Are CardioVascular Diseases a Cause For Concern in People of African Ancestry?
- Authors: Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2022-00
- Subjects: Cardiovascular system--Diseases--Treatment
- Language: English
- Type: Inaugural Lecture , text
- Identifier: http://hdl.handle.net/11260/8030 , vital:59356
- Description: Professor Benedicta Ngwenchi Nkeh-Chungag’s BIO Professor Benedicta Ngwenchi Nkeh-Chungag is a Full Professor of Physiology and Dean of the Faculty of Natural Sciences, Walter Sisulu University. Professor Nkeh-Chungag is an NRF rated researcher, a scholar of the Organization for Women in Science for the Developing World (OWSD), a Fellow of the International Hypertension Society, Deputy President and co-founder of the newly established Childhood Hypertension Consortium of South Africa, Deputy Chairperson of the South African National Committee for International Union for Physiological Sciences (ICSU-IUPS), Chairperson of the Cardiometabolic Research Niche Area – WSU and Chairperson of the Animal Research Ethic Committee. She oversees the Carrier Orientation and International Mentoring Program run by Harness Ideas Association (HIDAS).Professor Nkeh-Chungag has published extensively in the of cardiovascular research covering epidemiology and African medicinal plants. She has served as an Associate Editor for the journal Frontiers in Public Health and is on the editorial board of two journals, Bioinformatics and Clinical Interventions in Aging. She is a member of several knowledge bodies including the International Hypertension Society.As an accomplished and passionate scholar, Professor Nkeh-Chungag enjoys both national and international recognition in her field of research. Her focus on the risk for cardiovascular diseases in children of African ancestry has attracted interest and funding from both national and international organizations. Her research findings have been showcased at many scientific fora including as keynote addresses. Professor Nkeh-Chungag is married to Dr Anye Chungag and they are blessed with four boys. , Inaugural Lecture (Prefessorial) -- Faculty of Natural Sciences, 2022
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- Date Issued: 2022-00
Researcher Profile and List of Publications - Oyedeji.pdf
- Authors: Oyedeji, Adebola Omowunmi
- Identifier: http://hdl.handle.net/11260/4791 , vital:44254
- Description: Expertise: Organic chemistry-Natural Product Chemist
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Professor
- Authors: Oyedeji, Adebola Omowunmi
- Type: Researcher Profile
- Identifier: http://hdl.handle.net/11260/2721 , vital:42330
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Shuali Mathulo M Researcher Profile and List of Publications .pdf
- Authors: Shuali Mathulo, M
- Identifier: http://hdl.handle.net/11260/4823 , vital:44263
- Description:
Expertise:
Biomedical Research—Histology/medicinal plants
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s12872-021-02130-2.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7674 , vital:54760
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Phytochemical composition, and analgesic and antiinflammatory properties of essential oil of Chamaemelum nobile (Asteraceae L All) in rodents
- Authors: Adebola O Oyedeji , Benedicta N Nkeh-Chungag
- Date: 2017
- Identifier: http://hdl.handle.net/11260/1496 , vital:37761
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Biosynthesis of silver nanoparticles from Acacia mearnsii De Wild stem bark and its antinociceptive properties
- Authors: Avoseh, Opeyemi N , Oyedeji, Opeoluwa O , Aremu, Olukayode , Nkeh-Chungag, Benedicta N , Songca, Sandile P , Oyedeji, Adebola Omowunmi , Mohan, Sneha , Oluwafemi, Oluwatobi S
- Date: 2017
- Subjects: Metal nanoparticles , Acacia mearnsii , Nociceptive pain
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/1528 , vital:37774 , https://doi.org/10.1080/17518253.2017.1287310
- Description: The biosynthesis of silver nanoparticles (Ag-NPs) using the hydrosol extract of the dry stem bark of Acacia mearnsii as reducing and capping agents, and their antinociceptive properties are hereby reported. By varying the temperature and reaction time, the temporal evolution of the optical and morphological properties of the as-synthesized material was investigated. The NPs were characterized by UV–visible absorption spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive x-ray spectroscopy (EDS) and x-ray diffractometry (XRD) The optical analyses show that the position of the maximum surface plasmon resonance (SPR) peak is red-shifted as the reaction temperature decreased. The TEM micrographs show that the as-synthesized Ag-NPs are spherical while the X-ray diffraction shows that the material is highly crystalline with face-centered cubic structures. The anti-inflammatory efficacy, analyzed by the formalin model, indicates that the as-synthesized Ag-NPs are very effective, with an inhibition rate of about 76%.
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- Date Issued: 2017
Ellisras Longitudinal Study 2017: association of hypertension with increasing levels of adiposity in 10- to 14-year-old boys and girls in the Eastern Cape (ELS 31)
- Authors: CM Tata
- Date: 2019
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/5128 , vital:44352
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Prevalence of metabolic syndrome in adolescents living in Mthatha, south africa
- Authors: Sekokotla, Annah , Goswami, Nandu , Sewani-Rusike, Constance Rufaro , Iputo, Jehu Erapu , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2017
- Subjects: South Africa Metabolic syndrome Journal article
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5983 , vital:45061 , xlink:href="https://doi:10.2147/TCRM.S124291"
- Description: Objective Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa. Research design and methods Four hundred and ten adolescents (age range: 13–18 years, both sexes) were recruited into this cross-sectional study. In addition to a lifestyle questionnaire being administered, anthropometric measurements (weight, height and waist circumferences) were carried out for each participant. Fasting venous blood was collected for lipid profile and blood glucose assessments. Blood pressure was also measured. MetS was assessed using appropriate diagnostic criteria for children and adolescents. Results Complete data sets were collected from 371 participants. Females showed an elevation in the risk factors for MetS. Of the 371 participants, 40.2% were overweight/obese (47.5% females; 22.5% males). MetS was diagnosed in 3.1% female participants compared with 6.0% in male participants. Conclusions More risk factors for the MetS are seen among the overweight/obese as compared to lean adolescents. Given the fact that childhood overweight/obesity often continues into adulthood, it is important to address the causes of increased risk for MetS earlier in life to prevent the development of disease in adult life.
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- Date Issued: 2017
Biological evaluation and semi-synthesis of Isolated compounds from (Syzygium aromaticum (L.) Merr. & Perry) Buds
- Authors: Sibusiso, Rali
- Date: 2014
- Language: English
- Type: Thesis , Masters , MSc (Chemistry)
- Identifier: vital:11352 , http://hdl.handle.net/10353/d1021140
- Description: Natural products play a fundamental role in modern drug discovery as they continue providing diverse bioactive lead compounds for new drug formulation. However, isolation of these valued compounds is problematic. On the other hand, the morbidity and mortality rates caused by non-communicable diseases are increasing with improved longevity. Thus, the study herein focused on the isolation of plant-derived compounds from Syzygium aromaticum and evaluated their biological properties. Syzygium aromaticum is a well-known plant which belongs to family Myrtaceae. Dried flower buds of S. aromaticum were subjected to sequential solvent extraction. The ethyl acetate extract (15.535 g) was subjected to column chromatography using a silica gel (0.063-0.200 mm) for isolation. This has led to the isolation of three distinct compounds that were identified as eugenol, maslinic acid (MA) and oleanolic acid (OA). The structural elucidation of these valued compounds was done using NMR, GC-MS, LC-MS, FT-IR and Mp. Further semi-synthesis of the oleanolic acid afforded acetate and ester OA-derived compounds with better solubility properties. All these compounds were evaluated for analgesic and anti-inflammatory properties. All tested compounds were administered at a dose of 40 mg/kg to both Wistar rats and Swiss mice. Significant (p<0.01) analgesic and anti-inflammatory properties are obtained for all compounds. The effects of eugenol in all experiment were better except in the thermal-induced pain or tail flick test. In the case of modified compounds, the formalin induced pain test disclosed that oleanane derived compounds confessed analgesic and anti-inflammatory effects better than OA, whereas, in tale flick test oleanolic acid proved superior analgesic effects compared to all its derivatives with the exception of the acetyl-derivative. Acute anti-inflammatory test showed that acetyl-derivatives were more active than other compounds. In conclusion, chromatographic techniques and semi-synthesise of oleanolic acid have resulted to several plant-derived compounds with analgesic and anti-inflammatory properties. The semi-synthesized compounds may serve as alternative drug candidates for new analgesic and anti-inflammatory drug formulation
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- Date Issued: 2014
Mxinwa MSc Cover & Abstract.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7873 , vital:55151
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Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides
- Authors: Constance Rufaro Sewani-Rusike
- Date: 2019
- Language: English
- Type: Journal
- Identifier: http://hdl.handle.net/11260/5135 , vital:44353
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Volatile constituents and biological activities of the leaf and root of Echinacea species from South Africa
- Authors: M. Nyalambisa, , I.A. Oyemitan , B.N. Nkeh-Chungag , A.O. Oyedeji
- Date: 2016
- Identifier: http://hdl.handle.net/11260/1568 , vital:37788
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Cardiometabolic risk factors and early indicators of vascular dysfunction: a cross-sectional cohort study in South African adolescents
- Authors: Letswalo, Boitumelo Prescilla , Schmid-Zalaudek, Karin , Brix, Bianca , Matjuda, Edna Ngoakoana , Klosz, Fabian , Obernhumer, Natalie , Gaisl, Michael , Engwa, Godwill Azeh , Sewani-Rusike, Constance , Fredriksen, Per Morten , Nkeh-Chungag, Benedicta , Goswami, Nandu
- Date: 2021
- Language: English
- Type: Journal article
- Identifier: http://hdl.handle.net/11260/3864 , vital:43959
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The prevalence of pediatric metabolic syndrome—a critical look on the discrepancies between definitions and its clinical importance
- Authors: Carolin Reisinger , Benedicta N. Nkeh-Chungag , Per Morten Fredriksen , Nandu Goswami
- Date: 2020
- Language: English
- Type: article
- Identifier: http://hdl.handle.net/11260/4347 , vital:44107
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Volatile constituents and biological activities of the leaf and root of Echinacea species from South Africa
- Authors: M. Nyalambisa , S.P. Songca , A.O. Oyedeji , I.A. Oyemitan
- Date: 2017
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/5543 , vital:44602
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e042955.full.pdf
- Authors: Adelin Kantore
- Identifier: http://hdl.handle.net/11260/7709 , vital:54742
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Acute toxicity study and prevention of Nω-nitro-L-arginine methyl ester-induced hypertension by Osteopermum imbricatum
- Authors: Tata, Charlotte, M , Gwebu, Ephraim, T , Olukayode O Aremu , Nkeh-Chungag, Benedicta, N , Oyedeji, Adebola, O , Oyedeji, Opeopluwa, O , Sewani-Rusike, Constance, R
- Date: June-2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/4915 , vital:44303 , https://www.ajol.info/index.php/tjpr/article/view/174343
- Description: Purpose:To determine the phytochemical content, toxicity and hypertension prevention effects of Osteospermum imbricatum leaf and root extracts.Methods:Phytochemical screening of leaf and root extracts of O. imbricatum was performed by colorimetric procedure. Acute toxicity of leaf and root extracts was conductedin two phases; phase I consisted of three groups of mice (n = 3) for each dose level of 10, 100 and 1000 mg/kg while phase II had three mice that received 1600, 2900 or 5000 mg/kg. Wistar rats were grouped into 7 groups that were co-treated with L-NAME and normal saline or L-NAME and hydroethanolic leaf extract (150 and 300 mg/kg) or L-NAME and hydroethanolic root extract (150 and 300 mg/kg) or L-NAME and amlodipine (5 mg/kg) or normal saline only for 4 weeks. Treatment was carried out via the oral route while blood pressure was measured weeklyfor 4 weeks by non-invasive tail cuff method.Results:The phytochemical profile of the leaf and root extracts revealed the presence of phenols, terpenoids, flavonoids, glycosides, tannins, steroids and saponins. Both the leaf and root extracts were toxic at 5000 mg/kg with an LD50of 3807.89 mg/kg. In the fourth week of the study, only the leaf extract significantly (p less 0.01) prevented the progression of L-NAME induced hypertension; systolic and diastolic blood pressure of the group treated with L-NAME and leaf extract (300 mg/kg) were 183 ± 1 and 140 ± 1 mmHg, respectively, compared to the group that was treated with L-NAME and normal saline which produced systolic and diastolic BP values of 213 ± 3 and 172 ± 4 mmHg, respectively. The extracts, especially OIR300, exhibited diuretic effects in the second and third week of study by promoting excretion of 16 and 19 ml urine, respectively, compared to 11 and 14 ml for LN group.Conclusion:The results suggest that O. imbricatum is moderately toxic at a high dose and contains a wide range of phytochemicals which offer partial protection against the development of nitric oxide deficiency hypertension.
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- Date Issued: June-2018
Antihypertensive effects of the hydroethanol extract of Senecio serratuloides DC in rats
- Authors: Tata, Charlotte Mungho , Sewani-Rusike, Constance Rufaro , Oyedeji, Opeoluwa Oyehan , Gwebu, Ephraim Tobela , Mahlakata, Fikile , Nkeh-Chungag, Benedicta Ngwenchi
- Date: 2019
- Subjects: South Africa Hypertension Computer File
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/5847 , vital:44656 , https://doi.org/10.1186/s12906-019-2463-2
- Description: Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. Methods: Acute toxicity of HESS was first determined to provide guidance on doses to be used in this study. Lorke’s method was used to determine safety of the extract in mice. Female Wistar rats were treated orally once daily with L-NAME (40 mg/kg) for 4 weeks and then concomitantly with L-NAME (20 mg/kg) and plant extract (150 and 300 mg/kg), captopril (20 mg/kg) or saline as per assigned group for 2 weeks followed by a 2-week period of assigned treatments only. Blood pressure was monitored weekly. Lipid profile, nitric oxide, renin and angiotensin II concentrations were determined in serum while mineralocorticoid receptor concentration was quantified in the kidney homogenate. Nitric oxide (NO) concentration was determined in serum and cardiac histology performed. Results HESS was found to be non-toxic, having a LD50 greater than 5000 mg/kg. Blood pressure increased progressively in all animals from the second week of L-NAME treatment. HESS treatment significantly and dose-dependently lowered systolic blood pressure (p less 0.001), diastolic blood pressure (p less 0.01), low density lipoprotein cholesterol (p less 0.01) and triglycerides (p less 0.01). It significantly prevented L-NAME induced decrease in serum angiotensin II (p less 0.01), high density lipoprotein cholesterol (p less 0.001) and serum nitric oxide concentrations (p less 0.001). HESS also significantly (p less 0.01) prevented collagen deposition in cardiac tissue. Conclusion The hydro-ethanol extract of Senecio serratuloides showed antihypertensive, antihyperlipidemic and cardioprotective effects in rats thus confirming its usefulness in traditional antihypertensive therapy and potential for antihypertensive drug development.
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- Date Issued: 2019
Antihypertensive effects of the hydroethanol extract of Senecio serratuloides DC in rats
- Authors: Benedicta Ngwenchi Nkeh-Chungag
- Date: 2019
- Language: English
- Type: Article
- Identifier: http://hdl.handle.net/11260/5216 , vital:44380
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