A ring-closing metathesis approach to eight-membered benzannelated scaffolds and subsequent internal alkene isomerizations
- Authors: Taher, Abu , Aderibigbe, Blessing A , Morgans, Garreth L , Madeley, Lee G , Khanye, Setshaba D , Van der Westhuizen, Leandi , Fernandes, Manuel A , Smith, Vincent J , Michael, Joseph P , Green, Ivan R , Van Otterlo, Willem A L
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66252 , vital:28925 , https://doi.org/10.1016/j.tet.2012.12.043
- Description: publisher version , A set of eight-membered benzannelated heterocycles containing two heteroatoms (O,O, NR,NR and O,NR where R=protecting group) was synthesized by ring-closing metathesis from the corresponding ortho-bis-allyl precursors. In this manner, 7-methoxy-2,5-dihydro-1,6-benzodioxocine, 1,2,5,6-tetrahydro-1,6-benzodiazocines, 5,6-dihydro-2H-1,6-benzoxazocines and 5,6,9,10-tetrahydropyrido[2,3-b][1,4]diazocine were synthesized. A number of these compounds were then treated with the catalyst [RuClH(CO)(PPh3)3] to facilitate isomerization of the alkene into conjugation with the heteroatoms in the eight-membered ring. Quite surprisingly, an equal ratio of regioisomers was obtained, even if the heteroatoms were different.
- Full Text: false
- Date Issued: 2013
Farewell to Lawrence Schlemmer: initiator of quality-of-life studies in South Africa
- Authors: Moller, Valerie
- Date: 2013
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67175 , vital:29055 , https://doi.org/10.1007/s11205-011-9965-8
- Description: publisher version , Professor Lawrence Schlemmer, affectionately known as Lawrie, was the father of South Africa’s quality-of-life studies and social indicators movement. He died on 26 October 2011 at the age of 75 after a short illness. In 1978, Lawrence marched into my office at the Centre for Applied Social Sciences, University of Natal, brandishing two books. We need to do some work on quality of life in South Africa, he announced, before handing me the volumes. At the time, South Africa’s leaders assumed that smiling black faces meant that South Africans were happy with their lot in life under apartheid. Our surveys were to prove otherwise. That weekend was spent reading cover to cover the classic works by Frank Andrews, Angus Campbell and their colleagues. The next week we pored over lists of concerns voiced by South Africans which we later put to test in the field. In 1982, we submitted our findings by ‘slug’ post to the editor of Social Indicators Research. We received a letter by return mail from Alex Michalos to say he would publish our paper and we should not be too disappointed with our regression results!
- Full Text: false
- Date Issued: 2013