- Title
- Theoretical and photodynamic therapy characteristics of heteroatom doped detonation nanodiamonds linked to asymmetrical phthalocyanine for eradication of breast cancer cells
- Creator
- Matshitse, Refilwe
- Creator
- Tshiwawa, Tendamudzimu
- Creator
- Managa, Muthumuni
- Creator
- Nwaji, Njemuwa
- Creator
- Lobb, Kevin A
- Creator
- Nyokong, Tebello
- Subject
- To be catalogued
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/186089
- Identifier
- vital:44462
- Identifier
- xlink:href="https://doi.org/10.1016/j.jlumin.2020.117465"
- Description
- An amide mono substituted benzothiozole phthalocyanine: zinc(II) 3-(4-((3,17,23-tris(4-(benzo [d]thiazol-2-yl)phenoxy)-9-yl)oxy) phenyl)amide phthalocyanine (NH2BzPc) was covalently linked to undoped and heteroatom doped detonation nanodiamonds (DNDs): B@DNDs, P@DNDs, S@DNDs, N@DNDs, and SandN@DNDs There is a drastic decrease in highest occupied molecular orbital (HOMO) – lowest unoccupied molecular orbital (LUMO) energy gaps for nanoconjugates compared to DNDs alone. B@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc, and P@DNDs-NH2BzPc showed superior photodynamic therapy (PDT) effects. DNDs-NH2BzPc also had a small HOMO-LUMO gap, but did not show improved PDT activity compared to the Pc alone, suggesting doping of DNDs is important. This study shows improved PDT effect on Michigan Cancer Foundation-7 breast cancer lines at 7.63%, 7.62% and 6.5% cell viability for P@DNDs-NH2BzPc, SandN@DNDs-NH2BzPc and B@DNDs-NH2BzPc, respectively.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (15 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- Journal of Luminescence
- Relation
- Matshitse, R., Tshiwawa, T., Managa, M., Nwaji, N., Lobb, K. and Nyokong, T., 2020. Theoretical and photodynamic therapy characteristics of heteroatom doped detonation nanodiamonds linked to asymmetrical phthalocyanine for eradication of breast cancer cells. Journal of Luminescence, 227, p.117465
- Relation
- Journal of Luminescence volume 227 p. 117465 2020 0022-2313
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Tshiwawa, Tendamudzimu (Dr)
Nyokong, Tebello (Distinguished Professor)
RU DST/NRF SARChI for Medicinal Chemistry and Nanotechnology
RU Department of Chemistry
Lobb, Kevin Allan (Assoc Prof)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Theoretical and photodynamic therapy characteristics.pdf | 843 KB | Adobe Acrobat PDF | View Details Download |