- Title
- The design and synthesis of novel fluorescent coumarin-based derivatives as chemosensory for the application of toxic metal ion detection
- Creator
- Schoeman,Stiaan
- Subject
- Fluorescent polymers -- South Africa
- Subject
- Polymerization
- Subject
- Chemosensory
- Date Issued
- 2023-04
- Date
- 2023-04
- Type
- Master's theses
- Type
- text
- Identifier
- http://hdl.handle.net/10948/61270
- Identifier
- vital:69851
- Description
- The rise of humankind has caused pollution, increasing damage to the environment. The actions of humans over hundreds of years have led to an increase in the release of heavy metal cations in concentrations that are toxic to plants, animals and humans. These toxic metals can find their way into humans’ diets through water sources or bioaccumulation in plants and animals such as fish. Heavy metals such as lead and mercury are known to cause serious health issues when consumed, affecting the functioning of the circulatory and nervous systems and causing developmental disorders. Other metal cations, such as iron and copper, can be found in the human body. However, detrimental health issues can occur when normal concentrations are disturbed (either too high or too low). Iron, for example, can be toxic if in excess in the human body, causing damage to the liver and heart and can cause neuroinflammation and Alzheimer’s disease. Many methods have been employed to detect and measure the concentrations of toxic metal cations. However, these methods are performed in a laboratory and need skilled operators using expensive equipment. This results in long and tedious sample collection, long feedback time and costly analysis. Chemosensors have been researched and proposed as a cost-effective, on-site, real-time alternative for use as metal detectors. Chemosensory can selectively detect specific metal cations and can be sensitive up to the nanomolar range. Various chemosensors have been synthesised and screened for their colourimetric and fluorometric abilities. Colourimetric chemosensors can be used to visually detect cationic and anionic analytes, whereas fluorometric chemosensors are used to detect anions using their emission properties which handheld devices can measure.
- Description
- Thesis (PhD) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2023
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (295 pages)
- Format
- Publisher
- Nelson Mandela University
- Publisher
- Faculty of Science
- Language
- English
- Rights
- Nelson Mandela University
- Rights
- All Rights Reserved
- Rights
- Open Access
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Collections
NMU School of BioMolecular and Chemical Sciences
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Schoeman, S.pdf | 11 MB | Adobe Acrobat PDF | View Details Download |