Showing items 38281 - 38300 of 63372

On becoming literate in English: a literate life history study of selected Grade 12 learners in a Namibian secondary school

- Kangootui, Angela Lydia

  • Authors: Kangootui, Angela Lydia
  • Date: 2018
  • Subjects: English language -- Study and teaching (Secondary) -- Namibia -- Omaheke , Second language acquisition -- Omaheke , Language and languages -- Study and teaching -- Namibia -- Omaheke , Namibia. Ministry of Basic Education, Sport, and Culture
  • Language: English
  • Type: text , Thesis , Masters , MEd
  • Identifier: http://hdl.handle.net/10962/62252 , vital:28147
  • Description: This study sought to investigate English literate journeys of selected Grade 12 learners who come from educationally disempowering home backgrounds, and who ‘meet’ informal and/or formal exposure to English language mainly within the confines of school hours. Located within the qualitative, interpretive life history study design, the study used questionnaire and learners’ autobiographies to generate data. These data were then subjected to explore the literate journey of these learners in English as a second language through a comprehensive descriptive analysis. The study was conducted in an urban high school in Omaheke region, Namibia, and the research site and study participants were selected purposively. Theoretically, the study drew from Krashen’s (1981) Second Language Acquisition Theory, which offered this study the five hypotheses that were used as categories to generate, analyse, interpret and discuss data. Research findings reveal that, for various reasons discussed in the study, there is minimal parental involvement in the English literacy journey of their children at home. These include parents not reading regularly to their children, not encouraging visits to the library and the shortage of literacy materials such as newspapers and magazines. The educational level of parents is also a major contributing factor in the literacy journey of their children. The contribution of the community towards the literacy journey in English as a second language of these learners was minimal since the vernacular languages or Afrikaans were used to communicate. At the school level it was found that the attitude of some teachers was a hindrance, as was the way they taught. The use of the mother tongue during teaching also had an effect on the literacy development of the learners. Although the different methods used by various teachers at school level contributed in a way towards literacy development of the learners at school, the huge number of learners in the classrooms was a force to be reckoned with. It is hoped that the study’s findings will assist the Ministry of Basic Education Arts and Culture (MBEAC) in Namibia in informing the type of syllabus content and pedagogical practices to be utilised in teaching English as a Second Language.
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  • Date Issued: 2018

A study of mathematics teacher identity as shaped through participation in a mathematics teacher professional development programme

- Kangela, Nyameka

  • Authors: Kangela, Nyameka
  • Date: 2017
  • Subjects: Mathematics Teacher Enrichment Programme (MTEP) (Rhodes University) , Mathematics teachers -- Psychology , Mathematics teachers -- Psychology -- Case studies , Mathematics teachers -- Training of -- South Africa
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/7832 , vital:21305
  • Description: There is an abundance of evidence suggesting that all is not well in mathematics education in South Africa. It is also common cause that the role of mathematics teachers is central to finding sustainable solutions to what is commonly referred to as a mathematics crisis. The purpose of this study is to explore the process of change in selected mathematics teachers’ identities as they participated in a mathematics teacher Professional Development Programme (PDP) at Rhodes University. The core of the PDP was a teacher enrichment programme called the Mathematics Teacher Enrichment Programme (MTEP), under the aegis of the First Rand Foundation (FRF) Mathematics Education Chair at Rhodes University. MTEP foregrounded and emphasized the teaching of mathematics for conceptual understanding. The research approach was qualitative, and it used elements of the methods associated with educational ethnography. The data was collected from five teachers from five different schools that participated in the FRF Maths Chair project. I used Wenger’s (1998) three modes of belonging to analyse the identities of the five participants. This was achieved through analysing the teachers’ practice with a particular focus on teaching for conceptual understanding. I used Sfard & Prusak’s (2005) framework to analyse the participants’ journey from an actual to a designated identity through their participation in MTEP. The participants’ changing sense of belonging to MTEP was a key element in transforming their practice to teaching for conceptual understanding. I assumed the role of a participant observer during MTEP sessions, and of an outside observer as a researcher.The study found that the selected teachers’ participation in the MTEP community of practice strongly encouraged them to accumulate shared histories of learning and teaching. The study found that as participating teachers adopted and grew into their designated identity they partially embraced and implemented a conceptual teaching approach. The gap between their actual and their designated identity was partly closed as they sought to align their teaching with MTEP’s goal of conceptual teaching.
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  • Date Issued: 2017

Formulation development, manufacture and evaluation of hydralazine hydrochloride microspheres

- Kangausaru, Shakemore Tinashe

  • Authors: Kangausaru, Shakemore Tinashe
  • Date: 2017
  • Subjects: Hydralazine , Microspheres , Drugs Controlled release , Drugs Design , Drug development , Hypertension Chemotherapy
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/59220 , vital:27482
  • Description: Despite improvements in its detection and treatment since the 1970s, hypertension is the most common and important risk factor for cardiovascular diseases. Hypertension is a chronic condition often underdiagnosed and/or inadequately treated in Sub-Saharan Africa. Recent survey results illustrate that the condition continues to contribute significantly to mortality and morbidity in adults and that it is poorly controlled in clinical practice. Hydralazine (HYD) is used either alone or in combination for the management of chronic hypertension, chronic cardiac failure and hypertensive crises. Due to its short plasma half-life of between 2 to 4 hours, HYD is normally administered two to four times daily, therefore making it a potential candidate for inclusion in sustained release formulations. The formulation of sustained release microsphere dosage forms may be useful to improve patient adherence and to achieve predictable and optimised therapeutic plasma concentrations. A stability indicating reversed-phase high performance liquid chromatography (RP-HPLC) method for the quantitation of HYD in pharmaceutical dosage forms was developed and optimised using a Central Composite Design (CCD) approach. UV/Vis detection method was selected as HYD contains an ultraviolet light-absorbing chromophore. The method was validated with respect to linearity and range, limits of quantitation (LOQ) and detection (LOD), accuracy, precision, sensitivity, selectivity and specificity as per International Conference on Harmonisation (ICH) guidelines. The method was applied to commercially available HYD tablets. No interfering peaks were observed from excipients used in the commercially available tablets. Preformulation studies were conducted to ensure the manufacture of high quality, stable sustained release HYD microspheres. The results revealed that there was an interaction between HYD and Carbopol® 971P, therefore Carbopol® polymers were not included during formulation studies. HYD was found to be compatible with Methocel® K100LV, Eudragit® RS PO and Avicel® 101 and HYD formulations were developed and optimised using these excipients. An oil-in-oil (o/o) solvent evaporation technique was selected for the manufacture of HYD microspheres due to its simplicity and to avoid exposure of HYD to moisture that could have been encountered if a water-in-oil (w/o) manufacturing process was used. The selection of o/o solvent evaporation technique was also based on the hydrophilicity of HYD and the polymers selected. Different grades of Methocel® and Eudragit® were selected to evaluate their effect on encapsulation efficiency (EE), in vitro release and microparticle shape and morphology. The best combination of these polymers which resulted in the desired EE, in vitro release, microparticle shape and size were then selected for formulation optimisation. A numerical optimisation approach was used to predict a formulation composition that would produce minimal HYD release initially and maximum HYD release after 12 hours of dissolution testing. The release kinetics of HYD from the manufactured microspheres were established by fitting in vitro release data to several mathematical models. The in vitro release data for the optimised formulations was best described using Higuchi model. The short-term stability of the optimised formulations was established by undertaking stability studies at 4°C, 25 °C/60 % RH and 40 °C/75 % RH. The results revealed that there was no significant change in appearance and physicochemical properties of the microspheres over a period of one month. However, long-term stability studies would be required to determine the shelf-life of the formulations. In addition, a gas chromatographic (GC) method was selected for determining residual amounts of acetone and n-hexane in the optimised formulations. GC methods were developed and optimised by evaluation of process parameters. System suitability testing was performed with respect to resolution, theoretical number of plates and selectivity. Method validation was performed with respect to linearity, range, inter- and intra-day precision, retention time (Rt) precision, limit of quantitation (LOQ) and detection (LOD). A solvent extraction method was used to analyse residual solvents in the optimised formulations. The drying process was sufficient in evaporating acetone and n-hexane from the optimised formulations. Solvent evaporation technique has been successfully used in the manufacture of HYD microspheres. The microspheres have potential for further development, scale up formulation studies and long-term stability studies. , Thesis (MSc) -- Faculty of Pharmacy, Pharmacy, 2017
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  • Date Issued: 2017

Factors affecting the role of management accounting in manufacturing organisations in Namibia and in the Eastern Cape province of South Africa

- Kangala, Hendrina

  • Authors: Kangala, Hendrina
  • Date: 2016
  • Subjects: Managerial accounting -- Namibia , Managerial accounting -- South Africa -- Eastern Cape , Manufacturing industries -- Accounting
  • Language: English
  • Type: Thesis , Masters , MTech
  • Identifier: http://hdl.handle.net/10948/8318 , vital:26324
  • Description: Manufacturing is one of the important sectors needed to improve the economies of Namibia and South Africa. However, the manufacturing sectors of both countries are not performing as planned. Management accounting is one of the requirements needed for a successful organisation. With the aim of reducing costs, improving decision making, profits and customer satisfaction, the main role of management accounting in manufacturing companies of Namibia and the Eastern Cape Province of South Africa is to control cost, forecast and budget, make decisions, report internally, improve profits and manage working capital. This study used an online survey to examine the factors that affect the effectiveness of management accounting in executing this role. The findings of the study revealed that management accounting is affected by the external environment, developments in technology and customer satisfaction. It also found that organisational structure, relationships with stakeholders and management accounting reporting were internal factors affecting management accounting. Specific skills like numerical and analytical skills were also identified as important to the role of management accounting. Based on contingency and role theories, this research aims to find those factors which can be controlled to improve the effectiveness of management accounting systems in manufacturing organisations, and as a result improve the success of those organisations on which these systems are contingent.
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  • Date Issued: 2016

Alume yerani malo

- Kanga Mayele with Giryama men, Hugh Tracey

  • Authors: Kanga Mayele with Giryama men , Hugh Tracey
  • Date: 1950
  • Subjects: Giryama (African people) , Folk music--Kenya , Folk music , Field recordings , Africa, Sub-Saharan , Africa Kenya Malindi f-ke
  • Language: Giryama
  • Type: sound recordings , field recordings , sound recording-musical
  • Identifier: http://hdl.handle.net/10962/176603 , vital:42719 , International Library of African Music, Rhodes University, Grahamstown, South Africa , TR162-10
  • Description: The singer calls to those behind to hurry and catch up with the dance team as they are going to a big dance competition. This item is a fascinating example of the authentic 2 against 3 African cross rhythm. Msego dance song for men and women with Kayamba raft rattles and clapping (-12.03-).
  • Full Text: false
  • Date Issued: 1950

Achelamukani mulole Msego

- Kanga Mayele with Giryama men, Hugh Tracey

Safari ya Msanga-Tifu

- Kanga Mayele with Giryama men, Hugh Tracey

  • Authors: Kanga Mayele with Giryama men , Hugh Tracey
  • Date: 1950
  • Subjects: Giryama (African people) , Folk music--Kenya , Folk music , Field recordings , Africa, Sub-Saharan , Africa Kenya Malindi f-ke
  • Language: Giryama
  • Type: sound recordings , field recordings , sound recording-musical
  • Identifier: http://hdl.handle.net/10962/176612 , vital:42720 , International Library of African Music, Rhodes University, Grahamstown, South Africa , TR162-11
  • Description: "I was so much in love that I found myself in Msanga-Tifu, where my girl lives, without knowing how I had got there." The Msego dance is most attractive to watch and the ingenuity of the rhythm can be guessed from the sound of the dancers in this recording. Msego dance song for men and women with Kayamba raft rattles and clapping (-12.03-).
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  • Date Issued: 1950

Bwana Shanua kidzhere nguma inende

- Kanga Mayele with Giryama men, Hugh Tracey

  • Authors: Kanga Mayele with Giryama men , Hugh Tracey
  • Date: 1950
  • Subjects: Giryama (African people) , Folk music--Kenya , Folk music , Field recordings , Africa, Sub-Saharan , Africa Kenya Malindi f-ke
  • Language: Giryama
  • Type: sound recordings , field recordings , sound recording-musical
  • Identifier: http://hdl.handle.net/10962/176630 , vital:42722 , International Library of African Music, Rhodes University, Grahamstown, South Africa , TR162-13
  • Description: Bwana Shanua was an old singer famous in his day for inventing Juba dance steps. In this song they praise the old man for his cleverness. The facination of the Juba dance lies largely in the syncopated clapping which goes with it. Juba dance for men and women.
  • Full Text: false
  • Date Issued: 1950

Alume Yerani Malo

- Kanga Mayele and Giryama men, Composer not Specified, Tracey, Hugh

J iri ciande

- Kang'ethe Nduati with kikuyu boys, Hugh Tracey

Muthuu

- Kang'ethe Nduati with kikuyu boys, Hugh Tracey

'J' iri ciande

- Kang'ethe Nduati, Kikuyu boys, Composer not specified, Tracey, Hugh

Muthuu

- Kang'ethe Nduati, Kikuyu boys, Composer not specified, Tracey, Hugh

J iri ciande

- Kang' ethe Nduati, Kikuyu boys, Folk, Tracey, Hugh

Muthuu

- Kang' ethe Nduati, Kikuyu boys, Folk, Tracey, Hugh

Bulimia Nervosa: a case study in cognitive psychotherapy

- Kanfer, Josephine

  • Authors: Kanfer, Josephine
  • Date: 1990
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/192988 , vital:45287
  • Description: This project uses the case-study method to illustrate the application of integrating varied accepted modes of psychotherapeutic interventions. It concentrates on the first 22 out-patient sessions of therapy with a diagnosed bulimic, spanning a 6 month period. A brief summary of the subsequent 10 follow-up sessions is also given. The case presented is of a 22 year old female student diagnosed as bulimic (of 7 year duration), dysthymic and with a dependent personality disorder. She has symptoms of anxiety. She has a history of anorexia nervosa. Fairburn's (1985) cognitive-behavioural programme for bulimia was used initially. Its structured framework with the emphasis on the eating behaviour was an essential aspect in contributing to the success of the initial phase of the therapy. This patient had had previously experienced 8 sessions of non-directive depth psychotherapy which had confused and compounded her problems. The structure had provided her with a sense of control. In implementing the second stage of Fairburn's programme, where the focus is cognitive, the patient could no longer work in this this structured manner. The attempts to implement the standard cognitive techniques provided the catalyst for activating deeper underlying emotions and cognitions. Furthermore, this gave impetus to work actively with the interpersonal aspect of the therapeutic relationship. Young's (1989) model for identifying Early Maladaptive Schemas could be applied. The focus then moved from the behaviours and dealt with these schemas as activated in the therapeutic relationship. The patient was able to make links to her family and her past. The therapy proved successful, as not only were the behavioural symptoms alleviated, but also the patient's interpersonal problems which underlay her personality disorder were accessed. The patient had become more self-assertive, her mood had improved considerably, she was less concerned with body image and more accepting of herself. She had become more reality based and her interpersonal relational abi1ity had improved. , Thesis (MA) -- Faculty of Humanities, Psychology, 1990
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  • Date Issued: 1990

Phenylpropanolamine hydrochloride

- Kanfer, Isadore, Haigh, John M, Dowse, Roslind

  • Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
  • Date: 1983
  • Language: English
  • Type: Article
  • Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
  • Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
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  • Date Issued: 1983

Pharmacokinetics of cyclizine following intravenous administration to human volunteers

- Kanfer, Isadore, Walker, Roderick B

  • Authors: Kanfer, Isadore , Walker, Roderick B
  • Date: 1996
  • Subjects: To be catalogued
  • Language: English
  • Type: text , article
  • Identifier: http://hdl.handle.net/10962/184389 , vital:44214 , xlink:href="https://doi.org/10.1016/0928-0987(96)00177-7"
  • Description: The pharmacokinetics of cyclizine, a piperazine derivative useful in the prevention and treatment of nausea and vomiting, was investigated in six healthy male volunteers following an intravenous bolus dose. The drug is extensively distributed with a mean volume of distribution of 16.50 ± 3.33 l/kg and a mean total clearance of 0.870 ± 0.105 l/h per kg. Urinary excretion data showed that less than one percent of the dose was excreted up to 36 h as unchanged drug in the urine. The extremely low mean renal clearance (0.005 ± 0.002 l/h per kg) for the parent drug comprised only a small proportion of total clearance indicating that urinary excretion of parent drug is not a major route of elimination for cyclizine. The drug appears to exhibit biexponential pharmacokinetics and has a terminal elimination half-life of approximately 13 h.
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  • Date Issued: 1996

Analysis of macrolide antibiotics

- Kanfer, Isadore, Skinner, Michael F, Walker, Roderick B

  • Authors: Kanfer, Isadore , Skinner, Michael F , Walker, Roderick B
  • Date: 1998
  • Language: English
  • Type: Article , text
  • Identifier: vital:7011 , http://hdl.handle.net/10962/d1008394 , http://www.sciencedirect.com/science/article/pii/S0021967398002763
  • Description: The following macrolide antibiotics have been covered in this review: erythromycin and its related substances, azithromycin, clarithromycin, dirithromycin, roxithromycin, flurithromycin, josamycin, rokitamycin, kitasamycin, mycinamycin, mirosamycin, oleandomycin, rosaramicin, spiramycin and tylosin. The application of various thin-layer chromatography, paper chromatography, gas chromatography, high-performance liquid chromatography and capillary zone electrophoresis procedures for their analysis are described. These techniques have been applied to the separation and quantitative analysis of the macrolides in fermentation media, purity assessment of raw materials, assay of pharmaceutical dosage forms and the measurement of clinically useful macrolide antibiotics in biological samples such as blood, plasma, serum, urine and tissues. Data relating to the chromatographic behaviour of some macrolide antibiotics as well as the various detection methods used, such as bioautography, UV spectrophotometry, fluorometry, electrochemical detection, chemiluminescence and mass spectrometry techniques are also included.
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  • Date Issued: 1998

Interactions between steroidal anti-inflammatory agents and collagen

- Kanfer, Isadore

  • Authors: Kanfer, Isadore
  • Date: 1975
  • Subjects: Anti-inflammatory agents Collagen
  • Language: English
  • Type: Thesis , Doctoral , PhD
  • Identifier: vital:3849 , http://hdl.handle.net/10962/d1012620
  • Description: Much research has been done on the formation of fibrils from solutions of soluble collagen in vitro in order to gain some knowledge of the mechanisms which may occur in vivo. The in vitro formation of fibres from solutions of collagen has been shown to be extremely sensitive to the nature of the solution environment and the presence of added chemical compounds, and thus constitutes an interesting system for the study of collagen-small molecule inter actions. The present study is concerned with the effects of various corticosteroid drugs, used medicinally as anti-inflammatory agents, on collagen in solution. As these corticosteroids are administered to reduce inflammation in conditions such as rheumatoid arthritis and a host of other pathological conditions in which collagen is implicated, this work has been undertaken in order to establish and charac teri ze any binding mechanisms which may be involved. Furthermore, the corticosteroid drugs available commercially in pure form as the free base or as the water-soluble ester salts offer an interesting range of structural and stereochemical variants for the study of their reaction with a complex and biologically important protein molecule such as collagen. A great deal of research on drug- protein interactions (Goldstein, 1949; Meyer and Guttman, 1968a) and more specifically, steroid-protein interactions have been reported over the years (Daughaday, 1959; Sandberg et al., 1966; Villee and Engel, 1961; Westphal , 1971). Comprehensive reports, however, on steroid-collagen interactions in vitro are conspicuously absent from modern scientific literature although relatively superficial accounts have been published (Menczel and Maibach, 1972; Eik-Nes et al., 1954). Although work involving the above has appeared relating specifically to the effects of steroids on collagen biosynthesis both in vivo and in vitro there have been minimal accounts of steroid-collagen interactions tailored to characterize the binding at the molecular level. The effect of corticosteroids on the metabolism of connective tissue has also received special attention (Asboe-Hansen, 1959; Kivirikko, 1953; Nakagawa and Tsurufuji, 1972). Recently, Uitto et al. (1972) reported the effects of several anti-inflammatory corticosteroids on collagen biosynthesis in vitro, whilst Aalto and Kulonen (1972) reported the effects of several antirheumatic drugs on the synthesis of collagen and other proteins in vitro. The interactions between collagen and certain drugs has also been briefly reviewed (Chvapil, 1967). Much data also exists on the binding of a wide range of small molecules and ions with serum albumin (Steinhardt and Reynolds, 1969; Scatchard, 1949; Klotz, 1950). Serum albumin, being specialized for a very general transport function and apparently designed for the purpose of combining with a large range of small molecules, has a proportion of possible reactive sites 'buried' within the molecule itself because of its folded conformation. In addition, serum albumin shows a high degree of cooperative binding in contrast to collagen. The latter molecule, with its larger molecular size and weight is specialized for a biologically structural function and has a higher proportion of possible reactive sites which appear relatively more accessible to ligands. A study of the interactions between corticosteroids and collagen thus provides the opportunity to investigate a protein which is very different from the much studied serum albumin. Because of the limited information available regarding the interaction of steroid drugs and collagen at the molecular level, studies of this nature are relevant to the understanding of the mode of action of steroid compounds which are such an important group of therapeutic substances used in modern medicine.
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  • Date Issued: 1975
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