising construct for initiating and sustaining change for ESE in teacher education. In addition, the change project has proved to be a potential vehicle for mainstreaming the notion and practice of ESE into social systems and teacher education practices. We argue that reflexive ESE praxis provides a sensitising focus, initiating quality education with humanising properties necessary for the common good.
- Full Text:
- Date Issued: 2016
Hoofletter K Kleurling - 'n besonderse Suid-Afrikaanse
- Authors: Thomas, Cornelius
- Date: 2016
- Language: Afrikaans
- Type: book chapter , text
- Identifier: http://hdl.handle.net/10962/59771 , vital:27647 , http://naledi.online/product/ons-kom-van-ver/
- Description: Hoofletter K Kleurling.
- Full Text: false
- Date Issued: 2016
- Authors: Thomas, Cornelius
- Date: 2016
- Language: Afrikaans
- Type: book chapter , text
- Identifier: http://hdl.handle.net/10962/59771 , vital:27647 , http://naledi.online/product/ons-kom-van-ver/
- Description: Hoofletter K Kleurling.
- Full Text: false
- Date Issued: 2016