Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum

Knott, Michael G; de la Mare, Jo-Anne; Edkins, Adrienne L; Zhang, Angel; Stillman, Martin J; Bolton, John J; Antunes, Edith M; Beukes, Denzil R

Title: Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum
Creator: Knott, Michael G
Creator: de la Mare, Jo-Anne
Creator: Edkins, Adrienne L
Creator: Zhang, Angel
Creator: Stillman, Martin J
Creator: Bolton, John J
Creator: Antunes, Edith M
Creator: Beukes, Denzil R
Date Issued: 2019
Date: 2019
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/164446
Identifier: vital:41119
Identifier: https://doi.org/10.1016/j.phytol.2018.12.009
Description: The endemic South African red seaweed Plocamium maxillosum (Poiret) Lamouroux produces two unusual isomeric dichlorinated cyclohexenone monoterpenes, plaxenone A and B (1 and 2). The structures of the isolated compounds were determined from spectroscopic data and their absolute configuration was determined by comparison of the experimental and calculated ECD spectra. Compounds 1 and 2 inhibit the growth of MDA-MB-231 breast cancer cells.
Format: 4 pages
Format: pdf
Language: English
Relation: Phytochemistry Letters
Relation: Knott, M.G., de la Mare, J.A., Edkins, A.L., Zhang, A., Stillman, M.J., Bolton, J.J., Antunes, E.M. and Beukes, D.R., 2019. Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. Phytochemistry Letters, 29, pp.182-185
Relation: Phytochemistry Letters volume 29 number 182 185 February 2019 1874-3900
Rights: Publisher
Rights: Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

RU Department of Biochemistry, Microbiology and Biotechnology

De la Mare, Jo-Anne (Dr)

RU Department of Pharmacy

Edkins, Adrienne Lesley (Associate Prof)

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