A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat
- Authors: Skeef, Noel S , Duncan, John R
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6473 , http://hdl.handle.net/10962/d1006154 , http://dx.doi.org/10.1079/BJN19880052
- Description: The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.
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- Date Issued: 1988
Article by Ronald Atkins
- Authors: Atkins, Ronald
- Date: 1988
- Subjects: Brotherhood of Breath (Musical group) , McGregor, Chris -- 1936-1990 , Country cooking -- 1988 -- label (Brotherhood of Breath) , Marsalis, Wynton -- 1961- , Westbrook, Mike , Corea, Chick , Wilkerson, Edward
- Language: English
- Type: Article
- Identifier: vital:13464 , http://hdl.handle.net/10962/d1001330 , Brotherhood of Breath (Musical group) , McGregor, Chris -- 1936-1990 , Country cooking -- 1988 -- label (Brotherhood of Breath) , Marsalis, Wynton -- 1961- , Westbrook, Mike , Corea, Chick , Wilkerson, Edward
- Description: Photocopied article by Ronald Atkins about new releases by Mike Westbrook, Chris McGregor, Wynton Marsalis, Chick Corea and Edward Wilkerson. The author describes shortly each recording.
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- Date Issued: 1988
Comparison of the blanching activities of Dermovate, Betnovate and Eumovate creams and ointments
- Authors: Meyer, Eric , Magnus, Ashley D , Haigh, John M , Kanfer, Isadore
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6393 , http://hdl.handle.net/10962/d1006315
- Description: The human skin blanching assay was used to determine the blanching activities of Dermovate, Betnovate and Eumovate creams and ointments. Dermovate was found to elicit a superior blanching response to Betnovate which in turn elicited a superior blanching response to Eumovate, except in the comparison of Betnovate and Eumovate ointments under occlusion. The importance of employing the correct methodology of the blanching assay is emphasized and the good correlation between the results of this study and clinical trials is indicated.
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- Date Issued: 1988
Computer modelling of ore body formation by a multi-disciplinary approach : some initial results
- Authors: Rice, A
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6741 , http://hdl.handle.net/10962/d1007557
- Description: Reports on the initial efforts of a computational programme at Rhodes University in Cape Province, South Africa to model the formation of mineral deposits in the country. Initial results pertaining to the cooling of buried bodies of molten rock; Contribution to a better margin of success for South African mineral industries.
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- Date Issued: 1988
Dilution of topical corticosteroid formulations
- Authors: Haigh, John M
- Date: 1988
- Language: English
- Type: text , Article
- Identifier: vital:6377 , http://hdl.handle.net/10962/d1006295
- Description: It has been a long-held concern of a number of people working in this field that some dermatologists prescribing a 1:10 dilution of a corticosteroid preparation such as Dermovate cream believe that the final product will be one tenth as efficacious and also produce one tenth of the side effects as the undiluted formulation. This is certainly not the case. Dermovate falls into the very potent category of topical corticosteroid preparations (as defined in the United Kingdom Monthly Index of Medical Specialities) and a 1:10 dilution falls into the potent category.
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- Date Issued: 1988
Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilizing the human skin-blanching assay
- Authors: Meyer, Eric , Smith, Eric W , Haigh, John M , Kanfer, Isadore
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6400 , http://hdl.handle.net/10962/d1006327
- Description: The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halomethasone cream falls into the moderately potent group.
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- Date Issued: 1988
The Mfecane as alibi : thoughts on Dithakong and Mbolompo
- Authors: Cobbing, Julian
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6154 , http://hdl.handle.net/10962/d1007067
- Description: The ‘mfecane’ is a characteristic product of South African liberal history used by the apartheid state to legitimate South Africa's racially unequal land division. Some astonishingly selective use or actual invention of evidence produced the myth of an internally-induced process of black-on-black destruction centring on Shaka's Zulu. A re-examination of the ‘battles’ of Dithakong and Mbolompo suggests very different conclusions and enables us to decipher the motives of subsequent historiographical amnesias. After about 1810 the black peoples of southern Africa were caught between intensifying and converging imperialistic thrusts: one to supply the Cape Colony with labour; another, at Delagoa Bay, to supply slaves particularly to the Brazilian sugar plantations. The flight of the Ngwane from the Mzinyathi inland to the Caledon was, it is argued, a response to slaving. But they ran directly into the colonial raiding-grounds north of the Orange. The (missionary-led) raid on the still unidentified ‘Mantatees’ (not a reference to MaNtatisi) at Dithakong in 1823 was one of innumerable Griqua raids for slaves to counter an acute shortage of labour among Cape settlers after the British expansionist wars of 1811–20. Similar Griqua raids forced the Ngwane south from the Caledon into the Transkei. Here, at Mbolompo in 1828, the Ngwane were attacked yet again, this time by a British army seeking ‘free’ labour after the reorganisation of the Cape's labour-procurement system in July 1828. The British claim that they were parrying a Zulu invasion is exposed as propaganda, and the connexions between the campaign and the white-instigated murder of Shaka are shown. In short, African societies did not generate the regional violence on their own. Rather, caught within the European net, they were transformed over a lengthy period in reaction to the attentions of external plunderers. The core misrepresentations of ‘the mfecane’ are thereby revealed; the term, and the concept, should be abandoned.
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- Date Issued: 1988